Conserved Protein Domain Family
NeuC_NnaA

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TIGR03568: NeuC_NnaA 
UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
This family of enzymes catalyzes the combined epimerization and UDP-hydrolysis of UDP-N-acetylglucosamine to N-acetylmannosamine. This is in contrast to the related enzyme WecB (TIGR00236) which retains the UDP moiety. NeuC acts in concert with NeuA and NeuB to synthesize CMP-N5-acetyl-neuraminate.
Statistics
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PSSM-Id: 274654
Aligned: 56 rows
Threshold Bit Score: 413.075
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EAV37429       2 KILAITSIRSDYDLLSPLFFKLQQDTSFVLKLLVGGAHNSTSFGHTVNDIKNDGFDILMEIESLLDSNSSAGRLKSASIL 81  Shewanella wood...
ZP_01058927    4 KIAFLTGTRADFGKLKSLIQAIHDSTDFEYGIFATGMHLLEQYGLTVIEIEKAGF---QNIERYSNYTSEATMDLTLART 80  Leeuwenhoekiell...
AAY27727       3 KILFITGTRADYSKIKSLMYRVQNSSEFELYIFATGMHLSKNFGYTVKELYKNGF---KNIYEFINYDKYYQTDKALATT 79  Campylobacter j...
AAA20475       3 RILCITGTRADFGKLKPLLAYIENHPDLELHLIVTGMHMMKTYGRTYKEVTRENY---QHTYLFSNQIQGEPMGAVLGNT 79  Neisseria menin...
EBA13250       8 SVLFVTGTRADFGKLEPLAIATR-DAGLDVSFFTTGMHMLERYGLTKLEVHR---TPGVQVHEFLNQRIGDPQDMVLAKT 83  Roseobacter sp....
EAN08847       3 KILIVSGTRADYGIYKPVAENLLQDN-WDVSFVVSGMHLSHKYGFTKELILADGFRISGEVQSLFLENNKGNMARSVALE 81  Enterococcus fa...
WP_011499635   4 KIAVVTGTRADYGIYLPVLKAIQRSSKLDLSLIVTGMHLSETFGHTVDEIEKDGFSIDAKIPLGLLEDSGASMALDVGIC 83  Methanococcoide...
WP_011541868   6 RIVYLTGTRADFGLMLPTLRAIDRSPHLELELLVTGMHLSDRFGRTEREVEAAGLKIGRRIPVPIDDDSGHGMGVSTGLI 85  Sphingopyxis al...
WP_010946490   4 KIIYVTGTRADYGLMREVLKRLHQSEDIDLSICVTGMHLDALYGNTVNEIKADQFSICGIIPVDLANAQHSSMAKAIGHE 83  Legionella pneu...
WP_011233780   4 KVLFVTGTRADFGKLKSLIEVTDKADEFEVQLFITGMHMMSRYGMTSIEVER--LKIASS-YKYINQTKNDTMDVVLAKT 80  Idiomarina loih...
EAV37429      82 LISAIDVVKSFNPDLIIYAGDREEVMVGALLGGYLSIPTIHFYGGDHAaDgHIDNPIRHAVSKLSTCHFVSTDEHVRRLL 161 Shewanella wood...
ZP_01058927   81 IEGFSAYVKAFQPDLIIVHGDRVEALAGAIVGSLNNILVGHIEGGELS-G-TVDELIRHSVSKLSHIHFVSHGTAAKRLV 158 Leeuwenhoekiell...
AAY27727      80 IDGFSRYVNELKPDLIVVHGDRIEPLAAAIVGALNNILVAHIEGGEIS-G-TIDDSLRHAISKLAHIHLVNDEFAKRRLI 157 Campylobacter j...
AAA20475      80 ITFISRLSDEIEPDMVMIHGDRLEALAGAAVGALSSRLVCHIEGGELS-G-TVDDSIRHSISKLSHIHLVANEQAVTRLV 157 Neisseria menin...
