2P4Z,3H3E


Conserved Protein Domain Family
DHPS-like_MBL-fold
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cd07713: DHPS-like_MBL-fold 
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Methanocaldococcus jannaschii dihydropteroate synthase, Thermoanaerobacter tengcongensis Tflp, and related proteins; MBL-fold metallo hydrolase domain
This subgroup includes Methanocaldococcus jannaschii 7,8-dihydropterin-6-methyl-4-(beta-D-ribofuranosyl)-aminobenzene-5'-phosphate synthase (EC 2.5.1.15), a folate biosynthetic enzyme also known as dihydropteroate synthase and 7,8 dihydropteroate synthase. Thermoanaerobacter tengcongensis Tflp is a ferredoxin-like member. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
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Statistics
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PSSM-Id: 293799
Aligned: 291 rows
Threshold Bit Score: 125.042
Created: 21-May-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                             # # ##     
2P4Z_A        14 EVQVLIENVVFAr-NFVAEHGLSLLLKkgnkEIVVDTGQSe------nFIKNCGLMGIDVgrIKKVVLTHGHYDHIGGLK 86  Caldanaerobacte...
EMS77597      54 TLLPLVDFHAADp-SLKTEPGVSYLIKaddvTILMDCGFNkekahpspLLHNMEKLGISLsdPDMIFFSHLHLDHVGGMT 132 Desulfotignum p...
ABW66601      54 SILPLVDFYTDNp-RLKTEAGVAYLVKagetTLLMDVGFNkkkahpspLLHNMKALDIKPdaIDAVVISHVHLDHVGGMT 132 Desulfococcus o...
EIM62829      61 ELTVLLEHKAAP--GFLGAPGVSYVIKtnkgSILFDLGFGsem---paLAHNAAKLNFKLnqVDALVISHLHPDHMGGFK 135 Desulfobacter p...
KJS76985      54 TVLPIVDLLAESe-NYKTEPGTSFLIKtdndSILFDVGYNikkeetspLLHNLKELNISLddINIMAISHNHADHVGGFC 132 Desulfotomaculu...
KJS76012      54 EITPVIELLPGMe-GVKTEPGLSLLVKaeqdNILFDVGYNkdkaetspLLHNLELLNVHLddIDAIAISHNHPDHVGGMG 132 Desulfotomaculu...
YP_002249649   4 DIRILFDNYEGEs-GFRSGFGYSCFIKkgygGILFDTGADne-----iLIHNLNKAEIKPqmITRVVLSHCHKDHTQGLT 77  Thermodesulfovi...
KKP25477       8 KITVLLEDTAPRe-PFWSEHGLSLLIEadnkKFLFDTGYSgd-----vLLHNANILKIDLnkIDAFILSHPHDDHSGGME 81  candidate divis...
AIH04144       3 EVTIVFDNYKGEp-GFETGWGYSCVVKrndeFLLFDTGADgq-----kLIKNLKRAGITPslVSKIILSHAHKDHTGGLK 76  Thermodesulfoba...
AIZ57303       4 KITSVYDEGAVEgtPLIGAEGFSVLIEigsnKILFDTGRRgr-----yLMHNLSFLDIEPemINTVVISHGHKGHAGGLD 78  Methanomassilii...

Feature 1                                                                                        
2P4Z_A        87 GLLErn----------peVKIYTHKEILnkkyamrkggqfeeigfdlsfyekYKNNFVLIDk-DAEIEEGFYVITNTdit 155 Caldanaerobacte...
EMS77597     133 EQKTqtfslsrgpvslpdIPIYSPAPVTgsr-------------------wnPSANARVISd-PTELKPGIFSIGTIpry 192 Desulfotignum p...
ABW66601     133 EQRTktfsisqgpvdlreIPVYATSAMApsr-------------------wnPKPQVTVTDk-PQKLAEGVATTGAIprn 192 Desulfococcus o...
EIM62829     136 AFRN--------------NQIAMPPAFGkgngmacf---------apaevgaDGFETEIVQg-PRMLPAGIASTGPLsrs 191 Desulfobacter p...
KJS76985     133 FRDKrveltk--gkvdlnCKLILTPIPMt----------------------cESAVVRTVDk-PTLIAENIASTGPLaeq 187 Desulfotomaculu...
KJS76012     133 FRNSe-------------VMLSGKPLDLknrnvft-----------pvsmscATANTVTVDk-PQLVGDAVASTGPQavq 187 Desulfotomaculu...
YP_002249649  78 GIVNlk----------kdFNIYAGKSCAetlln---------------reelKNVNLTFVNseCVEIMNGVYLTGELg-- 130 Thermodesulfovi...
KKP25477      82 KASHfi----------stKPMYCTSDAFgehmpk------------sdllksVYTNVHHVTe-NIEITPGFWIIKERpti 138 candidate divis...
AIH04144      77 EIQSlm----------peAEIYAGVSFYeevk-----------------kllPYARLFKVSseVLRITQGVYLTGELe-- 127 Thermodesulfoba...
AIZ57303      79 TLLRere---------tpLLIYAPRFAMgtktmfgtgg-----giqigediaDKADIVEINd-WKEIADKVFVSAPMdi- 142 Methanomassilii...

