Conserved Protein Domain Family
Zfx_Zfy_act

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pfam04704: Zfx_Zfy_act 
Zfx / Zfy transcription activation region
Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.
Statistics
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PSSM-Id: 461400
Aligned: 9 rows
Threshold Bit Score: 327.589
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q95LI3        71 NVVIEDVQCSDILEEADVS--ENVIIPEQMLSSDVT--------EEVSLAHCTVPDdVLASDITSASMSMPEHVLTSESV 140 cattle
P20662        68 NVLIEDVHCSHILEETDIS--DNVIIPEQVLDLDTA--------EEVSLAQFLIPD-ILTSSITSTSLTMPEHVLMSEAI 136 house mouse
XP_003218933  71 DVVIEDVQCPDIMEDTDVS--QTVIIPETVLDSVVT--------EEVSLAHCNVPDdVLSSEITPSTMSVPEQVLTNESL 140
OCA44186      71 DVVIEDVQCSDILDGARVS--EAVIIPEQVLEDEVGtgdeeqvlEDDSLTSCDVPDnVLDSELVDGELTIPDSETGVHSV 148
XP_006632917  65 GLEAEVVEGPEI-GQGDVVtaDGVIVPESVLGAEVA--------IEEALd---aDHhVLTTDLIAESVRVPDQVFVADLV 132
XP_007228472  65 GLEAEVVEGPDI-GHEDVItaEGVIMSESILEAEVA--------IEEALd---aDHhVLTTDLIEETV--PDQVFVADLM 130
3_pfamImport   1 SLQSQGVEAHEITTEDMVSseHSVIMPDNILGSEVA--------IEDDLd------pILTSDLIQVS-DMPDQVFVAELL 65 
XP_005045771  65 GLAAEVVQGPDIIAETDVVt-EGVIVPDSVLEADVA--------IEEALd---sGDhVLTSDLITETVRVPEQVFVADLV 132 Collared flycat...
XP_005998519  75 DVVTDDVNCHNLMAETDVS--ETVIIPEQVLDMDVA--------TEVSLAHCTVPEdVLASDITAETMTIPEHVLTGESI 144 coelacanth
Q95LI3       141 HVSDVGHVEHIVHGSv--vEAEIVTDPLTADVvsEEVLVADCASEAVIDA------NGIPVDQ---QDDD----KGNCED 205 cattle
P20662       137 HVSNVGHFEQVIHDSl--vEREIITDPLTADI--SDILVADWASEAVLDS------SGMPLEQ---QDDA----RINCED 199 house mouse
XP_003218933 141 HIPDVGHMEHVIHDHnnvvESEIVTGSLGEDVvsE-VLVADCASEAVIDA------SGIPVE----HDED----KGNCED 205
OCA44186     149 S----GH------VV----GEEITDDALEEDMisEEVLVADCVSEAVIDA------NGIPVHE---NDSE----EVNCDD 201
XP_006632917 133 SHQD-GHLGH--------------------EMvsEEVMVTNSDSETVIQAhegvpaSTVTIKT---EDDEd--gKSTSED 186
XP_007228472 131 SAHE--NLDH--------------------ELvsEEVMVT--DTEAVIQAhet-mpSSVTLKNddeDDDDdedgKSTSED 185
3_pfamImport  66 SEHQDNTLDH--------------------QLvsEGLMVAEANSENIIHQql--psETVTLQT---DEDDd--aRSSSED 118
XP_005045771 133 TGPE-GHLEHVVQ--------DAVAEAESPTMvsEEVLVTNSDSEAVIQAagtvpgSTVTIKT---EDDDd--gKSTSED 198 Collared flycat...
XP_005998519 145 HVPEVGHVEHVSHAVs---ETEIVADALSTDVipEEVLVTDCASEAVIDA------NGIPIET---QEED----KGSCDD 208 coelacanth
Q95LI3       206 YLMISLDD-DGKMEHDCSSGMTMDA---ESEI--DPCKVDGTCPEVIKVYIFKADPGEDDL--GGTVDIVESEPENDHGV 277 cattle
P20662       200 YLMMSLDE-PSKTDHEGSSEVTMNA---ESET--DSSKLDEASPEVIKVCILKADSEVDDV--GETIQAVESETDNGNEA 271 house mouse
XP_003218933 206 YLMISLDE-AVKAETDNSVDIKSDS---EG----DPCKMDGICPEVIKVYIFKADPGEDDI--GGTVDIVESESENDHGD 275
OCA44186     202 YLMISLDD-AEKIDEDGAEEITMRG---AVEG--DSSKLDGSCPEVIKVYIFKADPGEEDL--GGTVDIVESESENDHGD 273
XP_006632917 187 YLMISLDDvGEKLD-IGNTPLKIST---EVTQd-DGSKEDGFGSEVIKVYIFKAE-AEDDVeiGGTEVVTESDFHNGHAV 260
XP_007228472 186 YLMISLDDvGEKLD-IGDTPLKITA---DVVQddDGSKEDEFGSEVIKVYIFKAE--DEDVeiGGTEVVAESDFPNGHAV 259
3_pfamImport 119 YLMISLDEvGEKLD-IGDTPLEMST---EVME--DKECKE----EVIKVYIFKAE-ADDDL--GGTEVITEDDYQNGHPD 185
XP_005045771 199 YLMISLDDvGEKLDHIGSTPLKIST---EVANd-DVAKDDGFGSEVIKVYIFKAE-AEDDVeiGGTEIVTESDFHNGHSV 273 Collared flycat...
