Conserved Protein Domain Family
DUF2009

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pfam09418: DUF2009 
Protein of unknown function (DUF2009)
This is a eukaryotic family of proteins with unknown function.
Statistics
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PSSM-Id: 401392
Aligned: 40 rows
Threshold Bit Score: 581.056
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004180058 156 SFIPMRLTYEERYLLKLLEATLEVSEYTNNVDILSYE-SKTKRIVKQLKELCSILSGLVIASNF---KIGLKLIENKE-Y 230
XP_657461    146 RFIPLRITQPERKMLRLLEASLHVSKYSDKVDQIKLI-GKPQRLQEQLKGIASLLNGILIATQP---SEKEDYSDVLNtF 221
XP_001469659   4 sqYPLRLTDLERQKLQLIVAALKVSEYTDDVDDFMRPyGKEGRMEAAMREFIDIVVGLAIASDAiprSVKNSFLAGEVkV 83 
Q4CS98         4 eNVLLRLTDTEREDLQLLIAALKVSEYTDDVDDIRHPnSREERMYRCMRELFDTTLGLCIASGSvsrEVREEVARGNTdV 83  Trypanosoma cruzi
Q383U1         4 ESVLLRLSDEEREELQLLIAALNVSEYTDDVDDIRRLsARDDRMCRCIRELFDTVLGLYVASGRvprEMKEGIASGRAsT 83  Trypanosoma brucei
XP_001469225  34 EHIPLRLSPQERKIQRLMRGVILASSYTDKVDSASAL-KLKNRELLIVKELTNALTGLIVGLDM---RKAASFMRDHE-F 108
Q4E4V2        31 DYIPLRLNPRERKIQRLMRAVIMASHYTDKVDNEAVL-KSNKRDAIIVKEITNSLSGLITGLDV---EKGAKLLREKD-F 105 Trypanosoma cruzi
Q38DU7        30 DYIPLRLNPKERKVQRLMRGIVMASHYTDKVDNESTL-KGNKRDSVIVKEVTSALSGLIVGLDV---EKGGALYRDKD-F 104 Trypanosoma brucei
XP_002673610  20 KYIPIRLTFEERKKLRLLEATLTVSEYTDKIDTIRTF-GKLKRIKEQCEEICAILCGLMVAADY---QKGQELIANKN-F 94 
XP_020436154 370 KYIPVRLSLQERNLLRLLEASLHVSEYTDKVDIQISN--RPKRINDQLRHICAILCGLLVASDF---KKGQQLVEKKD-F 443
XP_004180058 231 KKFSNWFKKIFEIGRRYKIMNPEKMKSNYGKLVYILMDSMLPE-IESIMEF--NLYKPINTIESFLiennskntDNNEIY 307
XP_657461    222 SQHEDILQAIFEIGRRYKIMNPDRMRDDYAKLIFILQDITVNS-INEELGV--SLLRPVETVYRYL--------ERKDLL 290
XP_001469659  84 ATVVPLLEDLFEIMRRHKRLNPFSHRGEFGKLMMMLQDVQKRS-IQRALEIqsTLVIPVRTVEAAL--------SSIHCE 154
Q4CS98        84 RLTISILIGLFEIFRRHKRLNPFSNRSEFGKLTMLLQDVQKRS-IQERLHIshSLLIPVQTVGMEL--------RRVGAE 154 Trypanosoma cruzi
Q383U1        84 QMTLKILPSLFEIFRRHKRLNPFSNRSEFGKLTMLLQDLRKPT-VQQRLEIchSLIIPVKTVGGEL--------QRVGAE 154 Trypanosoma brucei
XP_001469225 109 TPYQHEIRAAIEMCRRYKMMNPDLLRTDYVKFLYMIQDAVQSDmAREALGF--NVVKELVTVGRYC--------ETHNMQ 178
Q4E4V2       106 SPFAREIQLAVEASRRYKMMNPDFLRTDYVKFLYMVQDAVQNEnVREMLGF--VVAEQIVTVGFYC--------RALGFE 175 Trypanosoma cruzi
Q38DU7       105 TPFARDIQSAVETYRRYKMMNPDLIRTDYVKFLYMIQDAVQNQnVKEALGF--PVAERIITVGRYC--------SYLGVE 174 Trypanosoma brucei
XP_002673610  95 QDNEEFFQDVFEIGRRYKIMNPEKMRGTYGKLCYIIQDSQQPE-VQEMLGF--KLDRPVKTVHWFL--------EQHDAL 163
