Conserved Protein Domain Family
H2O2_YaaD
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pfam03883: H2O2_YaaD 
Peroxide stress protein YaaA
YaaA is a key element of the stress response to H2O2. It acts by reducing the level of intracellular iron levels after peroxide stress, thereby attenuating the Fenton reaction and the DNA damage that this would cause. The molecular mechanism of action is not known.
Links
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Statistics
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PSSM-Id: 461083
Aligned: 291 rows
Threshold Bit Score: 131.491
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EED87144           15 L-MVLSPAKTLdltpl--sdrefSNEDVNAdtiIEIsneysNPLCDKA---KT-MLVCDAMKAKSEGELRTLLklSASLA 87 
P45491              1 MkILFSPSESKnen------cvkNPINENSfifKELf---pYRM-------EAlKHYEEFIKNASLQNLQELF--GIKNE 62  Campylobac...
jgi:Sdel_0344       1 MkILFSPSETKtty------aseAPLHEKSfifPELy---qKRL-------FVvEQYRSLLQEANLSTLQTLF--GYKEE 62 
tigr:CHAB381_0799   1 MkILFSPAEDKisl------sdlPPINYKNfifNELy---kKRF-------EIlKLYDNFVQNAAITELSRVF--GLKKE 62 
jgi:Saut_0309       2 LkILFSPSEGKksg------sdeKP--------KELfgaldARK-------EIlDTYNNIVLSGDEEKIKQLF--GFKKF 58 
Q30TQ6              2 LkILFSPSENKktg------gteEQ--------KELfgsnsARE-------TIlNEYNSVVNSHNEEVIKELF--GFKKF 58  Sulfurimon...
WP_013554901        2 LkILLAPSEGKrqg-------gsGTFDPCAllfEELc---pLRK-------RLlSVYRDILQSGDPHRLQTLF--GLKKE 62  Nitratifra...
WP_012082343        1 MkILFAPSEAKrsg------gdhQKMQfcf---------nvDRE-------AIlQKYDEIVKHGNKEAILKLF--GTKEL 56  Nitratirup...
WP_006656106        1 MwFLFSPSEKKylhhisetpskeGFFKN----------------FLAQnlqAVlQQYTHYLKTSNESSLQKLF--GAKQI 62  Helicobact...
Q7VFJ1              1 MkILFSPSEGKnk--------pqNTTKTSHnalSHIld------------sQAvREYITFLQTASESEIASLF--GSKIL 58  Helicobact...

EED87144           88 KTSHEYWSDftlnkkpNsnlRP---AIFTFSGPAFQGLSPLTCTATTLSKLASQLFILDPVYGVLRSLDGIQPYRLEMGC 164
P45491             63 NEI-DKFKH-------DlkqAPtqeAILLYTGVSYEYLNFKALDKKSQAYILENTLIFSNLFGIVRANDTLPFYKFKQGA 134 Campylobac...
jgi:Sdel_0344      63 EKVIAHAAI-------DplkALtckAIERYSGVAYDYLDFRTLDEISQHFLEENLLIFSNLFGPILAKDLIPVYKVHQGQ 135
tigr:CHAB381_0799  63 TEI-LHYKN-------EifkLGtikAILRYNGVAYKALQYRSLNKQAQNFIDKNVIIFSNLFGPILAENAIPNYKLKQGE 134
jgi:Saut_0309      59 SEC-QPYIN-------DlynSPlmaAIQRYQGVAYDYLQYASLTPNAQTFLKSNTLIFSNLYGPILGGDIIANYKVKQGN 130
Q30TQ6             59 SDC-QPYIN-------DifkSPlmhSIERYDGIAYQYLNFETLNNSAKEYLMKNSIIFSNLYGPIFGGDTIANYKVKQGN 130 Sulfurimon...
WP_013554901       63 EEIKYYAAL-------DplkSPvlkAVERYSGVAYQYLDYPSLPAEAKEYVDRQLIIFSNLFGPVRASDPLPEYRLKQGN 135 Nitratifra...
WP_012082343       57 LDV-------------DifhSPtlkAVRRYTGVAYEYFDYDSLHPLYQEFIDEHLIIFSNLFGPLCAKDLIPFYKLKQGE 123 Nitratirup...
WP_006656106       63 ILEELALAQ-------NlftSPlldSILRYNGVAYNALDFETLDKKSQSYLKERVLIFSNLFGILRADDKIPYYDLKQGE 135 Helicobact...
Q7VFJ1             59 DMRDFALSQ-------NlptSPrveAIKLYSGVGYKALDFESLDFKAQSYVRENLYIFSNLFGAVRADEPLPYYNLHQGK 131 Helicobact...

