Conserved Protein Domain Family
HK_WalK
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NF033092: HK_WalK 
cell wall metabolism sensor histidine kinase WalK
This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Links
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Statistics
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PSSM-Id: 467964
Aligned: 97 rows
Threshold Bit Score: 812.831
Created: 24-Apr-2023
Updated: 3-May-2023
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_010279108   6 FFRTIQMKLIVIYVLLILFAMQLIGIYFIKAMETSFMNNFSESLNNQALYLADLVRPVLLDNqegriGLeEGNPTTDALN 85  Paenibacillus s...
WP_009167285   7 FFKSIHFKIALVFVLMMLLTLETVGAVFVRQLEYQNLSTFKYSIQLK-PYVNSSLKRELARK--------DHFKANKQIQ 77  Fructilactobaci...
WP_029237457  10 FFSSIHFKIALVFTLTLLVTLELVGAFFVKRLEQQNLASFRTQIALP-AYVNDSLTQQLTSS--------DQTKVNADIH 80  Weissella
WP_036066468   7 FFQSIRFRIALVFVLLMIIALELLGAFFVRQMEQQNLATFQQQITLP-KYLTDQITTALRDK--------DTESGNHQIQ 77  Leuconostoc
WP_040176538   7 FFKSIRFRIALVFVLLMIIALELLGAFFVRQIERQNLTTFQQQIALP-KYVTDQITTALKKK--------DSNEGNHEIQ 77  Leuconostoc cit...
WP_013641359  11 TFNSINMKLAIVFMLMLLATIEVIGAYFTRQLEQTSIENFQSSIQIQ-TVVSNQLANQLTS---------DSKNANDRLN 80  Lactobacillus a...
WP_035506801   4 PFTSINAKIAIIFMLLLLATIEIVGAYFTRQLEQNSIESFETSIQIP-NLISNQIATQLNKN--------NAKKANKQLN 74  Lactobacillus i...
WP_025729727   7 IFKSIQFKIPILFILMLLLSLQLISANFIRQLESQTIDNFESQLELHYDFLKTNVAQVLSSA-----Q--TVEQKETAIY 79  Atopobacter phocae
WP_048783712   7 FFRSIQFKIPMLFILLLVISLQLIVANFLTQLESQMISNFQEQIQLQVGFLKNNVQPILAKDa-------TDEAKMSEIS 79  Streptococcus s...
WP_067979397  13 KMKSIHFKIPFVFFMLLLLSLQLIGAYFIQQLEAEMLASFDEQVQVQTNYLMDAIQPILEND-----NL-SEVERNQQLN 86  Aerococcus urin...

WP_010279108  86 ETVNNWY---KVSnvDIQIIDSTGTIISASEQYPRSIIGQKNTQQVVSRALqnIKDKDNERVLTD--VDGKRKKVMAMPV 160 Paenibacillus s...
WP_009167285  78 TILQDIDv-sNVD--EITVVDSRGNIRGTNQTSQQSLVGQKNTDSDIKNSL--YSGKTIEKNTAR---GNNRYYTLVTPL 149 Fructilactobaci...
WP_029237457  81 TILTSVNn-aSIS--EITVVDSSGIVRGTSDINNQDEVGQKTTDANVKAAL--AGG-KYTKNPVEq-RSGTRYQVMVKPL 153 Weissella
WP_036066468  78 DVLSGLNn-tNIQ--EAQVIDKTGTIRGTISVSGQQTIGQKTTDINAQKAL--AGDQSYLQTRTIn-EGGDRKELMTTPL 151 Leuconostoc
WP_040176538  78 DILSSLNn-tNLQ--EAQVIDKTGTIRGTLSVSGQQTIGQKTTDLNAQKAI--AGEQSFLKSRTVn-ENNERKELLTTTL 151 Leuconostoc cit...
WP_013641359  81 QIVNDYNn-dAIS--EIIVVDNKDTIRAVSNLNDKSKIGQRINNTDVKRVI--STGHQINKVI----DDHGNYMIQISPL 151 Lactobacillus a...
WP_035506801  75 RIVSNYSn-dAIN--DITVVDSKSVIRSVSNVNDQGTIGQRATNSDIKKVL--TSGRQISKII----NDNGKYMIQISPL 145 Lactobacillus i...
WP_025729727  80 QLLQDASs-rGNV--EIRIVDRQGYIIGTNDQTKQSLVGTKATDIRLEKLT--LKSRSDAIQYVDq-ETNERQMRIIGPA 153 Atopobacter phocae
WP_048783712  80 QLLQDYPtgnSIV--EIRIMDMQGYILGTTNQTQQSVVGTRSTEADVQQVV-----VSNTVQSYNftEGETRYWKYVSPI 152 Streptococcus s...
WP_067979397  87 ETIRRFNn-aILN--EIQILDEDGFLMATGNPTMLSAIGRRSTSPEVEQAL--LSGGTQEKVYFDp-NQNIRAKTFITPV 160 Aerococcus urin...

