Conserved Protein Domain Family
McrC

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COG4268: McrC 
5-methylcytosine-specific restriction endonuclease McrBC, regulatory subunit McrC [Defense mechanisms]
Statistics
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PSSM-Id: 443409
Aligned: 147 rows
Threshold Bit Score: 160.936
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_011279538   1 MNnngrnqsaakhkiksahmsmpdsnltahimTVFE-HQRLIMhdf---------------syiSDFQWL--I------- 55 
WP_004154783   2 Mi-----------------------------iEAKE-RTEVNVdin---------------livKNGNKLdi-------- 28 
WP_014489078   1 Mi------------------------------KLKDnTKHEKLinikenisee-diisikeiasKTLSDVkdniiifp-- 47 
WP_014791950   1 M-------------------------------KVQDnSSKILElnqlhlsft----ediqrfanKSIKDLceVssdllvf 45 
WP_015075168   1 M-------------------------------RIQD-NNSYSKsefkktyp-----kisaklidKTLSVLs-Nesnifif 42 
WP_051568031   1 MAqi---------------------------sRTTDnNQGKKItdifkgsdhtkcasdlaliagIPVSTLveKndsllvf 53 
WP_043870406   1 --------------------------------------------------------mvvpegriieveergqryfprgdl 24 
WP_044636404   1 -------------------------------------------------mtispvprldqpgriiipcyeydeinidpde 31 
WP_075844800     --------------------------------------------------------------------------------    
WP_122951383   1 Ml-----------------------------iKLKE-HQSDRFgls------------------cwLDDIpn-------- 24 
WP_011279538  56 ---------AQELSVFSikrk--qgqWQLKVGHYIGVIVMp-sGMILEILPKLigntassptqqscqpnkpladtdifqt 123
WP_004154783  29 --------ypEIRNFFSidykpknnaliLFSGKYIGLIPIn-eSLAIDIKPKFs-------------------------- 73 
WP_014489078  48 -nsikeskdLEEDSRIfdi-----inDSLLTNNIMGFISYn--NTQIKISSRFavn---------------------dne 98 
WP_014791950  46 pnvlgyhkdDIGSATICyyd---sinNTLKTNNILGFVGCn--DTQLSIVSRFdnde--------------------lsk 100
WP_015075168  43 psdfsmiddLESSSKIiet-----inEELKFQNIAGFIGCg--GENLEIHSRFsqn----------------------kd 93 
WP_051568031  54 pavvneygdDIGNSSVfsl-----saDKLTTYNLMGFIGCn--QTELTIASRFysk----------------------gn 104
WP_043870406  25 idqyghslilpetrelkalefkdvadgvhlvalgligylpltstitlnivPKFp-------------------------- 78 
WP_044636404  32 vlgpdgrlniidgiqekyvvidfkhghlrlrargcsgliplteritlqVRPRFp-------------------------- 85 
WP_075844800   1 ------------------------------------MIPVs-hDLGIRVRPKVp-------------------------- 17 
WP_122951383  25 --------eANKKKYLGlhydvwrgkKQLKTKYFIGTCWLeenQLALQVEPKIq-------------------------- 70 
WP_011279538 124 RHWVQNMLsdlmns--dddksPHSKNFgQF----SSPLIALPVAA-LP-L-SDWLITQFLQRL---AHHQPITHYQTQIH 191
WP_004154783  74 IGNINRMIlt---------sgEYLQAL-TFf---NRHYSESAVDSn---ItFKFLIECFIREMkalYENGLLKDFIKRNA 137
WP_014489078  99 DYFLHYML-------------MKVLSI-NI------VNLEHSKDYdDS---FDFLIYMFISFFkraLRQGLFKQYKLIKH 155
WP_014791950 101 NYFMHYML-------------QRVFSI-NL------FNFDTDSNK-ES-I-WDFLIYLFPYFLkkaFSQGIYKAYIRNEY 157
WP_015075168  94 DYFLHYML-------------QKVLNI-NV------VDLNTNLSMeEQ-I-YQFLIYAFPQYLnaaMRKGIFKQYCRIEY 151
WP_051568031 105 DYFLHYML-------------QKVFSI-NL------FDLKHSTDK-EN-L-WDFLIYLLPFYLkkaLSQGLFKQYQNQEY 161