EED87144          165 kgvleSEGggkgkKDTLASFW----KESVTTYLgralaatsdgssdeSpILANLASEEYSSSIDI---SSLprntifL-N 236
P45491            135 -----KIG-----NFAIEKFYkehfSKALDEYLe-------------NeEILDLRAGFYDKFYTPk--KKF------Y-T 182 Campylobac...
jgi:Sdel_0344     136 -----SLN-----GFKIEPFYketfQDVLHTWLd-------------GeMVIDLRAGFYEKFFTLk--QPY------I-T 183
tigr:CHAB381_0799 135 -----KFC-----DINIENFYkqnfSENIDKFIe-------------NdDILDLRAGFYNKFYDIk--KEY------L-T 182
jgi:Saut_0309     131 -----SVG-----DISPDKFYkerfSYQLDLYLt-------------GhDVLDLRAGYYDKFYKLs--KPY------T-T 178
Q30TQ6            131 -----NIG-----NLIPDKFYkdrfSYQLDLFLs-------------NaDILDLRAGYYDKFYEIn--KPY------L-T 178 Sulfurimon...
WP_013554901      136 -----PLG-----ELRTEQEYkaaaTPLLDRSLd-------------SvDILDLRAGYYDKFYKPs--HPH------T-T 183 Nitratifra...
WP_012082343      124 -----AVG-----DIKPEKLY----APLCKNLLq-------------DeEILDLRAGYYEKFYKP----NF------SvK 166 Nitratirup...
WP_006656106      136 -----GFL-----NFETKKLYrd-nQEIFLQFLk------------kDkEVLDLRAGFYQKCLELp--EEFl-----IyE 185 Helicobact...
Q7VFJ1            132 -----GVG-----AFSLKNLYkd-lKAKIDKILc-------------GeKVLDLRAEAYIKAYKCecaRQY------Y-Q 180 Helicobact...

EED87144          237 VVFRHQGRVLAVHAKRARGLMARYLAENSSKTLEDVSKFDLEGYG 281
P45491            183 YKFVKNGKVISHFAKAYRGILLSISAKNQVKNNKELLANLPSNLK 227 Campylobacter jejuni subsp. jejuni NCTC 11168...
jgi:Sdel_0344     184 MKFLKNGKNVSHFAKAYRGMVVRALAQHRPSTEAELQNIPFSGLK 228
tigr:CHAB381_0799 183 MKFIKNGKVISHFAKYFRGKILKEIAQNQLDNNKKIIAFNFTDLK 227
jgi:Saut_0309     179 LKFLKNGKTVSHWAKAYRGIVLREIAKAGVNTLEDYMKLEIENLQ 223
Q30TQ6            179 LKFLKDGKVVSHWAKAYRGLVLRAVAENSINSIEEFMKIQIDTLS 223 Sulfurimonas denitrificans DSM 1251
WP_013554901      184 MKFLKNGKVVSHWAKAYRGWVLRHLALNRVESLEELLALPIPGLE 228 Nitratifractor salsuginis
WP_012082343      167 MKFIKNGKVVSHWAKAYRGKILRQIAENQIDSFKKLRDVSFKGLR 211 Nitratiruptor sp. SB155-2
WP_006656106      186 PLFIKNGKVVSHYAKHYRGILLRECAKKTLASLKDLENMEIQGLR 230 Helicobacter canadensis
Q7VFJ1            181 IVFLKNGKKVSHYAKFYRGIYARALAQKGISHLDELVRLKIENLH 225 Helicobacter hepaticus
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