WP_010279108 161 Ts----EN---RVIGAVYIVSSMEEIYSTINRVNRIFLSGILIALALTALLGVILAHTITSPIKEITRQVTSVAKGDFDR 233 Paenibacillus s...
WP_009167285 150 In---sAKnqnNIEGAVYIRANLSQVYHNINNITLIYLFAAVLSIILGLILTLIISRAITRPIEELKQQTEQIARGDYSG 226 Fructilactobaci...
WP_029237457 154 Vss--sAGe-sNIVGVVEVRASLETVYDNLNHISLIYFSASLLAVMLGVVMAVIISRSLTKPIAEINDRTTRIAQGDYSG 230 Weissella
WP_036066468 152 Gv---tNGrlkDVPGVIVVKASLSPVYKNINNVMKLFIIAGLVALVASIALALFLARTLTRPIEQINEQTTKIADGDYSM 228 Leuconostoc
WP_040176538 152 Gs---nNGrgkDIVGVLVVKASLAPVYKNIDSVMRLFVIAGILALMVSIALALFLARTLTRPIEQIDEQTTKIANGDYSM 228 Leuconostoc cit...
WP_013641359 152 Ts---gNGs-nNNVGAIYVKASMQDVFNNLRQISLTFLIASLIAALLGAFLALVISRAITQPIEEMQKQALHIADGDYSS 227 Lactobacillus a...
WP_035506801 146 Nv---gNGp-nTIVGVIVVKAGMQSVFNNIHRVSFLFLTASLVAATLGAGVALVIARAITKPIEEMKDQALRISNGDYSG 221 Lactobacillus i...
WP_025729727 154 Gvd--eNQ---NPLSYIVVDSNIEGQYRQVRNIAVIFFNSSLIAIILTIVIAVLISRGITRPITEMVEQTEKISEGNYSG 228 Atopobacter phocae
WP_048783712 153 DpvstaSG---NPVGIISVTSNIESRYTQVKDIGVIFISSSIFVIILAIVITVMISQGITRPIAEMKQQTEQIAEGNYTG 229 Streptococcus s...
WP_067979397 161 Tsr-qsSG---ENIGLMVVDVNLETVYSQVQNIVTIFVTSSAVSLAFATVLSILVSTGITRPLQEMRDQAEKIAEGNYTG 236 Aerococcus urin...

WP_010279108 234 QVKVWGHDEIGQLSQAFNDMTDRLKEALSVNEEEKEKLASVLTNMSDGVIATDDTDRVIVINRRAREMLQLQ-DKPADGK 312 Paenibacillus s...
WP_009167285 227 HVQVYGNDELGQLAHAVNNLSVQVEESQESTEAERRRLDSVLDNMTDGVVATDRRGIVTIVNDETLELLNIG-RDDVVGQ 305 Fructilactobaci...
WP_029237457 231 GILVRSNDEIGQLAENVNALAVRIEETTNSTEFERRRLDSVLEHMTDGVIATDRRGSINIINTAALQMTGIDdSTVAMGQ 310 Weissella
WP_036066468 229 VNHIYGSDELSQLAMSVNELSMRIEESTETVNAERNRLDSVLTHMADGVLAANRRGEVTIINQAAADFVGVD-REEALGK 307 Leuconostoc
WP_040176538 229 VNHIYGSDELGHLAQSVNELSTRVEESTETVNAERNRLDSALTHMADGVLAANRRGEVTIINQAAADFVGVD-RDAAIGQ 307 Leuconostoc cit...
WP_013641359 228 QVKIYSNDELGQLGRAFNTLSVRIERSQEESDSERRRLDSVLSHMSDGVLATDRHGNVSVVNQMALNFLNVK-EEDVINK 306 Lactobacillus a...
WP_035506801 222 HVKVYANDEMGELARAFNILSVRIERSQEVSDSERRRLDNVLMHMTDGVIATDRHGNITIINETALNFLDKT-ENEVKGE 300 Lactobacillus i...
WP_025729727 229 SVHIYGEDEIGLLGRAINMLSVRIRDAQEASEAERQRLDSVLHHMSDGVIATDRRGKIVIVNEAALDLLNLN-ESDAFGQ 307 Atopobacter phocae
WP_048783712 230 EVMIYGDDELGQLGQAINDLSVKIKEAQEGTEAERQRLDSVLRHMSDGVIATDRRGRIVIINAAALDILNLR-SERIVGT 308 Streptococcus s...
WP_067979397 237 EVVVHAKDEIGELAETINYLSVRVKEAQETTESERKRLDSVLKHMTDGVIATDRRGKVIIINNRALEFLDMV-QEEAIGQ 315 Aerococcus urin...

