Conserved Protein Domain Family
DUF4820

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pfam16091: DUF4820 
Domain of unknown function (DUF4820)
This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 320 and 483 amino acids in length. There are two conserved sequence motifs: WSLP and RPLPW.
Statistics
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PSSM-Id: 465015
Aligned: 10 rows
Threshold Bit Score: 234.746
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFN76898      19 IKSAVDRAARTWIGLIVLKQMDTFLWIVEKSMEWSLPRnedis-------------eneeSRRAD---LVRPMPWPLFLP 82 
Q7K1Q6        38 VREQAERFASTRVGQFVIERADKALAMIEDTAKWSLPQ----------------------DKSSAp--LERPLPWAPFLM 93  fruit fly
EDW31792      37 VREQAERFASTRLGQFIIERGDRALRMIEDTAKWSLPQ----------------------EKSADp--LQRPLPWGPFLF 92 
XP_002061463  39 VREQAERFASTRLGQFVIARGDRALRMIEITAKWSLPQ----------------------EKNAAp--LERPLPWMAFLM 94 
XP_002050279  42 VREQAERFASTRLGQFVIERADRALKLIEDTTKWSLPQ----------------------DKNSSavvLERPLPWASFLL 99 
EFN68095      26 LKFLQVVMVQSSLGQTILKLMNNFLWTVEKCAEWSLPDqeidl------------dedenKKKSG---LVRPLPWILFLP 90 
Q7QJT3        27 LYDVVARVATTSIGQFVYKRVDNLLWTMEKTARWSLPQpspvggavsskksspeadedigS-NISgppLIRPLPWLLFLP 105 Anopheles gambi...
Q174I3        25 LYDYTAQAMTTRVGNYVYHRFDTCLSVVEKTAKWSLPQsppps------------eedtsKVNISpppLIRPLPWIMFLP 92  yellow fever mo...
EDS45770      25 LYDVVAQGATTRLGGFVYRRIDSVLSTVEKTAKWSLPQpvldgg----------deassdGSKISappLIRPLPWMLFLP 94 
XP_001987734  38 VREQAERFASTRLGQLVIERVDRGLKLIEDTTKWSLPQ----------------------DKNSSavvLERPLPWAPFLL 95 
EFN76898      83 TLLFLRVIRASLNAGAFMLGLPLVSSVSMVRFVQRSRYRLASVRQgnRSRPSEKMRLKRdaqdkrlSMYQAKKALIRSIR 162
Q7K1Q6        94 LIVLLRLTRIWLSVGALMIGNGPISPTDMVYFIQTRRRKLRAIRV--HGLKVMRRRQQE-------VSYGSGKGMTQKLN 164 fruit fly
EDW31792      93 LIIMLRLTRMWLSLGALMIGNSPISPSDLVYFIQTRRRKLRAIRV--HGLKVMRQRQQE-------VSYGSGKGLTHKLT 163
XP_002061463  95 LIILLRVTRMWLSMGALMIGNGPVSPTDMIYFIQTRRRKLRAIRL--HGLKVMRQREQE-------LQYGAGKGLTYKIS 165
XP_002050279 100 LIVLLRLARIWVSLGALMIGNGPVSPTDMIYFIQTRRRKLRAIRV--HGLRVMRHRQQE-------TSSRTSCSYTQQLS 170
EFN68095      91 SLIILRILRMTVNAGALLIGYSQVTPSGLI-----SRKRLNDVKK--SGMKEKQnkd------ersSMNEARKALIKSIR 157
Q7QJT3       106 ALIVLRMVRSTLSLGARFIGRDPVLPSSMVGFLQNKRRKLRALKY--RGQRLQRIAKVEq------EADPKQVTWLQRII 177 Anopheles gambi...
Q174I3        93 ALIALRLIRASLSLVALMIGKQPVYPENMVAFLQSRRRKLRALKY--RGQKIQRMRRAEkes-egkPEALVAKSWLEKIT 169 yellow fever mo...
EDS45770      95 ALVVMRMVRVGLSLLALMVGRPPVTPASVVHFVQNKRRKLRALKY--RGQKLGRISRAEa-----kAEDELQTTWLSRII 167
XP_001987734  96 LIILLRLVRIWLSVGALMIGDGPVAPTDMIYFIQTRRHKLRAIRV--HGLRVMRNRQQE-------MS--PGKSFTQKLS 164
EFN76898     163 LTLSTLSCldgsKPSlspppt-------------rihisALDLDAATITGGKSATesAMSPVLEEKQReeptsatKSDIT 229
Q7K1Q6       165 QWFSRAMC----RPGv-----------------------QQDSSSRRVFVRHSEQ--GLSNFVVKRPR-------EEDCN 208 fruit fly
EDW31792     164 QWFSRAMC----RPGv-----------------------QKANSGRLFQVRNMEQttQTSPAVMKRPR-------EDETN 209
XP_002061463 166 QWLSRAIC----RPGv-----------------------QRANSGRLFTV-NSNS---LEQNVSKRPR-------EEESQ 207
XP_002050279 171 QWLSRAIC----RPGv-----------------------QRANSGRVLNLRDMEKpqQGNQLNNSVSKrp----rDDDSN 219
EFN68095     158 LTLSSLSCldmsKPTpspppt------------kihvssVLDPDAPTTT--TSEEksATESTDATEKQenltscsESSSS 223
Q7QJT3       178 LPLRMVICt---RPYrtid-----------------tnsDVAHAVIFRKDRPASSagQKRVESKKRNLnqreaesEEEEC 237 Anopheles gambi...
Q174I3       170 LPLRYMIClravRPGssihqkehhhhhhhrqgqsrdsnnEAAN-------KDGAKprDESARRRKRNAherdaddSESSV 242 yellow fever mo...
EDS45770     168 MPLRTIVC----RPGrv--------------------------------vRQQNQqqDQQQPGRKRNAqerdvddDDESG 211
XP_001987734 165 LWFNRAIC----RPGv-----------------------QRENSGRAFNMHSSDQq-PANQSVTKRSL-------EDESN 209
EFN76898     230 EteteTETEAELGRNEQLV-----DtSHDVTM 256
Q7K1Q6       209 A----DADLTIDQMLAKYAnenseD-DSDFVP 235 fruit fly
EDW31792     210 TdletDHNLTIDQMLAKYAlenseD-DSDFVP 240
XP_002061463 208 Te--aDHNLTIDEMLAKYAnvnseD-DSDFVP 236
XP_002050279 220 P----DQNLTIDEMLAKYAnenseD-DSDFVP 246
EFN68095     224 EdeknEEEETLKEKIDRLAlessdE-DEDFDP 254
Q7QJT3       238 SdeysFEDAGCKELLDKYAne----eDSSFNv 265 Anopheles gambiae str. PEST
Q174I3       243 -------DATVQELLEKYAde--eG-DSSFHA 264 yellow fever mosquito
EDS45770     212 Pe---VDEGTVSELLDKYAdd---agDSSFHA 237
XP_001987734 210 E----DDNLTIDEMLAKYAnqnseD-DSDFVP 236
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