2XMZ,4GDM,1R3D


Conserved Protein Domain Family
menH_SHCHC

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TIGR03695: menH_SHCHC 
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2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Statistics
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PSSM-Id: 274729
Aligned: 36 rows
Threshold Bit Score: 282.953
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2XMZ_A        15 TNQVLVFLHGFLSDSRTYHNHIEKFTDNYHVITIDLPGHGEDQSSMD-ETWNFDYITTl-LDRILDKYKDKSITLFGYSM 92  Staphylococcus ...
WP_015084850  19 EKPALLMLHGFTGTSETFQDSISDLKEHFNIIAPDLLGHGNTASPEEiSPYTMENICEd-LAGILHQLNISRCFVLGYSM 97  Listeria monocy...
WP_011702474  17 EKAVLLMLHGFTGSNKTFQESITHLEEHFSIVAPDLLGHGKTDSPDEiARYSIERIVDd-LVTILQELKIMQCFVLGYSM 95  Listeria welshi...
WP_010990952  17 EKPVLLMLHGFTGSSETFQDSISLLKEHFSIIAPDLLGHGKTSCPKEvARYSIENICDd-LASILHQLKIDSCFVLGYSM 95  Listeria innocua
WP_003184639  20 AEKTAVFLHGFTGSAATWDGIDGYF-QGMRLIKLNLLGHGGTDSPSDsRRYTTEKQAAd-LIEIFDRLNVKQAYLIGYSM 97  Bacillus lichen...
WP_004398592  23 ASEAVVCLHGFTGSKQSWTFLDEML-PDSRLIKIDCLGHGETDAPLNgKRYSTTRQVSd-LAEIFDQLKLHKVKLIGYSM 100 Bacillus subtilis
WP_011066717  15 DGEPIVLLHGFTGTLNTWESIKTYL-HGYQLILFDLPGHGSSK---GyTLTTMQACCNqlRKQLTEM-NIYKFHLVGYSM 89  Oceanobacillus ...
WP_002387682  21 kRTTVVCLHGFTGTLATFAAVFPSQTP-YNVLGIDLPGHGATASLVApERYTMKQVCHd-iAELTESLNLPCFCLLGYSM 98  Enterococcus fa...
WP_011553559  13 gSRPLVLLHGFTGSRRAFDGLRPLLGRDVRAVAVDLPGHGATPLPDQrGREAFVETVd-aLVALVDSLGQGPVDLLGYSQ 91  Myxococcus xanthus
WP_001103370  17 SGEPLLLLHGFTGSMETWRSFVPSWSEQFQVILVDIVGHGKTESPEDvTHYDIRNAALq-MKELLDYLHIEKAHILGYSM 95  Bacillus anthracis
2XMZ_A        93 GGRVALYYAINGHIPISNLILESTSPGIKEEANQLERRLVDDARAKVLDIAGIELFVNDWEKLPLFQSQLELPVEIQHQI 172 Staphylococcus ...
WP_015084850  98 GGRVATAFAATFPKRVRGLILVSSSPGLEQADIRESRVAADNRLADWIEEEGLVPFVDYWENLALFASQKVLSPEMKRRI 177 Listeria monocy...
WP_011702474  96 GGRVATAFASAHPEMVRGLILVSSSPGLAQKDLQESRVQADNRLADMLESEGIRSFVDYWEKLALFASQEVLSDELKKRI 175 Listeria welshi...
WP_010990952  96 GGRVATAFAAKYKELVRGLVLVSSSPGLRDEKARASRISADNRLADTLDADGIEPFVAYWENLALFASQKNLPFALKKRI 175 Listeria innocua
WP_003184639  98 GGRLALSLAMIHPERVSGLVLESSSPGLDSPEERKARREQDSRLSRRILEEGIKSFVDYWEGIPLFASQLSMDPSKRKKV 177 Bacillus lichen...
WP_004398592 101 GGRLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYWENIPLFSSQQRLAEDIRYRI 180 Bacillus subtilis
WP_011066717  90 GGRTAIHFANEFPDMVHSLILESASPGLFSELEQRQRQQNDKDLANYILQNGIEDFVDYWENIPLFLSQKELSEEKRQQI 169 Oceanobacillus ...
