Conserved Protein Domain Family
DUF229

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pfam02995: DUF229 
Protein of unknown function (DUF229)
Members of this family are uncharacterized. They are 500-1200 amino acids in length and share a long region conservation that probably corresponds to several domains. The Go annotation for the protein indicates that it is involved in nematode larval development and has a positive regulation on growth rate.
Statistics
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PSSM-Id: 397236
Aligned: 17 rows
Threshold Bit Score: 454.11
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O62436        78 TALQSQKCNIPKLEINGSEVINFFKTHAPLEcqkknsiednwvFINDEAIIrFTEKRAKAKCKIQYFSRVDDNnNKYEEP 157 Caenorhabditis ...
Q9VF91        73 KPVERINCGEGMDWVMCEKSICFVRPEIASS------------HEDVICSY-TDIIRKSDYKVRFGQSLRMKEpYVLQAS 139 fruit fly
Q19486        79 SKPSPLVCSTMQVQAVKSFNNGILTFEPQVIk-------------NARCYK--TGIRHDENVTDLDVIYEKPVpLNLTHT 143 Caenorhabditis ...
1_pfamImport   1 DDNIKTEIERDPLLTHHPFDNTCKFPLPNSYaediipfhlserMRQLKCEVkQKDYATMDSEGYIYVHPHFVDwPRLERD 80 
Q9VKK3        98 KPRPYS-CNRALIRTSDTIP---GQLHLNLEasellayynisdLSSVNCNY-TEVKRKTDSSNTHSPAVSFK----LDKV 168 fruit fly
Q9V9Q1        66 RGLRRDFCASNLNLTSFS-NCTYNYLRTEVNmelakarfgvetLESFKCMY-YAMERHTDFDNRYLYSREFEL--LTDGN 141 fruit fly
Q9V9P7        68 EPVNKLRCRMTQLLTAITQD---GSNFLEAKri----------sEDLSCRYwLKSGHTRNHSGHYTAYGHFDLkRGATRK 134 fruit fly
Q9VGG4        77 TPMPSSACPMIKLMKPQSID-GMNYLYLIASakelwkklgvrrLSDIFCAY-KRFVRFNDFVNIYFESTLFRF-SKLRNF 153 fruit fly
Q9VQH3        74 EPIEPVLCRMEQLMVAETIG-DRNYLVRNISrhg------ilsWRQVSCIY-REFVRVDDAHNKYISLKFFKL-TDRTRY 144 fruit fly
Q8SY05       180 KKHSYIVCDKSRDMITVNYNVTDSTYRLHKNe-------------NSTCCF-KQILRAGTSANADHKYKLGPC-VEFHQD 244 fruit fly
O62436       158 VEVLDGdrm------------------------------ngSDYATISCIQ-GFQKWKsil-------wdVNDEPEIHER 199 Caenorhabditis ...
Q9VF91       140 DFVKVV-----------------------------------CRSSSGESWF-GMAHGIrdt-------vpRPPASNFSPN 176 fruit fly
Q19486       144 SSIKIS-----------------------------------DEVFQITCES-DNLLKS--------------EIFKYHYT 173 Caenorhabditis ...
1_pfamImport  81 VQCKVDiiegglrkpernmtknsmfikktleipsnerlfvnADAFVINCYN-HSKKAVkpevpiwkkpfpGMKDKNLPED 159
Q9VKK3       169 MKLPLS-----------------------------------SEFICMWCYD-SLDKLF------------YKDCHFFAVD 200 fruit fly
Q9V9Q1       142 NTIEPH-----------------------------------ADIIRAECFI-NATSIY-------------NGVHFYVHP 172 fruit fly
Q9V9P7       135 IKIGTG-----------------------------------EQIVRIRCSD-KFKASK------------YHDVLYFLS- 165 fruit fly
Q9VGG4       154 TKVDSG-----------------------------------NITLRVWCWM-DYGRLV------------YHDVFIFLPF 185 fruit fly
Q9VQH3       145 LEVGTG-----------------------------------LQHIRTWCWV-DFGRII------------FHDVMYFLP- 175 fruit fly
Q8SY05       245 FLVPTE-----------------------------------VSAMITYCRRpPFDKVS------------QKDAFSFVHP 277 fruit fly
O62436       200 a----RKMRK-------------EQADP-EKKPYNVYFLGFDSLSQMSFRRKLPQTVKFLEeTLGSVVLNGYNIVGDGTP 261 Caenorhabditis ...
