1XCR


Conserved Protein Domain Family
DUF1907

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pfam08925: DUF1907 
Domain of Unknown Function (DUF1907)
The structure of this domain displays an alpha-beta-beta-alpha four layer topology, with an HxHxxxxxxxxxH motif that coordinates a zinc ion, and an acetate anion at a site that likely supports the enzymatic activity of an ester hydrolase.
Statistics
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PSSM-Id: 462636
Aligned: 51 rows
Threshold Bit Score: 303.34
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1XCR_A        22 QKGLKDNFADVQVSVVDCP-DLTKEPFTFPVKGICGKTRIAEVGGVPYLLPLVNQKKVYDLNKIAKEI--KLPGAFILGA 98 
CDS39472      24 REGLKDCFRSVKVNVVPCP-DLTASPFGLLRPGLAGKSVVCDVGSMTYLLPVADTSKRYSFCQVIESS--GVCGGQLLGA 100
BAH71971      37 lpELLDNFENASVEVVQCP-DLTQPPFNLTSEGLCGDENVFDIGDVTNLLPSLKREKLYNVKDLKQIT--GSDPLFIIGA 113
XP_016657413  35 lpELSNNFETVSVDAVQCP-NLTCSPFNLAAEGLNGDEMVIDIGSPSFLLPLVNLNKVYDIRDFAKVT--GTDPLFVIGA 111
EFN77930      31 TDGLTANFEKVIVKLGRCPrDPERQPNQY---DLCGDPTILEIGGPAYLLPLAQKDKFYNIETLLRRId-YHGSAFVIGA 106
XP_011052243  33 AGGLTANFAEATVEIADCP-NFNGWPYNFYREGLCGNPILLEVGGPAYLLPTVQTDKFYDVKSLLRQIn-YNYDTLVIGA 110
XP_011268699  33 AGGLTTNFEEATIEIADCP-DLDEWPYLFYRKGLCGNPIILDIGGPAYLLPTAQKDKFYDIKLILRHLn-YNHDTLVIGA 110
EFN73155      17 QVEFNKFYNEATVKVVNCP-DLRKAPFHLVAPGLCGNTALLEVGSLSNLFPFPRMEKKYDFISFLETSgrSNDDNFIIGA 95 
EFA09460      28 NKGLQSNFEHVTVEVVDCP-DLTQQPFTLAKKGLGGSPKLVEVGGVPYLLPLVKREKVYDLKKIATMI--GSDPAFIIGA 104
XP_002429531  24 NEHLKYNFEKVKVEVKDCP-DLTQPPFTLACKGLTGNERIVEIGGVPYLLPKPRKDKLYDLKDLSKIL--NLDPCYITGA 100
1XCR_A        99 GAGPFQTL--GFNSEFMP--VIQT-ESEHK---------PPVNG-----SYFAHV--N----PADGGcLLek-ySEKcH- 151
CDS39472     101 GGGPFFTH--GKSCEMAA--SLQFaNGKIAs-------nSTLHGvydeqTRTPQVinAt--------------------- 148
BAH71971     114 CAGPYPFF--GADSECVE--NVKM-TGDR-----------VENG-----THVHMT--K----SDDVPeCFhkslPDD-E- 164
XP_016657413 112 GAGPWPHV--GVNCEFIG--NVRLtSDDSV---------NNNNS-----SHLYKV--D----PQTGS-QVhhrlPQD-E- 164
EFN77930     107 GAGLWPHTtdGSNCELIIhhHINT-QIGS-----------VVNN-----SRYAFV--D----KCTGEcVVaqhlSHN-Eq 162
XP_011052243 111 GAGPWPHT--GCNCELIM--KLNI--VNDKvspgyrlgmGVANG-----THYAFV--N----KSNGEcILer-iVAN-Ed 171
XP_011268699 111 GAGPWPHT--GCNCELIM--KVNI-QVNNKvdp---rnnGVANG-----THYAFV--N----KSTGEcSVtr-vLAN-Ed 169
EFN73155      96 SLYPSSN---GHMGELIM--NASFsPLDEEg-------mRVKNR-----SYVAFL--AqdhtGENVKlDIlndyNR---- 152
EFA09460     105 GAGPHPYA--GVNCEGIL--NMNI---AKG---------VVDQQ-----TRISKV--N----PSNEEvPIqeilPNN-E- 155
