Conserved Protein Domain Family
T-box_TBX15-like

?
cd20198: T-box_TBX15-like 
DNA-binding domain of T-box transcription factor 15 and related T-box proteins
TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes. TBX15 also plays a role in the differentiation of brown and brite adipocytes. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.
Statistics
?
PSSM-Id: 410324
Aligned: 5 rows
Threshold Bit Score: 411.043
Created: 8-Mar-2019
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
 
DNA binding
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on related T-box transcription factors bound with DNA
  • Comment:T-box monomers dimerize upon DNA binding; some form weak dimers, others tight dimers, some may bind as non-associating monomers where the dimer is kept in register by the DNA

cd20198 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd20198 is a member of the superfamily cl00145
Sub-family Hierarchy
cd00182T-boxcd20187T-box_TBX1_10-likecd20188T-box_TBX2_3-likecd20189T-box_TBX4_5-likecd20190T-box_TBX6_VegT-likecd20196T-box_TBX6cd20197T-box_VegT-likecd20191T-box_TBX15_18_22-likecd20198T-box_TBX15-likecd20199T-box_TBX18_likecd20200T-box_TBX22-likecd20192T-box_TBXT_TBX19-likecd20201T-box_TBX19-likecd20202T-box_TBXTcd20193T-box_TBX20-likecd20194T-box_TBR1_2_21-likecd20203T-box_TBX21cd20204T-box_TBR1cd20205T-box_TBR2cd20195T-box_MGA-likecd20681T-box_Drosocross-likecd20682T-box-likecd20683T-box_Fungi_incertae_sedis
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                         ##                                #            
Q96SF7       107 MSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPvDNKRYRYVYHSSKWMVAG 186 human
NP_001315362 104 SASMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKIVGLDPHQQYYIAMDIVPvDNKRYRYVYHSSKWMVAG 183 zebrafish
XP_007894068 110 TSSMDEIQMELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPvDNKRYRYVYHSSKWMVAG 189 elephant shark
XP_017945766 107 VTSMDEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPvDNKRYRYVYHSSKWMVAG 186 tropical clawed...
PKK30590     106 PSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPvDNKRYRYVYHSSKWMVAG 185 rock pigeon
Feature 1                                         #  #            ##                             
Q96SF7       187 NADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDG 266 human
NP_001315362 184 NADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSELSPTKPVPTGEG 263 zebrafish
XP_007894068 190 NADSPVPPRVYIHPDSLASGDTWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSELCPTKVVPSGSG 269 elephant shark
XP_017945766 187 NADSPVPPRVYVHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRIHVIRKDFSSDLSPTKPIPTGDG 266 tropical clawed...
PKK30590     186 NADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPSGDG 265 rock pigeon
Feature 1                      ####    #  ##  #######  
Q96SF7       267 VKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 304 human
NP_001315362 264 VKTFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 301 zebrafish
XP_007894068 270 VKTFTFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 307 elephant shark
XP_017945766 267 VKTFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 304 tropical clawed frog
PKK30590     266 VKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 303 rock pigeon

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap
HHS Vulnerability Disclosure