EBA13250      84 VMGFSDFVKEFAPDLVVIHGDRVEALACALVCATNYIRCAHIEGGEVS-G-TIDEIYRHCNSKLASQHFVSSDDAARRVM 161 Roseobacter sp....
EAN08847      82 INGFTNIFEQTSPDFVLLLGDRGEMLAAAIACLYLGIKTAHIHGGEVS-G-TVDESIRHAITKIASVHFAATEKSKERLI 159 Enterococcus fa...
WP_011499635  84 ILGLTDALKKIKPDILLVLGDRGEMLATTIAGIYMNIPVAHLHGGEVS-G-TVDESIRHAITKLSHIHFPATEESAERIR 161 Methanococcoide...
WP_011541868  86 TCAVADYLAETACDVLLLLGDRGEMLAAATAGLFADVPIVHVAGGDRS-G-SVDESIRHAISKLAHIHCVSNEDARQRLI 163 Sphingopyxis al...
WP_010946490  84 LLGFTEVFESETPDVVLLLGDRGEMLAAAIAAIHLNIPVVHLHGGERS-G-TVDEMVRHAISKLSHYHFVATEASKQRLI 161 Legionella pneu...
WP_011233780  81 ITGLSDYIHENNPDVIVVHGDRVEAMAGAIVGSLNNILVAHIEGGEVS-G-TIDELIRHSISKMAHTHFVSNSEAQERLV 158 Idiomarina loih...
EAV37429     162 SLGEPPQRIFNIGSIALDKFNNVKPIPniKDLIANK-TV---TKPAAILIYHPIDEEKRISTQLIDTMVESLNSAGyHCF 237 Shewanella wood...
ZP_01058927  159 QMGELESSIFNIGSADLDVLFSETLPN--LKTVKTYyNIp--fESYAVVLFHSVTTAHQETAKHADDFVQALLEDNqNYV 234 Leeuwenhoekiell...
AAY27727     158 QLGEDEKSIFIIGSPDLELLNDNKI-S--LNEAKKYyDIn--yENYALLMFHPVTTEITSIKNQADNLVKALIQSNkNYI 232 Campylobacter j...
AAA20475     158 QMGEKRKHIHIIGSPDLDVMASSTLPS--LEEVKEYyGLp--yENYGISMFHPVTTEAHLMPQYAAQYFKALELSGqNII 233 Neisseria menin...
EBA13250     162 ALGEPEAHIHTIGSPELDFHAGPSGVT--FAQVQERyDLp--sDDYGICVFHPVTSEAATMGAQASALFGALDQSGhNFV 237 Roseobacter sp....
EAN08847     160 KMGEDSWRVFPVGAPRIDTILNNRLPS--FRDIKEKyHLkfeKKKYVLQVFHPVVTELENIEKQILALINSMEQQSqPII 237 Enterococcus fa...
WP_011499635 162 NLGEDEFRIYVVGAPALDTILSETFVP--KEEMGHFfDId-iNKPIILVVQHPVTTEVGAVERHIRETMDAVVELGeQTV 238 Methanococcoide...
WP_011541868 164 RMGEDPDRIFDVGAPGLVGLKKPDRAT--AAMVRNRyGId-dEESFVLVLFHPVVQQAAEAGAQWRAMFDALAGLPfRYV 240 Sphingopyxis al...
WP_010946490 162 RMGEKEETIFQVGAPGLDEIMQYKTST--RDVFNQRyGFd-pDKKICLLIYHPVVQEVDSIKIQFQSVIQAALATNlQII 238 Legionella pneu...
WP_011233780 159 QLGEAKSSIFTIGSPDLDVMNSPNLPS--LETVKEKyDIa--fKDYSVFMYHPVTTELESLESNIKSTVDAMLESDeNFV 234 Idiomarina loih...
EAV37429     238 LGLPNSDPGNAEIRSALKHAAKKYEDVTLYGNLSREQFVNLFKQSSLIVGNSSAGLLEAASIPVPCVNVGARQRDR-YCT 316 Shewanella wood...
