5OQR


Conserved Protein Domain Family
Cnd3
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pfam12719: Cnd3 
Nuclear condensing complex subunits, C-term domain
The Cnd1-3 proteins are the three non-SMC (structural maintenance of chromosomes) proteins that go to make up the mitotic condensation complex along with the two SMC protein families, XCAP-C and XCAP-E, (or in the case of fission yeast, Cut3 and Cut14). The five-member complex seems to be conserved from yeasts to vertebrates. This domain is the C-terminal, cysteine-rich domain of Cnd3. The complex shuttles between the nucleus, during mitosis, and the cytoplasm during the rest of the cycle. Thus this family is made up of the C-termini of XCAP-Gs, Ycg1 and Ycs5 members.
Links
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Statistics
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PSSM-Id: 463678
Aligned: 119 rows
Threshold Bit Score: 107.313
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5OQR_B               461 RCLSYVQCLFENITsSLNENLYMVDMLKTLIIPAVRSHDLPIREKGLECLSLVCLLNADLAFENVPLYL-HCYE-----K 534  Schizo...
EFA02258             541 RCLDILASVLSLDA-VTKLTPSLVACKENFLEPLIKNPNPDIHWRIIKCLGLFSFVDKQTADVYAKIVS-IPIAtyrsvE 618 
EFA06967             546 KCLTITESLL-LSP-KVQYTPTIATLTTEHINPAMLHEDKVVQAKALKCYALCCLIDRKCAIHGIHLFSsFIITs---vL 620 
WGS:AANI:GJ21233-PA  616 KGLYISFYMVASEH-VHTLNPSICKLYKDFICRHLASTELDIFEWAIKCGTTFSILYEAYTKEVFDVLV-DEFY-----K 688 
XP_002066179         553 KGLYITFYMVASQH-VQKLTPSICKLYKDFICRHLASTEEDIFEVAIKCGSTFSILYEPYAKEVFELLV-DQFC-----K 625 
EDW47668             603 KGLYISYYMTASPH-VHKLTPSLCQLYKDFICRYLPCAEVDIFEWSIKCGTTFSIFYESYSREVFEVVV-VQFC-----K 675 
XP_001959565         610 KGLYVSYYMVASPH-VTTLTPSICKLYKDFICRYLHSTEVDIFEWAIKCGTSYSMFYEAYAKEVFEVVV-EQFC-----N 682 
XP_002016265         609 KGLFTSYYMVASPH-VQKLTPSICKLYKDFICRHLHSSDVDIFEWAIKCGNAYSMFYEAYTKTVFRVVY-HQFY-----K 681 
XP_001848901         593 KCLQILYYLVNSSS-VKSLTPIVCELNKTFISRYVESSVIDTRDWALKCSITFSMLYDGLSKDTFQLLY-QQFF-----R 665 
ETN62452             293 KCLQICFHLVNSPS-VRVLTPMVCDLYTSFISRHVQSSELHTRNWALRASTAFSMLYDGLSKETFQLLY-QQFL-----H 365 

5OQR_B               535 G-SVVLKCTAIRTLTDMLIQHGKAKFTEYED------------------------------------------AISSILF 571  Schizo...
EFA02258             619 IrNIAALVQSMMATTDLVTKYGIEIISGEDLsdsastsdqdsqkrklyl-------adndkqvsckidkitlpYLLEIFL 691 
EFA06967             621 AkDSEILKLSLQAVTDILILYGTSFVEEKGEengesqptnt-----------------------cfiggtsltALIEAMT 677 
WGS:AANI:GJ21233-PA  689 NnNLRLCEISAQCVCELMDHYGVDYFMDLNQsvagqglapkskrrllftm----qdfdgeedrsqsqgndqntDIISMMG 764 
XP_002066179         626 NnNVRLCETSALCILELIDHHGLNYFIDLKPagsseasdvslskakrrrlytmvepydledersqsqiqeqnsDIIGMMA 705 
EDW47668             676 NnNVRLCEASANCILELLDRYGVDYFNDLNQtgcslsktkrrqlytmqe-------lyddddgsqsqnneqnsDILVVLG 748 
XP_001959565         683 NnVVRLCETAANCMLEMLDHHGLDYFSEFNQgnaggntshlskskrrqlyn--idlydddddgstsqtneqttDIIVVMC 760 
XP_002016265         682 SkEVRVCETSVSCLLELMDHYGIDYVDKLSRkigagglgsktsnrrqlytvq-dtydgeedgdqtvqnsehsvDIIMAMG 760 
XP_001848901         666 NhCTRIWETSISGIFELLDRYGFEHFDVESKkdesrknsrqlfntrdy---------ldqddegnssntgsgvDLMKMMT 736 
ETN62452             366 TsSTRLWKTAIECVFELLDRYGFEHFDLEDEskddsrvskssrqlfnr---------hsghdmeeevsacngnEFYKMSI 436 

