Conserved Protein Domain Family
FH_FOXJ1

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cd20023: FH_FOXJ1 
Forkhead (FH) domain found in Forkhead box protein J1 (FOXJ1) and similar proteins
FOXJ1, also called Forkhead-related protein FKHL13 or hepatocyte nuclear factor 3 Forkhead homolog 4 (HFH-4), acts as a transcription factor specifically required for the formation of motile cilia. It acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. FOXJ1 binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). It activates the transcription of a variety of ciliary proteins in the developing brain and lung. The FH domain is a winged helix DNA-binding domain.
Statistics
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PSSM-Id: 410797
Aligned: 23 rows
Threshold Bit Score: 152.567
Created: 17-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #                   ##  #                  ## ##  #      #         ### #   
Q92949       121 KPPYSYATLICMAMQASka--tKITLSAIYKWITDNFCYFRhaDPTWQNSIRHNLSLNKCFIKVPRekDEPGKGGFWRID 198 human
AHI16248      81 KPPFSYATLICMAMKETnr--nKITLSGIYSWITENYMYYRvaDPSWQNSIRHNLSLNKCFQKVPRrkDEPGKGGFWRIN 158 Dumeril's clam ...
XP_013395578 124 KPPYSYATLICMAMKETkk--aKMTLSAIYNWITDNFMYYRvaDPSWQNSIRHNLSLNKCFQKVPRrkDEPGKGGFWRIN 201 Lingula anatina
AGD98929     102 KPPYSYATLICMAMRDTkr--vKITLSAIYKWIKENFMFYRvaDPTWQNSIRHNLSLNKCFVKVPRkkDEPGKGGFWRID 179 starlet sea ane...
OQR76863     145 KPPFSYATLICMAMQANa---nKMTLSAIYAWIRENFKYYRtaDPGWQNSIRHNLSLNKCFIKVPRrkDEPGKGGFWRLD 221 Tropilaelaps me...
EFX76422       3 KPPYSYASLICMAMKSNk---hKMTLSSIYKWIKENFLYYRnvDPSWQNSIRHNLSLNKCFIKIPRskDEPGKGGFWRLD 79  common water flea
AFX62231     177 KPPFSYATLICMSMRELnk--sKITLSDIYGWITDNFIYYRlsDSSWQNSVRHNLSLNKCFEKVPRskDERGKGGFWRIN 254 Schmidtea medit...
XP_019849226 100 KPPFSYTTIIYLAIRSSkn--dKVTLGEIYQWIKDHFMYYRvaESTWQNSVRHNLSLNDFFIKIPRseGDPGKGSFWKIN 177 Amphimedon quee...
XP_014681615 109 KPPFSYAQLLFMAMSAQgvgkqKLLLAEIYQFIMDNFIYYKtaDPTWQNSVRHTLSLNRCFIRYPRenNRPGKGGYWTLN 188 Priapulus caudatus
XP_001744416  21 KPPFSYATLIFMAMQQAdk--pKLALSEIYDFIVNNFAWYRmaDPGWKNSIRHNLSQEKAFIKVDRgsSERGKGGYWALN 98  Monosiga brevic...
Feature 1         
Q92949       199 P 199 human
AHI16248     159 P 159 Dumeril's clam worm
XP_013395578 202 P 202 Lingula anatina
AGD98929     180 P 180 starlet sea anemone
OQR76863     222 P 222 Tropilaelaps mercedesae
EFX76422      80 P 80  common water flea
AFX62231     255 P 255 Schmidtea mediterranea
XP_019849226 178 P 178 Amphimedon queenslandica
XP_014681615 189 P 189 Priapulus caudatus
XP_001744416  99 P 99  Monosiga brevicollis MX1

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