ZP_01058927  235 VIYPNSDLGSSAILEAYRKFEK-HQRFRLFPSLRFEYFITLLKNAAFLIGNSSAGIHEAPYLGIPTVNVGRRQENRdLQT 313 Leeuwenhoekiell...
AAY27727     233 VIYPNNDLGFELILQSYEELKN-NPRFKLFSSLRFEYFITLLKNADFIIGNSSCILKEALYLKTAGILVGSRQNGR-LGN 310 Campylobacter j...
AAA20475     234 SIYPNNDTGTESILQELLKYQ--SDKFIAFPSIRFEYFLVLLKHAKFMVGNSSAGIREAPLYGVPSIDVGTRQNNR-HMG 310 Neisseria menin...
EBA13250     238 VIAPNNDPGSAAIFDAIAQVP--SNRFRVLPSMRFAHFSELMKNAKAMVGNSSAGVREAPFLGLPSLDIGTRQTNR-AKS 314 Roseobacter sp....
EAN08847     238 CILPNSDAGSEIIRKMYQKYL--KTDIIYITNLEPEEYLTILKECKFMIGNSSSGIIEAASFKIPVINLGTRQNGR-EQS 314 Enterococcus fa...
WP_011499635 239 VIYPNADAGGRKIIETIEQYRN-YAFIKIFKNIRHVDYLSLMRTTNVMVGNSSSGIIEAPSFGLPVVNIGTRQTGR-QRG 316 Methanococcoide...
WP_011541868 241 ALMPNADHGTTSIRTEIEAMRDA-GQLTTIDHMPRADYLALLAECRFLIGNSSSGIVEAATFGTPVVNVGDRQFGR-LRS 318 Sphingopyxis al...
WP_010946490 239 CLEPNSDTGGHLIREVIQEYID-HPDVRIIKHLHRPEFIDCLANSDVMLGNSSSGIIEAASFNLNVVNVGSRQNLR-ERS 316 Legionella pneu...
WP_011233780 235 VVYPNNDHGTDTILAELKR-CENHPRFRIYPSIRFEYFLVLLKNANMIIGNSSAGVREAPFYGIPTINLGSRQQSR-ATA 312 Idiomarina loih...
EAV37429     317 DNVLFV-DATLKAIKQGIKQ-ASSPEFTKKLAQISNPYGN-GNSAKLAYSLI 365 Shewanella woodyi ATCC 51908
ZP_01058927  314 DSIIHV-DNAKAAILKGIAS-------AKAL--KVNPKGT-KSTKTAASGFL 354 Leeuwenhoekiella blandensis MED217
AAY27727     311 ENTLKV-NANSDEILKAINTiHKKQDLFSAKLEILD-------SSKLFFEYL 354 Campylobacter jejuni subsp. jejuni
AAA20475     311 KSIIHT-DYETKNIFDAIQQaCSLGKFEADDTF---NGGDtRTSTERFAEVI 358 Neisseria meningitidis
EBA13250     315 PSVFFAdAGDADTIAQFLQS-EWGKAYPRHN-----AFGG-GSASERFAATL 359 Roseobacter sp. CCS2
EAN08847     315 KNIINA-NLNENEIETALNK-IQDPQFIKSLKNVKNIYGD-GNSSRRITKTL 363 Enterococcus faecium DO
WP_011499635 317 QNTIDV-DYDKDEIIKAIKVgLYDKDFKRKASKCISPYGN-GHAGTAIAEIL 366 Methanococcoides burtonii
WP_011541868 319 ANVFDA-PPESGAIGRAIEK-AIG----FDPQGLRNVYGD-PHADIRICEIL 363 Sphingopyxis alaskensis
WP_010946490 317 DNVIDV-DVTYDAILTGLR-----EALNKPKIKYSNCYGD-GKTSERCYQLL 361 Legionella pneumophila
WP_011233780 313 ESILNV-EEQTPAILEAIKT-FKTKRFEPS-----SEFGD-GNSAEGFISTL 356 Idiomarina loihiensis
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