Conserved Protein Domain Family
M28_like
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cd05640: M28_like 
M28 Zn-peptidase; uncharacterized subfamily
Peptidase family M28 (also called aminopeptidase Y family), uncharacterized subfamily. The M28 family contains aminopeptidases as well as carboxypeptidases. They have co-catalytic zinc ions; each zinc ion is tetrahedrally co-ordinated, with three amino acid ligands plus activated water; one aspartate residue binds both metal ions.
Links
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Statistics
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PSSM-Id: 349893
Aligned: 8 rows
Threshold Bit Score: 336.342
Created: 28-Sep-2007
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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metal binding
Feature 1: metal binding site [ion binding site], 6 residue positions
Conserved feature residue pattern:[NH] D E [HE] [DE] HClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
BAG03846       9 LSQHLEQIVR---ERNPFFSSqg------------hFYVREYLRQELGnw--gkVESHFFSFQGk--vYENLILDLPNn- 68  Microcystis aer...
CBE67501      23 LRAHVEHLAGeigERNVFRPEa-------------lRAAEHYIQEEWRsqg-yqVTPHWYEVSGg--rWANLEVTRLGsa 86  NC10 bacterium ...
CBE68508      20 IRTHLEQLVE---PRDPFEGHas------------mEAAADTIAETLRgfdlqfVEERFRCEGRw---YRNLIALHQGs- 80  NC10 bacterium ...
WP_002650109  12 LVKHVDCLAGligVRTLHHPAa-------------iEATIGYITQQWTasg-yeVRQQSYDALEg--qATNLIVETRGsk 75  Blastopirellula...
P76482        37 SPEQLEKTVRy-lTQTVHPRSadni--------dnlNRSAEYIKEVFVssg-arVTSQDVPITGg--pYKNIVADYGPa- 103 Escherichia col...
NP_497490     17 LALSLSTIADm--DRMKHDLSkflsisrfneteksvARAAIKRALEAVgl---nSMTHTFIHEEsnevGANVIAVQKGpy 91  nematode
XP_001641774  27 LRAYLSHFNA---TRNNHVDPta------------kAVARDYIIQLFVkhgldtWTEQFPSNQEny-pGLNVIGLLPGry 90  starlet sea ane...
WP_012266739   9 LSQHLEQIVR---ERNPFFSSqg------------hFYVREYLRQELGnw--gkVESHFFSFQGk--vYENLILDLPNn- 68  Microcystis aer...

Feature 1                     #                   #                                     ##       
BAG03846      69 ---sQKPPILIGAHYDTVPG--------SPGADDNATGLAVLLELARFFGENQa------nYPIRLIAFDLEEY------ 125 Microcystis aer...
CBE67501      87 ---rPHKILLIGAHYDSVRG--------SPGANDNASGVSALLELSRLFAELIp------aVTVRFVAFVNEEPpff--- 146 NC10 bacterium ...
CBE68508      81 ---sRNGQVLIVAHYDTVPN--------SPGADDNASGVAGLLEVAGTLARHRf------tHDLLFIAFPLEEY------ 137 NC10 bacterium ...
WP_002650109  76 ---rPEQIILLGAHYDSTPS--------TPGADDNASAVAVMLEVARLLQGHVg------qRTLRCVAFACEEApyf--- 135 Blastopirellula...
P76482       104 ----DGPLIIIGAHYDSASSyendqltyTPGADDNASGVAGLLELARLLHQQVp------kTGVQLVAYASEEPpff--- 170 Escherichia col...
NP_497490     92 fgtgNDKMMILSANYDTLEG--------NQGVDDNGSGVAAVLEAARVLSTLDnly--srqNTIVYVFFDMKHK------ 155 nematode
XP_001641774  91 ygtsQDKLVIIASHYDTVST--------TNGVDDNGSGMAALLHAIKNYTTTDedvkctqnHTLLFVAFDLEEVqdrgsc 162 starlet sea ane...
WP_012266739  69 ---sQKPPILIGAHYDTVPG--------SPGADDNATGLAVLLELARFFGENQa------nYPIRLIAFDLEEY------ 125 Microcystis aer...

