3ZZM,4EHI


Conserved Protein Domain Family
PurH

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COG0138: PurH 
AICAR transformylase/IMP cyclohydrolase PurH [Nucleotide transport and metabolism]
AICAR transformylase/IMP cyclohydrolase PurH is part of the Pathway/BioSystem: Purine biosynthesis
Statistics
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PSSM-Id: 439908
Aligned: 651 rows
Threshold Bit Score: 589.689
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3ZZM_A         9 PIRRALISVYDKTGLVDLAQGLSAAGVEIISTGSTAKTIADTGIPVTPVEQLTGFPEVLDGRVKTLHPRVHAGLLADLrK 88 
WP_012291022   1 --MRALISLTDKTDVAKLAKSLQELGYEIISTGGTYKEIEKSGVNVIDISKVTNFPEILQGRVKTLSPYVHGGILYKRdN 78 
WP_012463463   1 -MSAAFLSVYDKTGIVEVARVLSQAGIDIISTGGTARLLKNAHIPVQEVSDVTGFPELLEGRVKTLHAKIHAGILYKReK 79 
WP_015778038   1 --MRALLSVTDKTGIEKLAKDLRDLGVSLVSTGGTYKKIKDSGVDVSEIEEITNFPEILEGRVKTLSPYVHGGILYKRdE 78 
WP_014261817   1 -MKRALLSVTDKSGIGAFAKELEDLGYEIISTGGTLKTICDYGVNAKSIEEVTEFPEMLDGRVKTLHPMIHGGLLYRRdL 79 
WP_013360561   1 --MKALISVTDKTGIADFALGLEKFGYEIVSTGGTLKVLLDAGVKAISIDELTGFPEMLDGRVKTLHPKVHGGILHIRaN 78 
WP_041953822   1 MSKRVLISVFEKENIVEFASELVKLGWEIISTGGTYKILKESGLNVIEVDEVTNFKEILNGRVKTLHPFIHGGILYKRnE 80 
WP_128425349   1 -MKRALISVYDKAGIVDFAKGLESLDWEIVSTGGTYRLLKENGVEAVEIDQVTGFPEILDGRVKTINPLIHGGILFRRdL 79 
WP_075573424   1 -MKLALFSCYDKNGIEDFAKELINLGYGILSTGGTLKYLHDKGIEAMDVSEYTGFHECFDGRVKTLHPKVHAGILYRReN 79 
WP_126439423   1 --MRALISVYDKEGIVEFAKELANRGWEIISTGGTYKKLKDAGIYVISVDKVTGFPEILDGRVKTLNPKIHAGILARRdL 78 
3ZZM_A        89 SEHAAALEQLGIEAFELVVVNLYPFSQTVES-GASVDDCVEQIDIGGPAMVRAAAKNHPSAAVVTDPLGYHGVLAALRA- 166
WP_012291022  79 EEHKKTVEELNIQPIDIVVVNLYDFQNALKT--GDHDNIVENIDIGGPTLIRSAAKNYKDVLVVTDPSDYDELIDRLKN- 155
WP_012463463  80 PDHLREITELGIPQIQYVIVNFYPFVDAVKK-NLPIEEMLEYIDIGGCTLARSAAKNYPHVTVVVDPADYTELISQIQTm 158
WP_015778038  79 ASHVSTVEELGIKAIDIVVVNLYEFQKALDK--GNPEEIIENIDIGGPSMVRSAAKNHKDVLIVTDPSDYDELIERLKN- 155
WP_014261817  80 PEHVKTVEEYGIHPIDIVVVNLYAFEDSLKN-KKPHAEMIENIDIGGPSMVRSAAKNYKDVLIVTDPSDYDRVVELLKN- 157
WP_013360561  79 ETHVATVKEHGIDPIDMVVVNLYDFEGTLKS-GKPHDEIVENIDIGGPSMIRSAAKNYKDVAVVTDPKDYQEILERLSN- 156
WP_041953822  81 QSHVETVDNLGISSIDMVVNNLYPFEKVLNNeNKTHEDLIENIDIGGPSMIRAAAKNYNDVSIVVDPKDYSEIIERLKE- 159
WP_128425349  80 ESHRSVVELMGIVPIDIVINNLYPFEETVSRaDATPNEIIENIDIGGPSMIRAAAKNYKDVTVIVDPSDYGTVLAELRMn 159
WP_075573424  80 TKDVKELKELGAQPIDIVVNSLYPFVNTYLS-DASDDEIVEKIDIGGPSMIRAAAKNYKYTNIIVDNSDFEIVIEELKEr 158
