3V5S


Conserved Protein Domain Family
TIGR00367
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TIGR00367: TIGR00367 
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K+-dependent Na+/Ca+ exchanger related-protein
This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Links
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Statistics
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PSSM-Id: 273039
Aligned: 8 rows
Threshold Bit Score: 245.311
Created: 7-Oct-2014
Updated: 23-Jan-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3V5S_A         3 I--LGVGYFLLGLILLYYGSDWFVLGSERIARHFNVSNFVIGATVMAIGTSLPEILTSAYASYMHAPGISIGNAIGSCIC 80  Methanocaldococ...
P45394         2 L--LATALLIVGLLLVVYSADRLVFAASILCRTFGIPPLIIGMTVVSIGTSLPEVIVSLAASLHEQRDLAVGTALGSNII 79  Escherichia col...
Q57556         2 Li-LGVGYFLLGLILLYYGSDWFVLGSERIARHFNVSNFVIGATVMAIGTSLPEILTSAYASYMHAPGISIGNAIGSCIC 80  Methanocaldococ...
WP_010871591  67 mtwLTIPFLILGLGILVAGAEILVKGASRIALMAGLSPLIIGLTIVAYGTSMPEMVVSLQAAIAGQADISIGNVVGSNIF 146 Synechocystis s...
WP_010876779  18 L--ILIVGLVASLILVIKSADLFVDNLVDLGSSLGISEVILGVTASAIGTSLPEFGSALIASLSGSTDIGVGCVIGSNIW 95  Methanothermoba...
WP_010876697  13 I--ILLFLFTVSLIGVIKSADIFVDRIVDIGRALGISQIILGVTVAAAGTSLPEFGSALISVLTGNPDLGVGVVIGSNIW 90  Methanothermoba...
O54701       136 IilHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVF 215 Norway rat
WP_002658159   4 L--IQFFYVGFGIFLLYLGGNLLLKSSVGIATYLKVPTLLIGVTIVSFSTSAPELFTSLVAAFKGKNEIVVSNVIGSNII 81  Lyme disease sp...

3V5S_A        81 NIGLVLGLSAIIS-PIIVDKN--LQKNILVYLLFVIFAAVIGIDG---------FSWIDGVVLLILFIIYLRWTVKNGS- 147 Methanocaldococ...
P45394        80 NILLILGLAALVR-PFTVHSDv-LRRELPLMLLVSVVAGSVLYDGq--------LSRSDGIFLLFLAVLWLLFIVKLARq 149 Escherichia col...
Q57556        81 NIGLVLGLSAIIS-PIIVDKN--LQKNILVYLLFVIFAAVIGIDG---------FSWIDGVVLLILFIIYLRWTVKNGS- 147 Methanocaldococ...
WP_010871591 147 NVLLILGVCSIIT-PLIVAQQl-IRLDIPILIGVSGLLLMFGWDGq--------ISRVDGVILASGAILYTTFLIRQSKk 216 Synechocystis s...
WP_010876779  96 NIAGILGISSVVAgIIETNADg-LKRDFSATLVTGLILLFFMFFGn--------IGKIAALVMVLTYAVYLWRLIKAQK- 165 Methanothermoba...
WP_010876697  91 NIAGIIGISAILScAVTTNRDe-IRRDGLFGLLSILILTFFMLMGp--------VGPLTGVVLLALYGVYLWVLIKKQR- 160 Methanothermoba...
O54701       216 NILFVIGMCALFSrEILNLTWwpLFRDVSFYIVDLIMLIIFFLDNvi-----mwWESLLLLTAYFAYVVFMKFNVQVERw 290 Norway rat
WP_002658159  82 NMLLALPLAGFFL-KIKADFKr-LKLSFMFLFLLMFLLLLLSFDFrsysffvtpYNRFSSFSILILFLSYLLLFYKEEKe 159 Lyme disease sp...

3V5S_A           --------------------------------------------------------------------------------     Methanocaldococ...
P45394       150 aer---------------------------------------------------------------------------qg 154 Escherichia col...
Q57556           --------------------------------------------------------------------------------     Methanocaldococ...
WP_010871591 217 en------------------------------------------------------------------------------ 218 Synechocystis s...
WP_010876779     --------------------------------------------------------------------------------     Methanothermoba...
WP_010876697     --------------------------------------------------------------------------------     Methanothermoba...
O54701       291 vkqminrnkvvkvtvseaqakastagdkeeptlpnkprlqrggssaslhnslmrnsifqlmihtldplaeelgsygklky 370 Norway rat
WP_002658159 160 ya-----------------------------------------------------------------------------s 162 Lyme disease sp...

