4FU6,2M16,3ZEH


Conserved Protein Domain Family
PWWP_PSIP
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cd20151: PWWP_PSIP 
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PWWP domain found in PC4 and SFRS1-interacting protein (PSIP)
PSIP, also called CLL-associated antigen KW-7, dense fine speckles 70 kDa protein (DFS 70), lens epithelium-derived growth factor (LEDGF), or transcriptional coactivator p75/p52, acts as a transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. It contains a PWWP domain, which is necessary for DNA binding.
Links
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Statistics
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PSSM-Id: 438979
Aligned: 8 rows
Threshold Bit Score: 173.246
Created: 9-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on the structures of human HRP3 and rat HDGF domains with bound DNA
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 # ## #                                                    # #          
4FU6_A        23 FKPGDLIFAKMKGYPHWPARVDEVPDgavKPPTNKLPIFFFGTHETAFLGPKDIFPYsenKEKYGKPNKRKGFNEGLWEI 102 human
2M16_A         9 FKPGDLIFAKMKGYPHWPARVDEVPDgavKPPTNKLPIFFFGTHETAFLGPKDIFPYsenKEKYGKPNKRKGFNEGLWEI 88  human
3ZEH_A        10 FKPGDLIFAKMKGYPHWPARVDEVPDgavKPPTNKLPIFFFGTHETAFLGPKDIFPYsenKEKYGKPNKRKGFNEGLWEI 89  human
AAH76307      17 FKAGDLIFAKMKGYPHWPARIDEIPDgavKPSNIKFPIFFFGTHETAFLGPKDIFPYltnKDKYGKPNKRKGFNEGLWEI 96  zebrafish
Q5XXA9         5 FKPGDLIFAKMKGYPHWPARVDEVPDgavKPPTNKMPIFFFGTHETAFLGPKDIFPYsenKDKYGKPNKRKGFNEGLWEI 84  chicken
NP_001082534   5 FKPGDLIFAKMKGYPHWPARVDELPDgavKPPSNKMPIFFFGTHETAFLGPKDIFPYeenKEKYAKPNKRKGFNEGLWEI 84  African clawed ...
XP_006009433   5 FKPGDLIFAKMKGYPHWPARVDELPDgavKSPTNKLPIFFFGTHETAFLGPKDIFPYakfKEKYGKPYKRKGFNEGLWEI 84  coelacanth
O75475         5 FKPGDLIFAKMKGYPHWPARVDEVPDgavKPPTNKLPIFFFGTHETAFLGPKDIFPYsenKEKYGKPNKRKGFNEGLWEI 84  human

Feature 1                
4FU6_A       103 DNNPKVKF 110 human
2M16_A        89 DNNPKVKF 96  human
3ZEH_A        90 DNNPKVKF 97  human
AAH76307      97 ENNPKVEL 104 zebrafish
Q5XXA9        85 DNNPKVKF 92  chicken
NP_001082534  85 ENNPKVKF 92  African clawed frog
XP_006009433  85 ENNPRVKF 92  coelacanth
O75475        85 DNNPKVKF 92  human

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