XP_020436154 444 SDNEMFFQTVFEIGRRHKIMNPAKMRAEYGKMIHLLQDSSQRE-IRDALGL--ELVSDLKTVYAVL--------EECDGL 512
XP_004180058 308 QMFRDNLILDATSYISSIGKTRTQINKLIKKKESAIETLANKYGKINgFDDEKIRQIIYSIDDFNTYTFMNRTPILRMQR 387
XP_657461    291 KILDDELIEIAVSEIIPDNKSKSQIQDEIKRKENAIKVIAKKYSTMN-CDEEEIKQCLYSIADNNCYLRYNRDPVVKTIH 369
XP_001469659 155 TLADDEAVRT------------DYLKRTGTEKQAGMQSLIERYSKGDgHKKEIIEHCLRSIDDVYSFIQSNTRPLRTLRR 222
Q4CS98       155 ELLTDRDVD-------------KYLVTHGTEKAAVLQKLLDRYGGs--ECKPVVERCLRSIDDVSQFIEGNVRPLRWLRQ 219 Trypanosoma cruzi
Q383U1       155 AMLRDPDLG-------------EYLNSFDKNKVTAFDRLLGRYGG---AESSTVERCLRSIDDVHQFLESNIRPLVWMRN 218 Trypanosoma brucei
XP_001469225 179 DILQDTRLPHCITPV-PVMKDRNMLNRCLRGKDVVVGKLVKQYASEHrMHEDNVEVVVRSLNDANCFSNDNVETSERLLE 257
Q4E4V2       176 SILQDNRMPLCITPV-PFIKNRNKLNKALRHKDVTVNGLLKEYSRASgRTLDEVEIAVRSLNDANHFANDNVDSTNQMLH 254 Trypanosoma cruzi
Q38DU7       175 DMLQDKRLPLCITPV-PFMKKRSKLNEALRRKDVTVSSVVKEYSRKSgRSQDEVEIAIRSLNDANQFANENVESTNELLN 253 Trypanosoma brucei
XP_002673610 164 EILEDKDIDTATNEIFANGKTRMQVEEEIKMKEKAAKRICKVYSESCeMEEEDIEKCLYSIGDSSAYLRQAVYPVETILS 243
XP_020436154 513 KLLSDPLLDVATREVLPDGKQRHEIQHDIKVKERAIKMLSNKYASST-LSTDQIEQCIYSIGDNHTYLRENRDSVRKMIK 591
XP_004180058 388 RLDLFLEPEIMKKY--PIGIKYGRGGSKLTHDHSKQYHYVQQSLMIWSIVQREMIHLWYLADLD-LFS-TTHYQLANTGH 463
XP_657461    370 YLEKYFDPNEAKEPrfSLAINEGNEGSRLSHDHAKQFLFVKQTLVLWNIILENMYQLWILAELD-LFDpQHPYEMKNTGQ 448
XP_001469659 223 WLSRDFEPLPSDNAy-SISIRHGRSGACFTHSHATHCQYVTESLLLWENVQKNILNLWEAAEDDmLVEgQGQYVVANTGQ 301
Q4CS98       220 IILEEFLPLDGNPKy-DLSIRAGVNGAKFSHDHKRHCQYVVESLTLWENVQRNIFDFWQVSEDDmLIDgDGHYTFVNTGQ 298 Trypanosoma cruzi
Q383U1       219 IISEEFCPLDKNCKy-NLAIQQGVDGSLLTHEHSVQCAYVIESLSLWIKVQQSIFEFWQVSEDDmLIDgSGQYSLVNTGQ 297 Trypanosoma brucei
XP_001469225 258 LLKQYFTPISCTELt-SLAIDEGADGSRLTHNHKMQYIFVLQSLSLWKNMCRKMYLLWSLAEED-MLNpNEKYELRMTGQ 335
Q4E4V2       255 LLKEFFSPDAPTDLt-NLSIEEGENGSRLSHNHRRQYFFVLQSLSLWKNICRRMFSLWTIAEGD-MLNpNEPYEFRYTGQ 332 Trypanosoma cruzi
Q38DU7       254 LLLQHFSPNNVTEAt-DLNIVEGEGGSRLTHNHRRQYFFVLQSLSLWKNICRRMFSLWTIAEED-MLNpNEPYEFRSTGQ 331 Trypanosoma brucei
XP_002673610 244 FLLNNFKRDDYEDGh-SLAIMAGHEGARLSHNHAIQFDFVYQTLTLWKNVGRDMFELWFLAERD-LFSsTHTYSLRNTGQ 321
XP_020436154 592 YLKTYFDPENEEQYf-SLRITPGQAGARLNHSHQKQYMYVYQSLTLWKKILHDMFRLWYLAEYD-LLR-GNSYSLRNTGQ 668
XP_004180058 464 GLNRIKACPLIYKEMVKIIGECKMSSK-EWIGSSVIHLGDHAVPNALFFLDKYIQIPNILMPFDNTINKIDEYVSh---- 538
XP_657461    449 GYHRLQQSPRISLVMHRIVKEMQEKVG-NWVGSAQIHLGDHNVPNALVFIDKYTQISRFLGPIITTLENLEKIGEk---- 523