WP_043870406  79 IENLWTML-------------EVGGENydr--ilPTIRRYQSADKpAP---LQLLARSFCHYLkgaLSAGFERSYYPRT- 139
WP_044636404  86 IRNLTHIV-------------NMCGRT-PIa--iPALRRYEPSDDtGEwL-VDVMADALLDAFdiiTSNGLLRRYHRTVE 148
WP_075844800  18 VSQIVQML-------------SLISHD-IVelpfGLAEITASEDD-YD-L-LKAIRRSFCDQLptlIQKGPIRRYRRNRS 80 
WP_122951383  71 GLDYLSMFlkcfkhpqvsrhlSDIYAI-------DFNQAKIALEGdDFeI-TPLLIVHFLQVVkaiVKKGLKKNYYFVEE 142
WP_011279538 192 -NQTALQGRLLIKEQLRHNSMQP--HKFVCERSVLSKGMLANRIIKSALKLLAPLLSQSnlllylqpwqqvsvLHQYEIR 268
WP_004154783 138 -ISSNIKGKLNVSHSIKKLWSKGmfHKASVDFDKFTPDNDVNKFIKCALFQSLVELRRNh------------rELKKLIQ 204
WP_014489078 156 -NDANVKGTIDINRYIKNNIPFN--GKISYNTREYSYDNNITQLIRHTIEYINNKNR----------------YLLSYDS 216
WP_014791950 158 -NNANVKGAINVTRHIRQNIPFQ--GNVAYTTREHSYDNSVTQLIRHTIEHIRSKKLGN--------------GVLNSDT 220
WP_015075168 152 -NNINVKGNIDIARHIKRNIPFT--GKVAYSSREYTQDNDLMQLVRHTIEYIRLSTKNGq-------------LILNSSE 215
WP_051568031 162 -NNPSVKGAIDINRHIRSNIPFT--GNIAFRTREHVYDNWMTQLIRHSIEYVLKHKRGA--------------SVLNADV 224
WP_043870406 140 -VSGFYKPRVEFGPTISRYLSRGnpIDTVSSVFEFGLDSPVNQIVKAACLRFARIIPRQks----------weEERHLIQ 208
WP_044636404 149 -SGSYLHGHLDATDTMLRFASRGitHHAQFSWFERSIDNPPNRCLKATLLALHQRYAAQaqysaq--feeqrgTRIRRTG 225
WP_075844800  81 -IGPGARGRIDVSGTINRAWARGryDHLSTEFYEFDYSNFLNQAMKFAIGYLIDTMEESn------------nSIQQQMN 147
WP_122951383 143 nLNAKVKGKINLSHTLKHHIFKGqnHKTVCRYPVFGLDCLENRLLKKALRFVQSYLSKSpie--------teeKLGQLLS 214
WP_011279538 269 QLA---Si-YFQAKHE--------L---AIQP------------LQAQQLQAAQQLVDFAYWLLCQSHAetghSidsq-- 319
WP_004154783 205 DNVfflE--MFDGVKSfqgsnpl--------------nlynpynDFGIIRNYYKNIVKSAELILSKKGI----Sf----- 259
WP_014489078 217 EIK---N--YVQQVFYstss-yerNkreSIINknl-------kkLSHPYYYEYEPLRKICIQILRHEKL----K------ 273
WP_014791950 221 ETR---A--LVQKINYitqnsykkSqrrAIILkni-------qpISHPYFTEYKILQKLCLKILRHDKI----T------ 278
WP_015075168 216 LMK---Q--NISSIIFatps-fnlGnkrKVINanr------ntpLRHAYYTEYRLLQQLCLLILTYRHH----D------ 273
WP_051568031 225 ETQ---T--AITQIKLatpa-yneRhrtRIIQmnl-------kpANHPFFTEYRVLQKICLQILRRDGL----T------ 281
WP_043870406 209 IAL---D--TLQRVNAr-----------EPGPhdfy----ldeaVSLRLRGNYEGLLRVYQLLLTGGGI----Af----- 259
WP_044636404 226 AAL---Q--ILKEVPI------------TDRRsfledpqvrgltPLPEPRAYYRPALDLAFAILTDRGI----Tlnsrda 284
WP_075844800 148 ILVe--SrtILESVSEapp--ylfL---SPLRdhl------stdVSEEPYLSFRPLLNLALLIASGETP----------- 203
WP_122951383 215 YCL---A--SFELVSD------------DVDVrrf------ksfKNNAFFKEYAQGLKLAKMILKRFSY----N------ 261
WP_011279538 320 npfHKKLT-----PQRLCLLIDMNQAFEQWASQRIAL-FFQqlsDDYKpLf----QTQ-RVWLN----DAe-----gQAC 379
WP_004154783 260 --eLTEEN-----VFLNSYYIDMETIFEKYLFVFLKE-YFLnnhPELS-VkdgntDGK-KKFFN-------------AQS 316
WP_014489078 274 ---YGSND-----NTVYGLLFDGAWLFEEYLNTFLSKeNFIh--AEn-------rNSKnGIKLL-------------DNA 323
WP_014791950 279 ---YGENK-----DKVYGLLFDGAWLWEEYLNTILKD-DFIh--PEn-------kTRRyKQYLF-------------ENK 327
WP_015075168 274 ---LGGGA-----QNIHGILFDVSWLWEEYVNTILKD-QFIh--PRn-------kKSKdGISIF-------------SDR 322
WP_051568031 282 ---YGEEK-----DKVYGLLFDGAWLWEEYLNTILKQiNFVh--PRnkg----ksGDKnPIYLF-------------NGN 334
