1S1M,1VCO


Conserved Protein Domain Family
PyrG

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COG0504: PyrG 
CTP synthase (UTP-ammonia lyase) [Nucleotide transport and metabolism]
CTP synthase (UTP-ammonia lyase) is part of the Pathway/BioSystem: Pyrimidine biosynthesis
Statistics
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PSSM-Id: 440270
Aligned: 661 rows
Threshold Bit Score: 741.055
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1S1M_A         3 TNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFIRT 82 
AKM79280       4 TRYIFVSGGVLSGLGKGLITGAISLLLKSTGLKVVPVKCENYLNFDAGLINPIEHGDPFLCADGAETDMDIGTYEMFLNT 83 
AKM81560      17 TKYIFVSGGVLSGLGKGVTAASLGVLLKEQGYSVTNIKCENYLNIDSGNINPIEHGDVFLCEDGLEADLDLGSYERFLGE 96 
AKM83551       1 MKFIVISGGVLSGLGKGVTSASIGLLLKSRGIKVTAMKCDMYLNIDAGTMNPIEHGEVFVTDDGVETDQDLGHYERFLGI 80 
NP_212709      5 LKILVITGGVISGIGKGVTSASIARLFR-YDFRVTPIKCDGYLNTDPGTINPVEHGEVFVLDDGGEVDMDFGHYERFLNL 83 
WP_053230184  43 HRYVMVFGTVMSGLGKGIFASSLAKLLKDKGLTVAPIKLEGYLNLDSGTLSPYRHGEVFVLDDGLETDMDLGTYERLLDQ 122
WP_025208967   9 GKIIFITGGVLSSLGKGIFAASLAFMFKERGLKVNMMKFDPYLNVDPGTISPIEHGEVFVTKDGGETDLDIGHYERFINQ 88 
WP_043924462   5 LKILVVTGGVISGIGKGVTSASIARLFK-DNLRITPIKCDGYLNTDPGTINPVEHGEVFVLDDGGEVDMDFGHYERFLNL 83 
WP_085754716  34 TKYVVVLGTVMSGLGKGIFSSCVAKLMQDKGLKVSPVKLEGYLNMDSGTLNPFRHGEVFVLDDGMECDMDLGTYERMLNL 113
AKM78094       4 LKYIFVTGGVMSGVGKGVAAASIAKILQSKGFAVTALKIDPYVNVDAGTMNPTEHGEVFVLDDGMECDQDMGNYERFLNT 83 
1S1M_A        83 KMSRRNNFTTGRIYSDVLRKERRGDYLGATVQVIPHITNAIKERVLEGGE--GHDVVLVEIGGTVGDIESLPFLEAIRQM 160
AKM79280      84 NLSIDNFITLGQIYKTVIDRERNFDYGGEDVEAIPHVTDEIIRKIKAVGKkdQADVVVVELGGTAGEYQNILYYEASRIM 163
AKM81560      97 KVGYRNFTTMGQIYSTVIERTKNLEYGGATVDAIPYIPEEVIRRIKNASa--DHDIVLIELGGTAGEYQNIVYYEAYRIM 174
AKM83551      81 NLTKENYTTNGQIYKLVLDKERSLDYGGKCVEPYHHLPPEIIKKWYAAGEkhNADVVLVELGGTVGEYEGLLFFESIRRL 160
NP_212709     84 NAKSSWNITMGKIYKKILENERKGKYLGRTVQLIPHVTDEIKSTIFQIASseNSDMLIIEIGGTVGDMENILFIETVRQI 163
WP_053230184 123 DLTRQNYATAGRIFQEVLNKERAGDYLGRDVQMIPHVTGSVKHMLRSLAVetGADVVFIEVGGTVGDYENAFYIEALRQL 202
