Conserved Protein Domain Family
RING-H2_RNF181
?
cd16669: RING-H2_RNF181 
RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins
RNF181, also known as HSPC238, is a platelet E3 ubiquitin-protein ligase containing a C3H2C3-type RING-H2 finger. It interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3, suggesting a role for RNF181-mediated ubiquitination in integrin and platelet signaling. It also suppresses the tumorigenesis of hepatocellular carcinoma (HCC) through the inhibition of extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling in the liver.
Links
?
Statistics
?
PSSM-Id: 438331
Aligned: 17 rows
Threshold Bit Score: 78.1824
Created: 2-May-2013
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #               # #  #  #          #  #    
Q9P0P0        75 KCPVCLLEFEEee-taIEMPCHHLFHSSCILPWLsKTNSCPLCRYEL 120 human
XP_002741845  82 KCPVCLLEFDIhe-kaKQLPCQHQFHSGCILPWLkKTNSCPVCRHEL 127 Saccoglossus kowalevskii
AEL23142      77 QCPVCLKEWTEge-emKELPCKHSLHSSCILPWLkKTNSCPMCRHEL 122 Cherax quadricarinatus
XP_003731281  75 KCPICLLPYRRgd-vtKTLPCTHEFHQTCILPWLgKTNSCPLCRHEL 120 purple sea urchin
XP_002127501  65 KCPVCLVPYSGt---vIEMPCNHSFHKDCLHPWLnKTNSCPVCRFEL 108 vase tunicate
XP_013383970  73 KCPICLVPYDEae-atKQLPCQHKFHPECILPWLqKTNSCPVCRYEL 118 Lingula anatina
XP_013064148  78 KCSICLMEFDEed-etKILPCKHQFHSACILPWLgKVNSCPMCRHEL 123 Biomphalaria glabrata
ELT93759      78 QCPICRADFELge-tmLQMPCNHHFHSSCINPWLeRTNSCPVCRHEL 123 Capitella teleta
Q9VE61        69 ECSVCKEPAEEgq-kyRILPCKHEFHEECILLWLkKTNSCPLCRYEL 114 fruit fly
XP_002154423  60 SCPICLKVFEEkslvkELPKCKHSFHATCILPWLyKTNTCPMCRYEY 106 Hydra vulgaris

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap