Conserved Protein Domain Family
P-type_ATPase_SPCA
?
cd02085: P-type_ATPase_SPCA 
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p
SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.
Links
?
Statistics
?
PSSM-Id: 319779
Aligned: 9 rows
Threshold Bit Score: 1402.91
Created: 13-Jan-2005
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Feature 1: P-type ATPase signature motif, 7 residue positions
Conserved feature residue pattern:D K [TS] G T [LIVM] [TS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:a characteristic P-type ATPase conserved sequence motif: DK[TS]GT[LIVM][TS], in which D is the reversibly phosphorylated Asp
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
P98194         54 RRAFHGWNEFdise-depLWKKYISQFKNPLIMLLLASAVISVLMH-QFDDAVSITVAILIVVTVAFVQEYRSEKSLEEL 131  human
P13586         67 RRSLYGPNEItveddeslFKKFLSNFIEDRMILLLIGSAVVSLFMG-NIDDAVSITLAIFIVVTVGFVQEYRSEKSLEAL 145  Saccharomyces...
NP_001089971   54 RRMKHGWNEFqvdd-adpIWKKYLGQFTNPLILLLLGSALVSIITK-EYEDAVSITVAILIVVTVAFVQEYRSEKSLEEL 131  African clawe...
NP_001028821   44 RLHVHGPNEFeisk-eepLWKRYLGQFKDPLIMLLLVSAVVSVVMG-QFDDAFSITMAITIVVTVAFVQEYRSEKSLEKL 121  purple urchin
NP_001021862  115 RRQYHGYNEFdvge-eepIYKKYLEQFQNPLILLLLASAFVSIVMK-QYDDAISITVAVVIVVTVGFVQEYRSEKTLEQL 192  nematode
AAK50768       42 RLKLCGPNELkhpn-pdpLYKKYLEQFKEPMILLLLSSACISLIMK-QYDDTISITVAVLIVVTVAFIQSYRSEKVLEAL 119  Schistosoma m...
NP_730742     169 RAKIIGHNELllva-edpTWKKYIEQFRNPLILLLLGSALVSVIMK-QFDDAVSITIAILIVVTVAFIQEYRSEKSLEEL 246  fruit fly
O59868         34 RNKVHGDNDLkved-eenMVVQFLKQFVKDPLILLLFASSAISVTLgNIDDAISIALAIVIVVTVGFVQEYRSEQSLKAL 112  Schizosacchar...
O75185         85 RRLAHGWNEFvadn-sepVWKKYLDQFKNPLILLLLGSALVSVLTK-EYEDAVSIATAVLVVVTVAFIQEYRSEKSLEEL 162  human

Feature 1                                                                                         
P98194        132 SKLVPPECHCVREGkLEHTLARDLVPGDTVCLSvGDRVPADLRLFEavDLSIDESsLTGETTPCSKvtapqpaat----- 206  human
P13586        146 NKLVPAECHLMRCGqESHVLASTLVPGDLVHFRiGDRIPADIRIIEaiDLSIDESnLTGENEPVHKtsqtiekssfnd-- 223  Saccharomyces...
NP_001089971  132 NKLVPPECNCIRDGkQQHLLARELVPGDVVCLSvGDRVPADIRLIEttDLLVDESsFTGETEPCSKihgsidea------ 205  African clawe...
NP_001028821  122 SNMVPPMCRCIRDGhVKEFLARSLTPGDLVQLSiGDRIPADMRLIEavDLAVDESsFTGETKPSYKttqiatkdq----- 196  purple urchin
NP_001021862  193 TKLVPPTCHVLRDGkEAMMLARELVPGDIVLLNtGDRIPSDLRIAEsfSLQIDESsLTGETEPKHKetrsvpaasa---- 268  nematode
AAK50768      120 QKLMPPKCSCLRGGeMHTFLASYLVPGDIVCLSvGDRLPADLRLFDltDLRMDESsLTGETEAVPKssevlcthfpisnt 199  Schistosoma m...
NP_730742     247 KKLVPPECHCLREGrLDTFLARELVPGDIVHLNvGDRVPADVRLFEavDLSIDESsFTGETEPARKitdvllnnt----- 321  fruit fly
O59868        113 NNLVPHYCNVIRSGkTEHIVASKLVPGDLVILQiGDRVPADLRIVEatELEIDESnLTGENSPRKKsseaissn------ 186  Schizosacchar...
O75185        163 TKMVPPECNCLREGkLQHLLARELVPGDVVSLSiGDRIPADIRLTEvtDLLVDESsFTGEAEPCSKtdspltgg------ 236  human