5OQR_B               572 EALgefenAELQTLGAEAIAKLLVILHY---RDelfLKPLIIQYFEPNTVD-NHALRQVLGYFFPVYAFGAHEnqWRIAT 647  Schizo...
EFA02258             692 DFLdd-esDEIRYQAVQLLAILVQRFPL---TPn-vLSRILLKWFNPLTGKfDSRLQIALSWIINELNGNKQFd-EIVKE 765 
EFA06967             678 NYMqd-edPGIEETATRCICILLLRNRL---TSssvLSALIIKWANPATt--NEGVKQIIGHTLQSLTALPNC--EYFAD 749 
WGS:AANI:GJ21233-PA  765 FFVekvvdKGILLAIVRGLCRLVLRGHLdnrTDv--LEKLLKRYFNPNTEP---IISQVLGMFFENIVTQKLq--HLLEP 837 
XP_002066179         706 HFMervedKGIGLVLVRGLCRLVLRGHLd--DRpdvIEKLVKRFFNPNTEP---IINQALGMFLEQMVEQKLA--HLLEP 778 
EDW47668             749 HYLervqhRGVGMAIVRGLCRLVLRGHVddrTDv--MELLLKRYFNPNTEP---VINQVLGLFFEELRRLNKh--NLLQP 821 
XP_001959565         761 HYMervqnKGVGVAIARGLCRLVLRGHLddrPEv--LELLLKRYFNPNTEP---IISQVLGMFFEQLVARKQq--NLLQP 833 
XP_002016265         761 RYMemvadKGVSLAIVRGLCRLVLRGHIddrPEv--LEQLLKRYFNPNAEP---IISQVLGMFFENLVRLKKq--ALLQP 833 
XP_001848901         737 HFFetcedSVICMAIVDGFCRMIVRGHYt-sPDi--MAKLLLKYFNPTTEP---KMQQILSIFHESLIKKKRq--EILQK 808 
ETN62452             437 HFMdtcdePVICKTIIEGFCRLVLHGHCs-sTDi--VSKLLLRYFNPTTDP---ETQQILGIFFEGLIRKRRq--ELMQK 508 

5OQR_B               648 IFCDALLSLLEIYRdldeddvQLSIGHIAQQMLDWTDneklyerktqtgddyialnHNVHLHlaNMIFESLPNASEg-KE 726  Schizo...
EFA02258             766 SIVPTLTTIIKAPRtsp--lvDIDTDNVIKFFAEIMNtt---------------vsKSIRKNlaIDVCIKIAENRK--DR 826 
EFA06967             750 AVLSTIRTIVYAPGksp--lcDIDTDNITKFMVTLCKmssq--------------gtkILADlaLKMCNQMREKPKl-KI 812 
WGS:AANI:GJ21233-PA  838 CLLPIVWSVMNCSYdsl--lnDVLPEHVTKFFIDLTVqets------------kpqNNLHNRiaISFLHYIHNYYT--ER 901 
XP_002066179         779 CLLPCVWTMMDSdlp----lqEGQPSHVVKFFIGLTTqers------------tpqNHLHNKiaISFLEYIHNYYTdrKD 842 
EDW47668             822 CFLPTVWT---CNFdsp--lhGVQPEHLTKFFIEMTVqems------------tpqTNIHNKiaISFLQYIQNYFT--ER 882 
XP_001959565         834 CLLNTLWLIMNCSFdsp--lnSVQPDHVTKFFIDLTLqess------------spqTNIHNKiaLSFLHYINNYFT--ER 897 
XP_002016265         834 CLLPTLWTVMNCSFdsp--lnAVQPDYVVKFFIDLTTqeas------------spkSNIHNRiaLSFLHYIQNYFT--ER 897 
XP_001848901         809 ALLTTLFTILEAPNenp--lhEVKPDHVLRFVINSTKpvfc------------spgLNPHNTiaMSFLEVMKDNLTyk-- 872 
ETN62452             509 ALLGTLFTILEASNesp--laEVRPETVLKFVINSTRpifc------------npgVNPHNTiaISFLRVMQDNLSlk-- 572 

5OQR_B               727 ---RKFMISLLGKLKI 739  Schizosaccharomyces pombe 972h-
EFA02258             827 i--VPLLIKLLNLLEL 840 
EFA06967             813 ---NPYFAKALTMMDL 825 
WGS:AANI:GJ21233-PA  902 kemCRLLAKELTTLKL 917 
XP_002066179         843 m--CRLLAKELINLQL 856 
EDW47668             883 kdmCRLLAKELTNLAI 898 
XP_001959565         898 kemCRLLSKELTNLKV 913 
XP_002016265         898 remCRLLAKELTNLTV 913 
XP_001848901         873 -dlLKLLSKELLTLEI 887 
ETN62452             573 -dlLKLMSRELLTLEI 587
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