WP_126439423  79 NEHMETLKEEEIGTIDMVVNNLYPFEEKLLE-KADHDTMIENIDIGGPSMIRAAAKNYKDVYIVTDPADYDRVLEYIDK- 156
3ZZM_A       167 GGFTLAERKRLASLAFQHIAEYDIAVASWMQQTLAPEhpvaAFPQWFGRSWRRVAMLRYGENPHQQAALYGDPT-AWPGL 245
WP_012291022 156 DNVDITYREKLAMKAFSLTAYYDSVISRYFQEQVG------ERSKYRTFGFKKEDELRYGENSHQSANLYIDPF-VNGKL 228
WP_012463463 159 GSTSSSLRKKLAFKAFNLTSYYDSQIARFFQEKLHMR----FFPPESSIPLYGYSPLRYGENPHQHAALYGD------FW 228
WP_015778038 156 DDIDLAYRQRLAMKAFSLTAFYDSVIARYFTKLTG------EESKYKTYGFEKETDLRYGENPGQEASLYNDPF-VTGLM 228
WP_014261817 158 GLVDMKFREEMAMKAFSLTAYYDSMIARYFASYTG------KQSNTFTIGLKEDSTLRYGENPHQRAMLYSDNF-VDGLL 230
WP_013360561 157 KTLDEAYKRKLAYKAFSLTGYYDAMIGRYFAGLE-NE----TFPERTAIGLLKESSLRYGENPHQNAAVYEDAM-TTSLM 230
WP_041953822 160 NKLDKDFRLYLSCKAFNYTAYYDALISSYFNDLL-NI----DFPEKLTMTYKKVNDLRYGENPHQNASFYEKVYvKDDEK 234
WP_128425349 160 GVTTLETRTALARKAFSLTAFYDALIAGYFNEIQG-V----SFPELLTLPYRKRDSLRYGENPHQRAAFYVESTkLSGTI 234
WP_075573424 159 GDTKPETRMYLAKKAFNLTANYDAWIAKYFNEKM-DD----EFPDLLTIPFHKEGELRYGENPHQKAFRYNMYNgEVGGI 233
WP_126439423 157 --KDPKFNEYLANKAFSYTAHYDAVISNYFAKRE-GD----RFPRYINKSYKLVEELRYGENPHQRAAFYEDSY--TPDK 227
3ZZM_A       246 AQAEQLHGKDMSYNNFTDADAAWRAAFDH--EQ---TCVAIIKHANPCGIAISSvSVADAHRKAHECDPLSAYGGVIAAN 320
WP_012291022 229 TDCEVIHGKAMSFNNYNDLNVAVELADEL--GA---NSCVALKHQSPCGVAIAD-SVSEAYHKAYLADSTSIFGGIIAIN 302
WP_012463463 229 NYFQQLQGKDLSYNNILDIDAAVRILSEFgsDS---AIAAIFKHSSPCGVGMGM-TVKEAFEKAFKTDKESPFGGVIALN 304
WP_015778038 229 EDIEVIHGKEMSYNNYNDLNPALELAQEL--GD---NAVVALKHQSPCGVAVGS-DVYDSYIKAFECDSQSIFGGILAVN 302
WP_014261817 231 SDYEQLHGKELSFNNLNDLNIAVELAQSF--VKdgvTVTVALKHATPCGVGMGE-SVYDSYNKAYQADPLSIFGGIVACT 307
WP_013360561 231 TGMIQLHGKELSFNNLNDLNTALELASEF--EE---PAVAVIKHATPCAAAIGS-TIYEAFVRAYEADKMSIFGGIVAMN 304
WP_041953822 235 ADFKQLHGKELSYNNLTDMYSAIKIVKEF--DE---PCVVAVKHNNPCGLAISD-NIDDAYDKAYACDSVSIFGGIIALN 308
WP_128425349 235 AGAKQLHGKALSFNNINDANGAIALIKEF--DE---PAAVAIKHANPCGVGSAL-TLLEAFEKAYSADPESIFGGIVALN 308
WP_075573424 234 CQGKVLHGKELSFNNIYDASAAVEMVKLFy-EK---PAIVAVKHTNPCGVAEAD-TIKEAYLKAYACDTSSIFGGIIASN 308
WP_126439423 228 IEYKVLHGKQVSYNNLNDMYSALNAVINF--DK---PAAVAIKHTNPCGIGTGD-SLEEAFVKAYECDDESIFGGIIALN 301
3ZZM_A       321 TEVSVEMAEYVSTIFTEVIVAPGYAPGALDVLARKKNIRVLVAAE---PLAGGSELRPI-SGGLLIQQSDQLDAhgdNPA 396
WP_012291022 303 GVVDEKCAEEMSQIFLEIIAAKDFDEKALEILTKKKNIRLVKIKFd--NDSVKEDIKYL-NGKVLIQDKDFGV------D 373
WP_012463463 305 KPLDPALAEILADIFVEVIVSPEYEPESLQLLQKKKNLRLIQVSLn-kLPPPRYIIRSLcGNSYLLQEPDNMLL---DQE 380