Feature 1                                                                                         
P98194        207 ---------------------ngdlasrsNIAFMGTLVRcGKAKGVVIGTGenseFGEVFKMMQAEEAPKTPLQKSMDLL 265  human
P13586        224 -----------------qpnsivpisersCIAYMGTLVKeGHGKGIVVGTGtntsFGAVFEMMNNIEKPKTPLQLTMDKL 286  Saccharomyces...
NP_001089971  206 ----------------------sgiatlsNIVFMGTLVRyGRGKGLVIGVGeksqFGEVFKMMQAEETPKTPLQKSMDRL 263  African clawe...
NP_001028821  197 ---------------------ngkrttrkNIAYMGTLVRnGHGKGIVIGTGenseFGDIFKMMKAEEAPKTPLQKSMDSL 255  purple urchin
NP_001021862  269 --------------------tgsdvehltCIAFMGTLVCaGRGRGIVISTAansqFGEVVKMMMGEESPKTPLQKSMDDL 328  nematode
AAK50768      200 sevrfsstqnvnigdnkaverlrgchdliNIGFMGTLVCsGTGKGLVIGTGehseFGEVFRMMHSEEAPRTPLQKSMDKL 279  Schistosoma m...
NP_730742     322 --------------------nvkdhsnmkNIAFMGTLVRcGNGKGIVVSTGerseFGEVFKMMQAEEAPKTPLQKSMDIL 381  fruit fly
O59868        187 ----------------------islternNIAFMGTLVRhGHGRGIVVATGsdteFGRVFLTMQQTEKPKTPLQNSMDDL 244  Schizosacchar...
O75185        237 ----------------------gdlttlsNIVFMGTLVQyGRGQGVVIGTGessqFGEVFKMMQAEETPKTPLQKSMDRL 294  human

Feature 1                                                                                         
P98194        266 GKQLSFYSFGIIGIIMLVGWLLGKdILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKrAIVKKLPIVETLGCCn 345  human
P13586        287 GKDLSLVSFIVIGMICLVGIIQGRsWLEMFQISVSLAVAAIPEGLPIIVTVTLALGVLRMAKRkAIVRRLPSVETLGSVn 366  Saccharomyces...
NP_001089971  264 GKQLSLFSFGIIGLIMLIGWLQGKpLLSMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMANKrVIVKKLPIVETLGCCn 343  African clawe...
NP_001028821  256 GKQLSFYSFCIIGFIMFLGWLQSRkLLDMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRsAIVKKLPIVETLGCVn 335  purple urchin
NP_001021862  329 GKQLSIYSFGVIAVIFLIGMFQGRnVVDMFTIGVSLAVAAIPEGLPIVVAVTLAIGVMRMAKRrAVVKKMPAVETLGCVt 408  nematode
AAK50768      280 GKHLSAISLIIISSIVIIGLFQGRhILELLTIGVSLAVAAIPEGLPIVVTVPLAIGQMRMAARnAIVRRLPAVETLGCVn 359  Schistosoma m...
NP_730742     382 GAQLSFYSFLIIGVIMLLGWLQGKpLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRnSIVKKLPTVETLGCVn 461  fruit fly
O59868        245 GKQLSLISLIGIAVIVLVGFFQGKnWLEMLTIGVSLAVAAIPEGLPIIVTVTLALGVLRMSKKrAIIRRLPSVETLGSVn 324  Schizosacchar...
O75185        295 GKQLTLFSFGIIGLIMLIGWSQGKqLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKrVIVKKLPIVETLGCCs 374  human

Feature 1                       #######                                                           
P98194        346 ----------VICSDKTGTLTKNEMTVTHIFTsdglhaevtgvgynqfgevi---------------vdgdvvhgfynpa 400  human
P13586        367 ----------VICSDKTGTLTSNHMTVSKLWCldsmsnklnvlsldknkktk---------------nsngnlknylted 421  Saccharomyces...
NP_001089971  344 ----------VICSDKTGTLTANEMTATKLVTsdglhaevtgvgyegkghvnl-------------lpsneevhefsnvs 400  African clawe...
NP_001028821  336 ----------VICSDKTGTLTKNEMTALSIHTsdgiraevtgvgyngdgmvv---------------vddmhilgyqsps 390  purple urchin
NP_001021862  409 ----------VICSDKTGTLTKNEMTAQAIATpegklaeitgigysaeggvvq--------------yqgeqvhqwthpe 464  nematode
AAK50768      360 vvcsenlepcIQCGDKTGTMTKNEMTVSHIVTgslerytipieqankhtdtacvkldinyanhtnyltvssaatanttik 439  Schistosoma m...
NP_730742     462 ----------VICSDKTGTLTKNEMTATIIITsdgymadvtgagyndqgeih---------------irhcnnvemaktn 516  fruit fly
O59868        325 ----------VICSDKTGTLTMNHMTVTKIYTcgmlaafslpesehie------------------------lsvrrtvg 370  Schizosacchar...
O75185        375 ----------VLCSDKTGTLTANEMTVTQLVTsdglraevsgvgydgqgtvcl-------------lpskevikefsnvs 431  human

