1SU1,2AHD,3CK2,1S3L


Conserved Protein Domain Family
MPP_YfcE

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cd00841: MPP_YfcE 
Click on image for an interactive view with Cn3D
Escherichia coli YfcE and related proteins, metallophosphatase domain
YfcE is a manganase-dependent metallophosphatase, found in bacteria and archaea, that cleaves bis-p-nitrophenyl phosphate, thymidine 5'-monophosphate-p-nitrophenyl ester, and p-nitrophenyl phosphorylcholine, but is unable to hydrolyze 2',3 ' or 3',5' cyclic nucleic phosphodiesters, and various phosphomonoesters, including p-nitrophenyl phosphate. This family also includes the Bacilus subtilis YsnB and Methanococcus jannaschii MJ0936 proteins. This domain family belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.
Statistics
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PSSM-Id: 277320
Aligned: 46 rows
Threshold Bit Score: 120.452
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1SU1_A; Escherichia coli Yfce binds two Zn2+ ions and sulfate.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              # #                         #                                   ##        
1SU1_A        27 KLMFASDIHgslpatERVLELFaqsgaQWLVILGDVLNhgprnalpegyapakvverlnevahKVIAVRGNCDsevdqml 106 Escherichia coli
3CK2_A         8 TIIVXSDSHgdslivEEVRDRYvg-kvDAVFHNGDSELrpds-----------------plweGIRVVKGNXDfya---- 65  Streptococcus p...
15673262       1 MFVVMSDSHydrdvvQSIKSKYln-eaTAIFHCGDSELpssd-----------------eiwqGITVVAGNCDyds---- 58  Lactococcus lac...
NP_464765      2 KLLVVSDSHserdclIHLKEKYen-tvDAMIHCGDSELeadd-----------------paiqGFHTVRGNCDfgg---- 59  Listeria monocy...
YP_535992      2 KILVVSDSHskknilADLRDRYsn-eiDYFIHCGDSELdpns-----------------kwvsGYTIVEGNCDyy----- 58  Lactobacillus s...
NP_814853      2 KILVVSDNHgdrdclVDLVNHYeg-qvDALFHCGDSELeptd-----------------elwqKFIVVQGNCDfyd---- 59  Enterococcus fa...
15895922       2 IISVMSDTHlskhyiKKACSNLtn--vDVLIHLGDNVQdideik--------------kyyngELIYIRGNCDde----- 60  Clostridium ace...
NP_972184     28 RLILISDTHgnvdtiIDILGREgk-ksDAVLFSGDGLAdflnyitisqy----ekelmecmppVAALVMGNCDskkyvln 102 Treponema denti...
YP_001087529   2 KIGIMSDTHgsllyfEKALNVLsd--cDVLLHGGDVLYhgprndipegyn-pkkfietlnkleNIVIVKGNCDadvdqmv 78  Clostridium dif...
NP_228907      4 RILVISDTHgslsctEKALKSAgn--fDEIWHLGDVLYhgprnplpegys--pkelasllkkhRVKYIRGNCDadvdirv 79  Thermotoga mari...
Feature 1                                              #                            # #          
1SU1_A       107 ----------------lhfpitAPWQQVLLEKQRLFLTHGHlfgpenl-------palnqnDVLVYGHTHLPVAEQrgei 163 Escherichia coli
3CK2_A        66 --------------------gyPERLVTELGSTKIIQTHGHlfdinfnfqkldywaqeeeaAICLYGHLHVPSAWLegki 125 Streptococcus p...
15673262      59 --------------------gyHDFLTQEVEGKKVLITHGHlfyvglgldrysyfaeeknaDIALFGHIHQPVAQKinni 118 Lactococcus lac...
NP_464765     60 --------------------gfPNDWVGEVDGYRIFTTHGHlynikmtlmnlryrarelnaDFAFFGHSHELGVDMlddt 119 Listeria monocy...
YP_535992     59 --------------------dyPEKEVVATEEGNILVTHGHlygvnygldrlallakqenaKFVFYGHTHRLAVEYvdgt 118 Lactobacillus s...
NP_814853     60 --------------------efPKTVTKKVGDQVIYMTHGHlanvrmglttlalqaeeagaTIALFGHTHVLGAERhnni 119 Enterococcus fa...
15895922      61 --------------------kiPSEKTFLLGGKKFFITHGDrygvkysmmkleyrakeleaDIVLFGHTHISQIDFndgi 120 Clostridium ace...
NP_972184    103 ldarktgadfgfkknperylefFEFLFLETCRKKILLTHGHefyvdfelntllnfarqqdcSVAVFGHTHVPLIKEvngi 182 Treponema denti...
YP_001087529  79 ----------------iehpiqSPYVMSQFGEIRIILNHGYieseeeii----dkakkmggDILVLGHTHVKKLYMddnl 138 Clostridium dif...
NP_228907     80 ----------------leipemPRIGMEFLGDVKILLVHGDqfeyeggdp--vslaqahgcSVVLFGHTHVPLAERcegv 141 Thermotoga mari...
Feature 1                                              
1SU1_A       164 FHFNPGSVSipkg---gnpASYGMLDn-----dVLSVI 193 Escherichia coli
3CK2_A       126 LFLNPGSISqprg--tireCLYARVEidd-syfKVDFL 160 Streptococcus pneumoniae TIGR4
15673262     119 LYVNPGSVAqprg--kydiKMYAIIEieg-eefKVSYR 153 Lactococcus lactis subsp. lactis Il1403
NP_464765    120 IILNPGSISlprg--rirvKTYALIDstp-egiQVRFM 154 Listeria monocytogenes EGD-e
YP_535992    119 LFLNPGSVWfprgeyqklgGTYAIVSvne-skiKVTYY 155 Lactobacillus salivarius subsp. salivarius UCC118
NP_814853    120 LFVNPGSIRlprg--pvqeKTYAIIEstp-eqyLVQYY 154 Enterococcus faecalis V583
15895922     121 WYINPGSVSypr----nasNSTAYIEi-----vDGEIH 149 Clostridium acetobutylicum ATCC 824
NP_972184    183 FLINPGSVSrprm---gsnKSYGILTmskdakpSMEFK 217 Treponema denticola ATCC 35405
YP_001087529 139 IVINPGSTSipk----dgsHSVAIIDi-----iKTDDE 167 Clostridium difficile 630
NP_228907    142 LLLNPGSVSlpks---eagPTFGIIDm-----dEKKFY 171 Thermotoga maritima MSB8

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