XP_005998519 209 YLMISLDD--AKIEHDGHAEITMEPeilEQGI--DSSKANGSCPEVIKVYIFKADPGDDDL--GGTVDIVESEMDNGVG- 281 coelacanth
Q95LI3       278 ELL-DQNNSIRM--PREKmVYMTVNDSQQEDEDlnvaeiadevyMEVIVGEEDAAVAaaaattvHEQEMDDSE--I-KTF 351 cattle
P20662       272 EVT-DQRTSIHV--PRVN-IYMLASDSQKEEED-----------TKVIVGDEDAGGTaad-tpeHEQQMDVSE--IkAAF 333 house mouse
XP_003218933 276 TLV-NQNSSVRI--PREKmVYMAVNDSQHEDEElnvaeiadevyMEVIVGEEDAAAA-------HEQPIDDNE--M-KSF 342
OCA44186     274 GFL-DSHNGGRM--PREKmVYMAVNDSQNDD-DldvaeiadevyMEVIVGEEDAAVA-------HEHQLEDAE--LsKTF 340
XP_006632917 261 L---EPGSVGRL--PREKmVYMAVKDTSQEDEDincaeiadevyMEVIVGEEEAPAM-------QETQLDDST--VnKTF 326
XP_007228472 260 L---ESASTGRL--PRDKmVYMAVKDTSQGDEEtnvsemtdqvyMEVIVGEDEAPAL-------QEAQLEDST--CnKTF 325
3_pfamImport 186 L---EAASSGRLgvGRDKmVYMAVKNHTKEDMFlnvtcfspfslTDCVVRSQSQLYC-------QFLDVMQTGkgVeKTF 255
XP_005045771 274 AGViEQGGVGRM--QREKmVYMAVKDSSQEDEDiscaeiadevyMEVIVGEEEATSL-------PDTQLEDSG--VnKTF 342 Collared flycat...
XP_005998519 282 -LL-EQGTTGRV--SREKmVYMTVNDSQQEDEElnvtdiadevyMEVIVGEEEAAVA-------HEQQIDDTD--IsKTF 348 coelacanth
Q95LI3       352 MPIAWAAAY----------------GNNSD---GIENRSGTASALLHIDESAGLGRLTKHKPKKRRRPDSRQYQ 406 cattle
P20662       334 LPIAWTAAY----------------DNNSD---EIEVQNATASAMLHHDESGGLDRVPKQKSKKKKRPESKQYQ 388 house mouse
XP_003218933 343 MPIAWAAAY----------------GNNTD---AVENRNGTASALLHIDESAGLGRLAKQKPRKRRRLESRQYQ 397
OCA44186     341 MPVAWAAAY----------------GNNTD---GIEHRNGTASALLHIDESDGLDRLTKQKPKKKRRGENRQYQ 395
XP_006632917 327 VPVAWAAAY----------------GNNLDt--RLENKNGAATQYLQISDSISTSRALKQKAKKKKRGETRQCQ 382
XP_007228472 326 VPVAWAAAY----------------GNNLEs--RLESKNGTPTPYLQISDSISTSRALKQKIKKKRKGETRQCQ 381
3_pfamImport 256 LS---SLTY----------------KVNTDkydKVQVKNGAASPFLQIREGLSANRVLKPKLRKKKKGDTRQCQ 310
XP_005045771 343 VPVAWAAAYgderrlprryedgqaaGNNLDt--RLENKNGNATQYLQICDSISTNRVLKQKTKKRRRGEARQWQ 414 Collared flycatcher
XP_005998519 349 MPIAWAAAY----------------G--TD---GIENRNGTASALLHIDESASIEKLTKPRPKKRRRAESRQYQ 401 coelacanth
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