Conserved Protein Domain Family
RING-HC_RNF212
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cd16746: RING-HC_RNF212 
RING finger, HC subclass, found in RING finger protein 212 (RNF212) and similar proteins
RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. It plays a central role in designating crossover sites and coupling chromosome synapsis to the formation of crossover-specific recombination complexes. It also functions as an E3 ligase for SUMO modification. RNF212 contains an N-terminal C3HC4-type RING-HC finger.
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Statistics
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PSSM-Id: 438404
Aligned: 5 rows
Threshold Bit Score: 67.8457
Created: 24-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #                # #  #  #        #  #     
Q495C1         4 WVFCNRCFQPPHrt--scFSLTNCGHVYCDACLGKGKKnECLICKAPCR 50  human
XP_005994958   4 WVYCNTCFQQPRtdn-nsLYLTNCGHVFCQSCLQKGRKnECLVCGVHCR 51  coelacanth
XP_007896177   4 RIFCNFCFQQPRpnc-csFALTNCGHVVCEACLKKGSMkKCCVCKADCR 51  elephant shark
XP_015141509   4 RVFCNSCFCEPRkat-prFIFTSCGHVICELCLQKGKKdECLICRTPCR 51  chicken
XP_018096025   5 AVLCNVCFQKADvgesprFILTSCGHVLCEQCLQKGKKeECTVCRTSCR 53  African clawed frog

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