Q9VF91       177 l----AVLPPeava-----qaqqQMQDGaTAPIYNVLMFGFDSLSRNAFIRKLPRTYEYLTqQLGATVLKGYNIVGDGTP 247 fruit fly
Q19486       174 -----QIVPKssn-------iknKVIEQsTSDFPSVIMIGLDSMSRGNFVRQMQKTYKYMK-EAGFIDMEGHMKIHDNTY 240 Caenorhabditis ...
1_pfamImport 160 -----EILRVkdlysygdygnkiREQVSkAVDRYSIDILGFDSTARTMFMRHMPRTVEVMA-KLDYHYLYGYTKVADNSM 233
Q9VKK3       201 kp-riRPPLKtgtd-----rvsfNKSKE-EQERLSVMILGMDSLSHLNFLRQMRRTANYVRkHLSHVEFWGYNKVGDNTF 273 fruit fly
Q9V9Q1       173 tdewlRTAQGlp----------pLKLAS-DVGSLSVLIVGLDSISQMHFHRSMARTANFLL-SLPHVELKGFNRLGEDGF 240 fruit fly
Q9V9P7       166 -----PPDPK-------------LMSTE-SSEKLSVMVLGIDSVSHMHFVRYFPLVMAFLE-NHPHTKFFGYSRVGLDAN 225 fruit fly
Q9VGG4       186 -----PNPQKv------------NNSAP--VKRLSVLILGIDSISHMHYQRYFSRVRDLIE-GLPHTELWGYNRVGQNSY 245 fruit fly
Q9VQH3       176 -----PLPQAt------------NRSTEhQKRKLSVMILGVDSISHMHYMRYFHRVADFIE-HLPHTEFWGYNRVALNTY 237 fruit fly
Q8SY05       278 -----RKDQIe------------NPTTP-HRRRPSVLLWGIDSISRMNLELTMPRMYEYLN-NQHWFELQGYNKMGDNTF 338 fruit fly
O62436       262 QAFIPILTAq---------tETELPLTRKRY--KNANYVDDVYPFIWKNYSDK-GYVTMYAEDA--FSIGTFTYR----L 323 Caenorhabditis ...
Q9VF91       248 QALVPLLTG-----------FTELELPETRKr-LSGAGSVDSYPMIWKDFARL-GYMTSFNEDL--PNVGTFTYR----M 308 fruit fly
Q19486       241 GNLLAILTGk---------rGVGVKEFSTEIn-ESWHIAFDEFDFIWKTFSDN-GYATLFAEDR--PDIGTFTYKn--mL 305 Caenorhabditis ...
1_pfamImport 234 VNLAPILVGdmeealkkpkyDKSGDFNINWLlpTEDKMDPTKLNFLWKIMKEKyGCESLFNEDIstKGLGLFNYPptefQ 313
Q9VKK3       274 PNLVPLLSG-----------LDDQELNLACT--PKTLRSYDRCSFIWKRYQQL-GYRSIFAEDV--AMLSAFNYN----Q 333 fruit fly
Q9V9Q1       241 DSLMPLLSG-----------LSGQELKDVSS----NLSSLDSCPFIWKVFQKA-GYETGLGEDN--IDKSLFVKG----- 297 fruit fly
Q9V9P7       226 ANLVPFLGG-----------KSSRAAG--------SDILSDEKAWLWDSFKME-GYSTAYGEDN--AKGILSNRNg---D 280 fruit fly
Q9VGG4       246 PNLIPLLSGq---------sVDEVEAKSGCYg-ASGGTNFDRCHLLWHDFQAA-GYATIFGEDS--RVAGTFTYV----R 308 fruit fly
Q9VQH3       238 PNLIPLVSGl---------sVSEMEAS--CY---HDELNFDKCNFLWNEFKRA-GYSTIFAEDT--DTAGLFIYR----K 296 fruit fly
Q8SY05       339 PNLMAVLTG-----------FNKTYANARCH--PEKVRGLDACPFIWKDFKDK-GYTTAFAEDW--SKFSTFDYS----S 398 fruit fly
O62436       324 KGFRQQPTDHYTRTLFEEVEKLNDR------N----CIGSIPLHRMWLQNGRQFMKKYEDVP----RFLLMHQSLLSHDD 389 Caenorhabditis ...
Q9VF91       309 TGFEAQPVDHYLRTYYVQAEHMAAEsk---pN----CIGHQPDHITMLEYTKNFMLKYRDAP----RFAFSFHGGLSHDS 377 fruit fly
Q19486       306 EGFLKQPTDHYIRPFWISAFWSLISrrs-----vasCYDSTPQHKIQLKYLEEFLEKYDKKR----KFAFWWSQDMSHGF 376 Caenorhabditis ...
1_pfamImport 314 PGFTENPADHYYRAYYLAVYENWKYe---------aCRDGEQLQNEFVNIWRRFAHRYRNIC----HFGFTFVTTLTHEA 380
Q9VKK3       334 NGFRKQPTDYYLRPMIMEMEKTVAFkkdlnmHl---CMGSRRTADVLLEYMKKLVPRMSRDL----YFSFFWTVALTHDY 406 fruit fly
Q9V9Q1       298 --FRKPPTDFYLRPALLEMWLKTRTdglfgtH----CNEKDNYAMVLREFLFKMLPHHTSHR----FFTFLWWTQGIDHL 367 fruit fly
Q9V9P7       281 KELPKSPVDFDLTPVIVEMNNHTRYsi--dlKemihCTAGRKFQDVLRDFVLQLVPYMQGMP----FFSFFWQSQGVQEY 354 fruit fly
Q9VGG4       309 PGFKKRPTDFYLRSVINEIHMRSTYfargplEi--kCSGDRVYHHVLYDFIYRLLPHMQARMydrgFFAFFWQTMGVHDY 386 fruit fly
Q9VQH3       297 RGFQKQPTDIYMRPLMTEIESHSLYrt--tfDl--kCTGHRLYGEFYYDFVSKLIPHMERQL----FFSFLWNMHGIHDV 368 fruit fly
Q8SY05       399 RGFFNPPTDVYGRPLVLAVEKELTIlqrgqmPy---CLGRKPASEYIYDMGVQFTMVNRNST----FFGMFWTNTFSHND 471 fruit fly
O62436       390 INLVGVEDEDLSAHLSHMNDEGLFDDSVVIVMADHGHRFAKLRDTHQGQLEERMPFFSISLPKQLRntEKGRKMEQNLRE 469 Caenorhabditis ...
Q9VF91       378 INLVGAADDDVHDWLVALKERSLLDDTILIMMADHGNRFAEVRATLQGKQEERLPFFSFVFPESFK--KRFPQEYKNFLA 455 fruit fly
Q19486       377 LNLIGKVDDDFEKFFKNNEKR--MEDSIIIVFSDHGHRYDKIRETVIGRIESRMPFHSIRIPDGIK--KKYPQIVENLMV 452 Caenorhabditis ...
1_pfamImport 381 GLVLEILDEKLAAHLSQMHLNGDLDNTLSIIMGDHGNRIGAIKSRYTGRIEERMPLMAMRFPTGFA--ETYPVEYKNFLD 458
Q9VKK3       407 FNFPSLLDEAMLQQLMQLQDSGLLNRTVVMLLSDHGLRWGSFRRTYQGMMEERQPLMMLLYPPWMT--ERYPEAIANLRL 484 fruit fly
Q9V9Q1       368 FNYGRKLDQPFLKMFKAIGRSGLLKNTVLLVVSNHGLNKGRFYKTVQGKVEESQPLAILCYPRWLE--ERYPQAIGNLKS 445 fruit fly
Q9V9P7       355 YEYAWHLDLSYMMLLKKLLDADILNNTLLFLMSDHGLRAGEYRMSLQGMKEESQPLMVAIYPEWLK--RKYPLAVGNLES 432 fruit fly
Q9VGG4       387 FQYGERADWEYYRIMRALKRRKILERTLVLIVSDHGLRYGPFVDTFQGMRETSLPIMVAIYPRSLR--ERFPLAFANLEA 464 fruit fly
Q9VQH3       369 FPYAKFVDKDYLSILTRLHEKGVMENTLILFMGDHGLRFDKFARTAPGQHEMSQPLLIAIYPEWLK--RRFPLAMSNFER 446 fruit fly
Q8SY05       472 FSMPSAMDERMVKYMRTLDKNGIMDNTIIIFFSDHGSRFGPLRNLDSGFVEERLPFIYIRVPRWIR--EKYPKLLRNLQM 549 fruit fly
O62436       470 NAEKLTSPFDIHASLMDILNLSELGENELNR-MQDASS------------KRSLSVFKPIPVDRTCSQAGIEPHWCTCLS 536 Caenorhabditis ...
