3WFB,3EH4,2YEV


Conserved Protein Domain Family
COX1

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pfam00115: COX1 
Cytochrome C and Quinol oxidase polypeptide I
Cytochrome c oxidase (E.C:7.1.1.9) is a key enzyme in aerobic metabolism. Proton pumping haem-copper oxidases represent the terminal, energy-transfer enzymes of respiratory chains in prokaryotes and eukaryotes. The CuB-haem a3 (or haem o) binuclear centre, associated with the largest subunit I of cytochrome c and ubiquinol oxidases (E.C:1.10.3.11), is directly involved in the coupling between dioxygen reduction and proton pumping. Some terminal oxidases generate a transmembrane proton gradient across the plasma membrane (prokaryotes) or the mitochondrial inner membrane (eukaryotes). The enzyme complex consists of 3-4 subunits (prokaryotes) up to 13 polypeptides (mammals) of which only the catalytic subunit (equivalent to mammalian subunit I (COXI) is found in all haem-copper respiratory oxidases. The presence of a bimetallic centre (formed by a high-spin haem and copper B) as well as a low-spin haem, both ligated to six conserved histidine residues near the outer side of four transmembrane spans within CO I is common to all family members.
Statistics
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PSSM-Id: 459678
Aligned: 619 rows
Threshold Bit Score: 77.9984
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3WFB_B                  14 AVAKPYFVFALILFVGQILFGLIMGLQYvvgdflfpaiP------------FNVARMVHTNLLIVWLLFGF-MGAAYYLV 80  Pseud...
Q5P4L5                  91 rpAFVLLGFAVLWLLVASLAGLTSSIKL----------HepdwltqyawltFGRIRSIHLNAVAYGWAPMAaLGIALWMM 160 Aroma...
WP_013743220            98 YVTFVFLSCAVVWLIFASTAGLISSIKL----------HqpdfltgyawltFGRIRTVHLNAVAYGWAPMAaFGIAIWTL 167 Pusil...
Q1LF89                  73 pVVFLFICCAMVWLLVASVAGLTASIKL----------HepdllasvpwlsFGRIRTIHLNAVAYGWAPMAgLGIAMFLL 142 Cupri...
Q8XR68                  94 lVVFVFLCSAMVWLLVASLAGLTASLKL----------HlpdalatqawlsFGRIRTIHLNAVAYGWAPMAgLGIAQFVL 163 Ralst...
WP_013563280            48 lPVLVYFASALFWLIMGSVLAILASIKL----------HapwffdeaswltFGRVRPAHLNTMAYGWASMGsVATALWLT 117 Isosp...
PRJNA63271:OPIT5_22615  34 aPAIFFLGSAVLWLLVGTLYALIASIKL----------HqphflgniewlsFGHARTVHLNTVIYGWATNAaIAVSFWLM 103
jgi:Caka_0025           35 taSIFFTVSAVLWLMIGTIFALIAAFKM----------HqpdfvsatefttFGRMRSAHLNAMALGWGNNIiFAVCLWIM 104
Q2S5R3                  31 wPVIAFVVSGTFWLVAGSLLALIASFKF----------QfpdwwthqawltFGRVRPAHLNTMIYGWISMAgVGVSSWLW 100 Salin...
WP_015831040            51 tpVLFGFVIALLWLMVGTWLGDISSFKF----------DwpdllvseayltFGRLRPAHLNVMVYGWASNAmFAVALWIM 120 Methy...
3WFB_B                  81 PEE-SDCELYSPkLAWILFWvfaaAGVLTILGyLLVPYaglarltgnelwpTMGrEFLeQPTISKAGIVIV----AlgFL 155 Pseud...
Q5P4L5                 161 PRLlKTKLVGAR-FAISGALlwnlGLAVGIGC-IAAGI-------------NDGmEWL-EIP-WQVGTLFAvggaL--IG 221 Aroma...
WP_013743220           168 PRLlKTELMGGR-FALLGAMlwnaALIAGLGS-IAAGF-------------NDGlEWL-EIP-WQIDILFVvggaL--IG 228 Pusil...
Q1LF89                 143 PRLlKTELMGGR-WAVLGAAlwnaGLIAGIGS-IAAGI-------------SDGlEWL-EIP-WQVDILFViggaF--VG 203 Cupri...
Q8XR68                 164 PRVlKTPLVGGN-FAVLGAMmwnaGVVAGLGS-IAVGL-------------SDGlEWL-EIP-WQIGVLFAvggaL--VG 224 Ralst...
WP_013563280           118 ARLtRAPLAYPR-LVAGSAIlwnlGLLAGAIG-ILTGS-------------STSvEWL-ELP-PWSAPPIAaafvI--VS 178 Isosp...
