Conserved Protein Domain Family
phiKZ_IP

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pfam12699: phiKZ_IP 
phiKZ-like phage internal head proteins
Phage internal head proteins (IP) are proteins that are encoded by a bacteriophage and assembled into the mature virion inside the capsid head. The most analogous characterized IP proteins are those of bacteriophage T4, which are known to be proteolytically processed during phage maturation, and then subsequently injected into the host cell during infection. The phiKZ_IP family consists of internal head proteins encoded by phiKZ-like phages. Each phage encodes three to six members of this family. Members of the family reside in the head and are cleaved during phage maturation to separate an N-terminal propeptide from a C-terminal domain. The C-terminal domain remains in the mature capsid. The N-terminal propeptide domain is either mostly or completely removed from the mature capsid. In one case, an unrelated polypeptide is embedded in the propeptide and also remains in the mature capsid. The phiKZ-like IP proteins are not discernibly homologous to the T4 IP proteins, and it is not known if the phiKZ-like IP proteins are injected into the host cell, or have some other function within the head. The alignment and HMM model exclude most of the propeptide region, but include the cleavage sites. The first 100 residues, including the cleavage sites, constitute the most conservative part of the seed alignment.
Statistics
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PSSM-Id: 403791
Aligned: 14 rows
Threshold Bit Score: 185.314
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
YP_001956970  21 FA----S--------LERYQAILGDEEVSSEDV--AFVMSTA--LENIDPEFDIKEGSTI-----TLR------------ 67 
1_pfamImport   1 HRghdvD--------HDLAKAISIALESFDYKY--FNNTVPS--MESFISPLTRPKASIE-----VLD------------ 51 
Q8SD67       208 AGingiS--------QSTAAFIHSALLPHRHVLg-DNTLTSS--LENYTTGGKSHLYPVKi----STE------------ 260 Pseudomonas vir...
YP_001956878  23 LSneffAeldlyakrNDAICDEMAALENLFITLegSDPTLINyaLEKYNLTEVV-----------SNE------------ 79 
Q8SD70        34 LLp--------------SIEDIQSRLECTEKDI--LVKTYTDglFQKYADNQDVVSEHILktenvSLE------------ 85  Pseudomonas vir...
YP_001956969 214 RAgrefT--------PELRQSISWGLESIDGELffDERVA----LESCDPSARVSLEATGvaasgAREgtiddgedpgev 281
Q2Z120        51 QRtl-nT--------LEAHEVTPELAEQLDKELiaAEALPEA--VEGAEALGFTLLPKAYla--tRLA------------ 105 Pseudomonas pha...
2_pfamImport   1 VEayrhR--------LARYQDLLDGRDVASEDL--SKAMSFA--LESIDPAFSIKEGGII-----TLR------------ 51 
YP_001956881 154 TGangvS--------NQTAEVIQSQLRSINRRLg-VESKFVS--TESFIARDNREQHAIAt---iALE------------ 207
YP_001956880  56 AGpdglD--------HVAKHFMLVGLQQLk-----VRKNSTG--MESFDADRETV----------TVE------------ 98 
YP_001956970  68 --AIKEALVAAAKVAWEILKQIYQYLNALYVRFTGSIRRVRGNQVRVMRRLASLg-----SKTSYSSTINVAg--lQRLS 138
1_pfamImport  52 --NLQAKAKEVSTVALDFIKKLIRIVVETYQRIRQNVSNQIERVNKIMKRVKEN------ELPDEVRTIAIP----RDLI 119
Q8SD67       261 --DIKELSRKALAYIKKAIAKLREIISHVWDSLKNSVPRVSVKVDELILAIQNA------KFENIPSELTVPvkngGPVF 332 Pseudomonas vir...
YP_001956878  80 --DVNRAAIQAWERVKVNLRRFQSDLFGYAKVIQSGSERLVERLEMLQGIAEKA------NKVPFKDEITVKk--nQKFA 149
Q8SD70        86 --DLSKTARNTWDEMKKSQAKHRDELKEYARVITQGNQRTLERINMLLERAENI------KHEPFKQELKFKn--tKRFS 155 Pseudomonas vir...
