1KET,1BXK,2Z95,7KF3,1NAI


Conserved Protein Domain Family
Epimerase

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pfam01370: Epimerase 
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NAD dependent epimerase/dehydratase family
This family of proteins utilize NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions.
Statistics
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PSSM-Id: 396097
Aligned: 96 rows
Threshold Bit Score: 103.146
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1KET_B   7 IIVTGGAGFIGSNFVHYVYNNHpdVH-VTVLDKLtyagnkanleailgdrvelvVGDIADAE--LVDKLAA---KADAIV 80  Streptococcus suis
Q88PV5   3 ILLTGGTGLIGKHLCQYWLGQG--HR-LTVWSRRpeqv------------akicGSGVRGIA--RLEQLEAd-dHLDAVV 64  Pseudomonas putida KT...
Q83DM2  14 VVVLGANGFVGRALCQRLKQEA--VN-VLELTRQ--------------------QVDLLNPD--ATEQLLKqlqASDTLV 68  Coxiella burnetii
Q9S1L1  18 AVVVGASGFIGSRLCRALESIG--IR-TIGFSREkpfa-----------------------pfgSVRKELL---RADTIY 68  Streptomyces netropsis
Q9ZGC5   3 MEIVGN-GFLARNLHPYADR------------------------------------------------------HPDTVA 27  Streptomyces cyanogenus
Q82IP9   3 VLLIGANGYLGRFVADRLLADP-----AVQLTALgrgd------------dadvRFDLASGSpgALTRFLDa-vHPGVVV 64  Streptomyces avermitilis
Q82PA9   3 ILVLGFTGYLGRHVVERLRALP--GTrVLGGGRSagae-------------fgiDLATARPD--TLAKALAs-aAPDAVI 64  Streptomyces avermitilis
Q9ZGB2  10 VMVLGGTGFLGGHLRTAFPVPK--AP-KWSVSPEtspgpsart---gapdecfiALDLLTATprELRALFAd-tAPDVVV 82  Streptomyces cyanogenus
O54256   9 VAVVGATGCVGRHVCDAFTRAG--HD-VVALARRapagpgr-------hphrflACDPAGLAprDLADLFQd-aRVDTVV 77  Streptomyces nogalater
Q9RQ96   4 ILITGAHGFIGRHLAKSLALAGnrGD-WPRAWELatascsalg---lvllgsmaRSTIPNLS--LNSKSSSe--RVDIVI 75  Rhizobium etli
1KET_B  81 HY-AA-ESHNDNSLNDPSPFIHTNFIGTYTLLEAARKY--DI--RFHHVST--DEVYGDLPLredlpghgegpGEKFTAE 152 Streptococcus suis
Q88PV5  65 NLaGApIADRPWTAARRNVLWASRVTLTEQLLAWLGTReqRPe-VLISGSA--VGWYGDGGE-----------RELTEAS 130 Pseudomonas putida KT...
Q83DM2  69 IT-AAeAPCKNAAMLY------RNVRMMNVVCEVLQKQ--AIq-QVIYISS--DAVYADSDQp----------LTETSVT 126 Coxiella burnetii
Q9S1L1  69 YV-AG-SSTPALAEERPELVKADHWNLQMLLWSLIKVThrPL--VVLASSG--GTVYAPDAPq---------pFHETA-- 131 Streptomyces netropsis
Q9ZGC5  28 VA-----AGVSWASGTSDADFAREAALLADVAVRCRAT--GR--RLLFFSTaaTGMYGAMDGp----------GREDS-- 86  Streptomyces cyanogenus
Q82IP9  65 NC-AGaTRGGARELTR------HNTVAVATVCEALRRS--GCgaRLVQIGC--GAEYGPSQP-----------GSSTAED 122 Streptomyces avermitilis
Q82PA9  65 NC-AGaTGGDAVTLAE------VNSRGPAVLCAALREAapSA--RLVHLGS--AAEYGPGTR-----------GIRVTES 122 Streptomyces avermitilis
Q9ZGB2  83 NA-AG-----AVWKVTPQQMHRANTELTTTVTAALCETspGP--RLIQLGS--VHEYGAGTR-----------DSGLTEG 141 Streptomyces cyanogenus
O54256  78 NA----AGGWLNTEDDNRY---HHVRLVERLLAGTALMarTP--RLVQIGS--VHEYGPVPA-----------GDAVDES 135 Streptomyces nogalater
Q9RQ96  76 PS-RGwLFSGEQQSQIPAKIFHRTVSSTVELLECCARR--PQk-VYWVAVSs-AAVYGAGHIg---------qIAETA-- 139 Rhizobium etli
1KET_B 153 TNYNPSSPYSSTKAASDLIVKAWVRSF-GVKATISNCSNNYGPY----QH-IEKFIPRQITNILAGI----KPKLYGEGK 222 Streptococcus suis
Q88PV5 131 PPV--REDFA-SQLCIAWEETAQRSQAqGIRVVLVRTGLVLAS--------DGGFLSRLRMPFKLGL-----GGPLGNGR 194 Pseudomonas putida KT...
