Conserved Protein Domain Family
bac_FRK
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cd01167: bac_FRK 
Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate.
Links
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Statistics
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PSSM-Id: 238572
Aligned: 53 rows
Threshold Bit Score: 194.007
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative ATPputative
Feature 1:putative ATP binding site [chemical binding site]
Evidence:
  • Comment:Annotation is transferred from other members of the superfamily.
  • Citation:PMID 9519409
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
BAA17561      3 EVVCFGEMLFDCladqlgvpleqvkswtnyAGGAPANVACALVKQGvSAAFVGRLGADQAGQELKNVLQQCQVNTdglqi 82  Synechocystis sp...
NP_616765    30 KALTFGEALFDIikg------------tvhLGGAPLNLAAHLAKLGaKPAVLTAVGKDELGKTLLSRAEEMGVDTsyill 97  Methanosarcina a...
CAD31412      5 DVVGTGFTVLDRiyadsl------avssedLGGSCGNVLISLAMLQrNVAPVLSLGEDEVGIRLVVAFRHAGAETryirq 78  Mesorhizobium loti
AAN25139      5 IVLSLGELLWDMlps------------gkrAGGAPVNFAYHAMKNGtEGWAISAVGEDELGDELIAKANEAGINTviq-- 70  Bifidobacterium ...
AAO76864      4 IIVGMGEALWDVlpe------------gkkIGGAPANFAYHVSQFGfDSRVVSAVGNDELGDEIMEVFKEKQLKNqie-- 69  Bacteroides thet...
NP_841267    13 NVILFGEALADIfpd------------gpvMGGAPLNVSCHLQAFGlHPMLITRTGTDELHRKLIRLMRNAGMTIsgiqs 80  Nitrosomonas eur...
NP_866563    16 VAIIVGEVLWDCfpd------------rqvLGGAPLNVAWNLAGFGlEPLFVSAVGDDDLGNEILRRMREWGLSTdavav 83  Pirellula sp. 1
AAQ59099      5 QFVAFGEALTDFirvdgd-------awqsrPGGAGWNVARVVGRLGvGAAFAGAVSDDLLGRQLLEASAAAGLDTrflq- 76  Chromobacterium ...
ZP_00173618  15 AVAIFGEVLADVfpd------------gsvLGGAPFNVARHLQAFGlHPVMITRVGQDDLGRELLEEMQRLGMDTsgvqi 82  Methylobacillus ...
ZP_00212961   8 AFVSAGDILTDMvragda-------qwtsvPGGAGWNVARAVARLGvPSALAGSIGEDCFSDVLWHTSEAAGLDLrflq- 79  Burkholderia cep...

Feature 1                                                                                       
BAA17561     83 dphRPTRLVYVTrt-gdGDRHFAGFGEYHTGDfadtamqgetipeslFTSAQYLVMGTi--------ALAYAPSrtaTER 153 Synechocystis sp...
NP_616765    98 dekRPTGTVTVElq-aeGIPIFTINEGVAWDAitpder---efealaAEEWDVFCFGTl--------AQRSEENrktLKR 165 Methanosarcina a...
CAD31412     79 tehIRSPILAQRlh-gpGVHTFEFRCPETSIDlp------------rYEPIDWEDVSRalpaikncnVFYTDRLsgaIVD 145 Mesorhizobium loti
AAN25139     71 rnaWPTSTVEVAlk--nGIPEYTIVKGVAWDHilytr-----qlidvVSKADAVCFGTl--------ALRSPEShatITE 135 Bifidobacterium ...
AAO76864     70 rvdYPTGTVQVTld-deGVPCYEIKEGVAWDNipftd-----elkrlALNTRAVCFGSl--------AQRNEVSratINR 135 Bacteroides thet...
NP_841267    81 dphYPTGQVLIKpgenwYGHQFEILENQAYDFidpvta----ataasSIEPDLVYFGTl--------AQRSRLSg-sALE 147 Nitrosomonas eur...
NP_866563    84 lpgVATGTVAVTle--dGEPQYEIVRDVAYDQipvprdsvlqsikkrIREATAAGFPSlly----hgTLAYRSQr--NRE 155 Pirellula sp. 1
AAQ59099     77 plpYPPLLAMVPs---sQPPSYFFVGDNSADLhfdpar----lppdgLDALRIAYFGSi--------SLARPPLadrLLE 141 Chromobacterium ...
ZP_00173618  83 dpvHPTGQVKVHls--pSGHQFEILPAQAYDYihagvt----hmvtmATKPDLVYFGTl--------AQRNMESrlaLDN 148 Methylobacillus ...
ZP_00212961  80 rvaRPPLLAIVHe---tRPPAYFFIGEASADLafdpaq----lpagwTDHVKWAHFGCi--------SLVREPLagtLAA 144 Burkholderia cep...

Feature 1                                                           #                           
BAA17561    154 LVALAKkh-------qvKIFLDVNWRSVFWddeaqakeripalithAQILKCTDEEAVWLFghqdpvti---------hq 217 Synechocystis sp...
NP_616765   166 LLSEIKa---------kHFFYDVNLRAGFYrkewil-----sslerCTILKMNEEEAAKISgmlfgttyacrtlcrlltd 231 Methanosarcina a...
CAD31412    146 AMEAAAda-------gsTVYFEPSALGDKElfrr--------avaaASVLKFSAERLATLAgqvap-------------- 196 Mesorhizobium loti
AAN25139    136 LLKHTKpg--------aMKFFDINLRGDHYskdlie-----ellkaATVFKINDEELLLLRdmfdirgtsged-asrwfi 201 Bifidobacterium ...
AAO76864    136 FLDTMPdid------gqLKIFDINLRQDFYtkevlr-----esfkrCNILKINDEELVTISrmfgypgidlqd-kcwill 203 Bacteroides thet...
NP_841267   148 TIFRYTpq--------tPRLLDINLRKPWYtrdtvr-----ysltrADHVKVNEDELIELPgllnlhtrdprd-tasrli 213 Nitrosomonas eur...
NP_866563   156 TIHALRdqfaadgdlnlDVFFDINVRKPHYdvawld-----dlmpgAGLVKLNEDEMSDLAsrelsssndrraaahellc 230 Pirellula sp. 1
AAQ59099    142 LAHELAar-------gvAIAFDPNMRSAMSeagyrrr--fealaglASYIKVSDEDLQLLFpardqdrale------alr 206 Chromobacterium ...
ZP_00173618 149 FLNYGTs----------PRFLDINLRDPWYdkhtvr-----rsllrADLVKLNDEELAILVkmlrlpgrspqe-haaali 212 Methylobacillus ...
ZP_00212961 145 LAADLHar-------gvKISFDPNVRNLMTaafqptl---akmaalADLIKVSDEDLRHLFggdgpdaig-------avr 207 Burkholderia cep...

Feature 1                 #                                           #  ##  #                  
BAA17561    218 klphlqGVLVTAGd--kGCSYS------LGKNHGEVPafk---------vnVRDTTGAGDSFVAGFLAQALThgenlf-- 278 Synechocystis sp...
NP_616765   232 rypkisVICITKGp--eGAAVYq-----DGVYEEIKTtp----------veVADTVGAGDAFSAGFLYTFLSgy------ 288 Methanosarcina a...
CAD31412    197 --hdalFLIVTHGe--aGLEVRr-----GAEKAWCKSypa---------peLRDTCGSGDMVSVGVIDWLLSrrdratrk 258 Mesorhizobium loti
AAN25139    202 eefgldYVILTAGsa-ySTIISr-----KGEVSTLDTph----------veVNDTVGAGDSFSGTFTARILLgd------ 259 Bifidobacterium ...
AAO76864    204 akynlkMLILTCGi--nGSYVFt-----PGVVSFQETpk----------vpVADTVGAGDSFTAAFCASILNgk------ 260 Bacteroides thet...
NP_841267   214 eefqlhTLLVTCGa--eGAWLLd----qSGNEAETPGitd---------itVIDTVGAGDGFSAVFILGMLLgw------ 272 Nitrosomonas eur...
NP_866563   231 kysslkCLLVTLGadgaECHLS------ESSQTNVSGgsepisvaapqpdpLIDPVGAGDAFASVMIAGHLRkl------ 298 Pirellula sp. 1
AAQ59099    207 rlapraAILYTRGa--dGMSLLg-----SGGALEQAAlp----------aaVADTIGCGDASIGGLIASLLKypa----- 264 Chromobacterium ...
ZP_00173618 213 krfnldLLLVTEGd--kGSWLMnaagqvEAVEGAEPPq------------tFVDTVGAGDAFASAFILGILKgw------ 272 Methylobacillus ...
ZP_00212961 208 alnphaAVLVTRGa--qAATLYa-----DGDVHEASPpr----------veVADTVGAGDASIGGMLFSLMAapq----- 265 Burkholderia cep...

Feature 1                                  
BAA17561    279 idphlSCQAVTYASAIGALTTLHPGAI 305 Synechocystis sp. PCC 6803
NP_616765   289 ----gVSKAVSVAIMLGTYVASKPGSV 311 Methanosarcina acetivorans C2A
CAD31412    259 isideFVVGIEAGQRLAAENCAYVGAR 285 Mesorhizobium loti
AAN25139    260 ----tLAEAHRKAVNTAAYVCTQAGAW 282 Bifidobacterium longum NCC2705
AAO76864    261 ----sVPEAHKLAVEVSAYVCTQSGAM 283 Bacteroides thetaiotaomicron VPI-5482
NP_841267   273 ----pETLTLERANRFAAALCGIRGAI 295 Nitrosomonas europaea ATCC 19718
NP_866563   299 ----pVEESLKTATRFASQVCGLPGAT 321 Pirellula sp. 1
AAQ59099    265 ---rtMAEHLRFAAATAACTAGHAGAY 288 Chromobacterium violaceum ATCC 12472
ZP_00173618 273 ----pADVTLARANQFAAALCSVRGAA 295 Methylobacillus flagellatus KT
ZP_00212961 266 ---rsWREHLVFALAAGAAACRHTGAH 289 Burkholderia cepacia R18194

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