2RGK


Conserved Protein Domain Family
GlcNAc_2-epim

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pfam07221: GlcNAc_2-epim 
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N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
This family contains a number of eukaryotic and bacterial N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) enzymes (EC:5.3.1.8) approximately 500 residues long. This converts N-acyl-D-glucosamine to N-acyl-D-mannosamine.
Statistics
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PSSM-Id: 399891
Aligned: 14 rows
Threshold Bit Score: 299.698
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2RGK_F        32 G-FG---W-LGNKGQIKEEMG--THLWITARMLHVYSVAAA-MG-RPG-AYS-LVDHGIKAMNGALR--DKKYG---GWY 95  Escherichia coli
2_pfamImport   1 G-FF---D-LDAKGAPLQANDpvRGIHASARMVHCFSIGHL-LG-RPG-CGD-IVDHGMTYLWNNHR--DGEHG---GYF 66 
Q8AAL1        33 GyFS---C-LDREGKVFDTDK---FIWLQGREVWMFSMLYNkVEkRQE-WLD-CAVQGGEFLKKYGH--DGNYN---WYF 98  Bacteroides the...
Q92VN8       397 GgFHealS-FEAAPLIKPKRM--RTM---ARQVYAFSVAKL-RG-WDG-DADgLIGHGIAFMEKGR----TQRG---GWA 460 Sinorhizobium m...
Q89HM2        56 GfID---R-LHRDGTADAAAP--RRVFVQARQIYCYAKAAQ-MGwYPE-GRA-IALKGLEHL--LAR--AKAPDgrpGYV 122 Bradyrhizobium ...
Q9A2E8        38 GfFE---K-IDLDGQAVDGPR--RGRVL-PRQIYAYAIAGD-LG-WRGpWRA-AVEHGLAYFLSAYR----RSD---GQF 100 Caulobacter vib...
1_pfamImport   1 GfYE---R-LSQDAKPIFSDD--RRARVQPRQAYCFAAAGQ-HG-WQGpWKD-ALSHGLSWFEKVYRleNGLYG---NLA 68 
P29954        34 GgFV---EtIDMKGEPTRDDR--RSRVQ-PRQVYCFAAAGR-RG-WDGdWRT-AAEGGLLYFDRVY----GQPG---GFY 97  Sinorhizobium m...
Q88P39        40 G-FG---N-LDANGQLAPGAR--AETINTARMTHCFALAHL-QG-IPG-SLA-YAEHGVAALRGAMQ--DATHG---GWF 103 Pseudomonas put...
Q87ZZ4        40 G-FG---S-LDDYGRLMVGAT--AETMNTARMTHCFAMAHA-QG-IPG-CAA-LVDHGVAALSGPLR--DAEHD---GWF 103 Pseudomonas syr...
2RGK_F        96 ACV--NDEG-V-VDASKQGYQHFFALLGAAS-AVTTGHPEA--RKLL---D----YTIEII------EKYFWSEEEQMCL 155 Escherichia coli
2_pfamImport  67 WQV--NDAG-P-VDATKQGYGHAFVLLAASS-AKTVGHPLA--DQML---A----DITEVL------ETRFWEEKHGAIA 126
Q8AAL1        99 SLD--RSGR-P-LVEPYNIFSYTFATMAFGQlSLATGNQEY--ADIA---K----KTFKIIlskvdnPKSKWNKLHPGTR 165 Bacteroides the...
Q92VN8       461 RVL--QEDG-TiADACEDAYDHACVLLMLAH-AYQAGNPDA--LRLG---Q----ETFAFL------DEHLEDDRLTGFL 521 Sinorhizobium m...
Q89HM2       123 HRL--TPEGaV-MDGRRDAYDHAFILFALAT--VYALDKDAqvRAEI---D----ALLAFL------DGHLRSP-HGGVH 183 Bradyrhizobium ...
Q9A2E8       101 RTLvgPNGE-S-LDDTADLYDQAFALFALAA-VAKALPDRA--DDAR---T----LALVVR------ERLIAERKHPVAG 162 Caulobacter vib...