Feature 1                                                                                         
P98194        401 vsriveaGCVCNDavirn------------------ntlmGKPTEGALialamkmgl---------dglqqdyiRKAEYP 453  human
P13586        422 vretltiGNLCNNasfsqe----------------haiflGNPTDVALleqlanfem---------pdirntvqKVQELP 476  Saccharomyces...
NP_001089971  401 igklveaGCVANNaviqk------------------ntlmGQPTEGALivlgmkmgf---------snvsdnyiRKKEIP 453  African clawe...
NP_001028821  391 iarvveaSCVCNNseird------------------nvlyGQPTEGALlalamkmql---------hhsrsrytRLSEIP 443  purple urchin
NP_001021862  465 fariieaGLVCNNatiea------------------dkliGQPTEGAIvvlakkaql---------egvrseykRLREMP 517  nematode
AAK50768      440 ldnasllNKLMSNhithyqmsanarsasfdelrtpyyyppSLDSIIQIgcicnnatirdnqlfgqptegallrlTAQFHA 519  Schistosoma m...
NP_730742     517 itnlleiGAVCNNayiqn------------------gtllGQPTEGALvavamkngm---------yataenyvRIQEYP 569  fruit fly
O59868        371 iekallaAALCNNskvhnkads---------ildttcpwaGFPVDVALiecserfgl---------kdpretysRISEVS 432  Schizosacchar...
O75185        432 vgklveaGCVANNavirk------------------navmGQPTEGALmalamkmdl---------sdiknsyiRKKEIP 484  human

Feature 1                                                                                         
P98194        454 FSSEQKWMAVKCVhrtq---------------qdrpEICFMKGAYEQVIKYCttyqskgqt-----------ltltqqqr 507  human
P13586        477 FNSKRKLMATKILnpv-----------------dnkCTVYVKGAFERILEYStsylkskgkk---------teklteaqk 530  Saccharomyces...
NP_001089971  454 FSSEQRWMAVKCIerynk--------------kqgrCMLYERELFEEVIQHCtmynsggrs-----------lpitpqqk 508  African clawe...
NP_001028821  444 FSSETKWMAVRCRphdpapn----------llpsneEIYFVKGALERVLSKCrtynvedrs-----------eplnkqki 502  purple urchin
NP_001021862  518 FSSDTKWMGVQCAdah------------------gqNVYFIKGALDRVLDQCgtyyssdnqr----------kqcdqysr 569  nematode
AAK50768      520 LDERAFYTRLQEWpfssesklmivkcvrnnqpstdePVYFAKGAVDQLLDRCaftslsndsaismqsspsdshshmlsnr 599  Schistosoma m...
NP_730742     570 FSSEQKMMAVKCIhkyn---------------nnkeEIFFAKGALETLLPQCtkyqfgtqt-----------vpltkqne 623  fruit fly
O59868        433 FSSERKYMSVAVQyn-------------------ssKMNFMKGATEQVLSSCayfsdqdgvqh--------eltaemken 485  Schizosacchar...
O75185        485 FSSEQKWMAVKCSlkte----------------dqeDIYFMKGALEEVIRYCtmynnggip-----------lpltpqqr 537  human

