Conserved Protein Domain Family
Esterase_713_like-3

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cd12810: Esterase_713_like-3 
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds
This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.
Statistics
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PSSM-Id: 214009
Aligned: 44 rows
Threshold Bit Score: 315.312
Created: 21-Aug-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalytic site
Feature 1:catalytic site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
EFS25460      33 PIMIQEQGSFSVGGTVISTSgtyntn---tplkpdGQTLHGDHAYVSYQIPvNAHKNPLVFLHGagQSAQTWETTPDGRE 109 Fusobacterium u...
ACK50930      55 PLVIARQGSFMAGGSVLQTPgvfdpt----vtggpGQTLHGDHAYAQFQIPqNPRSLPLVFWPGggQSGKSFETTPDGRE 130 Methylocella si...
AEX00103      50 KVVLAEQGSFYIGGRTVTGPgkfdpskpvipysneGATFYINQMYVNFQAPvRPRGLPLVFWHGggLTGHIWESTPDGRP 129 metsulfuron-met...
ACK50735      49 PIVLKTQGSFMPGGAVVTNPgtfdpi----altpdGQTIHGDHAYAQYQVPlNARRYPLVMWHGggQFTKTWETTPDGRD 124 Methylocella si...
EFL82893      34 PLVLNQLGGLAFGGTVSHKPn--------------GLTFHGDHGYAQYVIPvNAKNYPIILWHGigQSGRSFETTPDGRE 99  Burkholderiales...
BAK68166      37 PIMIARQGSFAAGGTSIGDS---------------ANSSVCDHGYVEYQIPpGPRTVGLFLWHS--SSTHVWQNRWDGGE 99  Sphingobium sp....
BAK66202      32 PMLIARQGAFEAGGTLLREG---------------DRTLSCDHGHVEYQIPvNARRTSLLLWHS--SSVKVWQNRWDGGE 94  Sphingobium sp....
ACK52280      51 PIVLKRMGSFMVGGAVVTTPgdftpm----sptpaGQTLSGDHAYVQFEIPrGANRNSMLMWGS--LVKTPWETTPDGRD 124 Methylocella si...
EAQ84074      35 PIMLRQSGGFTIGGKIIPNPln------------pNMTLSCDHGYMEYFTPwRPRKTSIVMWHS--SSTQSFQNRWDGGE 100 Chaetomium glob...
YP_002362159  44 PIVLDSSGGFVIGGKVVPINpa-----------tpNRTLSCDHGYVEYFMPaTPRRTSLVMWHS--SSTQVWQNRWDGGE 110 Methylocella si...
Feature 1                                                                                        
EFS25460     110 GFDNIFLRRGFGIYLVDQPRRGRAGRSTvegtv-----snatdDQFWFDTFRIGEYPryf---------dnvQFAKGEKA 175 Fusobacterium u...
ACK50930     131 GYQSIFLRRNFGVYIIDQPRRARAGNTTvgttl-----tptpgEQDLFVAWRLGVWPkffpns----qfpqaKQGINSPA 201 Methylocella si...
AEX00103     130 GFQTLFVQDRHTVYTIDQPGRGRGNIPTfngpfgq-leeesivNTVTGNSSKEGAWVrdrlgpapgqffensQFPRGYED 208 metsulfuron-met...
ACK50735     125 GFQNIFLRQRYTTYLIDQPRRGNAGRATtngtiaavpgpgptgEQGIFIRFRLGLWPnyf---------pnvQFSHDPEA 195 Methylocella si...
EFL82893     100 GFQTLLPRDGWATYIVDQPRRGRAGRTEateakse--iptvtsEAGVWNAFRLGRWVppkpat----anpnmQMLLDGET 173 Burkholderiales...
BAK68166     100 GFQSIFLRKGFPVYLWDGPRVGRANLPCeevkvtaplgqdqrsFTSWRFGPAFGTWHpg------------vQFPVDDAE 167 Sphingobium sp....
BAK66202      95 GFQSIFLRRRYPVYLWDGPRVGRGNWGCeryvye---prtgrdQQNFVSWRLGSRYPdwfp--------gvqFPTGDAEA 163 Sphingobium sp....
ACK52280     125 GFEQIFLRQNWSVFLADRPRMGEAARTTvgati-----tptagEQGFFIQFRLGLCAagsppvq-cnlyrgsKFPPGPTA 198 Methylocella si...
EAQ84074     101 GFKDKFLRRDYPVFLWDGPRVGRANWACnat----------yyAPDYRDQGNFAAWNfgpryp---ewwpdvQFPTENEY 167 Chaetomium glob...
YP_002362159 111 GYKDMMLRREYPVFLWDGPRVGRANWSCesv----------tyTPSSRDQGNFTAWVfgpa-------ipvgQVPTAAEW 173 Methylocella si...
Feature 1                                                               #                        
EFS25460     176 LENFFRqm--------------tPNTAAYDEGVISDAMAALFek--iGNGVLVTHSQ-GGGPGWWTAi--kNSNVKGIIA 236 Fusobacterium u...
ACK50930     202 LNQFFRwa--------------tPDTGPQDRNVITDGVAALLee--iGPCILIIHSA-SGVLGWLTAm--kSPNVKAIYA 262 Methylocella si...
AEX00103     209 NYFKEM-----------------GFSPSISSDEIVDAVVKLVth--iGPCVLVTHSA-SGVLGMRVAt--hAKNVRGIVA 266 metsulfuron-met...
