Conserved Protein Domain Family
Peptidase_M43
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pfam05572: Peptidase_M43 
Pregnancy-associated plasma protein-A
Pregnancy-associated plasma protein A (PAPP-A) is a metallo-protease belonging to Merops family M43. It cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II. Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary and the cardiovascular system.
Links
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Statistics
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PSSM-Id: 368506
Aligned: 4 rows
Threshold Bit Score: 202.074
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_012143071  176 NYSSSDVKNDHWDNYKYMNVYIQNDLyADGVTNNSGVAWYPDSGMSDDGLARVTYNGAYLG--TNTDENFRSVLTHEFGH 253  Shewanella se...
Q46348        157 GGYDDQIAADAWDNTKYMNVYIQNDLyADGALNNSGVAWYPDSGMTASNTARVVFNGAYLYd-NSYSTEFSATLTHEFGH 235  Cytophaga sp.
EAZ79638      311 DLTNKFVFEHLWDPEKYVNVFIMD------LTKAGGFANYPRE-YPADQVPPLNFN--YMAavDPTSSNKSLTLTHELGH 381 
EAY29109      167 GTRDKDIARYAWNNFKYMNVHIQLIL-KSGSTTNSGTAWLPSTGMSEEGTARVVYNGKYLL-----YTPPASSLTHEFGH 240 

WP_012143071  254 FLDLIHTFEGG----CkrgAAkrcgktgDKSCDTPQQNSWQMN---PGDGGIlN------CLGETINWQNFMAYSD---Q 317  Shewanella se...
Q46348        236 FLNLIHTFEGG----C---TGt------DEVDDTPLEDGKHTL---ACTQGT-N------CNGDRVNNENYMGYNGaqgC 292  Cytophaga sp.
EAZ79638      382 FLGLRHIFNLDenypCed---------gDGFPDTESY---------LRNKDLfTyhlpifCNGIPFFSTNQMDYVG---V 440 
EAY29109      241 FLGLEHTFKGG----CtrgEG-------DKVSDTPATTGGEVSgdcSVNTDLqN------CFNEFINVQNHMDYNP---C 300 

WP_012143071  318 YANYTQDQVDRMVNGLA 334  Shewanella sediminis
Q46348        293 YKMYTQGQIDRMVAALE 309  Cytophaga sp.
EAZ79638      441 RNSFTLDQVLKMREVVA 457 
EAY29109      301 EAMFTQGQVTRMEGFLD 317
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