Conserved Protein Domain Family
7tmA_Peropsin
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cd15073: 7tmA_Peropsin 
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors
Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.
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Statistics
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PSSM-Id: 320201
Aligned: 9 rows
Threshold Bit Score: 408.356
Created: 10-Nov-2008
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Feature 1:putative ligand binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
NP_001073227  26 NIVAAYLITAGVISIFSNIVVLGIFVKYKEfrtaTNAIIINLAFTDIGVSGIGYPMSAASDLHg-----------sWKFG 94  chicken
NP_001004654  26 NIVAAYLITAGVISLSSNIVVLLMFVKFRElrtaTNAIIINLAFTDIGVAGIGYPMSAASDLHg-----------sWKFG 94  zebrafish
O14718        26 NIVATYLIMAGMISIISNIIVLGIFIKYKElrtpTNAIIINLAVTDIGVSSIGYPMSAASDLYg-----------sWKFG 94  Homo sapiens
BAC76023      37 LIVGLYLFVIGIIGTIENGITLATFSKFRSlrspTTMLLVHLAIADLGICIFGYPFSGASSLRs-----------hWLFG 105 Japanese lancelet
XP_001506416  26 NIVAAYLITAGIMSIVSNVIVLGIFVKFEElrtaTNAIIINLAVTDIGVSGIGYPMSAASDLHg-----------sWKFG 94  platypus
NP_033128     26 SVIAAYLIVAGITSILSNVVVLGIFIKYKElrtpTNAVIINLAFTDIGVSSIGYPMSAASDLHg-----------sWKFG 94  house mouse
EEN61859      36 LIVGLYLFVIGIIGTVENGITLATFTKFRSlrspTTMLLVHLAIADLGICIFGYPFSEILAYDvllclslvlhqshWLFG 115 Florida lancelet
BAJ22674      37 TIVGTYLIIIGILGTLGNGLVLVTFLRFRVlvtpTTLLLVNLAVSDLGLILFGFPFSASSSLSa-----------kWIFG 105 Hasarius adansoni
EKC42752      16 RNFSGLSGKLGIFSLIGNGITIVVICRFPKlrtaANIFIANLAAADLAITILTFPFSVVSHFYn-----------gWQFG 84  Pacific oyster

Feature 1              #   ##  ##                                                               #
NP_001073227  95 YtGCQIYAALNIFFGMASIGLLTVVAVDRYLTICRPdIGRRMtTRNYAALILAAWINAVFWASMPtVGWAGYASDPtgAT 174 chicken
NP_001004654  95 YmGCQIYAALNIFFGMASIGLLTVVAIDRYLTICRPdIGQKLtTRSYTLLIVAAWLNAVFWSSMPiVGWAGYAPDPtgAT 174 zebrafish
O14718        95 YaGCQVYAGLNIFFGMASIGLLTVVAVDRYLTICLPdVGRRMtTNTYIGLILGAWINGLFWALMPiIGWASYAPDPtgAT 174 Homo sapiens
BAC76023     106 GvGCQWYGFNGMFFGMANIGLLTCVAVDRYLVICRHdLVDKVnYNTYGVMAALGWLFAAFWAALPlVGWAEYALEPsgTA 185 Japanese lancelet
XP_001506416  95 HaGCQIYAGLNIFFGMSSIGLLTVVAVDRYLTICRPaIGRKMtRSNYTAMILAAWMNGFFWASMPlLGWASYASDPtgAT 174 platypus
NP_033128     95 HaGCQIYAGLNIFFGMVSIGLLTVVAMDRYLTISCPdVGRRMtTNTYLSMILGAWINGLFWALMPiIGWASYAPDPtgAT 174 house mouse
EEN61859     116 GvGCQWYGFNGMFFGMANIGLLTCVAVDRYLVICRQdLVDKVnYNTYGVMAALGWLFAAFWAALPlVGWAEYSLEPsgTA 195 Florida lancelet
BAJ22674     106 EgGCQWYAFMGFLFGSAHIGTLALLALDRYLIACRIsLRGKLtFKRYTQMITVVWTYAFFWALMPlLGWGRYGLEPsvTT 185 Hasarius adansoni
EKC42752      85 QdVCRWYGFNCMLFGLGSIAFLAAISCDRYLVTCRHeLYCKFsKRHYFIVSVLLWTNCMIWAAAPfMGWGCYDNDVtgVL 164 Pacific oyster