WP_025208967  89 NLSKNSSISSGKIYRNLIEKERRGKYLGKTVQIIPHVINEIIDLILNNLK--NNDLLIVEIGGTVGDIESIPYFEAIRQL 166
WP_043924462  84 NSKSNWNITMGKIYKNILENERHGKYLGRTVQLIPHVTDEIRDTIFKIAKeeCSELLVIEIGGTVGDMENILFIETMRQI 163
WP_085754716 114 DLSKQNFSTNGQVFSSVLKTERGGGYLGRDVQVIPHVTGEVKRKLRVLARdsEADVVFVEIGGTAGDLENAFYIEAMREL 193
AKM78094      84 SLSSANYMTTGSVYLSLINRERSLAFEGKCVEVVPHVPLEVIERINKAAKkeKADIVIVEIGGTVGEYQNVLFLEAVRML 163
1S1M_A       161 AVEiGREHTLFMHLTLVPYMAASGEVKTKPTQHSVKELLSIGIQPDILICRSDRAV-PANERAKIALFCNVPEKAVISLK 239
AKM79280     164 KLKh-HDTVVHVHVSYLPTPPHLGEPKTKPTQLSVKQLNSMGIQPDFIVARADRII-DKRRRERFALFCNLEAEDIISSP 241
AKM81560     175 KMTl-PKDVILLHVTYFPAPSHINELKSKPTQLSVKALNSMGIQPDFIVGRGELEI-DEKRKEKVAYFCTMDVGDIISNP 252
AKM83551     161 KLTn-PKDIILVHVGYLPAPPSIGELKSKPLQQSVGQLNSLGLMPDFIVCRSEKAV-DEKRKGKIALASGLLIENIVSNP 238
NP_212709    164 RQEiGSGNISFIHLTYVPSPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQVL-TDQIRKKVAMFCNVESTSIIDNV 242
WP_053230184 203 AFEeGPSSASMVALTYVIEPPALGEQKTKAAQLGLKKLLEAGVQPHIVATRSAEPL-TDPAREKIAMFSGVPVANVFSMH 281
WP_025208967 167 QFE--RENVINIHIGFVPFLSINKEYKSKPFQHSIKELHSLGVFPNFLIVRTENKInNQEVFNKISINCGVNKEYILELE 244
WP_043924462 164 RYEiGSDNIAFVHLTYIPNPAGINEQKSKPTQQSVKTLNKAGIFPDLIIARSSQLL-TKQIRQKIAMFCNVDAESIVDNT 242
WP_085754716 194 ANEeGDSNCCFVALTYILAPQTLGEQKSKAAQLGIRELLQKGIQPSIIACRCEEEV-TEQVREKISLFSNVPFSNVFSMH 272
AKM78094     164 KAR-NHDDVALVLVSYLPQQGEGGELKTKPTQYAVRTLNSAALQPDVILARAKIAL-DKPRKEKIAFNCNLDSDAVISAP 241
1S1M_A       240 DVDSIYKIPGLLKSQGLDDYICKRFSL------NCPEANLSEWEQVIFEE-A----NPV-S-EVTIGMVGKYI-----EL 301
AKM79280     242 DVANIYELPLIFDSQNLTQRLRAKLGL------KPKKPQLKDWHDFIKKT-N----QKKiH-SAEIAIVGKYFstgdyHL 309
AKM81560     253 DCKSIYEIPIIFNRQHFSQKVLKKLGL------KSKKIALTNWQDMVKNIyS----EKE-K-KVKIGIIAKYIttgdyEL 320
AKM83551     239 DVDSIYEVPLILEKQGLATKIIKKLKL------KHSKKDLSAWIALNKSI-K----SAK-K-EVKIGIVGKYQktgdyVL 305
NP_212709    243 DVSTIYEIPISFYKQGVHEILSSKLNI------KV-DPKIEELSKLVGVI-KsnffVPK-K-IINIAICGKYA-----EL 307
WP_053230184 282 DRESIYTIPEDLHEIGLDTEVLTRLRLldrvsvEKEEAARARWQRFVGKL-K----GER-RfSLKLGLTGKYA-----AL 350