YP_001956969 282 skGLSAKLKKLVEASIRMFWRAVNAVVDIFNHMTGDMKKIRDHLSDLRSKAKVL---------DGGKEFKMKg--aHRLM 350
Q2Z120       106 --GCESFLSDFFKSSREVVSLIGTFFRDSYVLFMESQESLSKQIDLLETRLSSV----------------------EKFG 161 Pseudomonas pha...
2_pfamImport  52 --ALKDALVRAAKAARDIVRMVIETLTAFYVKFTGSISHVRKTQQKLSRRLAKL------GNRTTNTRLTVSg--lQRLS 121
YP_001956881 208 --DIKTSVKVAKNKFIELLEKILALFKRAASNWLDGLVSLDKKVDQLDQRLGAL------KKPGGGGSLTLHna-gLVVY 278
YP_001956880  99 --DFSEWLSNLGERIKQLINKLIALAKQAASKIMSGIEGVKTQSEELMERARKSarrpsnERHGEGKEITIDs--pSLLW 174
YP_001956970 139 VDGKFVgidmsnlqdikaiaNYTLTVYPRCVTQIARNASRQFLNLLDTANG-ENNKEVSKQLIEVLSEIFERNFReppds 217
1_pfamImport 120 LGDTGE--------------SWVGVDPVQGVTVIRNLFDSIEKNGLRALKAaLAGKTTDDKALALAKGMFGTATK----- 180
Q8SD67       333 ANGKFIq-------------PSANVGYGPIVKWMASVYAKDYATYLTNIGTvLKAWDPERNDASELVEKMDKLQD----- 394 Pseudomonas vir...
YP_001956878 150 INGGFQ--------------PFDIRPVLEDTNNTFDFYDKVLLPYMKQIGKlLDTVELNLTWTENTEMRFELLNAnkwmk 215
Q8SD70       156 IDGKFE--------------PTTVDPILMQVNNLIAFYDKSLLLYIQSVADiLRKLSFDEKWTDRAAQDFSKFNVknwmk 221 Pseudomonas vir...
YP_001956969 351 VGDEFVgdgrqavdrvtrvaNELLIAWPNQLGKIVQKWGQGRRGAMSKTEDgHNNHINEARLKDEFADAIRRSFRdmqal 430
Q2Z120       162 SQGTFIl-------------GHRLFNRFKINGKVDENWSGNLTKLNQTLSGlSNNYYLNSK--NALAASFSYFGGfaglt 226 Pseudomonas pha...
2_pfamImport 122 INGEFIgdrpdnlldikevtNYILMTYPKMTSNIARNISRQALNILDNQGE-DTTTEIIDELLQSFADIVRRDFKappgd 200
YP_001956881 279 KDSIDI-----------------PEDIPGLAHFASVAYPDVVTKYLDQSAKtLLKYKPSDFDPERIKEEFERHAKp---- 337
YP_001956880 175 TDGEFC--------------VGDCKSEQNVVKFFVGAWPKYAIDQIQRAKKmISEYDVESGNSDNFESNMGFIGN----- 235
YP_001956970 218 sd----------------------vrqgeiGGQTKFLKRSTALVGNSAFVYTDPRVIgnefgktngnaadtvasalhMNF 275
1_pfamImport 181 ------------------------------INANGVRYASPVVPGNRVYTFGKDKAA--------------------VDF 210
Q8SD67       395 ------------------------------GPLKHYASTSNTLPGNKLVTTTATQVYlt--------------------- 423 Pseudomonas vir...
YP_001956878 216 nfk-------------------pleepddrFRAAAYVVRGITAQGERAIYYSGPEDTktenvkdwgy-fistirnmrYRY 275
Q8SD70       222 gav--------------------pikkddrFRVSSTVYRSMPVQGNKTLFGAGPTETqteeirdwdf-lvntvrdfaFKF 280 Pseudomonas vir...