Feature 1        ###                ##   #                                                       
NP_001073227 175 CTANWRKNDv-pFVSYTMSVIAVNFVVPLTVMFYCYYNVSRTMkqytssnc------lesinmdWSDQVDVTKMSVVMIV 247 chicken
NP_001004654 175 CTINWRNNDt-sFVSYTMTVITVNFIIPLSVMFYCYYNVSATVkrfkasnc------ldsinmdWSDQMDVTKMSVIMIV 247 zebrafish
O14718       175 CTINWRKNDr-sFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIkhhttsdc------teslnrdWSDQIDVTKMSVIMIC 247 Homo sapiens
BAC76023     186 CTINFQKNDs-lYISYVTSCFVLGFVVPLAVMAFCYWQASCFVskvlkgdiagdltfpvaanvdWEYQNHFSKMCLAMVA 264 Japanese lancelet
XP_001506416 175 CTINWRKNDa-sFISYTMTVIAVNFAVPLIVMFYCYYNVSKAMrqypasrv------lenlnidWSEQVDVTKMSVVMIL 247 platypus
NP_033128    175 CTINWRNNDt-sFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLrlyaasdc------tahlhrdWADQADVTKMSVIMIL 247 house mouse
EEN61859     196 CTINWQKNDs-lYISYVTSCFILGFALPLAVMMFCYWQASCFVnkvlkgdisgdltfpvavnvdWEYQNHFSKMCLAMVA 274 Florida lancelet
BAJ22674     186 CTIDWQHNDs-sYKSFLIVYFVLGFMVPFAIIAVSYIAIARRVgkksker--------pvvrdlWTNERSVTLMAFILIV 256 Hasarius adansoni
EKC42752     165 CTITWTCNGraaFASFIYALSVVCFILPCCIITVSYRKTYQFIkavgagg--------sqenieWTHQKQITKMCVVAVI 236 Pacific oyster

Feature 1             #   #                      #   #                     
NP_001073227 248 MFLVAWSPYSIVCLWSSFgdpkkiSPAMAIIAPLFAKSSTFYNPCIYVIANkKFRRAI 305 chicken
NP_001004654 248 MFLAAWSPYSIVCLWASFgdpqkiPAPMAIIAPLLAKSSTFYNPCIYVIANkKFRRAI 305 zebrafish
O14718       248 MFLVAWSPYSIVCLWASFgdpkkiPPPMAIIAPLFAKSSTFYNPCIYVVANkKFRRAM 305 Homo sapiens
BAC76023     265 AFVVAWTPYSVLFLFAAFwnpadiPAWLTLLPPLIAKSSALYNPIIYIIANrRFRNAI 322 Japanese lancelet
XP_001506416 248 MFLMAWSPYSIVCLWSSFgdpkkiSPAVAIMAPLFAKSSTFYNPCIYVVANkKFRRAM 305 platypus
NP_033128    248 MFLLAWSPYSIVCLWACFgnpkkiPPSMAIIAPLFAKSSTFYNPCIYVAAHkKFRKAM 305 house mouse
EEN61859     275 AFVVAWTPYSVLFLFAAFgnpadiPAWITLLPPLIAKSSALYNPIIYIIANrRFRSAI 332 Florida lancelet
BAJ22674     257 TFFVAWSPYAVLCLWTIFaepntvPPFLTLIPPLFAKSSTVVNPLIYFLSNpKLRTAI 314 Hasarius adansoni
EKC42752     237 LFLVAWMPFTIYFLIISIqeastlPALFHVVPAVFAKTSTCYNPVIYAIVNkRFRIAI 294 Pacific oyster

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