ACK50735     196 LNQWWRqq--------------tPDTATTTNDQATDPVAAMFnq--iGPAVLLTHSA-GGVLGWITAt--kSSNVRGVYA 256 Methylocella si...
EFL82893     174 INQFMRmqtp---------dtgaLPPTEAYGWKLGEAMRDLLkr--tGPAVVGTHSY-AGQIGWYGAmk-sPDLVKAVVA 240 Burkholderiales...
BAK68166     168 AWNQAIrgr------------yeEFDTVADIRRQAKAAAAALer--tGPVVLVTNSA-AGVRAMLTAi--eSDNVKAIVA 230 Sphingobium sp....
BAK66202     164 LDQAMRar-------------yfEFDTVANARLEAAAAAKAIdr--iGPSVLVTNSA-GGLRALLTAl--eSDNVKAIVA 225 Sphingobium sp....
ACK52280     199 LDQFNRwl-------------tqSVGPGDPALTLNDLLAIVDk---iGPTVLVTHSA-SSLSGYQAAm--qNPNIKAIIG 259 Methylocella si...
EAQ84074     168 AWQQATssr------------yvEYDTAANVHLETDAAAIAAdsgklGKSIVYLGNSaSGLRAQMTAvksnTTNIKGIVC 235 Chaetomium glob...
YP_002362159 174 WPGVQFpttnpqawldatasrydEFDIARNIEIETDAAAVAAdsgrlGNSIVYLTNSaGGLRAMRTTtksqKTNIKGIVT 253 Methylocella si...
Feature 1         #                                                                              
EFS25460     237 YEPGSGFVFPegevpeplqti-spfgalsagsIPMEEFIKLTKIPIVIYYGDNIAPapske---wtkdHWRVRYEMAKLW 312 Fusobacterium u...
ACK50930     263 YEPGGGNPDYafpsnelppalgsgptllspnpVPLSDFLKLTKIPIRMQFGDGLSAqsspy---prvqLWLNRFKMAQQM 339 Methylocella si...
AEX00103     267 YEPATSIFPKgkvpeipplad-kksqifppfeIQESYFKKLAKIPIQFVFGDNIPKnpksa--ywfldWWRVTRYAHSLS 343 metsulfuron-met...
ACK50735     257 YEPVTQVFPEgqvpppidsg---plgpitgtpIPLSSFLKLTKIPIEIIWGDNFPItgqppskypdleVWQGRYTMAQKF 333 Methylocella si...
EFL82893     241 YEPGQVVYPEgekvkemnseiplvqqrlnpvrVSKQEFLKLTKMPIFIIFGDNISTksskv---fneeVWRWALFNARQF 317 Burkholderiales...
BAK68166     231 YESVGLVLPAsedkgepa-------gpygpiyVPAEQFRKLARIPIQLVWGDNLSQp----------rGPQMAIPANHRF 293 Sphingobium sp....
BAK66202     226 YENPGYVFPDdeqapegp-------erfgpviVTPEVFERLTRIPIQFVFGDNLDKs----------pSWAEFAETARKF 288 Sphingobium sp....
ACK52280     260 LESTGVPCPSdhpfppvvg----nfgtttctpVDPALFRNLAKIPILMEFGDNIPSgpsny---fgldFWYRMHAIDLEF 332 Methylocella si...
EAQ84074     236 YEGYGYIFPDnagiepgpg-----lnpfgpyvVPLEDFKKLARIPAIQFLWGDHRD------------ESYSFLNQSRQA 298 Chaetomium glob...
YP_002362159 254 YESIGYVFPIgdpesptlctdpgpacafgpigVPLEDFKKLAKLTAIQFVWGDHRP------------ETYSFVIQSRLC 321 Methylocella si...
Feature 1                                  #                        
EFS25460     313 AEAVNRHGGDVKVVHLP-EIGIKGNTHFPFSDLNNIAVADEMSKWLKEKGL 362 Fusobacterium ulcerans ATCC 49185
ACK50930     340 VAAINKHGGNASILHLP-DIGIRGNTHFSFSDANNLQIADIFSQWLAKNRL 389 Methylocella silvestris BL2
AEX00103     344 LEAINKLGGQASLLDLP-TAGLRGNTHFPFTDRNNVQVASLLSDFLGKHGL 393 metsulfuron-methyl degrading bacterium S113
ACK50735     334 VDLVNKYGGHAHMTHLP-DIGIKGNTHFAMSDLNNKQIAGLLGKWLHDNRL 383 Methylocella silvestris BL2
EFL82893     318 VNLINKYGGDAKLIHLP-EIGIKGNTHALFSDLNNKEILKITEEWLAEKGL 367 Burkholderiales bacterium 1_1_47
BAK68166     294 VELIRQHGGNAEVLELA-SAGLKGNTHLPFADLNNVEVATLLMGFLERNGL 343 Sphingobium sp. SYK-6
BAK66202     289 VDIVNARGGRAEILMLP-SAGLKGNTHIPFADLNNVAVADLLSAYLGRHGL 338 Sphingobium sp. SYK-6
ACK52280     333 KKAVNAMGGHVTLLELT-QRGIKGNTHFAFTDVNNVQVAGLIQDYLDAQGL 382 Methylocella silvestris BL2
EAQ84074     299 AALINKYGGNAQVIKLGeDLGWKGTTHIAFADMHNDKAADLLESFLRKNGL 349 Chaetomium globosum CBS 148.51
YP_002362159 322 AKLINKYGGHAEVLKLAeDAGLKGSTHIAFADMDNDKVAALLDKFLKKNKL 372 Methylocella silvestris BL2

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