WP_002387682  99 GARTALGFALHYPQKVQHLLLESGSPGLATAAERQARICQDHRLAERLLEEPLVDFIDFWQELPLFQTQKALSVAQQMAI 178 Enterococcus fa...
WP_011553559  92 GARVALAAAVRAPDRFGRLIMESGSPGLHRRQERAARREADGQLAAFIRSRGVDAFVDRWEQLPLFDGLRQLPQERRDAL 171 Myxococcus xanthus
WP_001103370  96 GGRLAITMACLYPEYVRSLLLENCTAGLEREDERKERCEKDERLADKIEREGIESFVTMWENIPLFETQKSLAQNVQEAV 175 Bacillus anthracis
2XMZ_A       173 RQQRLSQSPHKMAKALRDYGTGQMPNLWPRLKE-IKVPTLILAGEYDEKFVQIAKKMANLIPNSKCKLISATGHTIHVED 251 Staphylococcus ...
WP_015084850 178 RSERLSQNSHGLAMSLRGMGTGKQPSYWNCLAN-FTFPVLLITGALDEKFEKIAQEMHQLLPNSTHVSIQEAGHAVYLEQ 256 Listeria monocy...
WP_011702474 176 RLERLAQNPNGLAMSLRGMGTGKQPSYWNHLAD-FTFPVLLMTGSLDEKFEKIAQEMQQLIPNNTHVTVQNAGHAVYLEQ 254 Listeria welshi...
WP_010990952 176 RLERLAQNPHGLAKSLRGMGTGKQPSYWENLAD-FTFPVLLITGNLDEKFEKIAREMKQLLPNSTHVTVQEAGHAVYLEQ 254 Listeria innocua
WP_003184639 178 REERLNNNPIGLRGSLIGMGTGSQPSWWNKLSG-INYPVLLIAGSLDQKFVAINESMAKRIPAARLEIVEHTGHAVHVEE 256 Bacillus lichen...
WP_004398592 181 RSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEE-IDVPVLLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQ 259 Bacillus subtilis
WP_011066717 170 RNERLSHQPEGLAHSLQSMGTGAQPSFWNDLKQ-FYMKVLLVTGEKDLKFVNINKNMREKFPNAALTVCKNVGHAVHVEN 248 Oceanobacillus ...
WP_002387682 179 RQERLSQSAFGLASSLWYMGTGAQESYWERLAElQPIPTDLLVGGEDQKFIGIAKKMQARQPLLRLTIFPEAGHCIHLEQ 258 Enterococcus fa...
WP_011553559 172 RSQRRACTAEGLAGALECLGLGVQPDFWPELHA-QRLPTLLLTGASDSKFTQIARRMATELPVVWRHAFEDCGHAPHLEA 250 Myxococcus xanthus
WP_001103370 176 RKERLANNSNGLANSLRGMGTGAQPSWWNELQN-LKMSVLLMNGEYDEKFFRILKNIEKCVSDAKFVKIDGAGHAIHVEQ 254 Bacillus anthracis
2XMZ_A       252 SDEFDTMILGFLK 264 Staphylococcus aureus
WP_015084850 257 PNSFSSQLNYWLE 269 Listeria monocytogenes
WP_011702474 255 PNIFLSQLTNWLE 267 Listeria welshimeri
WP_010990952 255 PNIFSSQLIYWLE 267 Listeria innocua
WP_003184639 257 PDFFGRIVSEFIl 269 Bacillus licheniformis
WP_004398592 260 PRLFGKIVSEFLT 272 Bacillus subtilis
WP_011066717 249 PQIFGKIVEEFLi 261 Oceanobacillus iheyensis
WP_002387682 259 PTIFYEKVTALLE 271 Enterococcus faecalis
WP_011553559 251 PEAYVREVLGFLQ 263 Myxococcus xanthus
WP_001103370 255 PEKFDTIVKGFLK 267 Bacillus anthracis
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