Feature 1                                                                                         
P98194        508 dVYQQEKARMGs----------aGLRVLALASGpel-----------gqlTFLGLVGIIDPPRTgVKEAVTTLiasGVSI 566  human
P13586        531 aTINECANSMAs----------eGLRVFGFAKLtlsdsstpltedlikdlTFTGLIGMNDPPRPnVKFAIEQLlqgGVHI 600  Saccharomyces...
NP_001089971  509 sLYIQEEKNLGm----------qGLRVLALASGsel-----------gklTFLGLVGIIDPPRPgVSEAVQILlesGVSV 567  African clawe...
NP_001028821  503 eEIKEEGRQMGv----------aGLRVLGMAVGpgt-----------enmTYLGMVGILDPPRPgVREAIDTLlssGVAL 561  purple urchin
NP_001021862  570 qHILEIGKELGq----------kGLRVLGLARGesm-----------qslMFLGMIGMMDPPRPgAADAISIVkasGVDV 628  nematode
AAK50768      600 sSNNSSIKPMDletrkailneasILGNLGLRVLalakgt------nseqmIFHGLVGLNDPPRPgVNSCIRILcesGVRV 673  Schistosoma m...
NP_730742     624 aEFLAEAYEIGr----------kGLRVLALAKGrsm-----------qdlIYCGLVGITDPPRPlVRESIEMLmqsGVRV 682  fruit fly
O59868        486 iQRNEFEMAAS------------GLRIIAVASGint-----------nklVFHGLFGINDPPRPqVRESVQYLmtgGVRV 542  Schizosacchar...
O75185        538 sFCLQEEKRMGs----------lGLRVLALASGpel-----------grlTFLGLVGIIDPPRVgVKEAVQVLsesGVSV 596  human

Feature 1                                                                                         
P98194        567 KMITGDSqETAVAIASRLGLyskt-------sqsVSGEEIDamdvqqlsqivpKVAVFYRasPRHKMKIIKSLQknGSVV 639  human
P13586        601 IMITGDSeNTAVNIAKQIGIpvidp-----klsvLSGDKLDemsddqlanvidHVNIFARatPEHKLNIVRALRkrGDVV 675  Saccharomyces...
NP_001089971  568 KMITGDAlETAQAIGRSIGLsngh-------lkaISGEELDqidesalssivtKVSVFYRtsPKHKLKIIKALQktGAIV 640  African clawe...
NP_001028821  562 KMVTGDSaETAIAVGSRLGLyakg-------stsLSGEEVEdmnfieltkminQVTIFYRasPRHKLKIVKALQatGAVV 634  purple urchin
NP_001021862  629 KLITGDAmETAQSIGQSLGIlsss-------dscLSGQQVDqmsdhdlelvirQVTVFYRasPRHKLKIVKALQalGEVV 701  nematode
AAK50768      674 IMITGDAkETACTIGSRLSLyrpg-------dlcLSGEEVErisveqlmsvvrNVTVFYRsgAKHKCKIVKALQqsNLVV 746  Schistosoma m...
NP_730742     683 KMVTGDAqETALAIANLIGIdtih-------hqtLSGQEMDqmnehqldkvanNVSVFYRvsPRHKLEIVKSLQrsGNIV 755  fruit fly
O59868        543 IMITGDSvVTAISIARSLGMaipsndeeairnyaLTGAQLDdldssslrdavsRVVVFARttPQHKMKIVEALQslGDVV 622  Schizosacchar...
O75185        597 KMITGDAlETALAIGRNIGLcngk-------lqaMSGEEVDsvekgeladrvgKVSVFFRtsPKHKLKIIKALQesGAIV 669  human

Feature 1                                                                                         
P98194        640 AMTGDGVNDAVALKAADIGVAMGqtGTDVCKEAADMILVDDDFqtimsAIEEGKGIYNNIKNFVRFQLSTSIAALTLISL 719  human
P13586        676 AMTGDGVNDAPALKLSDIGVSMGriGTDVAKEASDMVLTDDDFstiltAIEEGKGIFNNIQNFLTFQLSTSVAALSLVAL 755  Saccharomyces...
NP_001089971  641 GMTGDGVNDAVALKSADIGVAMGktGTDVSKEAADMILVDDNFstimnAIEEGKGIFYNIKNFVRFQLSTSISALSLITL 720  African clawe...
NP_001028821  635 GMTGDGVNDAVALKTADIGIAMGitGTDVSKEAADMILVDDDFttilsAIEEGKAIFYNIKNFVRFQLSTSIAALTLIAL 714  purple urchin
NP_001021862  702 AMTGDGVNDAVALKKADIGVAMGvcGTDVCKEAADMILCDDDFstmtaAIEEGKAIYHNITNFVRFQLSTSVAALSLIAA 781  nematode
AAK50768      747 AMTGDGINDAIALPSSDIGIAMGrtGTDVCREAADIVLLDDNFatilaAMEEGKALFHNIKNFIGFQLSTSIAALTLIAL 826  Schistosoma m...
NP_730742     756 GMTGDGVNDGVALKKADIGIAMGknGTDVCKEAADMILVNDDFhtiiaAIEEGKGIFYNIRNFVRFQLSTSIAALALIAL 835  fruit fly
O59868        623 AMTGDGVNDAPALKLADIGIAMGrqGTDVAKEAADMILTDDSFatilsAVEEGKGIFNNIKNFITFQLSTSVAALSLIAI 702  Schizosacchar...
O75185        670 AMTGDGVNDAVALKSADIGIAMGqtGTDVSKEAANMILVDDDFsaimnAVEEGKGIFYNIKNFVRFQLSTSISALSLITL 749  human