WP_025208967 245 NLPNVYQIPKKLMEEKIDQKIAKILNL------KLINKNIEKYDLFNNLI-Sy---QNK-D-KLRIAIVGKYH-----NL 307
WP_043924462 243 DVSTIYEIPISFYKQGLHEILGSKLKI------NV-KPKVDGLERLVGII-KrnfaSPR-K-VVNIAICGKYT-----EL 307
WP_085754716 273 DSKSIYLIPAMLRDSGVDFSIIKMLGIedkidlRKERSEWEKWCDFTDRVtK----DHK-N-EVTIGITGKYI-----SV 341
AKM78094     242 DVKSIYDIPINFEHDNLSGILMKRLRL------KPRKNDLKDWKAFVNKT-H----AVT-K-PVKVGIVGKYFssgefVL 308
1S1M_A       302 PDAYKSVIEALKHGGLKNRVSVNIKLIDSQDVET--------RGV-EILKGLDAILVPGGFGYRGVEGMITTARFARENN 372
AKM79280     310 TDSYRSLVEALRHAAANSRVDLKIREINSQKLNR--------FNVkKLLAGVDGIIVPIGWGPRGVSGMIQAIRYAREEK 381
AKM81560     321 KDSYTSLLESISHSSWHEKIEAEIIFISAENLEKn------kKNAgTSLKELDGIIVPIGWGSRGVEGKIEAIRYARENK 394
AKM83551     306 TDSYVCVVESLKHAGWKLGIKPKLIWIDSEEKDV--------D-----YSNLDGIIVPQGWGKRGVEGKINAVKFARENN 372
NP_212709    308 DDSYASIRESLVHVAAHLDLLIKSTLIDSNDLNE------------SCLKEFDGIIVPGGFGGKGYEGKIMAIKYARENN 375
WP_053230184 351 RDAYASVDKAIEHVGARLSCDIDVDWLDTTTFEP--------DEAaGRLAEMDAVIVPGGFGQRGTESKIGCVRHCRESG 422
WP_025208967 308 KDSYLSIIESLKIISIYKKIDLKIDLLDSKSLDL------------KKLNNYSGIIISGGFGTDGTDGKIKTIKYARENN 375
WP_043924462 308 GDSYASIFESLTHVSANLDLLVKTIVIDSTNFDE------------GMLKGIDGIVVPGGFGGRGYEGKMRAIKYARENN 375
WP_085754716 342 RDSYASISNAIEHCEAWLGCKVNVEWIEVTDITP--------ENTeAALRGVDGIIVPGGFGVRGTEGKIECIRYAREHD 413
AKM78094     309 ADSYISVIEAVKHAAYAEGRIPEIHWLNAGDFDPlgvgtkmsKDNlKLLKQYDGVIVPGGFGNRGIEGKISVIGYLREQK 388
1S1M_A       373 IPYLGICLGMQVALIDYARHVANMENANSTEF---VPDCK----YPVVALITEwrdengnvevRSEK---SDLGGTMRLG 442
AKM79280     382 IPYLGLCFGMQLSVVEFAQNVAQLKGAHSTEI---KPKTA----HPVIHIIPA----------QLRNlkaRAYGGTMRLG 444
AKM81560     395 IPYLGLCYGMQLASIEFARHVAGLENANTEEI---DQNAP----YKVIHSIPFde-------kYQKI---KGDGASMRLG 457
AKM83551     373 IPYLGLCFGMQMAVIEFARNVLNFKNANTTEA---DPNTK----YPVIHTMDY----------QKELiknKQYGGTIRLG 435
NP_212709    376 IPFLGICLGLQLAVIEFARNVCGILDADTEENlarDKPLK----SPVIHLLPE----------QKGI---KDKGATMRLG 438
WP_053230184 423 TPYLGICLGFQMAVIEHARHVAGLPGAGSSEL---SPGCE----DKVVDILPE----------QKAI---EGLGGNMRLG 482
WP_025208967 376 IPLLGICFGMQLLILEFANNVLNLN-LYHQEL---NPEKK----QKFIIHLLE----------DQDL---KNFGGTMRLG 434
