Conserved Protein Domain Family
AKR_AtPLR-like

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cd19093: AKR_AtPLR-like 
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins
Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Statistics
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PSSM-Id: 381319
Aligned: 31 rows
Threshold Bit Score: 315.321
Created: 23-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            ###                                      #    #                          
Q56Y42     46 SVSPMGFGTWAWGNqllwg-----yqtsmDDQLQQAFELALENGiNLFDTADSYGtgrl-ngqSERLLGKFIKesqglkg 119 thale cress
CEF99296   71 EIGRLGIGTWSWGNtavwe-----ydesmDPELRRVFNRAVDAGvRLFDTADSYGtgagfdgrSEVLLGQFLKqcps--e 143 Ostreococcus tauri
BAB77824   18 SLPGMGCGTWAWGNqllwg-----ynesmDAQLQAVFNLCVSNGvTLFDTGDSYGtgrl-ngrSELLLGKFSQeyqg--v 89  Nostoc sp. PCC 7120
GAX28037   13 LKVPLAIGTLQWGTtwlddkvvnhhgnlsDETCRDIVDICTAAGvTLYDTAEGYGgg-----tSEQRLGRLFEa------ 81  Fistulifera solaris
EGB12252   39 YDVPLAIGTWQAGNkllyd-----ysperDEALLAAWSLARDRGvRYFDTGDSYGtgdi-egnAELLLGRFAGgg----- 107 Aureococcus anopha...
BAA80660   13 RVSRVGLGLWQFGSpmwgg------kalsADVLARGLSIAVEEGiNLLDTAEVYGmg-----sSERMLGEALKrln---- 77  Aeropyrum pernix K1
AAL64543   12 RVSRIGLGAWQFSGdawg--------aitYEQAKAVVSKALEVGiNFFDTAAVYGrg-----rSEEFLGRAIRelg---- 74  Pyrobaculum aeroph...
ACB07373   12 KVSEVGLGTWQFSDswg---------vtnYDLAKSIIERALDVGvNFFDTAAVYGmg-----mSERFLGQALKelg---- 73  Candidatus Korarch...
SIM62179   12 QATRVGLGCWQAGLrgwg-------edygDKDIIEAIKFYVENGgNYLDTAEIYGmg-----hSEELIKQALSeip---- 75  Thermoplasmatales ...
OYT40659   12 KISVLGLGFWQIGSrlwnf-----rngnvEESSVKIVEKAYSYGvNFYDTAEIYGgg-----lSEKYLGLAIKklg---- 77  Desulfurococcales ...
Feature 1              #                                  ##                                 #
Q56Y42    120 kqnEVVVATKFAAYPWRltsgQFVNACRASLDRLqiDQLGIGQLHWSTasyap--lqelvLWDGLVQMYEKGLVRAVGVS 197 thale cress
CEF99296  144 kakDVILATKLAPFPWRvtsgSFVKAAKESAERLqvDKIPLGQLHWSTgnyqp--lqegaLWAGIADAYEEGVIGAVGLS 221 Ostreococcus tauri
BAB77824   90 nqeNICIATKLAAYPWRwtrqSMINACKSSAQRLg-RNVDLVQMHWSTanyap--wqevgLLDGLADLYEQGLVKGVGLS 166 Nostoc sp. PCC 7120
GAX28037   82 --sPPIFMTKFLPAPWRlwhsDFEAAVRASCQRLkvDCIPIYLLHSPVhwcr----sieyWVEAAALCKKKGLIQAMGLS 155 Fistulifera solaris
EGB12252  108 --aDAYVHTKLAVYPWRlrpdDFVRACEQSLKRLgaERVALVGQHWSAetyglggiqdpaVYGGLAKCCELGYASGVGLS 185 Aureococcus anopha...
BAA80660   78 areDFVIVSKVAGFRSTa--gDIVKGARGIAGRLs-SAPDVILHHWPPpvys----rlcsVVRGLEQAVNEGLASYYGFS 150 Aeropyrum pernix K1
AAL64543   75 ardHVYIATKIHGDWLRr--iDILTSVENQRRRLgvDAIDLYQIHWPAcwhnt---piceTMKTLEELVDRGLVRYIGVS 149 Pyrobaculum aeroph...
ACB07373   74 ereNVFIATKIPGEFLSr--hDVFKATKRSMERLg-SYIDLMQVHWPPcwdni---ptceYMRALEELVHIGVIRMIGLS 147 Candidatus Korarch...
SIM62179   76 -knRYIVATKVNPPHVKny-rTMERSVKGSLERLgiEKIDLYQLHWYEpyvp-----vseIMHSMEKLKNEGYIDQIGVC 148 Thermoplasmatales ...
OYT40659   78 irdEVIVASKVAGYKHTf--nSIIKSIERSNKRLg-FTMDLIQHHWVPpiyg----sicrVINTLEKTVEDRLASYYGLS 150 Desulfurococcales ...