YP_001956969 431 spn-------------------drdkvpsgFLGVDKLMWSGPLAGNRALYIGTSDGGkdmk------------gainFSF 479
Q2Z120       227 qvevderlcmmpvslpstpfkectypdkrrSGPNVVAKRSVELMGGAYFYDVRSTVKpvilknp------ddiqdfvIRY 300 Pseudomonas pha...
2_pfamImport 201 ep----------------------lkkgetTSTGT--HRSYILPANRAFVYTDADHIatsvtnkqsa-lemvrntftMEF 255
YP_001956881 338 -----------------------------lAYLIELQVEKDELPGGQHLDVDEGGLSfg--------------------- 367
YP_001956880 236 ------------------------------HQSLVATVTRDILPGNKQIAFKYVALGpe--------------------- 264
YP_001956970 276 QELSLNVADKSE--------REIELPTVRD-LTQLTEEISRILTIAEKAESGRRDFNSvkt-vvdDAIRQAMDSTENKAv 345
1_pfamImport 211 SILDAPGKPNYG--------ITVELLVDKNvVMAQLKAVHNLLNHLNNIRGISKESTA-------EIIAQMTDKEATNV- 274
Q8SD67       424 -nDETAAEPGTE--------VTLKNFDKSQ-AKKEAVALRNLVDDAADVITGGRNIV--------KAIKQLEDDVDQLSr 485 Pseudomonas vir...
YP_001956878 276 LKIPGQQPLNESd-------NKIDVENATT-IRQRLSYLIGIAKRIQGRKGYDQKISTe-----lRKIERSADKVRNNTr 342
Q8SD70       281 YTIPTMKDALEGn-------NTFKVNDTSS-IGRRLVLLSEMAKRIDARKDYATKLDFe-----fGRLMQLAETNRQQAg 347 Pseudomonas vir...
YP_001956969 480 SAIPGESTHAGE--------ITVETPTAGE-AIAIIRELEKMTHFIDDAKQGMNTIKKvydgifgDSIERFSRTVASTPq 550
Q2Z120       301 TEIDHTGFDNNEeytlrdvgAEVKALSSED-IKTVIKLLRQLLKDWGKVFEMAETYRVtds-dynDIIKGFLEADI---- 374 Pseudomonas pha...
2_pfamImport 256 TELQINAIDSTE--------RDIEVPSVTT-LSDIVTGIANILTIAERAKQGEVEYKTvkv-vvdDSIRQLAERSELLGr 325
YP_001956881 368 --iKGEVPAGVD--------KEVDLETTVE-LRKKVRAIKDIVEQIKKIRPEVEKID--------KAGKRLIEAARRSTs 428
YP_001956880 265 lVDAEDAQPAPDk-------HSFEIRTLVE-ITSTLKQNVATMNALGQMYRSESEVL--------TEMATLADALMKLEg 328
YP_001956970 346 ipvAQTV------MTVLGEVSKKLAEPMDNFMHWLAITLNVWL 382
1_pfamImport 275 ---GKAY------LTGTTEASNDLFKCVMIWITVLEKLVDSEI 308
Q8SD67       486 kleSDKI------DDVSKEQIEEVSRKVASIITDSAPKHDSII 522 Pseudomonas virus phiKZ
YP_001956878 343 nmrTQLD------QRNVEEERDEGRPNVSNIVKDMSTILNCMT 379
Q8SD70       348 rirAQQSnmrnrqAKVQDPDAPDGIPAISNIINSITLMINNVS 390 Pseudomonas virus phiKZ
YP_001956969 551 meeYYRG------GDLALTVSRVTFDANREFLGYMTSMVKAYI 587
Q2Z120       375 ---SDEA------KTVLSKTFAKVVRKNQTELLGIRAEVSNYL 408 Pseudomonas phage EL
2_pfamImport 326 --aNGEA------INMLAEISRKLAEPVGNYTHWLAVTLKVWL 360
YP_001956881 429 ---LKAE------DEKEAEDFYNIVHDAISRSAAAKPRVDEVI 462
YP_001956880 329 r-rGETV------WKSARDGLDDISKAMMDLIGRLKPNYDPIV 364
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