Conserved Protein Domain Family
BioC

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TIGR02072: BioC 
malonyl-acyl carrier protein O-methyltransferase BioC
This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]
Statistics
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PSSM-Id: 273953
Aligned: 21 rows
Threshold Bit Score: 193.272
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAP11034      10 RFNGAAVSYDRYANVQKKMAHSLLSILKERYsetASi----RILELGCGTGYVTEQLSKLFPKSHITAVDFAESMIAIAQ 85  Bacillus cereus...
AAP96448      12 RFVSHLTEYDQYAIAQQQINHQLVDLLQANTd-kTFq----RALEIGCGTGNLTEKLLAKIPIEHLTLNDFNAIYYPTVL 86  Haemophilus duc...
P45249        15 AFQKALNDYDRHALIQQKMTINLMAHLQDYLpngSLd----SVLELGCGSGMLSSLLQKQISADYWLFNDLCDVQT-QLA 89  Haemophilus inf...
AAO76552       9 RFSKAISTYPREANVQRQIANKMIRLLQKHIp-sPCp----KVIEFGCGTGIYSRMLLRTLRPEELLLNDLCPEMRYCCE 83  Bacteroides the...
AAP77804      18 SFHKTRDTYNDNSPIQRAMRFHLLNLVLGTNr-kSFd----SIFEFGAGTGELTALISKSFDFQHYITNDFYPYDMAGAL 92  Helicobacter he...
WP_010900034  11 HFSKSAHLYDGVNHVQRKMAHRLVQLLDEKRrdaKDep--rAILDIGCGTGWLTRECLKSFPQATIDAVDLSKQMLEVAE 88  Bacillus halodu...
WP_010931743  13 RFRRALPTYAGHAEVQRRMAVRLVALIENAG---ASth-lgRVFEFGSGSAMLTSILFERYSANEFFANDLVAESRAFVE 88  Chlorobaculum t...
WP_011711736  18 NFGRALN-YHRKALVQQHVADELAERLVDFP---LPer--pRVLEIGCGTGFLSRHLMRQWPGGSFLFTDISAPMLVRCQ 91  Magnetococcus m...
WP_011016700   2 NFNKHYNVYEKYSLAQKQVAKNLLDYMGKSN---IFntqinSIFEIGCGTGIFTKEYRKYFLHSDLILNDIFDVREFIKD 78  Fusobacterium n...
WP_002816240   2 NFLKA-KDYEKHAKVQDFMGLKLCEILKNLR---IShf--eKVFEFGCGRGELSKKLQNFITFDEYLKNDILDFKE---- 71  Campylobacter
AAP11034      86 TRQN----VkN----VTFHCEDIERLRlEES----YDVIISNATFQWLNNLQQVLRNLFQHLSIDGILLFSTFGHETFQE 153 Bacillus cereus...
AAP96448      87 QKIK----QkKplvvVDFMQGDAEQLV-FTRn---FDLVSAASVVQWFDSPQQFLRNSAYALKPGGVVLFNSFSPLNLQE 158 Haemophilus duc...
P45249        90 EKLP----Qs-----FDFYCGDAEHFL-FLQq---FDLIASASAVQWFHQPDAFIAHCKTGLKTNGLLAVATFGEDNLKE 156 Haemophilus inf...
AAO76552      84 DLLR----EkQ----VSFLSGDAETIS-FPDk---STLITSCSALQWFDSPEEFFKRCNTLLHSQGYFAFSTFGKKNMKE 151 Bacteroides the...
AAP77804      93 HDER----IlH----LAFDMAQLCTHSlAKKq---FELIISNACLQWLDCAS-TLTNLKSMITCGGILALSSFGQDNMHE 160 Helicobacter he...
WP_010900034  89 KNVSs--hP-N----VQFIQGDIEKMVrEKPsaktYDVIVANAVFQWLDKPTETVAQLRSWLKPNGLLLFSTFGPDTFYE 161 Bacillus halodu...
WP_010931743  89 KAVTgrnvE-R----LTFLPGDVERLDpLPGn---LDLAVSNATVQWLHDPARFFDRLATSVKPGGIVAFSTFGAENMHE 160 Chlorobaculum t...
