Conserved Protein Domain Family
DLP
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cd02986: DLP 
Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to interact with the U5 small nuclear ribonucleoprotein particle (snRNP)-specific 102kD protein (or Prp6). Dim1 protein, also known as U5 snRNP-specific 15kD protein is a component of U5 snRNP, which pre-assembles with U4/U6 snRNPs to form a [U4/U6:U5] tri-snRNP complex required for pre-mRNA splicing. Dim1 adopts a thioredoxin fold but does not contain the redox active CXXC motif.
Links
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Statistics
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PSSM-Id: 239284
Aligned: 6 rows
Threshold Bit Score: 201.984
Created: 29-Apr-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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first criticalsecond critical
Feature 1:first critical site
Evidence:
  • Comment:based on structure and functional studies of Dim1.
  • Comment:The inability of mutants to rescue null and temperature-sensitive mutations in S. pombe revealed two critical sites for Dim1 function.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                # ##                                                               ##
Q9NX01     10 SKKEVDQAIKSTAEKVLVLRFGRDEDPVCLQLDDILSKTSSDLSKMAAIYLVDVD--QTAVYTQYFDISYIPSTVFFFNG 87  human
AAH91710   10 SKRDVDQAIKTTAEKVLVLRFGRDEDHVCLQLDDILSKTSHDLSKMASIYIVDVD--KVPVYTQYFDISYIPSTIFFFNG 87  African clawed frog
XP_416612  10 CKKEVDQAIKSVAEKVLVLRFGRDNDAVCLQLDDILAKTAHDLSKMAVIYLVDVN--KVPVYTQYFDISYIPSTVFFFNG 87  chicken
AAS49089   18 TKEEIDRVIRDTIDEVLVLRFGRSSDAVCLQHDEILAKSVRDVSKFAKVALVDVDseDVQVYVKYFDITLFPSTIFFFNA 97  thale cress
AAV64210   11 LKSEVDAAIRDTLDKVLVLRFGRATDATCLHLDDILDKSSWDISKFAMVALVDMDseEIQVYIDYFDITLVPATIFFFNA 90  Zea mays
XP_706667  10 SKKDIDEAIKSVAEKVLVLRFGRDEDSVCLQIDEILSKTAHDLSNMASIYLVDVD--SAPVYSRYFDISFIPSTVFFFNG 87  zebrafish

Feature 1     #                                   
Q9NX01     88 QHMKVDYGSPDHTKFVGSFKTKQDFIDLIEVIYRGA 123 human
AAH91710   88 QHMKVDYGSPDHTKFVGSFKTKQDFIDLIEVIYRGA 123 African clawed frog
XP_416612  88 QHMKVDYGSPDHTKFVGSFKTKQDFIDLIEVIYRGA 123 chicken
AAS49089   98 HHMKLDSGTADHTKWVGAFHIKQDFIDVVEAIYRGA 133 thale cress
AAV64210   91 HHMKMDSGTPDHTKWIGSFSSKQDFIDVVEFYGRSS 126 Zea mays
XP_706667  88 QHMKVDYGSPDHTKFVGSFKSKQDFMDLIEVIYRGA 123 zebrafish

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