Conserved Protein Domain Family
Vps39_2
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pfam10367: Vps39_2 
Vacuolar sorting protein 39 domain 2
This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.
Links
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Statistics
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PSSM-Id: 402126
Aligned: 18 rows
Threshold Bit Score: 123.519
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q7QC83  787 VNILEKHAEKINPYAALQILPDTIPLVR------IKHFLENALKFYLEKKQRAQVLKGLYYAEHLQIMEQKM-------- 852  Anopheles gambiae s...
Q96JC1  772 LQVLELHHSKLDTTKALNLLPANTQIND------IRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERI-------- 837  human
Q1ZXS5  811 IKILAKHADKIDTVGALNMLPATTPLRV------VFSAINAVIQTTGRQASTRKMEKSVSQCAMSKKLERKN-------- 876  Caenorhabditis elegans
Q17M79  783 LAIMEINAEKINPYAVLQILPDNIPLMS------IKNFLEIALNHHLEKKRKTQILKGLCYAEHLQTHEQKI-------- 848  yellow fever mosquito
A0BVH3  796 LKKFATH-SQLNVLEVLDLIPDNWILSDqseddgLFQFLKSVI---SKLQGETQVIRYIRKVDLLYVQCQVA-------- 863  Paramecium tetraurelia
Q0TXX0  920 LDLLSKHGARLPASSTLDLVPPSLPVKD------LESYFRGRIRNANSVLNEERIVAKLRGVEKASVIEAVLlgdgkigr 993  Parastagonospora no...
Q5KCD5  917 LSLISKHSTSLPPSSVLDLLPPLVSIAD------IHPFFIKTLREEHRRKLEGRVMRQLGKGRKDEVEEMLM-------- 982  Cryptococcus neofor...
Q4D6I2  846 LWVLNEHSPCINPLSVMTTLPSEVCVAE------ISSYLVRAFQTLCNQVQMAEINANSVASMVADAERHNA-------- 911  Trypanosoma cruzi
Q4QGF6  841 LEVMNT-CDGVDAAAVLPMLPDEMPFAQ------ASSFLLHTLRSNTTAYHAAAVYSAILKARTLQSQESCV-------- 905  Leishmania major
Q54ZD6  938 IEFLNHYYEEMDPIKVLALLPNSIPINL------LESYLSNSFNYSISQQRESKIVKNLQKSLNLSTKSEYM-------- 1003 Dictyostelium disco...

Q7QC83  853 ------LCESKHFLVTDLSVCAVCKKKFSNqSAFVRLPDGVIVHFSCQDR 896  Anopheles gambiae str. PEST
Q96JC1  838 ------LHQQVKCIITEEKVCMVCKKKIGN-SAFARYPNGVVVHYFCSKE 880  human
Q1ZXS5  877 ------KAQSTKIIVNFSSECVVCEKKIAV-SAFVRYPDGRLAHLYCHND 919  Caenorhabditis elegans
Q17M79  849 ------HYESKHFLVTELSVCPVCKKKFSYqSAFVRTPEGNIVHYSCQDK 892  yellow fever mosquito
A0BVH3  864 ------TTKQSNVRMTSEKQCSVCSKTIGE-KVFVVYPNSVLAHHTCIKS 906  Paramecium tetraurelia
Q0TXX0  994 dgrvipGGLNRRVVIDEDRHCAVCHKRFGG-SAIRVYPDNSVVHSGCMRG 1042 Parastagonospora nodorum SN15
Q5KCD5  983 ------GLEVKRVRVTDQRICPQCHKRLGMsAIAVHAPRGEVTHLHCKDR 1026 Cryptococcus neoformans
Q4D6I2  912 ------LLRQRCVYVDEKRPCAVCGKALGV-GVIAVFPNLKATHFRCFHA 954  Trypanosoma cruzi
Q4QGF6  906 ------RLSSRAVVLEEGMVCPVCQRRLRPdTVLAVYPNNVVVHHGCTCD 949  Leishmania major
Q54ZD6 1004 ------MVCSASVYIGPDRRCAVCSKPISD-RVFVYFPNGTIVHPKCFQI 1046 Dictyostelium discoideum AX4
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