Conserved Protein Domain Family
Tox-HNH-HHH
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pfam15637: Tox-HNH-HHH 
HNH/Endo VII superfamily nuclease toxin with a HHH motif
A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with characteriztic conserved s[GD]xxR and HHH motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion system.
Links
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Statistics
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PSSM-Id: 434827
Aligned: 6 rows
Threshold Bit Score: 171.108
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EIT86176      546 PRLTVEMPYVGKGQKNTNAE-GWLRDKDFYWKEMLKKYPEAFSKSNRQKIELGFSPINNTKFRKHFPQYdlKELYNDTLI 624 
Q82QU7        252 PAEGVDMPWVGRGKGISSSElGYLRDSKYFWPRFQQSYGSAISLANAQLIASGQAPRVDATWIEHFPGH--AAYVNDTLE 329  Streptomyces ...
WP_058346293 4324 PGVEIDMR-LAPANSGLNAA-GFPRNGPWFWREMAKSSPQYFDATNRALIRAGRSPIVNKAWADEFPSH--AGFSGDKLV 4399 Caulobacter v...
EFC67227      162 PRYSIDTTTFESGKPTANGG---LRDNKQFWQKWEKLNPSSISKNNRWRIEHGLSPTIDNVWIKEFPEH--GGYKGEILI 236 
EHQ59284       51 PRLMVEMNYKGKGASGTNSA-GWERNSKKFFKELLKRNPEFWSEKNTSEIRRGRAPEVDEHFVKYFPQY--MDYLEDPLR 127 
GAP40240       32 DDLLVSMRYNGDYHSSSNSQ-GWDRNSSYYFENLLHNHPEYFSKKNMIRINNNQSPKVDSQFVKNFPQY--KGYENELLV 108 

EIT86176      625 HHHIGGGGQAVAVPSKLHPGLGGI-HN 650 
Q82QU7        330 HHHVGQGSRAVPLPSRLHDAYTVF-HP 355  Streptomyces avermitilis
WP_058346293 4400 HHHIDQGPIATPIPEKVHRAWYKAlHP 4426 Caulobacter vibrioides
EFC67227      237 HHHVDQGKYAVPVPASTHVGSGGVwHC 263 
EHQ59284      128 HHHIGEGGQAAALPVTLHPGYGGV-HN 153 
GAP40240      109 HHHIGKDGQAVAIPASIHKGSGEI-HR 134
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