Feature 1     #                       #                             #######                   
Q56Y42    198 NYgpQQLVKIHDYLktrGVPLCSAQVQFSLLSMGKEq-lEIKSICDElGIRLISYSPLGLGMLTGKYsssklptgprs-- 274 thale cress
CEF99296  222 NYgpKQLRKIHKYMsarGVPISTLQVQYHLLSRFPEl-nGTKETCDElGIKLIAYSPLALGLLTGKYsvenpppgirg-- 298 Ostreococcus tauri
BAB77824  167 NYgtKRLQRVHQKFaerGVPIKTLQVQYSLLSTYPVtelGLKDVCDElGIKLIAYSPLALGILTGKYsekgpfprgvrg- 245 Nostoc sp. PCC 7120
GAX28037  156 NCnaDQVRRAVAAGeryGVPVICNQVHYSLLDYNSKalqEMEATCRElGVKIVAFSPIGQGLLTGGLttekwqhnkpa-- 233 Fistulifera solaris
EGB12252  186 NLgpRALGRGVDAVnglGARVATHQTQFSLLCRAPLe-dGSFDVADAaGVTTVGYSPLALGLLSGRYsadaarsfgdrga 264 Aureococcus anopha...
BAA80660  151 NYgeDLLGDALSCTr--RLEPVADQILYNLAYRTPEq--RLIPLLHQhGMTPIAWSPLAKGALAGFKgeptraqagd--- 223 Aeropyrum pernix K1
AAL64543  150 NFplALLERARSCLs--RVDIVTSQNRYNIIEREADk--ELLPYLRReGIVLIAWSPLAKGVLTGKYtpsnlptfedvrr 225 Pyrobaculum aeroph...
ACB07373  148 DFppELIESAWSCLs--TEDIVSIQVKYNLVERDAEk--EIIPYAEAyDLSVLAWSPLAKGALSGKYrpenlpefsdvre 223 Candidatus Korarch...
SIM62179  149 NLskPVLKDAVDSMk--DYSIVSNQMEYSILERNIEr--ELIPYMKEkNITLIPYSPLAKGLLTGKYnsgeipqdnirkg 224 Thermoplasmatales ...
OYT40659  151 NYgeRELKKALECVk--KIEPVSNQVQYNLGYRVVEn--QLKPYMEKkGLTLIAWSPLAKGSLAGLKkplskaqrkd--- 223 Desulfurococcales ...
Feature 1                                                #                    ######  #  ##   
Q56Y42    275 --------------llfrqilpglePLLLALSEIAKKRGk-TMPQVAINWCICk------gTVPIPGIKSVRHVEDNLGA 333 thale cress
CEF99296  299 --------------faykgvlpplpGLLATMRAVGEEHGgkTLPQVALNWCMAk------gTVPIPGAKNMRQLEDNLGS 358 Ostreococcus tauri
BAB77824  246 --------------lllrqllpgvrSLLQCLQDVAQSRNk-TMSQVALNWCIAk------gTMPIPGARSVKQAQENIGA 304 Nostoc sp. PCC 7120
GAX28037  234 --------------kmlrlqwddiqPLRAKIEEKAQKYGk-TMGQVALNWCIQh------nVIPLVGCRSVEQARDSVGC 292 Fistulifera solaris
EGB12252  265 dasalpklprgvrgflfrtqlpklaPLLDALEQVAADRKa-TVGQVALAWCLNargpgkppPLPLVGARTPAMVRDVLGA 343 Aureococcus anopha...
BAA80660  224 ---------------pvfrtaledtGLQEVLESVARRLGa-SKASVALAWVAYk------gAVPIVGWRRPERVREAAAA 281 Aeropyrum pernix K1
AAL64543  226 n-----------dplftpqnlklvwPVVEEITRIAKAHGk-TPAQVALNWLIRdp-----wIYPIPGAKTPEQVVENAGA 288 Pyrobaculum aeroph...
ACB07373  224 g-----------savfhpenfrqvyEIVKLLEEIGAKYGk-KPSQVALKWLLMas----ekVIVIPGAKSPEQVEENTGA 287 Candidatus Korarch...
SIM62179  225 d-----------elfnnpknrkimkPVLDELGKMAKEKKc-SMAQLSLAYLLHk------nCLIIPGAKNKSQVESNMGA 286 Thermoplasmatales ...
OYT40659  224 ---------------pvfkaviqdsELLNVLEDIARKHNv-PVSAISLAWLIEm------nTIPIPGTRSPRRVDEYVQA 281 Desulfurococcales ...
Feature 1                   
Q56Y42    334 LGWKLTNDEQLQLE 347 thale cress
CEF99296  359 LGWGLTPSEVEELD 372 Ostreococcus tauri
BAB77824  305 LGWQLNSGEIAELD 318 Nostoc sp. PCC 7120
GAX28037  293 LGWSLAEKDVRDLD 306 Fistulifera solaris
EGB12252  344 LDVKLDAGDVAGLA 357 Aureococcus anophagefferens
BAA80660  282 ARLKLSEEDVALLD 295 Aeropyrum pernix K1
AAL64543  289 VGWSLSDDEWRTLD 302 Pyrobaculum aerophilum str. IM2
ACB07373  288 SGWTMSLDDWMKLE 301 Candidatus Korarchaeum cryptofilum OPF8
SIM62179  287 DSVKLSKEDMERID 300 Thermoplasmatales archaeon S5
OYT40659  282 VKIKLDQKDLSLLD 295 Desulfurococcales archaeon ex4484_58

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