Conserved Protein Domain Family
PI31_Prot_N
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pfam11566: PI31_Prot_N 
PI31 proteasome regulator N-terminal
PI31 is a regulatory subunit of the immuno-proteasome which is an inhibitor of the 20 S proteasome in vitro.PI31 is also an F-box protein Fbxo7.Skp1 binding partner which requires an N terminal FP domain in both proteins for the interaction to occur via the FP beta sheets. The structure of PI31 FP domain contains a novel alpha/beta-fold and two intermolecular contact surfaces. This is the N-terminal domain of the members.
Links
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Statistics
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PSSM-Id: 463296
Aligned: 97 rows
Threshold Bit Score: 76.168
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EJT78951      27 ATSDLSGSYEALALFTHACMACL-DFRLIG---------LTEGQKRagdd--dnnECrrlaprLPPGWNAsFNSYSFVYA 94 
Q17LA8        16 VQPSIQTKSDVLIAVVHWYLIKN-SFRNVG---------LGDDKTLsesd--eksEL------LPEGWNSnPHSYALRYV 77  yellow fever mo...
Q7QJC6        22 ESANLADKADAMMLFVHWFLVRN-GFRNVG---------VGDDKTLnnav--dqsEL------LPEGWNGnNKSYALRYI 83  Anopheles gambi...
XP_002027630  51 IRRSIRKKADLLLALAHFLVTKQyHLRSVdpehgqgirmSAGSRLIpvdpgrggsEL------LPMHWNReSSKYRLHYV 124
KRF98601      30 VNSDVHKKADLLIALVHFVLTKHySFRCLG---------IGDDKTLpeeeaesgsEL------LPDDWNSdDAKFSLRYV 94 
XP_016027068  23 VKADVSKKSDLLIALVHFLLTKHyNFRCVG---------IGDDKTLpee---egsEL------LPDSWNDdDTKYSLRYV 84 
KRF78440      28 VDGIIDKKADVLMVLAHFLLTKHyKFRCVG---------IGDDKTLpede--vgsEL------LPDHWNGdSSKYSLRYV 90 
1_pfamImport   1 VEKDVTRNTDIIVVMVHWFLTKNsSFRCIG---------IGDDRTVteqd--tgsEL------LPASWNDsSERYTLRYV 63 
Q5XIU5        11 AAPAMTCPQDALVCFLHWEVVTN-GYYGLG---------TGDQpdpn----dkksEL------LPAEWNSnKELYALRYE 70  Norway rat
EEN46053      14 VCEQVQSEHDALVCFLHWEMVQS-GFKCVG---------KGDEvmsw----skksEM------LPRGWNRtQDVYALRYQ 73 

EJT78951      95 HAQSAMTFVTKVDRMGQRAEVRGIASATDAVVRFDVAPRDYVSSAAlpvritlrkkstpagggggggggsgdattttttt 174
Q17LA8        78 NNGQl--YILHGIDSEGTMIVNLLQVKTLNVSNTTFQIEDTVKALK---------------------------------- 121 yellow fever mo...
Q7QJC6        84 MNNEl--YILHGTLSNDTMIVNLLQAQSLQVSNAAFNLDKTITSFN---------------------------------- 127 Anopheles gambi...
XP_002027630 125 DELDHQ-YVLLARLTHQDLVINLQNWTSKRMSITCLQPEDLVQTLH---------------------------------- 169
KRF98601      95 NNKTl--YLLLGHMTEDALLINLLDTNTKKVSNICIEPENLVIELK---------------------------------- 138
XP_016027068  85 HDKMl--YLLLGHITEGSLLINLLDINTKKVSNICVEPETLVPEVK---------------------------------- 128
KRF78440      91 HNKVl--YLLLGHITEDALIVNLLDINTKNVSNICITPESLVAEVK---------------------------------- 134
1_pfamImport  64 SDKIl--YILIGTHSANTFLINLLNTRTEKVSNVALKPNDIVKSLN---------------------------------- 107
Q5XIU5        71 SKDGARKLLLKAVSVENGMIINVLEHGTQQVADLTLNLDDYIDAED---------------------------------- 116 Norway rat
EEN46053      74 PSDTEENYLMKAIKMDDSLLVHVMRVKDEKVGSLTLNVKEYINKSD---------------------------------- 119

EJT78951     175 dsnngstddgggggedrtdlpakLGAVFVSPERIADLASLVKVSIVQRLAPGIAKD 230
Q17LA8       122 ------------------------GSITTLIPEAATVLDRIRRELLVPVFESNKKD 153 yellow fever mosquito
Q7QJC6       128 -----------------------DSNLTNVVVSIDDQITRLQTELIKPLCDGGSKS 160 Anopheles gambiae str. PEST
XP_002027630 170 -----------------------NSDLGQCIPTAHQVMHHLRVYLVNPVVRGRRKg 202
KRF98601     139 ------------------------GPLTNMIPTVSEIVDRFRKELLEPVFSGNSKE 170
XP_016027068 129 ------------------------GGITTIMPSASEIVERYRRELLDPVFTGNSRE 160
KRF78440     135 ------------------------GGITKIMPTATDIVERFRKELCDPVFTGNSRE 166
1_pfamImport 108 ------------------------GSIQNMVPSITYLMDRFRKELVKPVFTGTSRD 139
Q5XIU5       117 -----------------------LSDFHRTYKNSEELRSRIRSGIITPIHEQWEKv 149 Norway rat
EEN46053     120 -----------------------LQDFDSVYKNVESLEAAFQSGIVEEFKPQNRSS 152
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