3JA8,5V8F,5U8S


Conserved Protein Domain Family
MCM5
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cd17756: MCM5 
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DNA replication licensing factor Mcm5
Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Links
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Statistics
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PSSM-Id: 350662
Aligned: 15 rows
Threshold Bit Score: 546.211
Created: 20-Jul-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:3JA8; Saccharomyces cerevisiae MCM complex with ADP bound at the Mcm5-Mcm2 and Mcm5-Mcm3 ATP-binding sites; contacts at 4A
  • Comment:the Mcm2-7 MCM complex has 6 ATP-binding sites, one at each MCM intersubunit interface
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ###                                      #######                        
3JA8_5    369 ILTNSIAPSIFGnedIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKvsPIAVYTSGKGSSAAG 448 Saccharomyces cere...
Q8I5T4    368 KIFKSIAPELYGmdeVKKACACLLFGGTRKRIGEETKIRGDINMLMLGDPSVAKSQILKFVNRcaPVSVYTSGKGSSAAG 447 Plasmodium falcipa...
P41389    325 IISNSISPAIYGnvdIKKAIACLLFSGSKKILPDGMRLRGDINVLLLGDPGTAKSQFLKFVERlaPIAVYTSGKGSSAAG 404 Schizosaccharomyce...
Q9VGW6    331 RLSQSLAPSIFGsrdIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKvaPIAVYTSGKGSSAAG 410 fruit fly
Q21902    333 LIAKSIAPSIYGsadIKKSIACLLFGGARKKLPDGITRRGDINVLLLGDPGTAKSQLLKFVEQvsPIGVYTSGKGSSAAG 412 Caenorhabditis ele...
Q6R8Y2    311 KLIKSIAPAICGyddIKEAVLCLMLGGSGKALPDGTHLRGDINVLLMGDPGTAKSQLLKFVQMatPIGVYTSGKGSSAAG 390 Entamoeba histolytica
P33992    334 VISKSIAPSIFGgtdMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKcsPIGVYTSGKGSSAAG 413 human
Q8SRS4    283 RISRSIAPSVYGhedVKRALACMLFGGTRRVLEDKVTLRGDINVLLLGDPGMAKSQLLKFMELvsPVGVYTSGKGSSAAG 362 Encephalitozoon cu...
O80786    328 NICTKIAPSIFGhedVKRAAACLLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKtaPIAVYTSGKGSSAAG 407 thale cress
Q54CP4    322 IIASSIAPSIYGhedIKRAISCQLFGGSSKKLPDKMRLRGDINLLLLGDPGTAKSQLLKFVEKvaPISVYTSGKGSSAAG 401 Dictyostelium disc...

Feature 1                                                       #                             
3JA8_5    449 LTASVQRDPmtrEFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGiTTVLNSRTSVLAAANPIyG 528 Saccharomyces cere...
Q8I5T4    448 LTAAVMRDSq-gVFSLEGGAMVLADGGVVCIDEFDKMRDDDVVAIHEAMEQQTISISKAGiTTMLNTRCSVIAAANPSfG 526 Plasmodium falcipa...
P41389    405 LTASIQRDSvtrEFYLEGGAMVLADGGIVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGiTTILNSRTSVLAAANPIfG 484 Schizosaccharomyce...
Q9VGW6    411 LTASVMKDPqtrNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGiTTTLNSRCSVLAAANSIfG 490 fruit fly
Q21902    413 LTASVIRDPqsrSFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGiTTTLNSRCSVLAAANSVyG 492 Caenorhabditis ele...
Q6R8Y2    391 LTAAVNKDSstgEFYLEGGALVLGDGGVVCIDEFDKMNEVDRVAIHEAMEQQTISIAKAGiTAVLNARSAVLAAANPSfG 470 Entamoeba histolytica
P33992    414 LTASVMRDPssrNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGiTTTLNSRCSVLAAANSVfG 493 human
Q8SRS4    363 LTASVIRDSg-gEFYLEGGALVLADNGICCIDEFDKMDEHDRVAIHEAMEQQTISIAKAGiTTMLNTRTSILAAANPVfG 441 Encephalitozoon cu...
O80786    408 LTASVIRDSstrEFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGiTTVLNSRTSVLAAANPPsG 487 thale cress
Q54CP4    402 LTASVIREPstgEYYLEGGAMVVADGGVVCIDEFDKMNVDDRVAIHEAMEQQTISIAKAGiTTILNSRTSVLAAANPVyG 481 Dictyostelium disc...