1_pfamImport  69 --D--QTGR-L-IDPSFDLYNQAFALFAAAQ-A-AASLPER--KDEM---RvralDILAIL------ERDYRHPVAGF-- 127
P29954        98 GALanADGK-L-IDASFDLYNQAFALLAFAH-LAEVLPERG--AEMVgrsD----KLRRQL------EARCKHPLAGF-- 160 Sinorhizobium m...
Q88P39       104 --A--HPGG-H-DDSGKAAYLHAFVALAASS-AVVAGAVDA--NTLL---A----DAIQVI------EAHFWSEDEGALR 161 Pseudomonas put...
Q87ZZ4       104 SAA--PEDG---GKTDKQAYLHAFVALAASS-AVVAGRPGA--QALL---S----DAIQVI------QTHFWSEQEGAMR 162 Pseudomonas syr...
2RGK_F       156 ESWDEAFSKTeeYRGGNAN--MHAVEAFLIVYDVTH--DKK--WLDRAIRVASVIIHDVAR-----NNHYRVNEHFDTQW 224 Escherichia coli
2_pfamImport 127 EEFNRDWSPIdnYRGQNSN--MHLTEALMAAYEATG--DSN--YLTKAERIADLVIRRRAG-----ELDFRVPEHFDENW 195
Q8AAL1       166 NL--KNFALP-----------MILCN--LAL-EIEHllDPG--YLEQTM---ETCIHEVMDvfyrpELGGIIVE------ 218 Bacteroides the...
Q92VN8       522 ETSDG--TEL---RRSNPH--MHLLEAFLAWYAATG--ERG--YLRRAARIIDLFRSHFFD-----TESWTLGEYFDEAW 585 Sinorhizobium m...
Q89HM2       184 EGLPV--SLP---RRQNPH--MHLFEAMIACFDATH--DLS--FQNRAGEFFALFLANLYD-----KQKHVLSEYFEEDW 247 Bradyrhizobium ...
Q9A2E8       163 FHQTNPPSAP-----LQSNphMHLFEAMLAWNEIDK--DPI--WRTLADEIAELALSRFIH-----APSGQIREFFDLDW 228 Caulobacter vib...
1_pfamImport 128 EEENPPRTPL----CSNPH--MHLFEAMLAWEAQDP--QGP--WSALADEIAGLALTRFID-----GNNGGLREFFAHDW 192
P29954       161 EEDDPPRLPL----GSNPH--MHLFEACLASEEVEG--FDRvaWANLADEIAHLAMDRFID-----AESGALREFFDHDW 227 Sinorhizobium m...
Q88P39       162 ETFSRAWQLPeqYRGANSN--MHATEAFLALADVTG--NGL--WLQRALRIAERIIHTHAT-----ANGYRVIEHFDVHW 230 Pseudomonas put...
Q87ZZ4       163 ESFAQDWSHEeaYRGANSN--MHSTEAFLALADVTG--DAQ--WLDRALSIVERVIHQQAG-----ANNFQVIEHFTQGW 231 Pseudomonas syr...
2RGK_F       225 NPLPDYNKDnpaHRFRAFGGTPGHWIEWGRLMLHI-HAa-LearCEQPPAWLlEDAKGLFNATVRDAWAPDGAdGIVYT- 301 Escherichia coli
2_pfamImport 196 TLDKAYRGN---EMFRPSGSTPGHWLEWARLILQL-WV--L---GERQHDWMpVAAKSLFVQSMALGWDREKG-GFFYT- 264
Q8AAL1       219 NVDMDGNLV---DCFEGRQVTPGHAIEAMWFIMDL-Gk------RLNRPKLI-EKAKDVTLTMLDYGWDKQYG-GIYYF- 285 Bacteroides the...
Q92VN8       586 NPAVGPKGQ--------W-TEPGHHFEWASLLVEF-Aa------KSRQTDLI-AFARKLYASAIATGLNRSTG--LAYGa 646 Sinorhizobium m...
Q89HM2       248 SKIEPVSVE------------PGHQAEWVWLLKGF-ERitGcptGQRRAELL---ATALRYRDEATGCLIDEG------- 304 Bradyrhizobium ...
Q9A2E8       229 NPAPGVAGR---------ICEPGHQFEWGWLLMRWgQLa-GradATAAALRMiDDAE-------THGVDLSRGvAINAL- 290 Caulobacter vib...