WP_043924462 376 IPFLGICLGMQLAVIEFARNVCGILDADTEETl-fEGNSAfssiSPVIHLLPE----------QKEL---KDKGATMRLG 441
WP_085754716 414 LPYLGLCLGFQMAVIEYARNVCGIKDANSSEI---APNCG----SAVINLLPE----------QKKI---EGLGGNMRLG 473
AKM78094     389 IPFFGLCYGMQLATVEFARNVAGLKGAHTTEV---DKKAT----YPVIDILPE----------QREKmaqKEYGATMRLG 451
1S1M_A       443 AQQCQLVDDSLVRQLYNAP----------------------TI-VERHRHRYEVNNMLLKQIEDAGLRVAGRSGDDqLVE 499
AKM79280     445 SWRALVSPKTLAWQIYNRHrgfin-------------krrgLT-EERHRHRYEFNRDYLNRLRKAGLVISARALKEdLVE 510
AKM81560     458 AYDCVLKPKTLAHEIYKKHqafkd-------------erqnLI-SERHRHRYEFNNEYRKTLEDKGFVISGTSPDDfFVE 523
AKM83551     436 SWPCKIKKGTKLSNIYKKD----------------------LV-NERHRHRYEFNNIYKDKFEKKGLTISGTSPDGkLVE 492
NP_212709    439 GYPVILKKNTIAFKLYGQD----------------------RI-IERFRHRYEVNNDYIDLFAKNGLIVSGFSSDFkMAK 495
WP_053230184 483 GQSVLVQPDTLAAFLYRVReqdgggvk------gggphepfTV-RERFRHRYEVDPAYIQRLEAAGLVFSGRHPVQpIMQ 555
WP_025208967 435 EYECKIFPNTIASKIYKKD----------------------LI-NQRHRHRYEFNNQYKNILEKNGLVFSGINPQTnLVE 491
WP_043924462 442 GYPVLLKKDTLAFKLYGSE----------------------MI-VERFRHRYEVNNDYLDLFNKHGFVVSGFSEDSrIVK 498
WP_085754716 474 GRDVEIKKDTLAYKLFGDE----------------------QTaRLRFRHRYEVDPEYIEQLQNAGLVFSGKAPNHpIMQ 531
AKM78094     452 AYPAVVEKGTHAHMAYKGShfqiegnkrrkedklklpadelVI-FERHRHRYEVNPIYVEKLQEKGLVFSGTSPDRrLME 530
1S1M_A       500 IIEVP--N--HPWFVACQFHPEFTSTPRDGHPLFAGFVKAASEFQKR 542
AKM79280     511 IIELP--RkvHPFFLGTQGHPEYKSRPLFPHPIFIEYLKAASAYHSR 555
AKM81560     524 MIELP--ReiHPFFLATQAHPEYKSAPLKPHPIFIEYLRAIWSEKAK 568
AKM83551     493 AVEIT--N--HRFFVGTQFHPEYISRPLTPHPIFVEFLKSTQR---- 531
NP_212709    496 LIEIP--E--NKFFVACQFHPELITRIENPAKLFLGLIKACI----- 533
WP_053230184 556 VLELPpaQ--HPFFLAGQFHPELTSRPLRPQPMFMGLIAAAIRRKHP 600
WP_025208967 492 IVEYP--K--NDFFIAVQFHPEFNTKIFKLDPLFESFIEASNNYGKK 534
WP_043924462 499 IMEIP--K--NKFFVACQFHPELITRLESPSKLFVGLVKACL----- 536
WP_085754716 532 ILELP--E--HPYFIGTQAHPCLTSRPLNPSPMFLGLIVAAMKHKYP 574
AKM78094     531 IVELPktK--HPFFLATQFHPEFTARPLAPHPLFVAFVKAAIQMPKN 575
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