Feature 1                         #                  #      #                                 
3JA8_5    529 RYDDLKSpgDNIDFQTTILSRFDMIFIVKDDHneerDISIANHVINIHTGnanamqnqq-----------------eeng 591 Saccharomyces cere...
Q8I5T4    527 SYDDSQDttYQHDFKTTILSRFDIIFLLRNKQdvekDTLLCNHIVALHASkhksq------------------------e 582 Plasmodium falcipa...
P41389    485 RYDDMKTpgENIDFQSTILSRFDMIFIVKDEHdetkDRNIARHVINLHTNlqesset--------------------lai 544 Schizosaccharomyce...
Q9VGW6    491 RWDDTKGe-ENIDFMPTILSRFDMIFIVKDIHdesrDITLAKHIINVHLSsnksapse-------------------pae 550 fruit fly
Q21902    493 RWDESRGd-DNIDFMPTILSRFDMIYIVKDTHdvlkDATLAKHVIEVHVNasaakerdiagvpktattdsdgvmtmfdtd 571 Caenorhabditis ele...
Q6R8Y2    471 RFNERASfgDNVNLKTTILSRFDMIFMIRDKHdakrDKEIVKHIMDIHRQdvkv-------------------------- 524 Entamoeba histolytica
P33992    494 RWDETKGe-DNIDFMPTILSRFDMIFIVKDEHneerDVMLAKHVITLHVSaltqtqa---------------------ve 551 human
Q8SRS4    442 RYDDYKTpdENIEFGATILSRFDCIFILKDKHgp-nDIILAKHVLSVHQNkarednecqnglhddq---eeqisgsdrsp 517 Encephalitozoon cu...
O80786    488 RYDDLKTaqDNIDLQTTILSRFDLIFIVKDIRkysqDKEIASHIIRVHASankfsde---------------------nt 546 thale cress
Q54CP4    482 RYNDAAD--DNINFQSTILSRFDLIFIVKDPKnekrDFIISKHVINIHEKssrsggsgsvgnntydl-sntvvddshige 558 Dictyostelium disc...

Feature 1                                                                                 ##  
3JA8_5    592 seisIEKMKRYITYCRlKCAPrLSPQAAEKLSSNFVTIRKqllinel------------------esterssIPITIRQL 653 Saccharomyces cere...
Q8I5T4    583 geipLSKLTRYIQYAKrEIAPlLSKEARDSLRNFYVQTRAeyrgdr--------------------rsvtkkIPITLRQL 642 Plasmodium falcipa...
P41389    545 geipFDKFRRYINYCRhKCAPnLDAEAAEKLSSQFVAIRKlvhqseq------------------dsnsrstIPITVRQL 606 Schizosaccharomyce...
Q9VGW6    551 geisLSTFKKYIHYCRtHCGPrLSEAAGEKLKSRYVLMRSgagqqek------------------asdkrlsIPITVRQL 612 fruit fly
Q21902    572 gfltIEFLKKFVTYARlNCGPrLTPQASEKLVNHYVKMRNpvvnadafk--------------sgkkahnsaIPITVRQL 637 Caenorhabditis ele...
Q6R8Y2    525 dnlsTDILKEYIAYCKaYCIPrLTENASNKLSNYFVSIRQkvrenkl------------------endndegIPITVRQL 586 Entamoeba histolytica
P33992    552 geidLAKLKKFIAYCRvKCGPrLSAEAAEKLKNRYIIMRSgarqher------------------dsdrrssIPITVRQL 613 human
Q8SRS4    518 diipIHTIKRYVQYARsKVFPtLSEAASKQLSRYYVNTRKevrqleq------------------stlkrnaIPITVRQL 579 Encephalitozoon cu...
O80786    547 dskeDNWLKRYIQYCRaRCHPrLSKDAAENLQRKYVTIRMdmkrrah------------------etgeaapIPITVRQL 608 thale cress
Q54CP4    559 nevtIQYLKKYIAYARsRISPrLSEDAVTTLKNHYVSVRAkskeqeminngsyggggsknsveterkkrknaIPITVRQL 638 Dictyostelium disc...

Feature 1                                       
3JA8_5    654 EAIIRITESLAKLELSPIAqERHVDEAIRLFQAS 687 Saccharomyces cerevisiae S288c
Q8I5T4    643 ESLIRLAESFAKMELSQFAtDKHVQMSIDLFSAS 676 Plasmodium falciparum 3D7
P41389    607 EAIIRITESLAKMSLSPIAsEAHATEAIRLFLTS 640 Schizosaccharomyces pombe 972h-
Q9VGW6    613 EAVIRISESLAKIRLQPFAtDEHVNEALRLFQVS 646 fruit fly
Q21902    638 EAIVRIAESIAKMELQQFAtDKHVEEALRLFRVS 671 Caenorhabditis elegans
Q6R8Y2    587 EAIIRISEALAKMTMSDIAdENHVDEAIRLFELS 620 Entamoeba histolytica
P33992    614 EAIVRIAEALSKMKLQPFAtEADVEEALRLFQVS 647 human
Q8SRS4    580 EAIIRIGESLAKMELSQIVtEKHVEEAIRLFKVS 613 Encephalitozoon cuniculi
O80786    609 EAIVRLSESLAKMRLSHEAtPDDVDKAFKLFDTS 642 thale cress
Q54CP4    639 EAIIRISESLAKMSLSPIAtNEHAKEAIRLFDIS 672 Dictyostelium discoideum AX4

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