XP_001469659 302 GFHRMCSAPRSYGVMSRLVRDTEQRMG-GWVGIKVIHLGDRDVPNPLVFIDKYTVIPRLVKPVVQTLHALRYVFHeedee 380
Q4CS98       299 GFHRMCRAPKSYSRMARCVNEADQEMG-GWVGIKVIHLGDRDVPNPLVFIDKYTVIPRIVQPIMHTIMEIEKIFSpss-- 375 Trypanosoma cruzi
Q383U1       298 GYHRLCHARKSYARMSRVVNETEHQLG-RWIGIKVIHLGDRDVPNPLVFIDKYTVIPRIVQPIMHVMMALEKIFSpda-- 374 Trypanosoma brucei
XP_001469225 336 GLQRVQKAPQLFKAIQQVLQETKEELG-EWVGSERIHLGDDQVPNAFHFIDKYGQVSRIIIPILRTLGHIDHLER----- 409
Q4E4V2       333 GYQRVQKAPNLYRAISEVVQQTKDELG-EWVGSDRIHLGDDQVPNAFHFIDKYAQVSRIIIPILRTIAHIDTLAE----- 406 Trypanosoma cruzi
Q38DU7       332 GYQRVQKAPNLYNAIHEVVQETKKELG-EWVGSERIHLGDDQVPNAFHFIDKYGQVSRIIIPILRTVSHIDKLEE----- 405 Trypanosoma brucei
XP_002673610 322 GLNRVQYCPNVRRAMEKLLSQTQNSTS-SWVGSSVIHLGDDAVPNSLMFIDKYTQISRILNPIIQTITEIDNYMIk---- 396
XP_020436154 669 GLNRIQAAPKISSAMGKILHSAQTKVGqYWVGSSVVHLGDHNVPNALTFIDKYTQISRILNPIVIAIDFIPKIK------ 742
XP_004180058 539 -------------DVFFSEYITKEYGSTKDLKLIILQDSFTHMFDGSGADNFFMSGSCIDGRLTSAWNFCNELSKKKYYN 605
XP_657461    524 -------------NAHVKNYIIKTFGSYEELRMIILTDFFKHAFDGSGADNFYDAGSCIDGRLTSAWNWCSSVDKKEYYP 590
XP_001469659 381 eegqpqvvheydnYPGLRNLLRSKYHSYGELMMMILSDFFKHAFDGSGDD----GGSCIDGRLTSAWNWCHQLHKKKYYD 456
Q4CS98       376 ----------peeHPGLRNFFRAKFNSYKALRMMILSDFFRHAFDGSGDD----GGSCIDGRLTSAWNWCHQLEKKSYYD 441 Trypanosoma cruzi
Q383U1       375 ----------keeHPGVRNFLRSKYSSFPELRMTILSDFFRHAFDGSGDD----GGNCIDGRLTSAWNWCHQLHKKSFYD 440 Trypanosoma brucei
XP_001469225 410 -------------HAEHAAYLREVWGGGEQAKRAILRDFFRHGFDGSGGDNMDDAGSCIDGRLTSAWNWCNNIRFKEFYP 476
Q4E4V2       407 -------------SYEHNAYMKEVWDGSMNAKRAILRDFFRHGFDGSGGDNMDDAGSCVDGRLTSAWNWCNNIRWKPFYP 473 Trypanosoma cruzi
Q38DU7       406 -------------SPEHKAYVKEIWGSPTGAKLAILRDFFRHGFDGSGGDNMDDAGSCVDGRLTSAWNWCNSIRFKPFYP 472 Trypanosoma brucei
XP_002673610 397 -------------DQNLKEYINTTFGGPEEAKMTILIDLFRHGFDGSGADNFFMAGSCIDGRLTSAWNFCSKINKKNYFP 463
XP_020436154 743 -------------DPGLQTYILNTFGSQKNLVKLILSDFFKHAFDGSGADNFFDAGSCIDGRLTSAWNWCSKIEKKNYYS 809
XP_004180058 606 IFLLTGFTGFNG 617
XP_657461    591 IFQLAGFTGFDG 602
XP_001469659 457 AFVLTGFAGFD- 467
Q4CS98       442 AFVLTGFSGFD- 452 Trypanosoma cruzi
Q383U1       441 AFVLTGFNGFD- 451 Trypanosoma brucei
XP_001469225 477 LFLFSGFSSFDG 488
Q4E4V2       474 LFLLAGFSSFDG 485 Trypanosoma cruzi
Q38DU7       473 LFLLAGFSSFDG 484 Trypanosoma brucei
XP_002673610 464 LFLLGGFIGFDG 475
XP_020436154 810 IFLLSGFNGFDG 821
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