1NJ1,1NJ8


Conserved Protein Domain Family
proS_fam_I
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TIGR00408: proS_fam_I 
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prolyl-tRNA synthetase, family I
Prolyl-tRNA synthetase is a class II tRNA synthetase and is recognized by pfam model tRNA-synt_2b, which recognizes tRNA synthetases for Gly, His, Ser, and Pro. The prolyl-tRNA synthetases are divided into two widely divergent families. This family includes the archaeal enzyme, the Pro-specific domain of a human multifunctional tRNA ligase, and the enzyme from the spirochete Borrelia burgdorferi. The other family includes enzymes from Escherichia coli, Bacillus subtilis, Synechocystis PCC6803, and one of the two prolyL-tRNA synthetases of Saccharomyces cerevisiae. [Protein synthesis, tRNA aminoacylation]
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Statistics
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PSSM-Id: 273062
Aligned: 9 rows
Threshold Bit Score: 701.102
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1NJ1_A  38 TEFSEWFHNILEEAEIIDQrYPVKGMHVWMPHGFMIRKNTLKILRRILDR--------------------DHEEVLFPLL 97  Methanothermobacter t...
Q58635   1 MEFSEWYSDILEKAEIYDVrYPIKGCGVYLPYGFKIRRYTFEIIRNLLDEs-------------------GHDEALFPML 61  Methanocaldococcus ja...
O26708  18 TEFSEWFHNILEEAEIIDQrYPVKGMHVWMPHGFMIRKNTLKILRRILDR--------------------DHEEVLFPLL 77  Methanothermobacter t...
O28664   7 ENFSEWYHEVIQTAEIMDVrYPVKGLYVWFPFGFKIRQLVYSKLREIMDR--------------------EHDEVYFPAL 66  Archaeoglobus fulgidu...
O51363  10 DDYSKWYLDIVQKAKLADY-SPVKGCMVIMPYGYSIWSKIQSILDKKFKEt-------------------GHENAYFPML 69  Borrelia burgdorferi B31
P38708 193 LDFPGWYQQILTKGEMLDY-YDVSGCYILRPPSYAIWENIQKWFDDKIKAi-------------------GVQNAYFPMF 252 Saccharomyces cerevis...
P47525   6 QDLTSWYDQLLVKAKLICH-GEVKGTVCFLNNSWGLWMEIQQLYNDAIANknqlsaialtkfqpttsfcyQVFQVQLPTL 84  Mycoplasma genitalium...
P75382   6 QNLTLWYDQLLSKAQLVSY-GDVKGTNCFLPNSWNLWLQIQRLYNNATALiklkdkvilkqfipieplpyTVEQVQLPTL 84  Mycoplasma pneumoniae...
1NJ8_A   5 LEFSEWYSDILEKAEIYDVrYPIKGCGVYLPYGFKIRRYTFEIIRNLLDEs-------------------GHDEALFPML 65  Methanocaldococcus ja...

1NJ1_A  98 VPEDELAKEAIHVKGFEDEVYWVTHGGLSKLQRKLALRPTSETVMYPMFALWVRSHTDLPMRFYQVVNTFRYETKhTRPL 177 Methanothermobacter t...
Q58635  62 IPEDLLAKEAEHIKGFEDEVYWVTHGGKTQLDVKLALRPTSETPIYYMMKLWVKVHTDLPIKIYQIVNTFRYETKhTRPL 141 Methanocaldococcus ja...
O26708  78 VPEDELAKEAIHVKGFEDEVYWVTHGGLSKLQRKLALRPTSETVMYPMFALWVRSHTDLPMRFYQVVNTFRYETKhTRPL 157 Methanothermobacter t...
O28664  67 IPETELGKEGEHIKGFEDEVYWITHGGLTPLDVKLALRPTSETAMYPMFRLWVRNHADLPLKVYQIVNTFRYETKhTRPL 146 Archaeoglobus fulgidu...
O51363  70 IPYSFLEREKDHIDGFSPEFAIIKDAGGESLAEPLVLRPTSETIIWNMYSKWIKSYRDLPLKINQWANVVRWEKR-TRPF 148 Borrelia burgdorferi B31
P38708 253 VSSRVLEKEKDHVEGFAPEVAWVTRAGSSELEEPIAIRPTSETVMYPYYAKWVQSYRDLPLKLNQWNSVVRWEFKhPQPF 332 Saccharomyces cerevis...
P47525  85 SFYSEYQKEKTHIKGFNPELFLINQVGQKQLNDPLVLRPTSEIAFCNLWKKQELSYHDLPLIYNQWTQVFRAEKN-TRPF 163 Mycoplasma genitalium...
P75382  85 SFYSEYQKEKRHVEGFNPELFLIEQIGTKKLHDPLVLRPTSEIAFCNLWKKQSFSYQNLPVIYNQWTCVFRAEKN-TRPF 163 Mycoplasma pneumoniae...
1NJ8_A  66 IPEDLLAKEAEHIKGFEDEVYWVTHGGKTQLDVKLALRPTSETPIYYMMKLWVKVHTDLPIKIYQIVNTFRYETKhTRPL 145 Methanocaldococcus ja...

