Conserved Protein Domain Family
TraB_PrgY_gumN

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pfam01963: TraB_PrgY_gumN 
TraB/PrgY/gumN family
This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora Enterococcusfaecalis and gumN from the plant pathogen Xanthomonas. Tiki1 is homologous to TraB/PrgY. They have a pair of widely spaced GX2H motifs and a conserved glutamate. From the structural study, this group of proteins have been identified as an ancient metalloprotease clan with a common protein architecture (cobbled from the folds of the EreA/ChaN/PMT group) that mediates proteolytic activities. Tiki1 is a membrane-associated protease that inhibits Wnt via the cleavage of its amino terminus, diminishing Wnt's binding to receptors. TraB/PrgY is an inhibitor peptide that may act as a protease to inactivate the mating pheromone.
Statistics
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PSSM-Id: 426534
Aligned: 193 rows
Threshold Bit Score: 83.9446
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ADY45725      40 FLWSIESsdGAK----N-YMF-GTIHVPFTEVWeHVSERVKEAFK--KANSIVFELDLh-------------nPSTIETL 98 
Q82YU8        10 VEKIIVS--NKT----Y-YLV-GTSHISENSVK-LVKEVIERV----QPDTVSIELDKkry----------ekYTNSNQW 66  Enterococcus fa...
Q82YN8         4 dIVRLFYk--GS----EiILI-GTSHISAESAD-LVRKTIQE--E--NPDTICIEWDQkry----------kkNIHPDEW 61  Enterococcus fa...
WP_002366016   3 lVRRVFIk--DK----EiILV-GTAHISSESAE-LVKNIIEE--E--NPDVVCLEWDQsry----------dkYLNPDEW 60  eubacteria
Q52189         3 lVRRIFL--DKR----E-IILvGTSHISK-----ESAELVKEVIEkeSPDTVCLEWDKtry----------nkYMNPDEW 60  Enterococcus fa...
Q3JDP0         9 PLSIIKF--ADR----QiTLL-GTAHVSRASAE-HVKALLAT--G--DYDAVAVELCPsry----------qaLINPNAL 66  Nitrosococcus o...
Q8GXY6        95 vVILTCEs-TADggscDvYLV-GTAHVSKQSCL-----EVEAIISilKPEVVFVELCS---------------------- 145 thale cress
CAN73376      81 pAWRTEFv-EPE----EiWLL-GTTHISS-----FSAADVERVVEvvNPDNVVVELCRsr-----------qlMTDGLIW 138
XP_001633823   5 tVTKLETp-EGC----VvYVI-GTAHFSKESQE-DVAKTIQAV----QPDRVLVELCKsridilkydeefllrEAKNIDM 73 
Q9VG01       241 tVTLLNTp-FGS----KvYLV-GTAHFSEESQD-DVSYVIRN--V--RPDVVMVELCPsrihi------lkldEKTLLEE 303 fruit fly
ADY45725      99 VK------CKNMP--T-GDDVSCYLPAKLYARLKHYIRKyrQRLASwsnrVvsnkiEAKkrarhiynsvaggweqrRPvW 169
Q82YU8        67 GN------TDIIKiiK-EKKLVVLISNIVYSAYQKKLAN---T---------------------------------KGtT 103 Enterococcus fa...
Q82YN8        62 DD------TDIVKiiK-NKQFPVFIFGVIYKLFQKKVSQ-----------------DMN--------------------S 97  Enterococcus fa...
WP_002366016  61 SD------TDIVQviK-QKRLTVLISSVIYKLIQKHLAKi-----------------------------------nDS-V 97  eubacteria
Q52189        61 SD------TDIVQviK-QKKLIVLISSVIYSLIQNHLAK----IND----S-------------------------VPgA 100 Enterococcus fa...
Q3JDP0        67 SR------MDLLEvlR-KGKAAMVTASLALGAYQQRIAE---QFGI------------------------------EPgA 106 Nitrosococcus o...
Q8GXY6       146 SR------LSVLK----PQTLKIPTMSDMIESWKQKQNT----FGI----------LYG--------------------W 181 thale cress
CAN73376     139 IHgrirqnCLFFL--HiAGGQTALALRLLLAVFSSKISS-----------------DVN-----------------RP-- 180
XP_001633823  74 QK------LKLAI--K-QSGVVGGIMQVLLLSMSAHITQ---QLGM------------------------------AP-- 109
Q9VG01       304 AK------SINIPkiRgILHTHGYINGIFFILLLQMSAQiaKDLGM------------------------------AP-- 345 fruit fly
ADY45725     170 LLFLLYQLSEKFAQSEHI------------PM-LDLYLAqYAIESNKRLLSIETPI---EQCNPLs---sVDREQLLFAI 230
Q82YU8       104 QAGELIQAIKSAKEIGAN------------IQlIDRDIQvTFKRMWRHLSFLEKPK---LFMTFFt---eFDDIEQDKLE 165 Enterococcus fa...
