Conserved Protein Domain Family
MUS_TUS_MBL-B1
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cd16318: MUS_TUS_MBL-B1 
Myroides odoratimimus MUS-1, MUS-2, TUS-1 and related metallo-beta-lactamases, subclass B1; MBL-fold metallo-hydrolase domain
Includes the chromosome-encoded MBLs Myroides odoratimimus MUS-1 and related MBLs. MBLs (class B of the Ambler beta-lactamase classification) are a diverse group of metallo-enzymes that are capable of catalyzing the hydrolysis of a wide range of beta-lactam antibiotics. MBLs have been divided into three subclasses B1, B2 and B3, based on sequence/structural relationships and substrates, with the B1 and B2 MBLs being most closely related to each other. This subgroup of MBLs belongs to the B1 subclass. B1 enzymes are most active with two zinc ions bound in the active site, and have a broad-spectrum substrate profile.
Links
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Statistics
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PSSM-Id: 293876
Aligned: 3 rows
Threshold Bit Score: 461.433
Created: 20-Aug-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Feature 1:active site [active site]
Evidence:
  • Comment:based on Elizabethkingia meningoseptica BlaB metallo-beta-lactamase with the inhibitor D-captopril and two zinc ions bound in the active site
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                #                          # ###     
AKN19901   24 LKIKQLNDNMYIYTTYQEFqGVTYSSNSMYVLTDEGAILIDTPWDKDQYEPLLEYIRSNHnKEVKWVITTHFHEDRSGGL 103 Myroides odoratimimus
AAN63647   24 LKIKQLNDNMYIYTTYQEFqGVTYSSNSMYVLTDEGVILIDTPWDKDQYEPLLEYIRSNHnKEVKWVITTHFHEDRSGGL 103 Myroides odoratimimus
AAN63648   24 LKIEPLNDHMYVYTTYQVFqGVEYSSNALYVVTDEGVILIDTPWDKDQYAPLVEHIRREHnKEIKWVITTHFHEDRSGGL 103 Myroides odoratus ...

Feature 1                             #                            #                  #       
AKN19901  104 GYFNSIGAQTYTYALTNEILKERnEPQAQYSFNkEKQFTFGNEKLAVYFLGEGHSLDNTVVWFPKEEVLYGGCLIKSAEA 183 Myroides odoratimimus
AAN63647  104 GYFNSIGAQTYTYALTNEILKERnEPQAQHSFNkEKQFTFGNEKLAVYFLGEGHSLDNTVVWFPKEEVLYGGCLIKSAEA 183 Myroides odoratimimus
AAN63648  104 DYFNKAGAETYTYALTNEILKQRnEPQATFTFGsTKQFNLGKEKIEVYFLGEGHSKDNTVVWFPEEAILYGGCLIKSAEA 183 Myroides odoratus ...

Feature 1         #                             #                   
AKN19901  184 TTIGNIADGNVIAWPKTIEAVKQKFKNAKVIIPGHDEWDMIGHIENTERILSAY 237 Myroides odoratimimus
AAN63647  184 TTIGNIADGNVIAWPKTIEAVKQKFKNAKVIIPGHDEWDMTGHIENTERILSAY 237 Myroides odoratimimus
AAN63648  184 TTIGNIVDGNVEAWPTTIKAVKRKFKKAKVIIPGHDAWNQSGHLENTARILSAY 237 Myroides odoratus DSM 2801

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