1NJ1_A 178 IRVREITtFKEAHTIHATASEAEEQVERAVEIYKEFFn-SLGIPYLITRRPPWDKFPGSEYTVAFDTLMPDG-KTLQIGT 255 Methanothermobacter t...
Q58635 142 IRLREIMtFKEAHTAHSTKEEAENQVKEAISIYKKFFd-TLGIPYLISKRPEWDKFPGAEYTMAFDTIFPDG-RTMQIAT 219 Methanocaldococcus ja...
O26708 158 IRVREITtFKEAHTIHATASEAEEQVERAVEIYKEFFn-SLGIPYLITRRPPWDKFPGSEYTVAFDTLMPDG-KTLQIGT 235 Methanothermobacter t...
O28664 147 IRLREITsFKEAHTVHKDFEEAAEHVKKAIGFYKEFYd-FLAIPYMVIRRPEWDKFPGAAYTIAFDTIMPDG-RTLQIGT 224 Archaeoglobus fulgidu...
O51363 149 LRTTEFL-WQEGHTAHATEEEALEETLLILDVYKRFIedYLAIPVFCGKKSEKEKFAGAVSTYSIEALMQDK-KALQAAT 226 Borrelia burgdorferi B31
P38708 333 LRTREFL-WQEGHTAHLTAKDAEEEVLQILDFYAGVYeeLLAVPVVKGRKTEKEKFAGGDFTTTCEGYIPQTgRGIQGAT 411 Saccharomyces cerevis...
P47525 164 LRNSEFY-WQETHGLFVDQSQSEQAAISFWNLYQDLIinKLCIPAFVGLKSESEKFAGAKNTWTIEAIMPDG-QSLQCAT 241 Mycoplasma genitalium...
P75382 164 LRNSEFY-WQETHGLFSDGVNSESAAIAFWKLYQDIIvnQLCIPAFVGLKSPNERFAGAQNTWTVESIMPDG-QALQCAT 241 Mycoplasma pneumoniae...
1NJ8_A 146 IRLREIMtFKEAHTAHSTKEEAENQVKEAISIYKKFFd-TLGIPYLISKRPEWDKFPGAEYTMAFDTIFPDG-RTMQIAT 223 Methanocaldococcus ja...

1NJ1_A 256 VHNLGQTFARTFEIKFETPEG---DHEYVHQTCYGLSDRVIASVIAIHGDESGLCLPPDVAAHQVVIVPi-iFKKA---A 328 Methanothermobacter t...
Q58635 220 VHNLGQNFSKTFEIIFETPTG---DKDYAYQTCYGISDRVIASIIAIHGDEKGLILPPIVAPIQVVIVPl-iFKGK---E 292 Methanocaldococcus ja...
O26708 236 VHNLGQTFARTFEIKFETPEG---DHEYVHQTCYGLSDRVIASVIAIHGDESGLCLPPDVAAHQVVIVPi-iFKKA---A 308 Methanothermobacter t...
O28664 225 VHHLADNFARTFDIKYEAPNG---EHYYAHQTCYGISERCIAALISVHGDDLGLVLPFEVAPVQIVIIPi-lYKGK---E 297 Archaeoglobus fulgidu...
O51363 227 SHYLGLNFAKAFDVKFQDKDGk-mRHVFA--SSWGVSTRLIGALIMVHSDEKGLVLPPRIAPIEIIVIPi--FKKEd-eI 300 Borrelia burgdorferi B31
P38708 412 SHHLGQNFSKMFNLSVENPLGsdhPKIFAYQNSWGLSTRVIGVMVMIHSDNKGLVIPPRVSQFQSVVIPvgiTKKTseeQ 491 Saccharomyces cerevis...
P47525 242 SHDLGDTFTKSFTISYQSKTN---QKMTPSSFSCGMSTRILGAIFLTHSDDYGLVLPWYLASKQVKLYL---FDKN---N 312 Mycoplasma genitalium...
P75382 242 SHDLGQTFTKPFGLTFQNQAN---QQAIPYSFSCGISTRILGALLLTHSDDFGLVLPWKVAPIQVKLYL---FDKK---G 312 Mycoplasma pneumoniae...
1NJ8_A 224 VHNLGQNFSKTFEIIFETPTG---DKDYAYQTCYGISDRVIASIIAIHGDEKGLILPPIVAPIQVVIVPl-iFKGK---E 296 Methanocaldococcus ja...