WP_043870406 260 --tFEPGG-----KELPSFLFNLEDIFERFIRQTFVD-ALRe--KKIG-Vld--gNKH-QGKLF----ED-------SKV 314
WP_044636404 285 rveDRPGN-----PIMSTLLVNTEALFEEFVRLSLQE-AFAn-vPGLA-Vld-gnKDPgRKMIYqeltDKqhe-clpDSA 354
WP_075844800 204 ---DVAGEaegiqFSLPPLVLDMEKTFEQFCIAIFNK-SLNg--ESFE-Lld-tsGVS-NTPLLhppvESnhfwtpvRAT 274
WP_122951383 262 ---LKNTQn---tQKTPPFYIDMSLLFEQYVYALLLE-------NN-E-Vk---yQVKg--------------------- 302
WP_011279538 380 L-------SIRPDLLIYkQihSSaentamydnyvsqakdarekhsrHYSHVIDIKWKHLA--------HASAISA---SD 441
WP_004154783 317 Lat----gDAKPDVIIK-K--GE-----------------------STLLIADAKYK-------------SKTKD---TD 350
WP_014489078 324 W-------RVYPDFYKL----EN-----------------------DNNIVLDAKYKRLNy------yDNESIDR---ND 360
WP_014791950 328 Iq------PIYPDFISK-----E-----------------------KPTIVADAKYIPLDrsktssyhSESEKAL---SI 370
WP_015075168 323 Tr------TVYPDFYNN-----------------------------ELGIVIDAKYKKLEft-------sKGISR---ED 357
WP_051568031 335 Sy------SRFPDFYCH-----------------------------SKKMVLDAKYKHLDn---------KKISR---ED 367
WP_043870406 315 Y-------PTKSDLIFR-R--GKk----------------------NVIALGEVKYK-------------PRLKE---AD 346
WP_044636404 355 IpitkrseNMTPDIVFQhE--DG-----------------------TYPLIADVKCTKVH----------DYMER---SE 396
WP_075844800 275 E-------SAHPDFVIQ-Q--RD-----------------------SSWLIGEVKYS-------------LSPSS---SH 305
WP_122951383 303 -------gYGVVDFLIE-------------------------------DMIVDTKYKPKYk--------nKKINRdtiED 336
WP_011279538 442 AYQLSSYAQAYQA-E---------QVWLVYPVQDDQRQAVVLKQdtqdtynsenAs---------yAQL----WLIPF-- 496
WP_004154783 351 RYQIISHAVSFDC-K---------YTVLISPRPENHNGEKMRKI----------Gdvg------dtLKInvyeYFIDLsn 404
WP_014489078 361 KHQIVSYAYTLNA-K---------KAGFIYPLEEvNCTDANKIIk--------iGvlnnayngyadCGI----YKYAL-- 416
WP_014791950 371 YYKTITYMYRFNS-Q---------HGLLLFPIKNKNPFKNDLKIke------tlG------------KI----SKIGL-- 416
WP_015075168 358 LYQIIGYSYILKS-K---------TAGVVYPSVEKTKYNEIGRLsg-------yG-----------ALI----FKQSI-- 403
WP_051568031 368 IHQIVTYIHVLRS-E---------LGGFIYPIGTNGINEPVTIKt--------iGlln-----gfgGRV----ISAGI-- 418
WP_043870406 347 RYQIISHVTSAKA-P---------LGILFSPANEGESQRLDRI-----------Grla------tgAQFy--hYRVDIk- 396
WP_044636404 397 LEQVMTYGHRYRS-P---------MVMTIHPRTQESQPGLFVE-----------Grvg------ttLALq---YRVDLda 446
WP_075844800 306 IHQVCAHADAFSC-N---------TVLLIYPSKTTLKSPRLEML----------Gfl-------aeKRVf--rLWISI-- 354
WP_122951383 337 IRQLSGYARDEKIiEclgtngtiaKCLVIYPNKEGDKDSDLs------------GlwgdgeeiqgfVNF----KKIGV-- 398
WP_011279538 497 -NVLTA-----------TINTDllpTQ----DV----V 514
WP_004154783 405 pDLENEe---------sELAES---LF----NL----V 422
WP_014489078 417 -KIPSTksngedfqnikEFAEV---MR----NIenelI 446
WP_014791950 417 -PIPTEcen------ynDFSEK---MK----KRekifI 440
WP_015075168 404 -QIPQQvds------ykAFITL---MK----ESenkfK 427
WP_051568031 419 -PIYKQsks------fdDFASK---MK----ITesclV 442
WP_043870406 397 gDIRAAq---------aQMVRE---IT----AI----L 414
WP_044636404 447 eDLDEEm---------qTMASQ---IR----EL----I 464
WP_075844800 355 -DFTSLd----------kLIES---INmtalAL----L 374
WP_122951383 399 -RLPVHk-----------------------pRL----- 407
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