Q9VF91       456 NEHHLTTPFDIHATLKHVIQLQTAVDQFGEInDPKTETsppgiriselarGRAMSLLDPIPSNRSCADAYIEPHWCACLN 535 fruit fly
Q19486       453 NSKLMTTQFDVNDSLRKIATGKVGEKWTQTD------R------------KRSYSYFDPFPKRIGCYEAGIPSDFCPCFS 514 Caenorhabditis ...
1_pfamImport 459 NKHKLTSNFDVHKTLHDIVHMRLGDNKAKSD------E------------GRGISLFDAIPNTRTCADVIVPENFCMCMI 520
Q9VKK3       485 NARRLTTPFDVHATMLQLLNLHNLEADQLQRrSTEMDEpds-------tlPRGISLFLPIPAARTCEQAGIAAHWCTCHQ 557 fruit fly
Q9V9Q1       446 NNRRLVTAFDLHATLQNLPNLTSLEDEQLQQrRVDLWAmgk-------diPRGISLFLPIPDHRDCFLAAIPTANCLCQQ 518 fruit fly
Q9V9P7       433 NAHSLITPYDLRETLADVIALGQLKDANIEVsMKRLQShpp------nrlPRGISLFLPIPDHRTCDLAHIPSLFCFCRE 506 fruit fly
Q9VGG4       465 NAHRLVTTYDLHETLKDVVDLENLSDERILNrTLRLRN------------NHNVSLFLPIPEERSCFSARIPLHYCQCDG 532 fruit fly
Q9VQH3       447 NARSLITTFDLHETLKDVIHLDRLTDANVRNrTLYLTN------------ERGISLFLPIPQNRNCKTAEIKQHYCLCNE 514 fruit fly
Q8SY05       550 NKNRLTSPYDIHATLRHILELDTPKDKLPRP----DGC------------SSCHSVFEEVDWSRNCSQAGIEDHWCACNS 613 fruit fly
O62436       537 WKDAMDTGEdr-kLTRRIANAVVREINKEIVAE--------KDLCAPLSLAKII 581 Caenorhabditis elegans
Q9VF91       536 WLPLQLNDSrytgIILKAAQSIVNAINLATVEQ--------RQYCAPLEIHRVN 581 fruit fly
Q19486       515 EIEIPKSEAkeaaVELMRIVNDLLENTEKTEEYepdskeltEYMCTPMEIQNVE 568 Caenorhabditis elegans
1_pfamImport 521 DVSSIANP--------------LPNFNKKKPT-------------DQKMDQFNT 547
Q9VKK3       558 RQELQTNDP----RVQRAARYLVRLINNRLKD---------SSQCRTLYLNSIL 598 fruit fly
Q9V9Q1       519 PRNVSTSDG----YVQRAARLIIRNLNKMIHTH--------TPPCKTLYLDRVL 560 fruit fly
Q9V9P7       507 LTEVPTDDG----LVLRSSRFMVESINQLIKP---------FGQCRQLKLEMVL 547 fruit fly
Q9VGG4       533 YVKIPWNVR----SIQRIAKLAVANINRLLAP---------YPQCEQLELLNVE 573 fruit fly
Q9VQH3       515 LKSVSTHES----AIQEAASFAVDRINELIKP---------YPQCRVLSLQSVR 555 fruit fly
Q8SY05       614 FSDVPTTDP----SARSMSTQLVEAINEYVASKk------gTKRCSRLKLNRIS 657 fruit fly
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