1X4I,2QIC,2JMI,2PNX,3C6W,2G6Q


Conserved Protein Domain Family
PHD_ING
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cd15505: PHD_ING 
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PHD finger found in the inhibitor of growth (ING) protein family
The ING family includes a group of tumor suppressors, ING1-5, which act as readers and writers of the histone epigenetic code, affecting DNA damage response, chromatin remodeling, cellular senescence, differentiation, cell cycle regulation and apoptosis. They may have a general role in mediating the cellular response to genotoxic stress through binding to and regulating the activities of histone acetyltransferase (HAT) and histone deacetylase (HDAC) chromatin remodeling complexes. All ING proteins contain an N-terminal ING domain and a C-terminal plant homeodomain (PHD) finger.
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Statistics
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PSSM-Id: 276980
Aligned: 23 rows
Threshold Bit Score: 69.2495
Created: 7-Aug-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteH3K4me3 binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:2QIC; Human ING1 binds two Zn2+ ions through its PHD finger.
  • Structure:2PNX; Human ING4 binds two Zn2+ ions through its PHD finger.
  • Structure:2JMI; Yeast Yng1 protein binds two Zn2+ ions through its PHD finger.
  • Comment:The PHD zinc finger is characterized as Cys4HisCys3.
  • Citation:PMID 7583761
  • Citation:PMID 7701562
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #   #                 #    #     #  #              #  #
1X4I_A          8 YCI--CNQVsy-------gEMVGCDNQDCPiEWFHYGCVGLTEAPK--GKWYCPQC 52   human
2QIC_A         13 YCL--CNQVsy-------gEMIGCDNDECPiEWFHFSCVGLNHKPK--GKWYCPKC 57   human
XP_003386691  504 YCI--CQKEss-------gRMIGCDNPSCDiEWFHYACIRIKRAPK--GKWFCPNC 548  Amphimedon queenslandica
XP_004994383  227 YCVpnCTETt--------gDMVACDNDDCPgEWFHYQCVGLTAAPTs-KKWFCPEC 273  Salpingoeca rosetta
EAX91604      139 YCI--CRGLnv-------gQMVQCDNPKCPfEWFHVECVGITNKTT--KTWFCPYC 183  Trichomonas vaginalis G3
ESA44383      540 YCL--CQNVsf-------gDMVACDNDECPyEWFHWSCVGLKSEPN--GTWYCPVC 584  Neurospora crassa OR74A
NP_523775    2110 YCY--CRCPyde-----vsEMIACDGDNCLiEWFHFECVGIMVAPQ--GKWFCAEC 2156 fruit fly
XP_003730120  528 FCY--CQEPydqnddspdnVMVGCDGAKCKyEWVHLRCIVPKRKTVpkGKWYCKGC 581  purple sea urchin
O42871        230 YCF--CQQGsy-------gQMVACDNANCErEWFHMECVGLKAPPE--GTWYCEAC 274  Schizosaccharomyces pombe 972h-
EMR08521      249 YCY--CDQIsy-------gEMVACDGKKCQrEWFHLPCIGLPEPPQ--GEWYCDEC 293  Pneumocystis murina B123

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