Feature 1                                               #                                        
BAG03846     126 ---------GLLGSIAYAEKLKQtk-----qDLRLMLSLEMLGYCDKnphSQKYPAFle-----------yFYPNTGDFI 180 Microcystis aer...
CBE67501     147 -------frRKHGSEAYAKAAQTrg-----dAIRAMVSLETIGYYRDergSQHYPPLfq-----------fFYPRQGNFI 203 NC10 bacterium ...
CBE68508     138 ---------GNPGSVHYVEQAMAsg-----aPIAGVFDLEMIGYTGP---TQAAPPGi-------------QAPTMGDFI 187 NC10 bacterium ...
WP_002650109 136 -------nlGAMGSQHHAREARKqd-----eQIVGMLCLEMVGYFRDdphSQQIPETipki-------fhpLFPTTGNFL 196 Blastopirellula...
P76482       171 -------rsDEMGSAVHAASLER--------PVKLMIALEMIGYYDSapgSQNYPYPam----------swLYPDRGDFI 225 Escherichia col...
NP_497490    156 ---------ALAGSHAFVEDVLLplmertntKVVGTVIADGLLHFDPfpaSQAMPNEfesffpe-aaqklhEHSHMGDFI 225 nematode
XP_001641774 163 gnfscgcarALCGSGYFVSNLTRylne-tggSIQGAYVMDTVMNYNStpnSQVLPAGaghvmppeqlkrisDNLHRGNFL 241 starlet sea ane...
WP_012266739 126 ---------GLLGSIAYAEKLKQtk-----qDLRLMLSLEMLGYCDKnphSQKYPAFle-----------yFYPNTGDFI 180 Microcystis aer...

Feature 1                                                                                        
BAG03846     181 ALIGNLKT-----RKDLNFLSRVMREn----QTPCEWLPVIFGGYIvp----------dTRRSDHSPFWSRGYSAIMVTD 241 Microcystis aer...
CBE67501     204 TFVSDFRS-----RALMRRAVQAFRHa---sDFPLEHVATSRFVPG-------------VAWSDHWSFWRHGYRAIMVTD 262 NC10 bacterium ...
CBE68508     188 GVVGNRRS-----EGLVALFKEAAVLva--pSLPVQGLVVEGNGEHvp----------fVRQSDHAPFWDAGYPAVMITD 250 NC10 bacterium ...
WP_002650109 197 AAVGNLRS-----WSLNWIFRRGFKQg---sQLPLWSLNLPERVHE-------------IRRSDNSSFWDQNYPALMLTD 255 Blastopirellula...
P76482       226 AVVGRIQD-----INAVRQVKAALLSs---qDLSVYSMNTPGFIPG-------------IDFSDHLNYWQHDIPAIMITD 284 Escherichia col...
NP_497490    226 QVSSRSDIdddlvQKYTRAYDRSCEMlssdwSFHPWSLNLQMNLANitsld----rlhpFLYSDHSSFFFHSKQKSVQIP 301 nematode
XP_001641774 242 VAIGRKVPd----ASLQKAFYDSYKKd---dDFRIEDVLLPFTGQTsklpslqryameaFFRSDHRQFWDSEPSWPAVFL 314 starlet sea ane...
WP_012266739 181 ALIGNLKT-----RKDLNFLSRVMREn----QTPCEWLPVIFGGYIvp----------dTRRSDHSPFWSRGYSAIMVTD 241 Microcystis aer...

Feature 1                        #                               
BAG03846     242 TAN-------MRNPYYHSYRDT---IATLDLNFLTRVCQGLCFGLQSL 279 Microcystis aeruginosa NIES-843
CBE67501     263 TAF-------YRYPYYHTRKDT---PEKLAYPEFTRVTAGLAEAFAVL 300 NC10 bacterium 'Dutch sediment'
CBE68508     251 TAF-------LRNPHYHLPTDT---LDTLNLRFLRQVAATTAASAALL 288 NC10 bacterium 'Dutch sediment'
WP_002650109 256 TSF-------LRNPHYHQPTDT---PDTLDYDRMTEVTLGVAAAVKRL 293 Blastopirellula marina
P76482       285 TAF-------YRNKQYHLPGDT---ADRLNYQKMAQVVDGVITLLYNS 322 Escherichia coli str. K-12 substr. MG1655
NP_497490    302 TIYltdtlnlRGVRQYCVQCDGlymMTEQNMKFLALMTDSLIRLLIDM 349 nematode
XP_001641774 315 TDSady--rgFMTVCYHELCDDi-sHVTPEMITSLGKTADALVGAATL 359 starlet sea anemone
WP_012266739 242 TAN-------MRNPYYHSYRDT---IATLDLNFLTRVCQGLCFGLQSL 279 Microcystis aeruginosa

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