3V5S_A       148 --AEIEE------------------NNDKNN------------------------------------------------- 158 Methanocaldococ...
P45394       155 tdSLTRE------------------QLAELPr------------------------------------------------ 168 Escherichia col...
Q57556       148 --AEIEE------------------NNDKNN------------------------------------------------- 158 Methanocaldococ...
WP_010871591 219 npDVTEE------------------YLKEFGepvp--------------------------------------------- 235 Synechocystis s...
WP_010876779 166 --TYSDE------------------NSGKNEr------------------------------------------------ 177 Methanothermoba...
WP_010876697 161 --GYYTS------------------HLMDHGe------------------------------------------------ 172 Methanothermoba...
O54701       371 ydTMTEEgrfrekasilhkiakkkcQVDENErqngaanhvdyaaekielpnststevemtpsseasepvqngnlshsiea 450 Norway rat
WP_002658159 163 leNSFQE------------------GASNLNqs----------------------------------------------- 177 Lyme disease sp...

3V5S_A       159 ---------------------------PSVVFSLVLLIIG-------------------------LIGVLVGAELFVDGA 186 Methanocaldococ...
P45394       169 --------------------------dGGLPVAFLWLGIA-------------------------LIIMPVATRMVVDNA 197 Escherichia col...
Q57556       159 ---------------------------PSVVFSLVLLIIG-------------------------LIGVLVGAELFVDGA 186 Methanocaldococ...
WP_010871591 236 ------------------------ktgKQIFIQIAYVVGG-------------------------VALLVLGSSLLVKSS 266 Synechocystis s...
WP_010876779 178 --------------------------ePLDLKKLALTVVG-------------------------FAGLVIGCRILVYTG 206 Methanothermoba...
WP_010876697 173 ----------------------------VDAKTIISAILG-------------------------FTGLVVFCRILVYSA 199 Methanothermoba...
O54701       451 adapqatetaeedddqplslswpsntrKQITFLIVLPIVFplwitlpdvrkpaskkffpitffgsITWIAVFSYLMVWWA 530 Norway rat
WP_002658159 178 --------------------------fNFIFFNLLSFAIS-------------------------MYFLYLGSKLLVDGA 206 Lyme disease sp...

3V5S_A       187 KKIA-LALDISDKVIGFTLVAFGTSLPELMVSLAAAKRNLGGMVLGNVIGSNIADIGGALAVGSLFMH--LP----AENV 259 Methanocaldococ...
P45394       198 TVLA-NYFAISELTMGLTAIAIGTSLPELATAIAGVRKGENDIAVGNIIGANIFNIVIVLGLPALITP--GEidplAYSR 274 Escherichia col...
Q57556       187 KKIA-LALDISDKVIGFTLVAFGTSLPELMVSLAAAKRNLGGMVLGNVIGSNIADIGGALAVGSLFMHl------pAENV 259 Methanocaldococ...
WP_010871591 267 VAIA-KSLGISELVIGLTLIAAGTSLPELATSVVASYRGERDIAVGNVVGSNIFNILAVLGFAAIFSPngIQvsnsAFNF 345 Synechocystis s...
WP_010876779 207 VELA-DIAGIPAMIMGLFTLAIGTSIPELVVTLSSAVKGLHELSIGTVLGSNTFNILVGIGVPALIAP--VPverlSLTF 283 Methanothermoba...
WP_010876697 200 VGIA-EIMNVPEMIIGLFALAIGTSLAELVVAVNSAMKRMCSLSLGTVLGSNIFNILIGIGVPSLFVR--IPveplSLIL 276 Methanothermoba...
O54701       531 HQVG-ETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTiiHRfkpvTVSS 609 Norway rat
WP_002658159 207 LYIAnNVFNVSEKLIGIILVAFGTSVPELVVSLFAIIRKESDIAFGNIIGSNIFNIGFILASSSFFRP--Ill-qdIYIL 283 Lyme disease sp...

3V5S_A       260 QMAVLVIMSLLLYLFAKY-S-KIGRW-----QGILFLALYIIA 295 Methanocaldococcus jannaschii DSM 2661
P45394       275 DYSVMLLVSIIFALLCWRrSpQPGRG-----VGVLLTGGFIVW 312 Escherichia coli K-12
Q57556       260 QMAVLVIMSLLLYLFAKYs--KIGRW-----QGILFLALYIIA 295 Methanocaldococcus jannaschii DSM 2661
WP_010871591 346 DIPVMFAVALVCLPVFIT-GrLIDRW-----EGFLFLFYYIAY 382 Synechocystis sp. PCC 6803
WP_010876779 284 DAPVMILVTVLLVLLIRQgDmKLKRT-----GGIVLLAVYISY 321 Methanothermobacter thermautotrophicus
WP_010876697 277 DAPVLMGVTVAVMYFMWT-DmELRRV-----EGVALVAFYLAY 313 Methanothermobacter thermautotrophicus
O54701       610 NGLFCAIVLLFIMLIFVIlSiALCKWrmnkiLGFIMFGLYFAF 652 Norway rat
WP_002658159 284 DFSIMVFITLVLFLVVKF-KgVFGRG-----ISliflllyfly 320 Lyme disease spirochete
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