Conserved Protein Domain Family
bHLH_TS_TWIST2
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cd19700: bHLH_TS_TWIST2 
basic helix-loop-helix (bHLH) domain found in twist-related protein 2 (TWIST2) and similar proteins
TWIST2, also termed Class A basic helix-loop-helix protein 39 (bHLHa39), or Dermis-expressed protein 1, or Dermo-1, is a bHLH transcription factor that regulates the development of mesenchymal tissues and plays a critical role in embryogenesis. It binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C.
Links
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Statistics
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PSSM-Id: 381543
Aligned: 4 rows
Threshold Bit Score: 136.457
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         #   # ### #    #                ####                           
Q8WVJ9        51 GKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKM 130 human
KFO11180      43 GKKSSPSSQSYEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDSKM 122 Balearica pavon...
NP_990010     51 GKKSSPSSQSYEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDSKM 130 chicken
XP_005995994  51 GKKPSPASQSYEELQNQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKL 130 coelacanth

Feature 1          
Q8WVJ9       131 TS 132 human
KFO11180     123 TS 124 Balearica pavonina gibbericeps
NP_990010    131 TS 132 chicken
XP_005995994 131 SS 132 coelacanth

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