Feature 1                             ##                   #                             #       
2P4Z_A       156 ydnefttknffvekegkripDKFLDEVFVVVKeeDGINVVTGCSHAGILNILETARNrfgv-syiKSLIGGFHLrgmeee 234 Caldanaerobacte...
EMS77597     193 l----------------flmGRTLENALAIHVkgKGIVLIVGCGHQTIERIIDRAKAlfd--epiHGIIGGLHYpvnggr 254 Desulfotignum p...
ABW66601     193 l----------------ylmGYTLEQSLAVRVkdKGIVIIIGCGHPTVERIVERVKMlfd--dpvYAIIGGLHFpvhggr 254 Desulfococcus o...
EIM62829     192 l----------------ffmGLTEEQAIVARLkhKGMVVITGCGHPTIETIIQMAKRlsd--dpiYAVGGGLHFpvtdsp 253 Desulfobacter p...
KJS76985     188 m----------------fipGTLNEQSLLVNLkgKGLVLISGCGHPGIITMVKAAQKitg--ipvYAVVGGLHLyytqpq 249 Desulfotomaculu...
KJS76012     188 v----------------fvtGKLLEQALLINVkdKGLVVVSGCGHPNIVRTVEMAREitg--lpvYAVVGGLHLyytdip 249 Desulfotomaculu...
YP_002249649 131 --------------------ENIKEISLLMDTg-GGLVVITGCAHAGLKEIFKKAKEiin--dkiFALVGGLHLkdkkee 187 Thermodesulfovi...
KKP25477     139 n---------------talkTYEINAVAKIKD--KGLVIIVGCAHQGLPAIIEDAKKafnneipvYALIGGLHLkssnal 201 candidate divis...
AIH04144     128 --------------------GKVKETSLVLEAk-DGVIVLTGCAHPGIEKIIEKVISein--pkvLAILGGLHLldknae 184 Thermodesulfoba...
AIZ57303     143 -------------------gKEETESFIVIRSr-KGPIVISSCSHAGADKVMEAVKSkfg--aypHGYVGGLHMgkkekt 200 Methanomassilii...

Feature 1                                                      ##                              
2P4Z_A       235 --------------------------kvkdiARKIEEYgVKKVLTGHCTGIDEYGFLKSVLkd---kiSYLTTSSSIV 283 Caldanaerobacter ...
EMS77597     255 imlgpvniqrivgsdtppwqgireadvenaiAAIQKVSpGIVALSPHDTSDWAIDRFRQAFga---ayVDVKVGQPIE 329 Desulfotignum pho...
ABW66601     255 imagpvnlqslvgtdrppwkaigeadvdnaiTAMKTVNpALVSLSPHDSSDWSLERFKAAFgd---ryLDLKVGTPIQ 329 Desulfococcus ole...
EIM62829     254 lrkpglkvqmiwgtgkppwqkiteqdleqtiENLNAVCpKHIFLSPHDTCDYALQRFKTSLnc---qtHILESGVTYS 328 Desulfobacter pos...
KJS76985     250 vgfwgnifgss----klycgtpsqkevtniiDELKQLGvKKVFISPHDADKPTLDIFADKFgl---dfEALKVGRLVI 320 Desulfotomaculum ...
KJS76012     250 agvwgnimgss----rlfsrspnreevvetvRRLKELGiQKAFISPHDSDQPTLQIFSDQFgd---dySPLKVGQKVT 320 Desulfotomaculum ...
YP_002249649 188 --------------------------eihelIEFLKSEgVRYIAPSHCTGDLARRLFKKSFhs---gfIEAGAGSRIY 236 Thermodesulfovibr...
KKP25477     202 --------------------------einknIDLIKQEnIKLLLPNHCSGFGSIKKLIDVMpnqteliSKTASGTFHS 253 candidate divisio...
AIH04144     185 --------------------------eirnvIACLESKdVRLLAPSHCTGDLALKLFKQHFke---rfLKVGVGTKIT 233 Thermodesulfobact...
AIZ57303     201 --------------------------kaeavANLFSEKnCNSLYINHCTGVNGIMYMRAVLgik--gvNNFYVGSSIS 250 Methanomassiliico...

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