1_pfamImport 193 TP-----HEgekGRI----MEPGHQFEWAWLLVRW-GS--L----RGNDEAI-TKARRLFEIGEEHGICPRRK---VAI- 251
P29954       228 APFPGEKGR---------IVEPGHLFEWAWLLLRW-Ae------RRGNAQAI-VKARRLFEIGEKDGTCPDRD-VVVMT- 288 Sinorhizobium m...
Q88P39       231 QPLPDYNLEhpaDPFRPYGTTPGHALEWARLLLHL-EAs-LeraGLYAPQWLpDSARALFDTACQQAWNVDGEpGFVYT- 307 Pseudomonas put...
Q87ZZ4       232 QPLPDYNHDnpaDGFRPFGTTPGHAFEWARLVLHL-ETa-RrhaGRSSPDWLlEDARQLFANACRYGWDVDGApGIVYT- 308 Pseudomonas syr...
2RGK_F       302 VDWEGKPVV----RERV--RWPIVEAMGTA---YALYTV-TGD--RQYETWYQTWWEYCIKYLMDY-E-NGSWWQELDAD 367 Escherichia coli
2_pfamImport 265 LDWNDNPDK----RAKL--WWPMCEAAGAA---HFLNENlPAD--AFYEDSYRRIWSTIANNFIDH-E-NGGWHEELTED 331
Q8AAL1       286 MDRNGCPPQqlewDQKL--WWVHIESLISL---LKGYQL-TGD--RKCLEWFEKVHDYTWSHFKDP-E-YPEWYGYLNRR 355 Bacteroides the...
Q92VN8       647 VSRAALPLD----LISR--SWPQAEAVKAA---LALEGT-GGP--DLKPEIEARVGRLFRWH-IDP-ApLGMWIDRVDEK 712 Sinorhizobium m...
Q89HM2       305 -DATGNIRR----STRR--LWPQTE-IAKA---WIAQAE-SGE--AGAADEARAALVRLERHYLSHpV-RGGWYDQFDRD 369 Bradyrhizobium ...
Q9A2E8       291 LDDFSTHDD----GARL---WPQTERIKAA---VLAAEI-TGQ--ARYWDMAAAAAEGLMAYLRTA-I-PGLWRDKYQPD 355 Caulobacter vib...
1_pfamImport 252 MSLYDDFSV----HDGLarLWPQTEWLKAA---VRLASVtSGEerQRYLTSGLRAIGALQPFLDTP-V-KGLWFDKWPAD 322
P29954       289 LFDDFSVADp---TARL---WPQTEWLKAAirfAALTEG-AER--ERYLASAGRAAAALQRFLNVP-V-RGLWRDKQKAD 357 Sinorhizobium m...
Q88P39       308 LDWADRPVV----HARL--HWVHAEACAAA---AALLQR-TGE--AHYEQWYRCCWGFIANHFIDP-I-GGSWHHELDAH 373 Pseudomonas put...
Q87ZZ4       309 LDWGNKPVV----RHRL--HWVHCEAAAAA---AALLQR-TGE--QQYEDWYRCFWEFNETLFIDQ-E-HGSWRHELNEL 374 Pseudomonas syr...
2RGK_F       368 NK-VTTKVWDGKQDIYHLLHC 387 Escherichia coli
2_pfamImport 332 LV-PAHTLFPGKGDIYHALQA 351
Q8AAL1       356 GE-VLLPLKGGKWK-----GC 370 Bacteroides thetaiotaomicron
Q92VN8       713 GSaVATEVPA--SIFYHLVTA 731 Sinorhizobium meliloti
Q89HM2       370 GKsLVDTIPA--SSFYHVLCA 388 Bradyrhizobium japonicum
Q9A2E8       356 ETfIEEPVPA--SSFYHIALA 374 Caulobacter vibrioides
1_pfamImport 323 -R-PMLDEPAPASTFYHIVCA 341
P29954       358 GSfVEEPAPA--STFYHILCA 376 Sinorhizobium meliloti 1021
Q88P39       374 NQ-PAGSLWPGKPDLYHAYQA 393 Pseudomonas putida KT2440
Q87ZZ4       375 NQ-PSADIWPGKPDLYHAYQA 394 Pseudomonas syringae pv. tomato
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