2A1F,2JJX,2VA1,1YBD,4A7W


Conserved Protein Domain Family
pyrH_bact

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TIGR02075: pyrH_bact 
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uridylate kinase
This protein, also called UMP kinase, converts UMP to UDP by adding a phosphate from ATP. It is the first step in pyrimidine biosynthesis. GTP is an allosteric activator. In a large fraction of all bacterial genomes, the gene tends to be located immediately downstream of elongation factor Ts and upstream of ribosome recycling factor. A related protein family, believed to be equivalent in function and found in the archaea and in spirochetes, is described by a separate model, TIGR02076. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]
Statistics
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PSSM-Id: 213681
Aligned: 20 rows
Threshold Bit Score: 281.436
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2A1F_A     8 YKRILLKLSGEALQG-EDGLGIDPAILDRMAVEIKELVEMGVEVSVVLGGGNLFRGAK-LAKAGMNRVVGDHMGMLATVM 85  Haemophilus influenzae
Q99UL3     7 YKRVVLKLSGEALAG-EKGFGINPVIIKSVAEQVAEVAKMDCEIAVIVGGGNIWRGKT-GSDLGMDRGTADYMGMLATVM 84  Staphylococcus aure...
Q9PPX6     3 KQRIVIKISGACLKQnDSS-IIDFIKINDLAEQIEKISKK-YIVSIVLGGGNIWRGSI-AKELDMDRNLADNMGMMATII 79  Ureaplasma parvum s...
P47672     9 RQRIIIKLSGAGLTKeNSQ-PFSNDFFETIINQLKVLKES-YQVGIVIGGGNIIRGNN-CQEFNIAEYHGHQLGIIATVV 85  Mycoplasma genitali...
AAP56439   3 KPNIIIKISGASLQDkNSNDCYSYQRINSLADQLKSLAKK-YNIGLIVGGGNIFRGKL-AKDFGVEINKADYIGMLATVI 80  Mycoplasma gallisep...
Q9Z7K7     5 TRRVLFKISGEALSK-DSSNRIDEMRLSRLVSELRAVRNNDIEIALVIGGGNILRGLAeQKELQINRVSADQMGMLATLI 83  Chlamydia pneumoniae
BAC24536   9 NKKILLKLSGECLKK-GKKNLVDFDILNKITNEIKNLFNLGIQIGIVIGGGNLFRGSQ-LKIHGIKRNIGDHIGMMSTLI 86  Wigglesworthia glos...
AAP08714   4 YKRVLIKLSGGALAD-QTGNSFNSKRLEHIANEILSIVDLGIEVSIVIGGGNIFRGHL-AEEWGIDRVEADNIGTLGTII 81  Bacillus cereus ATC...
2JJX_A    12 YKRVLIKLSGGALAD-QTGNSFNSKRLEHIANEILSIVDLGIEVSIVIGGGNIFRGHL-AEEWGIDRVEADNIGTLGTII 89  Bacillus anthracis ...
2VA1_A    24 KQRIVIKISGACLKQ-NDSSIIDFIKINDLAEQIEKISKK-YIVSIVLGGGNIWRGSI-AKELDMDRNLADNMGMMATII 100 Ureaplasma parvum
2A1F_A    86 NGLAMRDSLF-RADVNAKLMS--AFQLN-GICDTYNWSEAIKMLREKRVVIFSAGTGNPFFTTDSTACLRGIEIEADVVL 161 Haemophilus influenzae
Q99UL3    85 NALALQDSLE-QLDCDTRVLT--SIEMK-QVAEPYIRRRAIRHLEKKRVVIFAAGIGNPYFSTDTTAALRAAEVEADVIL 160 Staphylococcus aure...
Q9PPX6    80 NGLALENALN-HLNVNTIVLS--AIKCDkLVHESS-ANNIKKAIEKEQVMIFVAGTGFPYFTTDSCAAIRAAETESSIIL 155 Ureaplasma parvum s...
P47672    86 NGYFLKAKLD-AHNLKSALLS--AISCPsLAVQILSQQTIDKAFEENDFVIFSGGTGNPYFSTDTALALRAVQTKAVAIL 162 Mycoplasma genitali...
AAP56439  81 NSTLLESKLQ-SLGLKTKVLS--ALEVKgLTNEIN-PKSLAEVFSDCQIAFFSGGTGNSHFTTDTATVLRAIQINAQLVL 156 Mycoplasma gallisep...
Q9Z7K7    84 NGMAVADALK-AEDIPCLLTS--TLSCP-QLADLYTPQKSIEALDQGKILICTTGAGSPYLTTDTGAALRACELNVDVLI 159 Chlamydia pneumoniae
BAC24536  87 NGLFIYNHFE-RLNIKSQLISpfPFNIN-GICESYNIFRINKILKK-KIVIFCFGIGHTLFTTDSAACLKAIEIDANLLL 163 Wigglesworthia glos...
AAP08714  82 NSLMLRGVLTsKTNREVRVMT--SIPFN-AVAEPYIRLRAVHHLDNGYIVIFGGGNGQPFVTTDYPSVQRAIEMNSDAIL 158 Bacillus cereus ATC...
2JJX_A    90 NSLMLRGVLTsKTNKEVRVMT--SIPFN-AVAEPYIRLRAVHHLDNGYIVIFGGGNGQPFVTTDYPSVQRAIEMNSDAIL 166 Bacillus anthracis ...
2VA1_A   101 NGLALENALN-HLNVNTIVLS--AIKCD-KLVHESSANNIKKAIEKEQVMIFVAGTGFPYFTTDSCAAIRAAETESSIIL 176 Ureaplasma parvum
2A1F_A   162 KATK-VDGVYDCDPAKNPDAKLYKNLSYAEVIDKELKVMDLSAFTLARDHGMPIRVFNMGKPGALRQVVTGTEEGTTIC 239 Haemophilus influenzae
Q99UL3   161 MGKNnVDGVYSADPKVNKDAVKYEHLTHIQMLQEGLQVMDSTASSFCMDNNIPLTVFSIMEEGNIKRAVMGEKIGTLIT 239 Staphylococcus aureu...
Q9PPX6   156 MGKNgVDGVYDSDPKINPNAQFYEHITFNMALTQNLKVMDATALALCQENNINLLVFNIDKPNAIVDVLEKKNKYTIVS 234 Ureaplasma parvum se...
P47672   163 IGKNgVDGVYTADPKKDKNATFLPTLNYDHAIKNDLKIMDITAFTMCKENNLKIIIFNINAENALLDALNKKGRFTIIE 241 Mycoplasma genitaliu...
AAP56439 157 IGKDgVDGVYTDDPKKNKKAKFIEQITYQQALNDQLRVMDLTAFSLAKDHNLKLLIFNIEAEQSIIKTIENKNKHTKIT 235 Mycoplasma gallisept...
Q9Z7K7   160 KATMhVDGVYDKDPRLFPDAVKYDFVSYKDFLSNQLGVMDASAISLCMDSHIPIRVFSFLQHS-LEKALFDPTIGTLVS 237 Chlamydia pneumoniae
BAC24536 164 KITN-VDGVFSEDPAKNPNATLYKKISYDYALKKNLKIMDFTAFAIAKEHKLPIRIFNIKEPNSLYKAIIGKDIGTLIN 241 Wigglesworthia gloss...
AAP08714 159 VAKQgVDGVFTSDPKHNKSAKMYSKLNYNDVVRQNIQVMDQAALLLARDYNLPAHVFNFDEPGVMKKICLGEHVGTLIN 237 Bacillus cereus ATCC...
2JJX_A   167 VAKQgVDGVFTSDPKHNKSAKMYRKLNYNDVVRQNIQVMDQAALLLARDYNLPAHVFNFDEPGVMRRICLGEHVGTLIN 245 Bacillus anthracis s...
2VA1_A   177 MGKNgVDGVYDSDPKINPNAQFYEHITFNMALTQNLKVMDATALALCQENNINLLVFNIDKPNAIVDVLEKKNKYTIVS 255 Ureaplasma parvum
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