PRJNA63271:OPIT5_22615 104 ARLsRSTIRHSG-LLFIAGAfwniGVTIGVIG-IMRGD-------------SNAiEWL-EMP-SYATPLLFvayaL--IG 164
jgi:Caka_0025          105 ARLcRSPIRHGG-LLLIAGAfwnvGLTVGIAG-IIKGD-------------ITSvEWL-EIP-RYASPLLAisyiL--VG 165
Q2S5R3                 101 ARLlKTKLRGRG-LLLLSAAlwnvGVLVGTIG-ILAGY-------------SRAiEWV-EMP-YVAFAFIVpamgL--LV 161 Salin...
WP_015831040           121 PRLcHTRLHWQR-VALAGIAiwnmGVFMGVLL-LLLGT-------------SDGlEWL-EFDRYSADPMMVagalL--VG 182 Methy...
3WFB_B                 156 FNVGMTVLRgrktAISMv------lMTGLIGLALLFLFSFYNPenl-----trDKFYWWWVVHLWVeGVWELIMGAILAF 224 Pseud...
Q5P4L5                 222 LPLVFTLRH----RQVEhlyvsvwyMGAALFWFPVLYIVAKLPnlhf---gveQATMNWWFGHNVLgLFYTPLSLAAVYY 294 Aroma...
WP_013743220           229 LPLVFTLQN----RKVEhlyvsiwyMGAALFWFPVLFLVGNLPgvhf---gveGATMNWWFGHNVLgLFYTPVALASVYY 301 Pusil...
Q1LF89                 204 FPLVLTLVN----RKVDhlyvsvwyMGCALFWFPVLFLVANIPglhf---gveQATMNWWFGHNVLgLFYTPLALASIYY 276 Cupri...
Q8XR68                 225 IPLVLTLLA----TRVShlyvsvwyMGCALFWFPVLYLVAKVPyvhf---gveQATMNWWFGHSVLgLFYTPLALASIYY 297 Ralst...
WP_013563280           179 VSAFVTFAR----RTEKhvyvslwyILAAVLWFPWLYTAANLMmfsqpvsgvpLATLNWWYAHNALgLWFTPVGLAAAYY 254 Isosp...
PRJNA63271:OPIT5_22615 165 AWAIITFRF----GKSRhiyvsqwyILAALFWFPWLYSIAQIMlvfspargtvQSLVNWWFAHNVLgLWFTPIGLGSVYY 240
jgi:Caka_0025          166 IWGIMAFHF----RKGEhvyvsqwyFLGALFWFPWLYVVAQLMiiwvpaqgvvQSVTNWWFAHNVLgLWLTPMALGTAYY 241
Q2S5R3                 162 VSFVRTLWH----RHARhlyisvwyLGAAILWGP-LLVIAILLpiys---gvpEATANWWYAHNILgLWITPPGLAAAYY 233 Salin...
WP_015831040           183 MSVWKTLLA----RKVHhlyvsvwyVSASFPWFVIIFTAGNLPlyq----gveSAAVNWFYAHNALgLWLTTINLGLIYY 254 Methy...
3WFB_B                 225 VLVKITGvdREVI-EKWLYVIIAMALISGIIGTGHHYFWIGVpgYWLWLGSVFSALEPLPFFAmvlfafntinrrrrdyP 303 Pseud...
Q5P4L5                 295 LLPKVIG--RPIQsYNLSLIGFWCLAFFYGQVGGHHLVGGPVpeWLITLSIVQSVMMIIPVVAfsvnqhlt-mrgnfsaL 371 Aroma...
WP_013743220           302 FLPKIIG--RPIQsYNLSLLGFWALAFFYGQVGGHHLVGGPIpsWLVTLSIVQSMMMIVPVLAfsvnqhlt-mrhhfktL 378 Pusil...
Q1LF89                 277 FLPKIIG--QPVRsYGLSLLGFWALAFFYGQVGGHHLVGGPVpgWLITLSIVQSMMMLIPVIAfsinqhqt-lrghfrqL 353 Cupri...
Q8XR68                 298 FLPKIIG--KPIQsYGLSLLGFWTLAFLYGQVGGHHLVGGPVpgWLITLSIVQSMMMLIPVVAfsvnlhqt-mrghfkaL 374 Ralst...
WP_013563280           255 LIPKVIG--RPIYsYALSVIGFWSLALFYNWNGGHHLIGGPVpaWLVTVSIVASVSMIIPVIAvainhhmt-mtshfsvL 331 Isosp...
PRJNA63271:OPIT5_22615 241 FLPKVLG--KPIHsYYLSILGFWSLALFYNWAGVHHLIGGPVpvWVQSCGIVASLMMTVPVIVtginhhmt-mvgsfgkL 317
jgi:Caka_0025          242 LIPKVLG--RPIYsYYLSVLGFWSLALFYNWAGVHHLIGGPVpvWLVSAGIVASVMMVIPVVVvginhhms-ivgfhkeG 318
Q2S5R3                 234 LIPKVIG--RPVHsYHLSYLGFWTLALFYNWAGVHHLVGGPApqWVATVSIVFSAMMIIPVIVvavnhhlt-vvghfkkL 310 Salin...
WP_015831040           255 LMPKILG--RPVYsYWLSLIGFWGLALFYALNGMHHLIGGPMpsWMIATSITASILMVIPVVAvginqhmt-vvgrfgaM 331 Methy...