WP_011711736  92 SHLSdl-pG-Q----RQFMVMDGEHCAvRGP----FDLVVSSMAMQWFGDLPGALQGLSSLLKTNGMLAFATLGDETFRE 161 Magnetococcus m...
WP_011016700  79 IDYN------------IFIQENIEELDiPKS-----DLVVSSSVFQWIKDKDSLIRNIAENTDN---LCFSSYVSGNLIE 138 Fusobacterium n...
WP_002816240  72 --NS----S-I----LIFDMNEIAKQDlSKEk---FDLIVSNATLQWL-DLKRIIPSLRDMLNQNGILLLSTFAEQNLKE 136 Campylobacter
AAP11034     154 LHASFQrakeerniknetsIG-----QRFYSKDQLLHICKIETGDVHVSETCYIESFTEVKEFLHSIRKVGATNSn-EGS 227 Bacillus cereus...
AAP96448     159 IRQLTG-------------IG-----LNYPTRLQWQEWLAQDFEQCQLIEQPIKLTFDSPLAVLIHLKKTGVTAVs-NKP 219 Haemophilus duc...
P45249       157 VRQITN-------------IG-----LNYPTLSQWQTWLAKDFELLWCEDFKVILDFDTPLDVLKHLKYTGVTATn-QKN 217 Haemophilus inf...
AAO76552     152 IRELTG-------------KG-----LPYRSREELEAALSLHFDILYSEEELIPLSFEDPMKVLYHLKQTGVNGLs-AQS 212 Bacteroides the...
AAP77804     161 IREITG-------------VG-----LKYESLDTIRALLEKDFEILVLESTHHRLHFDSSLEVFRHLKLSGVNAFg-INK 221 Helicobacter he...
WP_010900034 162 LHDSFQlaakql-giiderRG-----LDYLSKTEWKRTLDGLFAELTIHEEKAIESYATVEQFLHTVKKMGATYSqsSRP 235 Bacillus halodu...
WP_010931743 161 IAAL-Ge------------AA-----LPYRSLDKIAALSGELFELVAIEDDIVRQEFDTPEAVLRHIRKTGVNGVa-RRA 221 Chlorobaculum t...
WP_011711736 162 WRGVCAq------------YGspfgrPDYPDVAQLQEMWP-SGGEGDVEEDHIPVAHSSGHGFLRALREVGAHQPs-GQ- 226 Magnetococcus m...
WP_011016700 139 IKNHFD-------------IS-----LDYLNIEEFKEILKKYFSSVKYYSETIKLDFEDPMAVLKHLKYTGVTGF---QK 197 Fusobacterium n...
WP_002816240 137 IKQSTG-------------FG-----LNYFSLNELEQIFKVYFNEVKITQELIKLSFDNALDVFRHLKLSGVNSLg-F-- 195 Campylobacter
AAP11034     228 y--------cQSPSLFRAMLRIYERDFTGn-EG-IMATYHALFIHITK 265 Bacillus cereus ATCC 14579
AAP96448     220 ----------WNRHQIKQFCMEYQAHFACe-QG-VYLTYTPILMLGIK 255 Haemophilus ducreyi 35000HP
P45249       218 ----------WTRKNLNGFIGDYLSAFGMp-SGkVRLTYHPLFFIARY 254 Haemophilus influenzae Rd KW20
AAO76552     213 slypkhekqtWTRRDLQHFCERYTQEFTQg-TS-VSLTYHPIYIIAKK 258 Bacteroides thetaiotaomicron VPI-5482
AAP77804     222 -----------PFHLTKTMLKNYTQRFNN---T---LTYEPVYILALK 252 Helicobacter hepaticus ATCC 51449
WP_010900034 236 ----------LSKRYYQLMKEIYEQRYRTe-DS-IPATYDCLYVLCQA 271 Bacillus halodurans
WP_010931743 222 ----------WTRSQYLDFLQRYRSAYPSg-EG-VTLTWHPVYCCFRK 257 Chlorobaculum tepidum
WP_011711736 227 -----------HRPVSAALMRRMLQATRGgqHG-FTVTYHVLYGFYTR 262 Magnetococcus marinus
WP_011016700 198 ----------TSISKIKTFKDN-------------ILTYEVAYFICKK 222 Fusobacterium nucleatum
WP_002816240 196 ------------YPLNKGFLKEFEEKFQN------KLTYHPVFILCKN 225 Campylobacter
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