Conserved Protein Domain Family
RING-H2_SIS3
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cd23118: RING-H2_SIS3 
RING finger, H2 subclass, found in Arabidopsis thaliana protein SUGAR INSENSITIVE 3 (SIS3) and similar proteins
SIS3 is an E3 ubiquitin-protein ligase that acts as a positive regulator of sugar signaling during early seedling development. SIS3 contains a C3H2C3-type RING-H2 finger.
Links
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Statistics
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PSSM-Id: 438480
Aligned: 11 rows
Threshold Bit Score: 90.116
Created: 14-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #               # #  #  #           #  #    
Q8GYT9       233 GECLICLEEFHIGhe-vRGLPCAHNFHVECIDQWLr-lNVKCPRCRCSV 279 thale cress
XP_002961047 228 DTCVICMEEYEDGqk-lRVLPCRHAFHAACVDQWLvtrKPFCPVCKRDA 275 Selaginella moellendorffii
KJE91897     457 ETCVICLDDFKEGdt-lRCLPCSHDFHQNCVDQWLltkNRACPLCRSQP 504 Capsaspora owczarzaki ATCC 30864
NP_597269    189 KGCIICLEDFEDGgy-vRSLDCGHAFHKECVDRWLr-kNFVCPICRSKM 235 Encephalitozoon cuniculi GB-M1
XP_014159207 231 DTCTICLEDFTADeq-lRVLPCNHEFHVECVDRWLinqKKTCPVCKCDA 278 Sphaeroforma arctica JP610
EFA78995     324 HRCTICLEDFEENiivkELAGCDHQFHPDCIDRWLt-eHKKCPYCRLEL 371 Polysphondylium pallidum PN500
PSC73339     278 HACAICLEDYEGGdk-mRVLPCQHRFHSECVDQWLsnrHPVCPVCKADA 325 Micractinium conductrix
XP_024387456 271 ETCAICLEDYVAGek-lRLLPCQHEFHLDCIDQWLttrKPFCPVCKRDA 318 Physcomitrium patens
VDP52928      83 KSCCICLEEFVAGee-vRVLPCTHFFHTACIDRWLi-tNRKCPLCRRNI 129 Soboliphyme baturini
XP_018442430 172 KRCTVCLDDFEPKet-vMLTPCKHMFHEECIVQWLk-tKGQCPLCRFVI 218 radish
XP_005707237 239 MSCSICLEAYVDGeq-lRVLPCMHQFHSLCVDKWLr-rYARCPICKFAI 285 Galdieria sulphuraria

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