4FDY


Conserved Protein Domain Family
CwlT-like

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cd16891: CwlT-like 
Click on image for an interactive view with Cn3D
CwlT-like N-terminal lysozyme domain and similar domains
CwlT is a bifunctional cell wall hydrolase containing an N-terminal lysozyme domain and a C-terminal NlpC/P60 endopeptidase domain (gamma-d-D-glutamyl-L-diamino acid endopeptidase), and has been implicated in the spread of transposons. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).
Statistics
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PSSM-Id: 381612
Aligned: 64 rows
Threshold Bit Score: 128.104
Created: 30-Mar-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: catalytic residue [active site], 1 residue position
Conserved feature residue pattern:EClick to see conserved feature residue pattern help
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    #                                                    
4FDY_A         29 HRPLIEKYGKEYGIEdYVSYILAIXQVESG---GTAEDVXQSSESLGlpp--------------nsLSTEESIKQGVKYF 91   Staphylococcu...
P96645         60 FRAVFEKYARQEGVFdQVNIIMALTMQESG---GRSLDIMQSSESIGlpp-------------nsiTDPERSIEVGIKHF 123  Bacillus subt...
EQB38297       57 YRPLVEKYAADYGVTeHVDTILGMMMQESG---GRGKDPMQASESYCger-------------eciKDPELSIKQGVSYF 120  Virgibacillus...
NP_052777      72 YLPKIKEMAEKHGVAqYVGILAAQMMQESQ---GEGNDPMQAAEGHYgdlsssciglkgsarigciKDPNISIEAGVQEF 148  Bacillus anth...
CDQ41806     1784 LGPKIEAEAKKQGKPeYAEILKAKCMQETGgnyNRYPDVFQASESLGlpr--------------nsIGLERSLQQGVKYF 1849 Virgibacillus...
Q8EM02         64 YHSIVSRYAKQNGIEeHTPVILAMMMQESG---GRGLDPMQSSESLCger-------------nciKDPDLSIQQGVSFF 127  Oceanobacillu...
AIC92708       64 YRSYFERYAKENGIEdHIEILMAMTMQESG---GRLADVMQSSESLGlpv-------------ntiSDPELSIKQGVSYF 127  Bacillus lehe...
YP_001840995   77 YRGLVESELSKHGLAeQTNLVLALMMQESG---GRGNDPMQASESKCgri-------------gciTSPEESIVYGVEHF 140  Exiguobacteri...
WP_017895794   44 WRPLVSEVANKYKVGnYTEVLLAIVYQESGd--TGTNDIMQSSESEGlpp-------------nsiVDPETSLNVGIKYF 108  Clostridium t...
GAE42711      269 LSPLIEEEAARNGVSeWTELLKAITMQESTgnyIKYPDVMQSSESTCgti-------------rciSDYKKSIENGVAIF 335  Bacillus weih...
Feature 1                                                                                         
4FDY_A         92 SELLTSAEqq-gvDIDSVIQSYNYGGGFLNYVr-sHGKk-YTYELAEqFSKeksggqkadypnp-iaipvnggwrynYGN 167  Staphylococcu...
P96645        124 KKVFKQAGg----DVRLTLQAYNFGSGFIDYVk-kNGGk-YTKKLALdFSRlqafk----------------mgwksYGD 181  Bacillus subt...
EQB38297      121 SQTLEEANg----DIKLAVQSYNFGKGFIQYIh-dKEKd-YSQEAAItFSQemyandpdkekyr-clrdeakeidacYGD 193  Virgibacillus...
NP_052777     149 KDVLAKANg----DIALALQSYNYGPGFISYAl-aKGG--YSEETAIaFSRehagenpagcsd---pnnfrtkvgacYGD 218  Bacillus anth...
CDQ41806     1850 GQMMNKANg----DVALALQSYNFGGGFIDYVn-nNGGk-WTQELTNkFSDkkaae----------------lgwnrYGD 1907 Virgibacillus...
Q8EM02        128 ALALDKANg----DIELAVQAYNFGHGFIEFVq-dSGGe-YTQEAAItFSQkmydqsgrdnsiytcrreeakeleacYGD 201  Oceanobacillu...
AIC92708      128 ANVLESAGg----NTELALQSYNMGHGFIDYAnehNNGn-YSKELAQqFSNhmkar----------------lgwsvYGD 186  Bacillus lehe...
YP_001840995  141 ASVFERANr----DVQLTLQSYNFGGGFIDYVq-eNGGr-YSKELAIsFSQmmyqrvkhtgiyr-chrpsaiqhgacYGD 213  Exiguobacteri...
WP_017895794  109 SSIVQYADkk-kcDLATIIQSYNFGQGYVDYVa-sNGGk-STKELAEsFSAshg---------------------ggYGD 164  Clostridium t...
GAE42711      336 KKRVEAASkmfngDIRMGIQAYNYGPNFLKKAk-eWGAteYSQELSQrYSQylke------------------nygfGGD 396  Bacillus weih...
Feature 1                      
4FDY_A        168 QFYVQLV-SQYLT 179  Staphylococcus aureus subsp. aureus Mu50
P96645        182 PSYVDHV-MRYVK 193  Bacillus subtilis subsp. subtilis str. 168
EQB38297      194 IYYVKSV-ITYRN 205  Virgibacillus sp. CM-4
NP_052777     219 FTYVSKI-LKYYK 230  Bacillus anthracis
CDQ41806     1908 KKYVEHI-MRYYE 1919 Virgibacillus sp. Vm-5
Q8EM02        202 IYYVSSV-MDYRL 213  Oceanobacillus iheyensis
AIC92708      187 PNYVDNV-MRYLD 198  Bacillus lehensis G1
YP_001840995  214 IEYVDAV-LKYLA 225  Exiguobacterium sp. RFL1109
WP_017895794  165 PSYYDHV-MRYVS 176  Clostridium tyrobutyricum
GAE42711      397 PLYVKHVlSRYLN 409  Bacillus weihenstephanensis NBRC 101238 = DSM 11821

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