Conserved Protein Domain Family
SpoIISA_toxin

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pfam14171: SpoIISA_toxin 
Toxin SpoIISA, type II toxin-antitoxin system
SpoIISA is a toxin which causes lysis of vegetatively growing cells. It forms part of a type II toxin-antitoxin system, where the SpoIISB protein, pfam14185, acts as an antitoxin. It is a transmembrane protein, with a cytoplasmic domain accounting for approximately two-thirds of the protein. The structure of the cytoplasmic domain resembles that of the GAF domains, Pfam: PF01590. SpoIISB binds to the cytoplasmic domain of SpoIISA with high affinity.
Statistics
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PSSM-Id: 404952
Aligned: 9 rows
Threshold Bit Score: 251.907
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ADO59854        7 LvigFFAIV--------GLASISHWANPVWYANNLINIRKTSYSLFILMYGGMILAGHIH-LKDWGMAVQFASIAIFIDL 77 
ABV61844        3 L---FFQLTvwlllgalAVYVFAVWRFEQKVKEKMFAIRKTWYWIYVAGAVVYWTNDPSSiFTDWMHYLIIAVFFALTDA 79 
Q65KZ9          3 L---FYQFLvwlivlalALYVAAVWRFEKQLAEKTVAIRKTWYLLYVIGAVIYWTHDPQSiFTNPLHYLIVAVFFTLTDA 79  Bacillus liche...
O34853          3 L---FFQIMvwcivaglGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSlFTHWERYLIVAVSFALIDA 79  Bacillus subti...
Q5WGM8          3 L---LYQLLvwltvlglGLYVFASWRWEEETKKRLPIIRRLWYAWFVTGAAFTWTFYPESiFTEWNHYLIVALLFVVVDA 79  Bacillus claus...
jgi:Bcoa_3146   4 L---FFKTFvwlcfaglVIYTYLYGKNEEKMDAKVFLIRKIWYLVYLFGALVYWTIHPASiFTDFKNYAITALIFAAIDG 80 
Q81QD6         12 L---FILAIvfl------vlVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGID-LTLWKNLLMFTAMVIFVDI 81  Bacillus anthr...
WP_014645259    1 --mafnffvgallvftiGNYLFFLWD-QQKYWLSLTKIRKTLYTLFVSALAVGLLVRETH-LSNWPFILTLTTIIIFMDL 76  Halobacillus h...
WP_013488995    4 FflgYFLLIiafl---icslIYYGFR-SDLFIENLGVIRKGFYVLFIVLLCVGFLYEAID-YTNWKLILQLTVFIIFIDI 78  Evansella cell...
ADO59854       78 AVLETPSILKIGNAEFKKNdmeIEKTIKDNQKTILQSFQKSEQFTDVVQYTSNHFYpldsdnFIEWDLYMEQLKKYLRLY 157
ABV61844       80 FIFLSSYIKKLGNHELETD---THQLLEQNNDLLHSYLNKLKTYQYLLKNEPIHVY------YGSVEAYIEGIERLIYSF 150
Q65KZ9         80 FIFLNAYFKKLGSSELATD---TRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIY------YGNIEAYAEGIEKLIKRF 150 Bacillus liche...
O34853         80 FIFLSAYVKKLAGSELETD---TREILEENNEMLHMYLNRLKTYQYLLKNEPIHVY------YGSIDAYAEGIDKLLKTY 150 Bacillus subti...
Q5WGM8         80 FVFLSAYVQRIGSNVFTID---TGQLIEANDQVLKAQQDRLKAFFRLLKSDSINVY------YGGQRAYITGVREILARL 150 Bacillus claus...
jgi:Bcoa_3146  81 FIFLNMYFRKAGKYELER----FTKTVSANESLIQDNLSMAKNMLDILNNEGIVGY------YGSKEGYLLGLKEVLSSY 150
Q81QD6         82 AFILTPNISEIWGAKFSD----IGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFgt--meWHTEEEYTKSLNAFLDSY 155 Bacillus anthr...
WP_014645259   77 ALLLTPSIMKLWKAEFEHNn-dLQNIILTYEKVRKANYRRVETMSAMIQNAHNYFPe----dYFPMLSRARDIERYLKEY 151 Halobacillus h...
WP_013488995   79 AVFQTPNMLKFWSGDQTKSe-yIEKTIKKNEETLGYNTRKVEKFMEVIQYSSFHFYnk--ttPDSKDKYISNLKDYIRLY 155 Evansella cell...
ADO59854      158 TDTFHFKLSITQFTYK-------------------EDIEQREQNIEGSLVqierfhsi---nikdkaeLAGTLAKANVSV 215
ABV61844      151 ADKMNIQAVLCPYDTQ-------------------EQKDDLLRTLDQRAL------------------IQAKLDRQEVYY 193
Q65KZ9        151 AEKMNISAALCEYNSE-------------------ESKDHLLEHMENRFD------------------VQEKLDRKDVYY 193 Bacillus liche...
O34853        151 ADKMNLTASLCHYSTQ-------------------ADKDRLTEHMDDPAD------------------VQTRLDRKDVYY 193 Bacillus subti...
Q5WGM8        151 ADKTEIQASVFPFMTQ-------------------GDKDHLLVHFKDRTT------------------VRATLERQDVYY 193 Bacillus claus...
jgi:Bcoa_3146 151 AEKADMSVNILPFTTP-------------------LEKDQALYRYKNPGS------------------VRAKLDRLETVY 193
Q81QD6        156 GEK--IGAKIVVFEAA-------------------KELNTNFRGIRSQFStii------------pleYIEQLNEQRAV- 201 Bacillus anthr...
WP_014645259  152 TDLYGISVQVSPLEVSppeynpgwetmseeekyeyEEVQPVYEAILRQLDtieathnf--emgnhkeeYADYLLQYEVVS 229 Halobacillus h...
WP_013488995  156 TDTFQFHISIFPFEVT-------------------GNDDELKESVRQTFSnvekcynyiiediserenIISSLSSGKSMM 216 Evansella cell...
ADO59854      216 IKEQEIIGVPFFG-NRFSYIVTLeanAQESVINAIDAYHIVNLLTVFEWF 264
ABV61844      194 DDFGKLVLIPFSV-ADDHFVIKL---TSDDIVTEFDYLLMTSLTTIYDLI 239
Q65KZ9        194 EENGKMVLIPFSI-HDFDYVMKL---TSEDLVTEFDYLLFTSLTSIYDLL 239 Bacillus licheniformis DSM 13 = ATCC 14580
O34853        194 DQYGKVVLIPFTI-ETQNYVIKL---TSDSIVTEFDYLLFTSLTSIYDLV 239 Bacillus subtilis subsp. subtilis str. 168
Q5WGM8        194 GEKDKLVFIPVIL-QGESHVIKL---SSEERLTEFDALLFASLVAIYDLL 239 Bacillus clausii KSM-K16
jgi:Bcoa_3146 194 HVDGNDALHPIYLfHDELYLLKI---SGSRAITEMDCILFVIMAHVYDFA 240
Q81QD6        202 -QVENVGIIPAKIvSDVFIVID----GKKNNLQDRDFENVYNLTIHHSYF 246 Bacillus anthracis
WP_014645259  230 LIEEESMIVPVIN-QKEHYLIVLk--SERGEVLEIDALHIVNLTNLYHLy 276 Halobacillus halophilus
WP_013488995  217 LKQDKLFIVSYFG-EQYNLLICIk--SEDVSVDGIDASHVINLAHIFDWW 263 Evansella cellulosilytica
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