WP_010279108 313 SLFELLGLPKRLALPESRTEEINKLIEIrppD-AEEGRKVRVTFTPIHRREVGTTGSIVVLQDVTEQEEIEQSRREFVAN 391 Paenibacillus s...
WP_009167285 306 PLLKILKLDQKYGLKDLIERPVQEFLDFs--T-PERKLILSARFSLLQRKSGFINGIVCVFHDVTAQQKIDSDRRQFVSN 382 Fructilactobaci...
WP_029237457 311 SILEVLQISDRYNLRELLDNQEELLLDFs--T-DERQLIIRAYFSLIQRASGFISGLVIVLHDVTEQQRIELERRQFVSN 387 Weissella
WP_036066468 308 NVIDLLHLKNKRTLREMLENLDDFRVDLs--D-DSKDLLVQAYVSLIKRQSGFISGLVVVLHNITEQQRIDSERRMFVSN 384 Leuconostoc
WP_040176538 308 NVIELLQLKGKRTLRDMLENLDDFRVDLs--D-DSKDLLVQAYVSLIKRQSGFISGLVVVLHNITEQQRIDAERRMFVSN 384 Leuconostoc cit...
WP_013641359 307 PIAEVLGLKDT-SSQDLISSQKEIVVTId-pN-TRDEMILHASFSLIKRVTGFVSGSVCVLHDVTEQQKNEDSQKQFVSN 383 Lactobacillus a...
WP_035506801 301 PITQLLGLK-EVTIQDLMSTQQELIVTAn--AnTHDELILHADFSLIQRVTGFVSGLICVLHDITEQQKNENEQRQFVSN 377 Lactobacillus i...
WP_025729727 308 DILSVLRLPKKTTFRSLFTKQDQQIISY-------DSSILKCDFSVIQRETGFISGIVCVLSDITEQQKIEAERRNFVSN 380 Atopobacter phocae
WP_048783712 309 PLLDVLRLDRTVTFRDLLESQEERMITFe--E-DGEDTIVQCEFSVIQRESGFISGLVCVLTDVTEQEKIDRERRNFVSN 385 Streptococcus s...
WP_067979397 316 AVIEILNLKDRYTNRDLFDLPEAIYLNId--QvDEGESIIKAEVSAIQRESGFVSGLVVVLTDVTEHEKIEQDRRLFVSN 393 Aerococcus urin...

WP_010279108 392 VSHELRTPLTTIKSYLEALGDGALEDKQLAKRFVGVTRNEAERMIRLVTDLLHLSRLDSKQAMLNKEKVEVSEMLDEVAD 471 Paenibacillus s...
WP_009167285 383 VSHELRTPLTSVHSYLEALLDGAWQDHTLAPKFLHVAQDETNRMIRMINDLLTLSRMDSGTQQYNLELVNVNKLFNYILD 462 Fructilactobaci...
WP_029237457 388 VSHELRTPLTSVKSYVDALQEGAIDDPEVARNFLAVAQDETTRMIHMINDLLELSRMDSGTMKLETEYVNVGELFNYILN 467 Weissella
WP_036066468 385 VSHELRTPLTSVRSYVDALAEGAINDPDMAQNFLGVVQDETQRMIRMINDLLELSRLDQGTMDVKLEVINLNSLFNFVLN 464 Leuconostoc
WP_040176538 385 VSHELRTPLTSVRSYVDALAEGAINDPEMAHNFLGVVQNETQRMIRMINDLLELSRLDQGTMAVKLEVINLNSLFNFVLN 464 Leuconostoc cit...
WP_013641359 384 VSHELRTPLTSLQAYIEALNEGAWKDPNIAPKFLEVTQQETSRMIRMINDLLSLSRMDRGVSKMDLEFVNLNDFVNHILN 463 Lactobacillus a...
WP_035506801 378 VSHELRTPLTSLRAYVEALNDGAWKNENIAPQFLGVIQNETERMIRMINDLLNLSRMDRGVVKMDLEWVNLNDFLSHILN 457 Lactobacillus i...
WP_025729727 381 VSHELRTPLTSIRSYTEALSDGAWKDEEVAPEFLDVIQTEANRMIRMITDLLNLSRMDQKRMHLEKELTNMNDLFNHVLN 460 Atopobacter phocae
WP_048783712 386 VSHELRTPLTSIKSYTEALVDGAWENKEIAPEFLHVIETETDRMMRMITDLLNLSRMDQNRLELDKEFVNMNELVKHIAN 465 Streptococcus s...
WP_067979397 394 VSHELRTPLTSVRSYSEALMEGAMSDPELSKSFLQVIQTETDRMIRMITNLLNLSRMDSDQLELNVEFVLFNDLINHILD 473 Aerococcus urin...

