Conserved Protein Domain Family
CortBP2
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pfam09727: CortBP2 
Cortactin-binding protein-2
This entry is the first approximately 250 residues of cortactin-binding protein 2. In addition to being a positional candidate for autism this protein is expressed at highest levels in the brain in humans. The human protein has six associated ankyrin repeat domains pfam00023 towards the C-terminus which act as protein-protein interaction domains.
Links
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Statistics
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PSSM-Id: 462860
Aligned: 33 rows
Threshold Bit Score: 121.94
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q179Y2          2 DFSKTDLLKLLSYLEGELQARDVVIAVLKTEKVKQLLNTARYSKPTNlNDPHAALYRDNlassgniasrQSSIQAAYSEH 81   yellow fever ...
ELW65268        5 KLSKPELLTLFSILEGELEARDLVIEALKAQH-RDTFIEERYG-KYNiSDPLMALQRDF----------ETLKEKNDGEk 72  
XP_007256204   10 TLSKAELLMLLSILEGELEAQDLVIHTLRAQH-RDAFVQERYG-QYDlSDPFLALQRDS----------EVLQGRERAQP 77  
XP_003448340   10 ALSRAELLTLLSILEGELEAQDVVIHTLRAQH-KDAFVQERYG-QYDlSDPFLALQRDN----------EAMECQNTAAE 77  
XP_014328870   10 ALSRAELLTLLSILEGELEAQDVVIHTLRAQH-RDEFVQDRYG-EYDlSDPFLALQRDE----------EAAERQTTIR- 76  
XP_006628428   10 NLSKPELLMLFSVLEGELEARDLVIEALRAQH-RDAFVQERYG-KYNlSDPFLALQRDN----------EVGRGLAQPEr 77  
XP_003454327   20 SLSKPELLMLFSILEGELEARDLVIEALKAQR-KELFIQERYG-RYNlSDPFQALQRDS----------EAVGGQDKEAG 87  
XP_002119326   40 KLSKGELLRLLSILEGELEARDIYITTLQ-AQLNVGHANARYFQHKI-RDPFLALIRDN----------EAMNGNVTTDT 107 
XP_027144331   10 ALSRAELLTLLSILEGELEAQDVVIHALRAQH-RDAFVQERYG-QYDlSDPFLALQRDN----------ESEERQNTLT- 76   large yellow ...
AAL40377      407 iqscvracfdmeegrvllvvsenlwregeAQR-KEVFLQERYG-HYNlTDPFLALQRDF----------ESGVPGGDKE- 473  torafugu

Q179Y2         82 EMRLLNDqrlgvkEQMDSLAALVMQQRQTQAKMVEVLKDAEERYKKV--------VQELEEERRKHEHTTAQGDDITYGL 153  yellow fever ...
ELW65268       73 qp--------vctNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKV--------ILDLEEERQRHAQDTAEGDDVTYML 136 
XP_007256204   78 QDHSHSLrtqvspNPLAVLKLVMTHCKRMQEKMMAQLATAERRHRRV--------IADLEEEKRRHAQDTAEGDDVTYML 149 
XP_003448340   78 PHTHLQGrav-gpNPLAVLKLVMAHCKRMQERMMGQLAAAENRHRRM--------IADLEEEKRRHVQESAHHADFTFML 148 
XP_014328870   77 QPQTHPLgravgpNPLAVLKLVMTHCKRMQERMMGQLAAAESRHRRM--------ITALEEEKQRFVQESARRADYVFVL 148 
XP_006628428   78 gp--------lcsSPLTILKLVMSHCKRMQERMLAQLAAAESRHRKV--------IADLEEEKRRHAQDTAEGDDVTYML 141 
XP_003454327   88 CSSSTS-------NPLVVLKLVVSHCRRMQEKMLAQLAAAESRHRRV--------IADLEEEKRKHAEDTAEGDDVTYIL 152 
XP_002119326  108 NFTRIPMlntktmQPLPLLEKLIQQFKNQQNKLQQHVALGEMYYQLV--------NEELLRTKRLHV----QANDTE-NL 174 
XP_027144331   77 QPHAHLQgravgpNPLAVLKLVMAHCKRMQERMMGQLAAAESRHRRM--------IADLEEEKRRHAQDSAHSDDFTFML 148  large yellow ...
AAL40377      474 -RRAMGS------SPISVLEAVMAHCRKMQERMSAQLAAAESRQKRVrtfivhlhNLKLCWELQRRARARARAELRSCVI 546  torafugu

Q179Y2        154 -----EIERSRLKQELEHEKEQRKVLELELQKIQEQFEEEKNRQKQIVLLLLAERKK 205  yellow fever mosquito
ELW65268      137 -----EKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKK 188 
XP_007256204  150 -----EKERERLLQQLEFEKSRADRLEQDQQAASGQAQEDLAQQQQISSALAKECQR 201 
XP_003448340  149 -----QTERDKLLQQLEVERTTVQRLEKDKAQVVSKVEESLSQQQQLSSTLTLELQK 200 
XP_014328870  149 -----ETERDKLLQQLEVELATVQRLEKEQAQVVSKVEESLSQEQQLSSSLTLELQK 200 
XP_006628428  142 -----EKERERLLQQLDFEKAQVKRLEKEQKKLSGQAEEDRAQHKQLSSALAKECKR 193 
XP_003454327  153 -----EKERERLQQQLDFERSQVRRLEKEQRRISDQLEEERAQHKQLSCALAKECKW 204 
XP_002119326  175 -----RKEQIKLRTLAFLEQKKVKHVANEYKKLLQIISSERKKYRMILSLLLEEKAC 226 
XP_027144331  149 -----QTERDKLLQQLEVEHATVQRLEKEQAQAVSKVEESLSQQQQLTSTLSTELQK 200  large yellow croaker
AAL40377      547 vsdkrINLCDFF--QLEMEKLQLQSLEQEHRKLTAQLKDEREKNKHIVMMLVRECKQ 601  torafugu
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