Q83DM2 127 ---APTSLHGVMHLAREMMLQSVCSEN-NISLAILRPSLLYGAEdphnGYgPNRF--RRLADNHE------SIILFGEGE 194 Coxiella burnetii
Q9S1L1 132 -PTRPSSAYGAAKLAQERALTA--ADW--TVPVILRFSNLYGAGq--rPRrGYGVIAHWAKAVHEGR----PVTLIG--S 198 Streptomyces netropsis
Q9ZGC5  87 -HIVPCTPYGAHKFALEQQLRASGADY-----LILRLGHLVGPG-----QpAHQLIPALIRQMREG-----DVRV--QRD 148 Streptomyces cyanogenus
Q82IP9 123 AVPRPGGPYGVSKLAATELVLGS-----GLDAVVLRVFSPAGPGtp-aGSpLGRLAEAMRRAMQSGD----GELKLGGLG 192 Streptomyces avermitilis
Q82PA9 123 AATRPLTPYGATKLAGTITITTS-----GLDAVVLRVGNPVGPGap-lTGlPGRVAGLLLASGGDPD----AVIRLGDLS 192 Streptomyces avermitilis
Q9ZGB2 142 STEAPVTPYGRSKLAASRSVLDAAAAG-ALDGVVLRMANIVGPGvp-aGS-LLGDIAARLERYAEDPgatdAELLFPPLR 218 Streptomyces cyanogenus
O54256 136 REPRPVTVYARTKHAGSQAVLRATRAG-DADGVVLRAVNVCGPW-----VtPASFLGTVTRRLSEAApgepVELTLS--D 207 Streptomyces nogalater
Q9RQ96 140 -RPNPFSPYGHHKHIMESLCISYSESY-ELKVVIGRLFSVYGEG-------LRKQLLWDVCSQLEVHp--dQILLGGSGN 208 Rhizobium etli
1KET_B 223 NVRDWIHTNDHSTGVWAILTKgr---mGE---TYLIG 253 Streptococcus suis
Q88PV5 195 QWMPWVHIDDQVALIDFLLQHkda------sgpYNAC 225 Pseudomonas putida KT2440
Q83DM2 195 EQRDHVYIDDVAEIITRVIQRcs-------rgVLNIA 224 Coxiella burnetii
Q9S1L1 199 SSRDYLHIDDAVEALLAVHRHvaslraARtpiTLNIG 235 Streptomyces netropsis
Q9ZGC5 149 AARDLIDVRDVVTVIDRLLAQgl---rGE---IVNVA 179 Streptomyces cyanogenus
Q82IP9 193 VQRDFIDVRDVARAVHAASLSaa-------qgVINIG 222 Streptomyces avermitilis
Q82PA9 193 AHRDFVDVRDVARAAVLAATApa--plPR---VLNIG 224 Streptomyces avermitilis
Q9ZGB2 219 AERDFVDVRDVVDAVLAAARApraevsGR---VINIG 252 Streptomyces cyanogenus
O54256 208 ARRDFVDGRDLADAVLRAATRpv---tGE---IFNIG 238 Streptomyces nogalater
Q9RQ96 209 ELRDWTAVTDVVRALSFIHTEan--lpPK---VINIG 240 Rhizobium etli
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