WP_015778038 303 GVVDEKAASKMHEIFLEIIAAKDFTKEALEILTKKKNLRLVKVDFa--NESVREEIRYL-NGKVLIQGKDFGK------D 373
WP_014261817 308 GTIDLDTAKLMNEIFLEIVCAPDFTEEALEELKKKKNLRILKIDFs--KETLDMDLKYI-NGKVLIQDRDFVE-----KE 379
WP_013360561 305 KEMDAETATAMDEIFLEIVAAPSYSEQALEILKKKKNLRILVINYn--NKKSGLDVKFA-SGKVLIQETDNLNC-----E 376
WP_041953822 309 REVTKYIAEKINSFFVEIVIANKFSKEAIEILTQKKNIRLIEVGNisdFKLPKTTIKEV-LNGIVVQDYDNILF----KE 383
WP_128425349 309 GEVTGQIAEMLKEIFLEIIIAPSFSSEALDILTAKKNLRLLAVDGlmnAESPRLQLKQV-QGGLLLQDSNQRLL---G-E 383
WP_075573424 309 REIDKETAEEMVKIFLEVIIAPSFSEEALEVLTSKKNLRLIEIPEivdGPKDGMDMKIV-PGTMIIQERDMAE-----DC 382
WP_126439423 302 REVDIKTAEHLSKIFLEIVAAPSFSKEAYDLLAQKKNIRLIEIPDfekLYEPGFRFKQV-LNGIIIQNFDDKIW---DED 377
3ZZM_A       397 NWTLATGSPADPATLTDLVFAWRACRAVKSNAIVIAADGATVGVGMGQVNRVDAARLAVERGGE---RVRGAVAASDAFF 473
WP_012291022 374 EYNVVTDEKPSDEDKKDLEFAMKVVKFTKSNAIVLAKDSHTLGIGGGQTSRIWALENIANNHPDv--DFTGCVLASDAFF 451
WP_012463463 381 KMKIVSLRKPTPEEMNKCLFGWKVVKHVRSNAIVFSDADRTLGIGAGQPSRVDAVRIAIDKAGReglSLKGSAVASDAFF 460
WP_015778038 374 EVNIVTDKKPSEEEIKDLLFAQKVVKYVKSNAIVVAKGMKTLGCGAGQQSRVWALESIKDHFKDr--DFEGAVLGSDAFF 451
WP_014261817 380 GFDIVTIKEPTAQEKQDMLFGMKVCQYVKSNAIVLVKNGVTMGIGGGQTSRIWALNSIRSNHPDr--DFQGCVLVSDAFF 457
WP_013360561 377 KLETVTTTAPTKAQLDDMKFAMIVCKHVKSNAIVIAKGGATVAISGGQTSRIWALQNAIRNNPDk--DFAGCSLASDAFF 454
WP_041953822 384 DLKVVTKRKPTEEELKNLIFGFKACKTVCSNGIVIVKNNATIGIGQGEVRRSWAVEEGLERAKE---NLKDAVLASDAFF 460
WP_128425349 384 EIPSVTKRFPDDAEIEDLLFAWKVAKHISSNGVVLAKNKMTVGIGLGEVNRFWAVEEAIKRSGD---RAPGSVLASDGFF 460
WP_075573424 383 KLTVMSKVQPTDSELEDIKFALKAVKFAKSNAVVLAKDGATVGIGLGNVNRFFAVEAALKQAGD---KANGAVLASDGFF 459
WP_126439423 378 KLDFVSNRKPSEKELEELKFAFTCCKTSFSNSVVIAKDGGTLAIGQGETKRSWAVEEAIERAGE---KIKGAVLASDGFF 454
3ZZM_A       474 PFPDGLETLAAAGVTAVVHPGGSVRDEEVTEAAAKAGVTLYLTGARHFAH 523
WP_012291022 452 PFSDCVEFAHKLGVKAIIQPGGSIKDQDSIDKCNEYGISMVFTKNRHFKH 501
WP_012463463 461 PFPDGLELAASAGATVVIQPGGSVRDKEVIEAANKHNMAMIFTHLRHFLH 510
WP_015778038 452 PFSDTVELAHEMGISSIIQPGGSIRDEDSIDKCNEYGMSMVFSKSRHFKH 501
WP_014261817 458 PFSDCVELAKEMGVTAIIQPGGSIRDQDSIDKCNEFNMSMVFTGIRHFKH 507
WP_013360561 455 PFDDCVTLSAEHGIAAIMQPGGAGRDQDSIDACNKSGIAMVFTGTRHFKH 504
WP_041953822 461 -FEDTVELLKENGIKAVIQPGGSIKDENVIKLCDEYGIAMVFTSTRHFRH 509
WP_128425349 461 PFRDSLKALAAAGVTAVIQPGGSVKDEEVIEEADENGIAMLFTGIRHFRH 510
WP_075573424 460 PFDDCIRLLAKHGVKAIVEPGGSIKDKDTINAADELELALLFSGKRHFKH 509
WP_126439423 455 -FRDTIELLDKAGIEVIVQPGGSVKDQEVIDYANENNICLVFTNMRHFRH 503
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