XP_002429531 101 GAGPWPYA--GTNCEMII--NMEH-NGDK-----------VNNK-----TRIAKV--N----VTDGK-CIqevlPND-E- 150
1XCR_A       152 -DFQCALLANLFASEGQPGKVIEVKAKRRTGPLNFVTCMRETLEKHYG-NK-PIGMGGTFIIQKGKVKSHIM-PaEFSSC 227
CDS39472     149 -DNNFGLVGQLLSTEGLPGSVVEVDVAGRLKEGSVYVFLREALTAAYEkLDkPVALGGVFVLTDSKARFHVLqP-NFPPY 226
BAH71971     165 --MRFSMMANFFTSNGFKGEVLKIVCEVRKGPLSYSTCIKEALVKHFG-NE-IIALGGVILIENGKVKVHVIkP-SLTKI 239
XP_016657413 165 --TRFALLANFYTSRGMTGEVLKIVCETRNGPLDFVTSIRKALAKYFG-DK-PVGLGGVILIETSKVKVHVM-P-DFSKI 238
EFN77930     163 hQATCPILANLYVCKGEPGMVIKVYAKKRTGKLDFIASMQKALGNYYK-DE-LVGLGGMFTMRNGKIKQHVM-P-DYSNT 238
XP_011052243 172 -ETTFALLANLYVCEGKPGKVIKVRAKKRTGNLDFISCMQKALTKHYE-DK-LVGLGGMFEVRNGKVKQHIM-P-AFSDT 246
XP_011268699 170 -ETTFALMANLYVSEGNPGKVIRVRAKKRTGKLDFISCMQNALENHYK-DN-LVGLGGMFVMKNGKIKQHVM-P-NFFDT 244
EFN73155     153 --VKCFLHGNFFISEGKPGRVLEIHAKARREDKELTKVIQHTLQKYYEaTStLVGLGGTFVVHNGLVRHHLM-P-DIGQI 228
EFA09460     156 --TRVALLANLFFSSGEPGKVLKIHAKKRTGPLDFIASIRQTLVNEYK-NK-VVGLGGAFLLKEGKAKQHVM-R-DFSKT 229
XP_002429531 151 --CRNAVLSNLYCSSGEQGKVLEISCSKRIGNDDFITSIRKILGENFK-DK-ILGLGGVFVIKKGKVKQHVM-P-DFSNR 224
1XCR_A       228 PLN--SDEE-VNKWLHFYEMKAPLVCLPVFVSRDP------------GFDLRLEHTHFFSRHGE--GGHYHYDT-TPDIV 289
CDS39472     227 PVD--TPAR-RAEFIKIFEMDPPVLGMGTLVSHDPy-----------GIDLKLEHFHCYN-EAKtlAGHFYWDT-DPEKA 290
BAH71971     240 PIK--SEKE-LGNLLHFIELSPPLVGVGCIVSHDP------------GLNLRLQHFHLYTDHNQ--GGHYYNDT-EPETI 301
XP_016657413 239 PLD--SEAD-LNNWLKFFEVSTPLVALGYLVSHDP------------GLDLRPQHFHLFGNHGE--GGHYHHDT-EPTTV 300
EFN77930     239 PLT--TEAQ-LNDWLHFYEMKTPLTAVGTFVSAET------------ELDLRVQHFHSFAHNNKm-AGHYHIDT-TPDTI 301
XP_011052243 247 PLT--SETQ-LNNWLRFYDMKTPLIAVGTFVSAET------------DLDLRVQHFHSAFDENRl-GGHYHIDT-TPDTI 309
XP_011268699 245 PLN--TETQ-LNNWLHFYDMETPLVAVGTFVSAET------------DLDLRVQHFHSASNENQl-GGHYHIDT-TPDTI 307
EFN73155     229 SLEncSDESrIRNWVKTRILTTPLVAVGTIVNKSSfpvvltnsklqtDLQLTTNHFHSFS-FEPlvGGHYYTNVeYGNSA 307
EFA09460     230 PIN--TDEE-LNNWLKFYNMRAPLVAVGTLINNDH------------GLDLRVQHFHSFSHHGE--AGHYHIDV-TPETA 291
XP_002429531 225 EIS--SEDD-LNKWLKFYEMNTPLIAVGTLVNNDP------------GLDLRVQHFHSFSHHGE--GGHYHIDT-TPNDV 286
1XCR_A       290 EYLGYFLPAEFLYRI 304
CDS39472     291 HYRLYLTAAKSLLRI 305
BAH71971     302 KYTGYFGVSKQFTKi 316
XP_016657413 301 KYTAYLNVAKKLIRV 315
EFN77930     302 EYEGYFNIASVLYRV 316
XP_011052243 310 EYEGYFNVAATLYRV 324
XP_011268699 308 EYEGYFNVATTLYRV 322
EFN73155     308 EYLGYFCPAKKLYRL 322
EFA09460     292 EYLGYFNTGEEIYRV 306
XP_002429531 287 EYLAYFGLGEKLYRI 301
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