Conserved Protein Domain Family
HAD_SAK_2

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pfam18143: HAD_SAK_2 
HAD domain in Swiss Army Knife RNA repair proteins
Family of HAD domain phophoesterases observed in large eukaryotic proteins with predicted role in RNA repair, the so-called 'Swiss Army Knife' repair proteins. May be involved in phosphate group removal during RNA re-ligation.
Statistics
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PSSM-Id: 436304
Aligned: 84 rows
Threshold Bit Score: 73.1855
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KZX16676            4 IIFLDIDGVLQPTYSENRFDYVDDENIsklyknllkeksidysiydkydvaavyYDWnKeAVSELKRIIETTNAKIVISS 83 
EFG47931           13 TIFLDVDGVLNSFPVKGKRFKKEGRKEvqawn------------------yilhFRP-K-IIKALEKIVKTRDADIVWLS 72 
WP_009377504       19 TVFLDVDGVLNSYPVPQLRLMTEGRKKlqawd------------------felhYRP-A-VIEFFDRLVETHEVDVVWLS 78  Brevibacte...
KZX21565            4 LILLDVDGVLNPSVRSDRGAGGHRLe----------------------------LAP-E-REALVHRLA-AIGS-VVWAT 51 
SeoPNU:A6122_0562   4 LILLDVDGVLNPSVRSDRAAGSHRLe----------------------------LEP-E-REALVARLA-AVGT-IVWAT 51 
WP_056866494        4 LILLDVDGVLNPSVVSDRAAGGHRLv----------------------------LDA-D-RAALVARLA-AAGT-IVWAT 51  Rathayibac...
EFL21366           68 LLFLDIDGVLNPVLPTDGFTAHDILDFt-------------------------vLLS-LtHANWLRELSSTYE--LVWAT 119
WP_014139847        5 LLYLDVDGVLNPVFPHPDDDFDTHTLLgys----------------------vlLSP-R-HGDWLRELADRYE--IVWAT 58  Kitasatospora
Q6QGI2              8 IIFLDIDGVLNSSISHHHAPDDEKIFFgsd----------------------wvFKP---LLKAFQDFIRPSPIMIVGVS 62  Escherichi...
WP_056665997       10 LLFLDLDDVLCLNRPYGGRHLQLTPRPpdly--------------------qriWSV-P-AIEALQQVLREARPQVVLTT 67  Acidovorax...
KZX16676           84 DWRIFGDiQR--LIDLFEIHNlgk--yiIDITPNWDYeesenikkhyeeklinedgsigfitSRELEILEYMRNNn--nE 157
EFG47931           73 TWSALCR-TE--IEPKLKFERsy---piIE-MPDATYnrhag---------------dhtkwWKSLAMKQWLADN----P 126
WP_009377504       79 TWSRRCK-TE--LEPKFGLRNsf---dvIE-MPDDTHnryan---------------dpekwWKARAMEEWLDSH----G 132 Brevibacte...
KZX21565           52 TWPPRLT-SV--LTADLGLPRgtraivfDGGLPHDPRfpg--------------------qtGKLQPVAAWLEAQr--eP 106
SeoPNU:A6122_0562  52 TWPPRLT-SV--LAEDLGLPGgteaivfDGGLPRDPRfpg--------------------qtGKLQPVAAWLESAaergP 108
WP_056866494       52 TWPPELT-SV--LARDLRLPEgteaivfRGGLPRDARfpg--------------------gtGKLQPVALWLDQAratgP 108 Rathayibac...
EFL21366          120 TWEHEAN-RH--IAPLLELPQlpv-vefTGYVPRPDDpklp-----------------vldlFSGRKWAPIL-RYa---a 174
WP_014139847       59 TWEDKAN-LH--IAPLLGLPElpv-vvfSGYVPQPGDprvp-----------------lmelFSATKWAPIL-RHa---q 113 Kitasatospora
Q6QGI2             63 SWFSVRN-EMenVQIMTGLGLid---rfLGTTDFTGGg-----------------------lSRGNSVLRFVEKH----K 111 Escherichi...
WP_056665997       68 SWLSFLDla--aARQLFELTGlaq-lsqA-LHPDGEApql-------------------rgqTRLEAIDAWLRRHa---w 121 Acidovorax...
KZX16676          158 IEEYVAIDD-----------LTIDKILKEHF-VETSP--YLTKEDA 189
EFG47931          127 GKRAVWVDDdlahe--ntreYFEKTYRNRMLlIAPEFkyGLTEEQV 170
WP_009377504      133 HQRAVWIDDdlaapvtrqyfTERYSAQRLKI-IAPDFahGLTKAHL 177 Brevibacterium
KZX21565          107 VDAVVWIDDnlre---davaWAREQPLPFHL-IRPESavGLTDDEV 148
SeoPNU:A6122_0562 109 IDAVVWIDDnlre---daylWAREQSTPFHL-IRPDSaaGLTDDEV 150
WP_056866494      109 IDAVVWIDDnlre---dayaWAREQDTPFHL-VRPESaeGLTADEV 150 Rathayibacter sp. Leaf296
EFL21366          175 GRPFAWVDDvmpe----rlvSRSRLRRDQLL-LPIDPayGLCREHV 215
WP_014139847      114 GRPFAWVDDcipp----rlvRRSVLRADRLL-VPVDPaqGLQREHV 154 Kitasatospora
Q6QGI2            112 LKHWCVLDDag--------aMMYQYPT-----VIVNGrtGINLQDL 144 Escherichia virus T5
WP_056665997      122 TGKYAIIDDllsg----tglRRSRHEKSGRL-VLCEVdvGLSQVHV 162 Acidovorax sp. Leaf160
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