3WFB_B                 304 nRAVALWAMGTTVMAfLGAGVWGFMHTLAPVNYYTHGTQLTAAHGHMAFYGAYAMIVMTIISYAM-------------Pr 370 Pseud...
Q5P4L5                 372 rHSPTLRFVVLGGMMyTLSSIQGSFEALRSVSTVTHFTHFTVAHAHLGLYGFVTLVMFGAIYFAMprivsrewpypklI- 450 Aroma...
WP_013743220           379 iYSPTLRFIVLGGMMyTLSSVQGSFEALRSINTVTHFTHFTVAHAHLGLYGFFSLVMFGAIYFVMprvmswewpypklI- 457 Pusil...
Q1LF89                 354 iESPTLRFVTFGGMMyTLSSIQGSFEALRAVNRVTHFTHYTVAHAHLGLYAFVSFAFFGAIYFIVpritgrewpyrwmI- 432 Cupri...
Q8XR68                 375 lYSPTLRFVTFGGMMyTLSSVQGSFEALRSVNVITHFTHYTVGHAHLGLYAFVSFVFFGSIYFIVpritqrewpypslI- 453 Ralst...
WP_013563280           332 kRSPTLRFVVFAAVAyTLTSLQGSMEALREVNRITHFTHYTIGHAHLGLYGFVTMMLFGTMYYAVprltgrewasataA- 410 Isosp...
PRJNA63271:OPIT5_22615 318 kSSPTLRFIVFGAVNyTLVSLQGSAMSLRSWAEITHFTQFTIAHAHWGMYAFFTMVMFGAIYYIMprlvlkewpsaklI- 396
jgi:Caka_0025          319 wRSPTIRFVVFGAINyTFVSLIGSAMALRDVNLVTHFTHFTVGHAHHGAYAFFAMIMFGGVYYMMprmlkrewpsatlI- 397
Q2S5R3                 311 kYSPTLRFVVFGAMSyTAVSLQGSLQSFRYWQEVTHFTHYTIAHAHLGVYAFATMIAFGAIYYIMprvtnwewgskrlV- 389 Salin...
WP_015831040           332 rYSPALTLLVLAAMAyTAVSLQGIMTALVNINRVTHFTHWTIAHSHLGLYMFVTFSLFGGIYYILpkilqrewpsaalI- 410 Methy...
3WFB_B                 371 lrgigeamdnrsqvleMWGFWLMTVAMVFITLFLSAAGVLqVWLQRMP--------Adga-amTfmatqdQLAIFYWLRE 441 Pseud...
Q5P4L5                 451 ----------------ALHFWLVTIGFAIYFVTLTIGGVLqGLSMLDAs-------Q------PfmesvrVTLPYLQGRS 501 Aroma...
WP_013743220           458 ----------------ALHFWLVVLGFGIYFVGLSIGGWLqGVAMLDAs-------L------PfmesvrVTIPYLESRT 508 Pusil...
Q1LF89                 433 ----------------YCHFWLAAGGICVYFVSLTIGGWLqGMAMLDAa-------R------PfmdsvqVTIPYLKARS 483 Cupri...
Q8XR68                 454 ----------------TAHFWCAAIGIGIYFVALTIAGTLqGLTMLDAs-------R------PfidsvtVTVPYLEARS 504 Ralst...
WP_013563280           411 ----------------RLHFWTCALGVVLYVGALSIGGWIqGMMLNDAe-------T------PfmkiveTTIPYLQARS 461 Isosp...
PRJNA63271:OPIT5_22615 397 ----------------SIHFWATAIGILAYVIGLSWGGILqGILTNAPklaeslgmQegtdpvAfietvkvtlpwlefrt 460
jgi:Caka_0025          398 ----------------QIHFWGSGLGILVMVFALQIGGWIqGLEMNNAe-------I------SfletvqNTMPWLKARS 448
Q2S5R3                 390 ----------------SLHFWTTGLGIGAYVTALTIGGVIqGLQLLDPd-------V------AfltiveDTKPWLVVRS 440 Salin...
WP_015831040           411 ----------------RAHILLIVAGMVLYVVALGIGGVLqGLSLLDAs-------Q------SfqasveAAKPWLLTRS 461 Methy...
3WFB_B                 442 GAG 444 Pseudomonas aeruginosa PAO1
Q5P4L5                 502 IGG 504 Aromatoleum aromaticum EbN1
WP_013743220           509 VGG 511 Pusillimonas sp. T7-7
Q1LF89                 484 VGG 486 Cupriavidus metallidurans CH34
Q8XR68                 505 VGG 507 Ralstonia solanacearum
WP_013563280           462 VAA 464 Isosphaera pallida
PRJNA63271:OPIT5_22615 461 ysg 463
jgi:Caka_0025          449 ISG 451
Q2S5R3                 441 VSG 443 Salinibacter ruber DSM 13855
WP_015831040           462 VAA 464 Methylovorus glucosotrophus
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