Q82YN8        98 LVGKEFVVAVDESKKLNIk-----------FYlIDRDSSlTFKRAWRMLNFREKVKlpyAFGKIF-----EGAEETEEEV 161 Enterococcus fa...
WP_002366016  98 AGAEFFEAVSSAEKV-GAk-----------IAlVDRDSQvTFKRFWRLIPLRKKAL---LPYA-FgsvleGAEESEEEML 161 eubacteria
Q52189       101 EFFQAVNSAEKIGAKLAL---------------VDRDSQvTFKRFWRLIPLRKKALfphAFGKVL-----EGAEDSKEEM 160 Enterococcus fa...
Q3JDP0       107 EMRAAVDSAHSAKLPVLL---------------IDREVGtTLKRIYRNVPWWQRFN---LIGGLFas--lISRDTVSEEE 166 Nitrosococcus o...
Q8GXY6       182 FLAKIASHLEVFPGAEFRvayeeaikyggkVIlGDRPVQiTLKRTWAKMPLWHKVK---FLYSILfqavfLPGAEELEKM 258 thale cress
CAN73376     181 -FGDEFRAARKASEKVGAq-----------IVlGDRPIEiTLERAWNSLEWNEKLS---LVISVIrg--iTSSELSTNEM 243
XP_001633823 110 --GGEFRAAYREARKLGCq-----------VHlGDRPIQvTLSRAMAALTVWQKVK---LAWHLLt----TKEPISPEDV 169
Q9VG01       346 -GGEFRRAFEEIHKLPGCi-----------LHlGDRPIRiTLYRALRALSMWQTMK---LVWRLT-----FTDSISIEEV 405 fruit fly
ADY45725     231 NYTLSYLEfEQdrlskrsTDDgntgLPDLIHhyncgsleastfsldskrfnhlgfslsPDLDRKAQQIdiqlREDIIVKR 310
Q82YU8       166 E----YLE----------SDS----FDKVFI----------------------------SLSKKYPSL----YQDMITDR 195 Enterococcus fa...
Q82YN8       162 Q---NLLE----------SEN----FEPVFE----------------------------ELKESYPNL----WEVFVTER 192 Enterococcus fa...
WP_002366016 162 K----LLN----------SEN----FEPIFE----------------------------QLQEAYPEL----WKVLLVER 191 eubacteria
Q52189       161 KKLLN-------------SEN----FEPIFE----------------------------QLQQTYPEL----WESFLIER 191 Enterococcus fa...
Q3JDP0       167 VERL-----KE-------GDV----LETTFS----------------------------QFAMEAENL----YLPLIDER 198 Nitrosococcus o...
Q8GXY6       259 LKDMDNVD-----------------MVTLVI---------------------------QEMSKEFPTL----MDTIVHER 290 thale cress
CAN73376     244 K----XLStDD-------STF------QLYD----------------------------QLSVAYPSL----LQPLIHER 274
XP_001633823 170 E---RCKQ----------KDL----LAEMLA----------------------------EMTGDFPLL----YKVFVTER 200
Q9VG01       406 E---ECKQ----------SDL----LEKLMQ----------------------------EMAGEFPAF----SDVFVRER 436 fruit fly
ADY45725     311 NVRMAKRIA--S--------LLr-RADtNH-----YFFALGAGHFLGENSVLELLKEHGFTIRA 358
Q82YU8       196 DKYMSTKLK--N------------NSS-QV-----NVVVVGKAHMKGIK--EKLEKRTEFSLdn 237 Enterococcus faecalis
Q82YN8       193 DDYLATKIQ--N------------TAN-GK-----TVAVLGKAHLKGVSDRLKNNQKSDLqkle 236 Enterococcus faecalis
WP_002366016 192 DQYLAQKIS--D------------QEA-GK-----IVVVIGQAHLRGVE--KNLKSNQQINIke 233 eubacteria
Q52189       192 DLYMSTKIL--N------------EEG-EK-----IVVVIGQAHLNGVEKNIKENRKANIeeld 235 Enterococcus faecalis
Q3JDP0       199 DRYMAARLR--E--------EInqNEY-RH-----LLGVIGAGHLRGVTRYLEQDDATPAKKTI 246 Nitrosococcus oceani ATCC 19707
Q8GXY6       291 DQYMASSLL-----------RVasDH--SS-----VVAVIGKGHINGIKKNWKQPITMNDLMEI 336 thale cress
CAN73376     275 DTYLAWSLKrsK--------AV--NGG-KR-----VVGVIGKGHMNGV------------IYAL 310
XP_001633823 201 DQYLARSLRlsAvp-----nIL--SNEiGGiipsvTVGVVGIGHVAGIVENFHKFEEIDIqelm 257
Q9VG01       437 DVFLCHSLQlaAlpqaapggQQ--VRP-VR-----VVGVVGIGHANGIAKMWGTVDPKKIpail 492 fruit fly
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