WP_010279108 472 RFSFQLQQ---------RSIAIEIKIGEGTSPIQLDRDKIDQVLDNLVSNSIKYTPDGGKIGITAEknEVSHSLDITVED 542 Paenibacillus s...
WP_009167285 463 RFDMIVKNet-----ttKKYLIKRDFTKQDLWAEVDTDRFTQVIDNIINNAVKYSPDGGTITCRLY--ENHNQIVLSISD 535 Fructilactobaci...
WP_029237457 468 RFDMIIANddk----peKYYTIKREIPKVQIWVELDTSKFTQVIDNIMNNAIKYSPDGGVVTARMI--DNQKEVVLSITD 541 Weissella
WP_036066468 465 RFDMILENdakndespsKRYNILREFTKEDVWVEVDPDKFTQVLDNIMNNAVKYSPDGGTITARLI--KTKTRAILSISD 542 Leuconostoc
WP_040176538 465 RFDMIIENdakntetpnKNYSIQREFTSEDVWVEVDPDKFTQVLDNIMNNAVKYSPDGGVITARLI--KTKTRAILSISD 542 Leuconostoc cit...
WP_013641359 464 RFDMIVKTdknn--dkkKKYTIKRELGNQALWVEIDTDKMMQVIDNIMNNAIKYSPDGGVITVRLT--QNKNHVILSISD 539 Lactobacillus a...
WP_035506801 458 RFDMMLKNdg------vKKYKIRRIFPHQALWVEIDTDKMMQVIDNIMNNAIKYSPDGGLITIRLL--QTHKHVILSVSD 529 Lactobacillus i...
WP_025729727 461 RFDHILKQdey----keKNYQIEREVTPTDIWVEIDQDKMTQVLDNIMNNAIKYSPNGGKITAHLE--ASNDRILIFIKD 534 Atopobacter phocae
WP_048783712 466 RFDMVLSSdqy----reKNYRILTDITQRDLWVEIDQDKITQVLDNIINNAIKYSPDGGRIIIRLM--ETHTDLIVSVSD 539 Streptococcus s...
WP_067979397 474 RFDFMLKSedy----qdTNIRIVREFTDETVWVEIDTDRITQVVDNIMNNAIKYSPDGGDIYVRLM--TTHNEVVLSIQD 547 Aerococcus urin...

WP_010279108 543 NGIGIPKKDIDRIFERFYRVDKARSRNMGGTGLGLSIAREIIKAHGGSIRLDSEYNHGTQVTFSLPY 609 Paenibacillus senegalensis
WP_009167285 536 QGLGMPQAAIKHIFDRFYRVDKARARAQGGSGLGLAISKEIMESFGGDIRVTSQEGRGSTFYISLPF 602 Fructilactobacillus florum
WP_029237457 542 QGLGIPKKDLGHIFDRFFRVDKARSRAQGGTGLGLAISKEIIERFGGRIWVESAEGQGSTFSISLPY 608 Weissella
WP_036066468 543 QGLGIPRKDLDNIFNRFFRVDKSRSRAQGGTGLGLAISKEVVEKFNGRIWVDSVENKGSTFYISLAY 609 Leuconostoc
WP_040176538 543 QGLGIPKKDLNNIFNRFFRVDKSRSRAQGGTGLGLAISKEVVEKFNGRIWVDSVENQGSTFYISLAY 609 Leuconostoc citreum
WP_013641359 540 QGLGIPRKDLGKIFDRFYRVDKARSRAQGGTGLGLAIAKEIVEAHHGRIWADSSEGKGSTFYISLPY 606 Lactobacillus amylovorus
WP_035506801 530 QGLGIPRKDLSRIFDRFYRVDKARSRKQGGTGLGLAISKEIVEAHHGKIWADSSEGNGSTFYISIPY 596 Lactobacillus iners
WP_025729727 535 EGMGIPRRALPKIFNRFYRVDKARSRQMGGTGLGLAISKEVIEMSGGKIWVESVENRGSIFYIELPY 601 Atopobacter phocae
WP_048783712 540 EGLGIPRKDIPHLFDRFYRVDKARSRAMGGSGLGLAIAKEVVQLHGGKIWVNSIENKGSTFFVSLPY 606 Streptococcus sp. 263_SSPC
WP_067979397 548 QGLGLPQKAIPHVFERFYRVDKARSRAQGGTGLGLAIAKEVVELHHGRIWVNSIEDKGSTFFIALPY 614 Aerococcus urinaehominis
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