Feature 1                                                                                         
P98194        720 ATLMnfpnPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRnwkdsiltknlilkilvssiiivcGTLFVFWRELR 799  human
P13586        756 STAFklpnPLNAMQILWINILMDGPPAQSLGVEPVDHEVMKKPPRkrtdkilthdvmkrllttaaciivGTVYIFVKEMA 835  Saccharomyces...
NP_001089971  721 STVMnlpnPLNAMQILWINIIMDGPPAQSLGVEPVDKDAIKQPPRnakesilsralilkillsaaiiisGTLFVFWKEIP 800  African clawe...
NP_001028821  715 STMLsfpnPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRqvrdpmitrsllmnvimsatiivaGTLWVFWREMQ 794  purple urchin
NP_001021862  782 STMFkfdnPLNAMQILWINIIMDGPPAQSLGVEPVDDDIIRQRPRntkqpmltgkliadilasaaiivvGTLSVFYKEMS 861  nematode
AAK50768      827 STLLslpsPLNAMQILFINILMDGPPAQSLGVEPPDPHVVRQPPRrandsildgrlmfnvltasslivsGTLWIFFRELS 906  Schistosoma m...
NP_730742     836 ATLMdianPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRnvkqpmitksvvvnvllsasiivlGTLWVFQREMA 915  fruit fly
O59868        703 SSVFgfqnPLNAMQILWINILMDGPPAQSLGVESVDEDVMMKPPRprnapiisvqllqrvllsafiivtVTIVVFRVQMQ 782  Schizosacchar...
O75185        750 STVFnlpsPLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRsvrdtilsralilkilmsaaiiisGTLFIFWKEMP 829  human

Feature 1                                                                                         
P98194        800 Dnvi--tprDTTMTFTCFVFFDMFNALSSRSqtksvfeiGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLsilD 877  human
P13586        836 Edgkv-tarDTTMTFTCFVFFDMFNALACRHntksifeiGFFTNKMFNYAVGLSLLGQMCAIYIPFFQSIFKTEKLgisD 914  Saccharomyces...
NP_001089971  801 Dgkv--tprTTTMTFTCFVFFDMFNALACRSlnktifeiGLFKNRMFWYSVLGSILGQMAVIYIPPLQKVFLTQNLhalD 878  African clawe...
NP_001028821  795 Dnii--tprDTTMTFTCFVFFDMFNALSSRSqtksifsiGFLTNRMFLYAVGGSIMGQLLVIYFPPLQRIFQTEALtvhD 872  purple urchin
NP_001021862  862 Adnkv-tprDTTMTFTCFVLFDMWNALSCRSsrkmiwqiGLRRNRMFSLAVSASLICQLLVIYWAPLQHIFQTEALslfD 940  nematode
AAK50768      907 Dnkv--tphDTTMTFTCFVLFDMFNALSFRSqnksifslGFFSNRLFVLAVGLSLFGQLLVIYFPPLQAVFQTEALtlkD 984  Schistosoma m...
NP_730742     916 DgtlgktkrDTTMTFTCFVFFDMFNALSCRSqtksvftiGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALtpyD 995  fruit fly
O59868        783 Dgnv--tarDTTMTFTCFVFFDMFNALACRSetksvfklGIFSNRMFNIAVGGSLIGQALVVYASPFQRIFQTEAIglkD 860  Schizosacchar...
O75185        830 Edras-tprTTTMTFTCFVFFDLFNALTCRSqtklifeiGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLgalD 908  human

Feature 1                            
P98194        878 LLFLLGLTSSVCIVAEIIK 896  human
P13586        915 ILLLLLISSSVFIVDELRK 933  Saccharomyces cerevisiae S288c
NP_001089971  879 LLFLAGLASSVFVVSELIK 897  African clawed frog
NP_001028821  873 IGLLVMLTSSVFIVSEIKK 891  purple urchin
NP_001021862  941 LIFLTTITSSVFIFNETRK 959  nematode
AAK50768      985 LVLLVCLTSSVFFVSELRK 1003 Schistosoma mansoni
NP_730742     996 IFFLVSLTSSVLVVSEIKK 1014 fruit fly
O59868        861 VLILLACTSSVLWVDEIRK 879  Schizosaccharomyces pombe 972h-
O75185        909 LLFLTGLASSVFILSELLK 927  human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap