Conserved Protein Domain Family
SGNH_hydrolase_like_7

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cd04502: SGNH_hydrolase_like_7 
Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid.
Statistics
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PSSM-Id: 239946
Aligned: 13 rows
Threshold Bit Score: 217.541
Created: 18-Oct-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Citation:PMID 7773790
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Comment:the histidine side chain may be oriented by a backbone oxygen or by an acidic sidechain

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #                        #                            #                  
ZP_01403619  70 GVLFVGSSTIRLWtdlredfrqlpVVINRGFGGSTMADCQYFVKNLVlqyqPRHVMVYAGDNDLAEGrt---peQVLESF 146 Acidovorax avena...
ZP_00243715  71 GVLFVGSSSIRLWsglea-qfageTIVKRGFGGSRMFDCAAYLERLVlpykPRLVIVYAGDNDLAEGrt---pqQVLASF 146 Rubrivivax gelat...
AAM40096     60 GIVFVGSSSIRFWetlaq-dfpgkPVINRGFGGSEVRDSTCYADRIVipyaPRQVVLYAGDNDLNSGrs---peQVRDDV 135 Xanthomonas camp...
ZP_01121689  58 TYLFTGSSSVRMWesldr-dfpdrQVINTGFGGSQASDLLFYLDPLIlnyrPMVVSIYEGDNDLAEGks---pgRAFRDI 133 Robiginitalea bi...
ZP_01356145  85 AVVFYGSSSLRLWttlsd-dmapwPVVNRAFGGSTLAACVHFFDRLVppcaPRAIVLYAGDNDLGDGrt---pdDVVRSL 160 Roseiflexus sp. ...
ZP_01062103 674 LYVFYGSSSVRLWvhmqe-dlapmHTLNLGFGGSTYAWCLHYFEEIFqdvnPSKLILYAGENDITQGrt---plEVLADF 749 Leeuwenhoekiella...
ZP_01093581  48 GIVFIGSSSIRMWdlpky--fpdqAVINHGFGGSHLEDSVYYADRLVtslqPRAVVLYAGDNDVGHGyt---peRVKDDF 122 Blastopirellula ...
ZP_01107875  49 TIVFTGSSSIRLWkelnd-lfpdhQIVNTGFGASLSTDLLHYCKELVinfnPYRVFIYEGDNDLASKrk---pkEILTTT 124 Flavobacteriales...
AAK90830     35 PIAFYGSSSFRLWnslae-dlnslNVVNLGFGGGTFLSAIHYMGQLLvplkPRQTLLYFGENDIASDgqt--aeTAFRHF 111 Agrobacterium tu...
ZP_01075280 696 AAAFYGSSTFKLWenmqh-alghiNTVNLGFGGATLEACVYYFERLVvaqqPKSLVLYLADNDIGNRqs---ynQIAEHY 771 Marinomonas sp. ...
YP_097673     8 DVLFLGSSSINLWdniyr-dmaplKILRRSYGGAALRDMLYNYDVIArg-yHPRSIVIYVENDLAGTpedltvgETFDFF 85  Bacteroides frag...
ZP_01101701  50 TTLLVGTSTIRRIpfnal--aecrPFRLRGLNSALLIDVSLYMSAIKpddqVHTILLYAGENDLSNGkk---fyDIQEKF 124 Congregibacter l...
CAD77011     76 GILLIGSSSIRRWdtaad-dlapfRVIPRGYGGAKYSDLAVFAERLItp-hDFRAVVIFVGNDISGKetdatpeEVERLV 153 Rhodopirellula b...
Feature 1                                                                                 #  #  
ZP_01403619 147 QSFVRSVrealPDTRISYISIKPSPLRLSLLPRMREAnallaqyvrtvpnsDFIDIFTPMLDAQglpraeLFGADHLHMN 226 Acidovorax avena...
ZP_00243715 147 STFVEGVrralPDTRIAFLSIKPSPLRSALMPQVVETnalvadysrhtpnlDYIDIYSKMLDAQgqpraeLFLPDALHLN 226 Rubrivivax gelat...
AAM40096    136 VAFVTRIraalPEARIGYLSIKPSPSRAQLLPAIVRAnqlikqalanvprtDYIDIYTPMLDATgkprpeLFREDMLHMK 215 Xanthomonas camp...
ZP_01121689 134 AEILSRIrsryPGMPVVLISAKPSISRWKLRGKYERFnrklsrlaeadpltRYADVWTPMLQADgslnetLFIEDGLHMN 213 Robiginitalea bi...
ZP_01356145 161 RAMLARIdaslGPIPVAYMSIKPSLARWNLRERIKRVnaearllmeqrpagYYVDVYTPMLGADgrpraeLFDADGLHLS 240 Roseiflexus sp. ...
ZP_01062103 750 KELIKAVkakyPKVPLAVISLKPSVERAHLIPQFMELnellseyvitgldaQFINVFSQMISLDdkpnpeLYMSDGLHLN 829 Leeuwenhoekiella...
ZP_01093581 123 LKFVDKVhaklPETEILFIAVKPSLSRWKLVDQVRATnrliaaeceksdllTFIDVDAPMIGEDgkpraeLFQKDGLHMT 202 Blastopirellula ...
ZP_01107875 125 KEIVSNIwmnnNKTQIILISAKPSITRWSLKRKYKRLnrkfkrlakkeeliQFVDVWSPMLEGKkin-qeLFLEDGLHMN 203 Flavobacteriales...
AAK90830    112 QTLMNRIseglPQTRLYILAIKPSPARWIYRDEFDRFnrltqawcenrykvTWLDLSGDLLGENglpmfrYYQPDLVHLN 191 Agrobacterium tu...
ZP_01075280 772 IQLLEKIdqhfTDLPVAIVSVKPSPARMHHQQEIIKVnkllerlaftrpntAFIDIYSAFFNKDkklkttLFCDDELHLN 851 Marinomonas sp. ...
YP_097673    86 RLLTNRLqrdyPDIPIFILSYKPSLARKEMIPKHEIInallqeyaskrgglTYIDVASCLYDNNgklrkdIFKQDGLHMN 165 Bacteroides frag...
ZP_01101701 125 TELLNMLekkfSRAKIIIIGLKFSTARKAAWPEFRQFnafakqwasansrgNYIDTAWSEEENAs----aFFEEDGVHLN 200 Congregibacter l...
CAD77011    154 RHVVEIArehrSDAPVLLVEVTPTRSRYDAWPKIRELnamlrevcftepnvHFVATAETFLTHDnqprenLFVDDQLHLN 233 Rhodopirellula b...
Feature 1                      
ZP_01403619 227 DAGYDLWRAVIGSYV 241 Acidovorax avenae subsp. citrulli AAC00-1
ZP_00243715 227 TQGYALWRTVIADHL 241 Rubrivivax gelatinosus PM1
AAM40096    216 PEGYALWRKAVAPVL 230 Xanthomonas campestris pv. campestris str. ATCC 33913
ZP_01121689 214 AEGYRIWKSVLGPLI 228 Robiginitalea biformata HTCC2501
ZP_01356145 241 SAGYRLWRDVLRPYV 255 Roseiflexus sp. RS-1
ZP_01062103 830 KKGYIIWSEVIKQAL 844 Leeuwenhoekiella blandensis MED217
ZP_01093581 203 DAGYQIWTKLVQPEI 217 Blastopirellula marina DSM 3645
ZP_01107875 204 ARGYEIWYPLIKPFV 218 Flavobacteriales bacterium HTCC2170
AAK90830    192 AAGYAVWAQSLKAAL 206 Agrobacterium tumefaciens str. C58
ZP_01075280 852 EKGYALISQCILAFE 866 Marinomonas sp. MED121
YP_097673   166 QNGYDLWTAILKPKI 180 Bacteroides fragilis YCH46
ZP_01101701 201 DRGYRKLLPTITEAC 215 Congregibacter litoralis KT71
CAD77011    234 EEGYVIWGKIIRDRL 248 Rhodopirellula baltica SH 1

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