1NJ1_A 329 -EEVMEACRELRSRLEAAgFRVHLDDRDI-RAGRKYYEWEMRGVPLRVEIGpRDLEKGAAVISRRDtg--eKVTADLQGI 404 Methanothermobacter t...
Q58635 293 -DIVMEKAKEIYEKLKGK-FRVHIDDRDI-RPGRKFNDWEIKGVPLRIEVGpKDIENKKITLFRRDtm--eKFQVDETQL 367 Methanocaldococcus ja...
O26708 309 -EEVMEACRELRSRLEAAgFRVHLDDRDI-RAGRKYYEWEMRGVPLRVEIGpRDLEKGAAVISRRDtg--eKVTADLQGI 384 Methanothermobacter t...
O28664 298 -EAVMEACRKLAEKLKAF--RVVLDEGED-RPGAKYYKWELKGVPIRFEIGpRDAEKGVAVVSFRDek--rKFEVPLDEV 371 Archaeoglobus fulgidu...
O51363 301 nKKILDYSDCVVDALKKAeFRVEIDKDVRsSPGFRFSSAEFKGIPIRLEVGiNDVLLNSVTISRRDkdrkfKYQISLDSL 380 Borrelia burgdorferi B31
P38708 492 rKHIHETARSVESRLKKVgIRAFGDYNDNyTPGWKFSQYELKGIPIRIELGpKDIEKNQVVVVRRNds--kKYVVSFDEL 569 Saccharomyces cerevis...
P47525 313 nPKTRALAFLVKDFLEKLkIRFSFIEINN-QLGKQLLKGEIEGIPLQMIVD-NEKTINIFNRLTRL-----KTSLTFANL 385 Mycoplasma genitalium...
P75382 313 dTKTVELAQKVQTLLEQLaIRFQFIKVEN-QLGKQLGQGEVNGIPFQLIVD-NPQTVNIFNRLTRV-----KTAYSFEQL 385 Mycoplasma pneumoniae...
1NJ8_A 297 d-IVMEKAKEIYEKLKGk-FRVHIDDRDI-RPGRKFNDWEIKGVPLRIEVGpKDIENKKITLFRRDtm--eKFQVDETQL 371 Methanocaldococcus ja...

1NJ1_A 405 EET-LRELMKDILENLRTRAWERMESEIREAETL-----EEASRIVDEKRgIISFMWCgEEECGMDVEEKVR-------- 470 Methanothermobacter t...
Q58635 368 MEV-VEKTLNNIMENIKNRAWEKFENFITILEDIn---pDEIKNILSEKRgVILVPFK-EEIYNEELEEKVE-------- 434 Methanocaldococcus ja...
O26708 385 EET-LRELMKDILENLRTRAWERMESEIREAETL-----EEASRIVDEKRgIISFMWCgEEECGMDVEEKVR-------- 450 Methanothermobacter t...
O28664 372 DEGkVLEWARELKQRLRNAAAERMAEKVKFVENT---------GEIEEWGgVVAVYLCsDEDCGHSVEEHGK-------- 434 Archaeoglobus fulgidu...
O51363 381 ISK-VKVELDLMQKDLFQRALNFRILNTKEIFRSskdsyETFKAYVNDYSgFVLSCWCgSLNCENIIKNETK-------- 451 Borrelia burgdorferi B31
P38708 570 EAR-IPEILEEMQGDLFKKAKELFDTHRVIVNEW-----SGFVPALNKKN-VILAPWCgVMECEEDIKESSAkkddgeef 642 Saccharomyces cerevis...
P47525 386 QTE-FVNLVNNYHTEMYRKANDLVEQKLARVQTL-----KEIEQAFKNKK-AVLCTVKlTGELEQHLKTKYQ-------- 450 Mycoplasma genitalium...
P75382 386 ASR-FVELVQQYHQAMYDKAKAVVQQKVVQATTL-----KQIEQAFNDKK-AVLCAVRlTDTLEQQLKERYQ-------- 450 Mycoplasma pneumoniae...
1NJ8_A 372 MEV-VEKTLNNIMENIKNRAWEKFENFITILEDIn---pDEIKNILSEKRgVILVPFKeEIY-NEELEEKVE-------- 438 Methanocaldococcus ja...

1NJ1_A 471 ----------VDILGiqeeg-------sgtciNCGREAPYRAYLARTY 501 Methanothermobacter thermautotrophicus
Q58635 435 ----------ATILG-----------------ETEYKGNKYIAIAKTY 455 Methanocaldococcus jannaschii DSM 2661
O26708 451 ----------VDILGiqeeg-------sgtciNCGREAPTGLTLPEHI 481 Methanothermobacter thermautotrophicus str. Delta H
O28664 435 ----------SLLGWfeevpdwldlepegkcvVCGREG-RLAALAKTY 471 Archaeoglobus fulgidus DSM 4304
O51363 452 ----------ATIRCipddfkar-dltgmtciYCSSKAKYFVLFAKSY 488 Borrelia burgdorferi B31
P38708 643 eeddkapsmgAKSLCipfdqpvl--negqkciKCERIAVNYCMFGRSY 688 Saccharomyces cerevisiae S288c
P47525 451 ----------VSVRCvfkksd-----vtqncpFTNQPCFDSVLIARAY 483 Mycoplasma genitalium G37
P75382 451 ----------VTVRCcleqlq-----kpqicpFSGESAQDYVLIARAY 483 Mycoplasma pneumoniae M129
1NJ8_A 439 ----------ATILG-----------------ETEYKGNKYIAIAKTY 459 Methanocaldococcus jannaschii
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